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Wang_QSP_Model.xml
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<?xml version="1.0" encoding="UTF-8"?>
<sbml xmlns="http://www.sbml.org/sbml/level2/version4" level="2" version="4">
<annotation>
<SimBiology xmlns="http://www.mathworks.com">
<Version Major="5" Minor="8" Point="2"/>
</SimBiology>
</annotation>
<model id="mw033a9aa2_7ddc_4742_8342_b2d3564d452f" name="Immune Oncology Model">
<listOfUnitDefinitions>
<unitDefinition id="MWBUILTINPREFIX_milli_MWBUILTINUNIT_liter" name="milliliter">
<listOfUnits>
<unit kind="metre" exponent="3"/>
<unit kind="dimensionless" multiplier="1e-06"/>
</listOfUnits>
</unitDefinition>
<unitDefinition id="MWDERIVEDUNIT_millimeter___3" name="millimeter^3">
<listOfUnits>
<unit kind="metre" exponent="3"/>
<unit kind="dimensionless" multiplier="1e-09"/>
</listOfUnits>
</unitDefinition>
<unitDefinition id="MWDERIVEDUNIT_micrometer___2" name="micrometer^2">
<listOfUnits>
<unit kind="metre" exponent="2"/>
<unit kind="dimensionless" multiplier="1e-12"/>
</listOfUnits>
</unitDefinition>
<unitDefinition id="MWUSERUNIT_cell" name="cell">
<listOfUnits>
<unit kind="mole" exponent="1" multiplier="1.66053872801495e-24"/>
</listOfUnits>
</unitDefinition>
<unitDefinition id="MWBUILTINUNIT_liter" name="liter">
<listOfUnits>
<unit kind="metre" exponent="3"/>
<unit kind="dimensionless" multiplier="0.001"/>
</listOfUnits>
</unitDefinition>
<unitDefinition id="MWBUILTINUNIT_molecule" name="molecule">
<listOfUnits>
<unit kind="mole" exponent="1" multiplier="1.66053872801495e-24"/>
</listOfUnits>
</unitDefinition>
<unitDefinition id="MWDERIVEDUNIT_1__day" name="1/day">
<listOfUnits>
<unit kind="second" exponent="-1"/>
<unit kind="dimensionless" multiplier="1.15740740740741e-05"/>
</listOfUnits>
</unitDefinition>
<unitDefinition id="MWBUILTINUNIT_day" name="day">
<listOfUnits>
<unit kind="second" exponent="1" multiplier="86400"/>
</listOfUnits>
</unitDefinition>
<unitDefinition id="MWDERIVEDUNIT_micrometer___3__cell" name="micrometer^3/cell">
<listOfUnits>
<unit kind="metre" exponent="3"/>
<unit kind="mole" exponent="-1"/>
<unit kind="dimensionless" multiplier="602214.199"/>
</listOfUnits>
</unitDefinition>
<unitDefinition id="MWDERIVEDUNIT_cell__day" name="cell/day">
<listOfUnits>
<unit kind="mole" exponent="1"/>
<unit kind="second" exponent="-1"/>
<unit kind="dimensionless" multiplier="1.92191982409137e-29"/>
</listOfUnits>
</unitDefinition>
<unitDefinition id="MWBUILTINPREFIX_centi_MWBUILTINUNIT_meter" name="centimeter">
<listOfUnits>
<unit kind="metre" exponent="1" multiplier="0.01"/>
</listOfUnits>
</unitDefinition>
<unitDefinition id="MWDERIVEDUNIT_1__minute" name="1/minute">
<listOfUnits>
<unit kind="second" exponent="-1"/>
<unit kind="dimensionless" multiplier="0.0166666666666667"/>
</listOfUnits>
</unitDefinition>
<unitDefinition id="MWDERIVEDUNIT_1__centimeter___3_minute" name="1/(centimeter^3*minute)">
<listOfUnits>
<unit kind="metre" exponent="-3"/>
<unit kind="second" exponent="-1"/>
<unit kind="dimensionless" multiplier="16666.6666666667"/>
</listOfUnits>
</unitDefinition>
<unitDefinition id="MWDERIVEDUNIT_nanomole__cell__hour" name="nanomole/cell/hour">
<listOfUnits>
<unit kind="second" exponent="-1"/>
<unit kind="dimensionless" multiplier="167281721944.444"/>
</listOfUnits>
</unitDefinition>
<unitDefinition id="MWBUILTINPREFIX_nano_MWBUILTINUNIT_molarity" name="nanomolarity">
<listOfUnits>
<unit kind="metre" exponent="-3"/>
<unit kind="mole" exponent="1"/>
<unit kind="dimensionless" multiplier="1e-06"/>
</listOfUnits>
</unitDefinition>
<unitDefinition id="MWDERIVEDUNIT_cell__milliliter" name="cell/milliliter">
<listOfUnits>
<unit kind="metre" exponent="-3"/>
<unit kind="mole" exponent="1"/>
<unit kind="dimensionless" multiplier="1.66053872801495e-18"/>
</listOfUnits>
</unitDefinition>
<unitDefinition id="MWBUILTINUNIT_molarity" name="molarity">
<listOfUnits>
<unit kind="metre" exponent="-3"/>
<unit kind="mole" exponent="1"/>
<unit kind="dimensionless" multiplier="1000"/>
</listOfUnits>
</unitDefinition>
<unitDefinition id="MWDERIVEDUNIT_mole__cell" name="mole/cell">
<listOfUnits>
<unit kind="dimensionless" exponent="1" multiplier="6.02214199e+23"/>
</listOfUnits>
</unitDefinition>
<unitDefinition id="MWDERIVEDUNIT_1__day__cell" name="1/day/cell">
<listOfUnits>
<unit kind="mole" exponent="-1"/>
<unit kind="second" exponent="-1"/>
<unit kind="dimensionless" multiplier="6.97007174768519e+18"/>
</listOfUnits>
</unitDefinition>
<unitDefinition id="MWDERIVEDUNIT_1__day__molarity" name="1/day/molarity">
<listOfUnits>
<unit kind="metre" exponent="3"/>
<unit kind="mole" exponent="-1"/>
<unit kind="second" exponent="-1"/>
<unit kind="dimensionless" multiplier="1.15740740740741e-08"/>
</listOfUnits>
</unitDefinition>
<unitDefinition id="MWDERIVEDUNIT_molecule__micrometer___2" name="molecule/micrometer^2">
<listOfUnits>
<unit kind="metre" exponent="-2"/>
<unit kind="mole" exponent="1"/>
<unit kind="dimensionless" multiplier="1.66053872801495e-12"/>
</listOfUnits>
</unitDefinition>
<unitDefinition id="MWDERIVEDUNIT_molarity__cell" name="molarity/cell">
<listOfUnits>
<unit kind="metre" exponent="-3"/>
<unit kind="dimensionless" multiplier="6.02214199e+26"/>
</listOfUnits>
</unitDefinition>
<unitDefinition id="MWDERIVEDUNIT_1__second_molecule__micrometer___2" name="1/(second*molecule/micrometer^2)">
<listOfUnits>
<unit kind="metre" exponent="2"/>
<unit kind="mole" exponent="-1"/>
<unit kind="second" exponent="-1"/>
<unit kind="dimensionless" multiplier="602214199000"/>
</listOfUnits>
</unitDefinition>
<unitDefinition id="MWDERIVEDUNIT_1__second" name="1/second">
<listOfUnits>
<unit kind="second" exponent="-1"/>
<unit kind="dimensionless" multiplier="1"/>
</listOfUnits>
</unitDefinition>
<unitDefinition id="MWDERIVEDUNIT_1__micromolarity_nanometer_second" name="1/(micromolarity*nanometer*second)">
<listOfUnits>
<unit kind="metre" exponent="2"/>
<unit kind="mole" exponent="-1"/>
<unit kind="second" exponent="-1"/>
<unit kind="dimensionless" multiplier="1000000000000"/>
</listOfUnits>
</unitDefinition>
<unitDefinition id="MWDERIVEDUNIT_liter__second" name="liter/second">
<listOfUnits>
<unit kind="metre" exponent="3"/>
<unit kind="second" exponent="-1"/>
<unit kind="dimensionless" multiplier="0.001"/>
</listOfUnits>
</unitDefinition>
<unitDefinition id="MWDERIVEDUNIT_milliliter__second" name="milliliter/second">
<listOfUnits>
<unit kind="metre" exponent="3"/>
<unit kind="second" exponent="-1"/>
<unit kind="dimensionless" multiplier="1e-06"/>
</listOfUnits>
</unitDefinition>
<unitDefinition id="MWDERIVEDUNIT_liter__day" name="liter/day">
<listOfUnits>
<unit kind="metre" exponent="3"/>
<unit kind="second" exponent="-1"/>
<unit kind="dimensionless" multiplier="1.15740740740741e-08"/>
</listOfUnits>
</unitDefinition>
<unitDefinition id="MWDERIVEDUNIT_1__molarity_second" name="1/(molarity*second)">
<listOfUnits>
<unit kind="metre" exponent="3"/>
<unit kind="mole" exponent="-1"/>
<unit kind="second" exponent="-1"/>
<unit kind="dimensionless" multiplier="0.001"/>
</listOfUnits>
</unitDefinition>
<unitDefinition id="MWDERIVEDUNIT_1__nanometer" name="1/nanometer">
<listOfUnits>
<unit kind="metre" exponent="-1"/>
<unit kind="dimensionless" multiplier="1000000000"/>
</listOfUnits>
</unitDefinition>
<unitDefinition id="MWDERIVEDUNIT_1__hour" name="1/hour">
<listOfUnits>
<unit kind="second" exponent="-1"/>
<unit kind="dimensionless" multiplier="0.000277777777777778"/>
</listOfUnits>
</unitDefinition>
<unitDefinition id="MWDERIVEDUNIT_nanomole__cell__day" name="nanomole/cell/day">
<listOfUnits>
<unit kind="second" exponent="-1"/>
<unit kind="dimensionless" multiplier="6970071747.68519"/>
</listOfUnits>
</unitDefinition>
<unitDefinition id="MWDERIVEDUNIT_molarity_microliter__cell__day" name="(molarity*microliter)/cell/day">
<listOfUnits>
<unit kind="second" exponent="-1"/>
<unit kind="dimensionless" multiplier="6970071747685.19"/>
</listOfUnits>
</unitDefinition>
<unitDefinition id="MWUSERUNIT_mU" name="mU">
<listOfUnits>
<unit kind="metre" exponent="-3"/>
<unit kind="mole" exponent="1"/>
<unit kind="dimensionless" multiplier="1000"/>
</listOfUnits>
</unitDefinition>
<unitDefinition id="MWDERIVEDUNIT_mole__liter_hour" name="mole/(liter*hour)">
<listOfUnits>
<unit kind="metre" exponent="-3"/>
<unit kind="mole" exponent="1"/>
<unit kind="second" exponent="-1"/>
<unit kind="dimensionless" multiplier="0.277777777777778"/>
</listOfUnits>
</unitDefinition>
<unitDefinition id="MWDERIVEDUNIT_mole__liter" name="mole/liter">
<listOfUnits>
<unit kind="metre" exponent="-3"/>
<unit kind="mole" exponent="1"/>
<unit kind="dimensionless" multiplier="1000"/>
</listOfUnits>
</unitDefinition>
<unitDefinition id="MWBUILTINUNIT_hour" name="hour">
<listOfUnits>
<unit kind="second" exponent="1" multiplier="3600"/>
</listOfUnits>
</unitDefinition>
</listOfUnitDefinitions>
<listOfCompartments>
<compartment id="mw324aaeb5_4cad_4b2e_ae0c_8951b343415d" name="V_C" spatialDimensions="3" size="6" units="litre" constant="true">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">Central compartment (C) (assumed based on patient weight)</body>
</notes>
</compartment>
<compartment id="mw1c783bd7_0eca_4d87_8829_58863541c89c" name="V_P" spatialDimensions="3" size="61.321" units="litre" constant="true">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">Peripheral compartment (P) (assumed based on patient weight)</body>
</notes>
</compartment>
<compartment id="mw97bd60ee_8383_4db2_9408_852aad33afcd" name="V_T" spatialDimensions="3" size="1e-06" units="MWBUILTINPREFIX_milli_MWBUILTINUNIT_liter" constant="false">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">Tumor compartment (T) (estimated)</body>
</notes>
</compartment>
<compartment id="mwf7ed76cd_3f43_4158_88cb_5e0047c1285b" name="V_LN" spatialDimensions="3" size="1112.64739814639" units="MWDERIVEDUNIT_millimeter___3" constant="true">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">Lymph node (LN) compartment volume calculated based on number of LNs (estimated) and average LN diameter (Schmidt 2007, PMID: 17724531)</body>
</notes>
</compartment>
<compartment id="mwfae11d7c_6828_4a44_b69a_64a0e3656d85" name="V_e" spatialDimensions="3" size="4e-16" units="litre" constant="true">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">APC endosomal comparment calculated based on the volume of a single endosome (Agrawal and Linderman 1996, PMID: 8944895) and the number of endosomes per cell (Agrawal and Linderman 1996, PMID: 8944895)</body>
</notes>
</compartment>
<compartment id="mw8e40eb56_eaaa_4cf2_9b7b_ccf6f0f37bae" name="A_e" spatialDimensions="2" size="15" units="MWDERIVEDUNIT_micrometer___2" constant="true">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">APC endosomal surface comparment calculated based on the surface area of a single endosome (Agrawal and Linderman 1996, PMID: 8944895) and the number of endosomes per cell (Agrawal and Linderman 1996, PMID: 8944895)</body>
</notes>
</compartment>
<compartment id="mwb87553d5_6aac_4f53_b8c4_a288e46766fa" name="A_s" spatialDimensions="2" size="900" units="MWDERIVEDUNIT_micrometer___2" constant="true">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">APC surface comparment (Agrawal and Linderman 1996, PMID: 8944895)</body>
</notes>
</compartment>
<compartment id="mw15045a9f_a547_4e70_8547_035eaec325d3" name="syn_T_C1" spatialDimensions="2" size="37.8" units="MWDERIVEDUNIT_micrometer___2" constant="true">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">synapse comparment between T and C1 (Jansson 2005, PMID: 16034096)</body>
</notes>
</compartment>
<compartment id="mw8a3f7b63_2487_4017_931c_3f17eb64c5f6" name="syn_T_APC" spatialDimensions="2" size="37.8" units="MWDERIVEDUNIT_micrometer___2" constant="true">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">synapse comparment between T and APC (Jansson 2005, PMID: 16034096)</body>
</notes>
</compartment>
</listOfCompartments>
<listOfSpecies>
<species id="mw69f7efe7_ac08_48bd_a951_50b4fbfab6eb" name="T0" compartment="mw324aaeb5_4cad_4b2e_ae0c_8951b343415d" initialAmount="0" substanceUnits="MWUSERUNIT_cell" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">Number of T0 cells in the central compartment</body>
</notes>
</species>
<species id="mw8b7e1ba3_459e_43bf_acd4_ca0b2b71a72c" name="T1" compartment="mw324aaeb5_4cad_4b2e_ae0c_8951b343415d" initialAmount="0" substanceUnits="MWUSERUNIT_cell" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">Number of T1 cells in the central compartment</body>
</notes>
</species>
<species id="mw092b1fb2_83fd_4769_ac98_cf59f0bb2784" name="nivo" compartment="mw324aaeb5_4cad_4b2e_ae0c_8951b343415d" initialConcentration="0" substanceUnits="mole" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">Concentration of nivo in central compartment</body>
</notes>
<annotation>
<SimBiology xmlns="http://www.mathworks.com">
<Unit Numerator="mole" Denominator="liter"/>
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</species>
<species id="mwf124d3c7_c221_45c2_9a79_cead823b24ee" name="durv" compartment="mw324aaeb5_4cad_4b2e_ae0c_8951b343415d" initialConcentration="0" substanceUnits="mole" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">Concentration of durv in central compartment</body>
</notes>
<annotation>
<SimBiology xmlns="http://www.mathworks.com">
<Unit Numerator="mole" Denominator="liter"/>
</SimBiology>
</annotation>
</species>
<species id="mw444e73d2_30fb_4f3f_836e_05322210264a" name="ipi" compartment="mw324aaeb5_4cad_4b2e_ae0c_8951b343415d" initialConcentration="0" substanceUnits="mole" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">Concentration of ipi in central compartment</body>
</notes>
<annotation>
<SimBiology xmlns="http://www.mathworks.com">
<Unit Numerator="mole" Denominator="liter"/>
</SimBiology>
</annotation>
</species>
<species id="mw0a530416_36c0_4c4c_99db_b0e03f18805b" name="ENT" compartment="mw324aaeb5_4cad_4b2e_ae0c_8951b343415d" initialConcentration="0" substanceUnits="mole" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">Concentration of ENT in central compartment</body>
</notes>
<annotation>
<SimBiology xmlns="http://www.mathworks.com">
<Unit Numerator="mole" Denominator="liter"/>
</SimBiology>
</annotation>
</species>
<species id="mw115206c3_1b63_42f2_a4c3_0f04995e2a65" name="ENT_Buccal" compartment="mw324aaeb5_4cad_4b2e_ae0c_8951b343415d" initialConcentration="0" substanceUnits="mole" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">Concentration of ENT in central compartment</body>
</notes>
<annotation>
<SimBiology xmlns="http://www.mathworks.com">
<Unit Numerator="mole" Denominator="liter"/>
</SimBiology>
</annotation>
</species>
<species id="mw4c0976aa_d375_4932_9573_ed585072c3dc" name="ENT_GI" compartment="mw324aaeb5_4cad_4b2e_ae0c_8951b343415d" initialConcentration="0" substanceUnits="mole" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">Concentration of ENT in central compartment</body>
</notes>
<annotation>
<SimBiology xmlns="http://www.mathworks.com">
<Unit Numerator="mole" Denominator="liter"/>
</SimBiology>
</annotation>
</species>
<species id="mwd6e1b481_4751_4d04_ac02_5fb6a8c321ec" name="Dose2" compartment="mw324aaeb5_4cad_4b2e_ae0c_8951b343415d" initialConcentration="0" substanceUnits="mole" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false">
<annotation>
<SimBiology xmlns="http://www.mathworks.com">
<Unit Numerator="mole" Denominator="liter"/>
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<notes>
<body xmlns="http://www.w3.org/1999/xhtml">Number of T0 cells in the peripheral compartment</body>
</notes>
</species>
<species id="mwb4354006_cde2_457e_8b5a_8019a03cfa19" name="T1" compartment="mw1c783bd7_0eca_4d87_8829_58863541c89c" initialAmount="0" substanceUnits="MWUSERUNIT_cell" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">Number of T1 cells in the peripheral compartment</body>
</notes>
</species>
<species id="mw5fe8db7e_a2bc_4869_afa7_7f5ca0145daf" name="nivo" compartment="mw1c783bd7_0eca_4d87_8829_58863541c89c" initialConcentration="0" substanceUnits="mole" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">Concentration of nivo in peripheral compartment</body>
</notes>
<annotation>
<SimBiology xmlns="http://www.mathworks.com">
<Unit Numerator="mole" Denominator="liter"/>
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<species id="mw509329f2_a9f6_4506_baaf_1511256fcb86" name="durv" compartment="mw1c783bd7_0eca_4d87_8829_58863541c89c" initialConcentration="0" substanceUnits="mole" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">Concentration of durv in peripheral compartment</body>
</notes>
<annotation>
<SimBiology xmlns="http://www.mathworks.com">
<Unit Numerator="mole" Denominator="liter"/>
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</species>
<species id="mw664b5eef_723d_49ec_b1d9_acc99bd3d148" name="ipi" compartment="mw1c783bd7_0eca_4d87_8829_58863541c89c" initialConcentration="0" substanceUnits="mole" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">Concentration of ipi in peripheral compartment</body>
</notes>
<annotation>
<SimBiology xmlns="http://www.mathworks.com">
<Unit Numerator="mole" Denominator="liter"/>
</SimBiology>
</annotation>
</species>
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<notes>
<body xmlns="http://www.w3.org/1999/xhtml">Number of free CTLA4 molecules on Treg in Peripheral compartment</body>
</notes>
</species>
<species id="mw3415a9cc_b566_4856_aaef_4d86f91f703b" name="Treg_CTLA4_ipi" compartment="mw1c783bd7_0eca_4d87_8829_58863541c89c" initialAmount="0" substanceUnits="MWBUILTINUNIT_molecule" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">Number of CTLA4-ipilimumab complex on Treg in Peripheral compartment</body>
</notes>
</species>
<species id="mw29b7a526_7019_4266_9931_9827a36a92a9" name="Treg_CTLA4_ipi_CTLA4" compartment="mw1c783bd7_0eca_4d87_8829_58863541c89c" initialAmount="0" substanceUnits="MWBUILTINUNIT_molecule" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">Number of CTLA4-ipilimumab-CTLA4 complex on Treg in Peripheral compartment</body>
</notes>
</species>
<species id="mwdab736c4_6bbd_4ddb_9748_6fbc4abc0c23" name="ENT" compartment="mw1c783bd7_0eca_4d87_8829_58863541c89c" initialConcentration="0" substanceUnits="mole" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">Concentration of ENT in peripheral compartment</body>
</notes>
<annotation>
<SimBiology xmlns="http://www.mathworks.com">
<Unit Numerator="mole" Denominator="liter"/>
</SimBiology>
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</species>
<species id="mw3fb8ca45_3a74_4e8a_8db4_87f50476daca" name="C_x" compartment="mw97bd60ee_8383_4db2_9408_852aad33afcd" initialAmount="0" substanceUnits="MWUSERUNIT_cell" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">Dead cancer cells in the tumour compartment</body>
</notes>
</species>
<species id="mwce590c3a_6cf5_45ba_8bb2_904a2e3dde91" name="T_exh" compartment="mw97bd60ee_8383_4db2_9408_852aad33afcd" initialAmount="0" substanceUnits="MWUSERUNIT_cell" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">Exhausted T cells</body>
</notes>
</species>
<species id="mwe7ebcac4_fadd_4936_8667_c34cf469fe3a" name="C1" compartment="mw97bd60ee_8383_4db2_9408_852aad33afcd" initialAmount="1" substanceUnits="MWUSERUNIT_cell" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">Number of cancer cells in tumour</body>
</notes>
</species>
<species id="mwddfbf0aa_a5c3_4212_8a86_85208843c43f" name="T0" compartment="mw97bd60ee_8383_4db2_9408_852aad33afcd" initialAmount="0" substanceUnits="MWUSERUNIT_cell" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">Number of T0 cells in the tumour compartment</body>
</notes>
</species>
<species id="mw29266435_9932_4c05_9b63_03d1754056f1" name="T1" compartment="mw97bd60ee_8383_4db2_9408_852aad33afcd" initialAmount="0" substanceUnits="MWUSERUNIT_cell" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">Number of T1 cells in the tumour compartment</body>
</notes>
</species>
<species id="mw73386c66_d30c_401e_98d0_eccb28102e1a" name="APC" compartment="mw97bd60ee_8383_4db2_9408_852aad33afcd" initialAmount="0" substanceUnits="MWUSERUNIT_cell" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">Number of naive antigen presenting cells in the tumour</body>
</notes>
</species>
<species id="mw58612907_55a0_4a82_8cf2_f75a5c495c0b" name="mAPC" compartment="mw97bd60ee_8383_4db2_9408_852aad33afcd" initialAmount="0" substanceUnits="MWUSERUNIT_cell" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">Number of mature antigen presenting cells in the tumour</body>
</notes>
</species>
<species id="mw6ac93b40_ddaa_4388_b5e6_f541274b93df" name="c" compartment="mw97bd60ee_8383_4db2_9408_852aad33afcd" initialConcentration="0" substanceUnits="mole" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">Concentration of maturation cytokines in the tumour</body>
</notes>
<annotation>
<SimBiology xmlns="http://www.mathworks.com">
<Unit Numerator="mole" Denominator="liter"/>
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</annotation>
</species>
<species id="mw4e5b59d9_0b34_42a8_95c4_29a1da1a3161" name="nivo" compartment="mw97bd60ee_8383_4db2_9408_852aad33afcd" initialConcentration="0" substanceUnits="mole" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">Concentration of nivo in tumour compartment</body>
</notes>
<annotation>
<SimBiology xmlns="http://www.mathworks.com">
<Unit Numerator="mole" Denominator="liter"/>
</SimBiology>
</annotation>
</species>
<species id="mwfc65be48_9503_4263_9409_c76d8526daa1" name="durv" compartment="mw97bd60ee_8383_4db2_9408_852aad33afcd" initialConcentration="0" substanceUnits="mole" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">Concentration of durv in tumour compartment</body>
</notes>
<annotation>
<SimBiology xmlns="http://www.mathworks.com">
<Unit Numerator="mole" Denominator="liter"/>
</SimBiology>
</annotation>
</species>
<species id="mwdab20b92_e602_424b_9dbc_1cc52e0946d6" name="ipi" compartment="mw97bd60ee_8383_4db2_9408_852aad33afcd" initialConcentration="0" substanceUnits="mole" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">Concentration of ipi in tumour compartment</body>
</notes>
<annotation>
<SimBiology xmlns="http://www.mathworks.com">
<Unit Numerator="mole" Denominator="liter"/>
</SimBiology>
</annotation>
</species>
<species id="mweb4943a4_297b_4316_8595_07d7fe602cb8" name="Treg_CTLA4" compartment="mw97bd60ee_8383_4db2_9408_852aad33afcd" initialAmount="0" substanceUnits="MWBUILTINUNIT_molecule" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">Number of free CTLA4 molecules on Treg in Tumour compartment</body>
</notes>
</species>
<species id="mwea43ca96_26b6_408a_8d84_0539f63fc11f" name="Treg_CTLA4_ipi" compartment="mw97bd60ee_8383_4db2_9408_852aad33afcd" initialAmount="0" substanceUnits="MWBUILTINUNIT_molecule" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">Number of CTLA4-ipilimumab complex on Treg in Tumour compartment</body>
</notes>
</species>
<species id="mwf4a7b54b_9a68_48f3_91c2_6d25453adb85" name="Treg_CTLA4_ipi_CTLA4" compartment="mw97bd60ee_8383_4db2_9408_852aad33afcd" initialAmount="0" substanceUnits="MWBUILTINUNIT_molecule" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">Number of CTLA4-ipilimumab-CTLA4 complex on Treg in Tumour compartment</body>
</notes>
</species>
<species id="mw83cbb11d_d1ab_4c5d_ab9b_31621cc6e61a" name="MDSC" compartment="mw97bd60ee_8383_4db2_9408_852aad33afcd" initialAmount="0" substanceUnits="MWUSERUNIT_cell" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">Number of MDSCs in the tumour compartment</body>
</notes>
</species>
<species id="mwabb84d39_4d5e_43df_b89a_95c16ee105f4" name="CCL2" compartment="mw97bd60ee_8383_4db2_9408_852aad33afcd" initialConcentration="0" substanceUnits="mole" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">Concentration of CCL2 in the tumor compartment</body>
</notes>
<annotation>
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<Unit Numerator="mole" Denominator="liter"/>
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</species>
<species id="mwa8265122_d899_4576_a773_f4e09670d29c" name="NO" compartment="mw97bd60ee_8383_4db2_9408_852aad33afcd" initialConcentration="0" substanceUnits="mole" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">Concentration of NO in the tumor compartment</body>
</notes>
<annotation>
<SimBiology xmlns="http://www.mathworks.com">
<Unit Numerator="mole" Denominator="liter"/>
</SimBiology>
</annotation>
</species>
<species id="mwcca6c729_26bf_4d26_b929_1aa139452cc5" name="ArgI" compartment="mw97bd60ee_8383_4db2_9408_852aad33afcd" initialConcentration="0" substanceUnits="mole" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">Concentration of Arg I in the tumor compartment</body>
</notes>
<annotation>
<SimBiology xmlns="http://www.mathworks.com">
<Unit Numerator="mole" Denominator="liter"/>
</SimBiology>
</annotation>
</species>
<species id="mw407aec6d_b728_4aec_a53e_b75ab77d05f1" name="ENT" compartment="mw97bd60ee_8383_4db2_9408_852aad33afcd" initialConcentration="0" substanceUnits="mole" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">Concentration of ENT in tumour compartment</body>
</notes>
<annotation>
<SimBiology xmlns="http://www.mathworks.com">
<Unit Numerator="mole" Denominator="liter"/>
</SimBiology>
</annotation>
</species>
<species id="mwebc60bab_74db_4cea_b897_335ba47a6603" name="nT0" compartment="mwf7ed76cd_3f43_4158_88cb_5e0047c1285b" initialAmount="0" substanceUnits="MWUSERUNIT_cell" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">Number of naive T0 cells in the lymph node</body>
</notes>
</species>
<species id="mw191547e0_918d_40cc_8fd8_9b683bb54293" name="aT0" compartment="mwf7ed76cd_3f43_4158_88cb_5e0047c1285b" initialAmount="0" substanceUnits="MWUSERUNIT_cell" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">Number of activated T0 cells in the lymph node</body>
</notes>
</species>
<species id="mwf44705b4_092e_44fc_85fc_cf33ecad0d28" name="T0" compartment="mwf7ed76cd_3f43_4158_88cb_5e0047c1285b" initialAmount="0" substanceUnits="MWUSERUNIT_cell" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">Number of T0 cells in the lymph node compartment</body>
</notes>
</species>
<species id="mw6f1c494d_2927_4261_99e2_28f145f431c9" name="IL2" compartment="mwf7ed76cd_3f43_4158_88cb_5e0047c1285b" initialConcentration="1e-24" substanceUnits="mole" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">Concentration of IL2 in the lymph node compartment</body>
</notes>
<annotation>
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<Unit Numerator="mole" Denominator="liter"/>
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</annotation>
</species>
<species id="mwcf120fb7_0510_49c1_96c4_f69eec93f4e1" name="nT1" compartment="mwf7ed76cd_3f43_4158_88cb_5e0047c1285b" initialAmount="0" substanceUnits="MWUSERUNIT_cell" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">Number of naive T1 cells in the lymph node</body>
</notes>
</species>
<species id="mw6ff1f892_a9b4_46bc_acdf_1a640e96eac7" name="aT1" compartment="mwf7ed76cd_3f43_4158_88cb_5e0047c1285b" initialAmount="0" substanceUnits="MWUSERUNIT_cell" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">Number of activated T1 cells in the lymph node</body>
</notes>
</species>
<species id="mw58d7bb5f_2358_4c5b_bf9d_18dd7703a714" name="T1" compartment="mwf7ed76cd_3f43_4158_88cb_5e0047c1285b" initialAmount="0" substanceUnits="MWUSERUNIT_cell" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">Number of T1 cells in the lymph node compartment</body>
</notes>
</species>
<species id="mw5a98782c_dfde_4296_8212_90500fa83148" name="APC" compartment="mwf7ed76cd_3f43_4158_88cb_5e0047c1285b" initialAmount="0" substanceUnits="MWUSERUNIT_cell" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">Number of naive antigen presenting cells in the lymph node</body>
</notes>
</species>
<species id="mw6e2081f5_2ee1_4152_9153_d8b7f7373b50" name="mAPC" compartment="mwf7ed76cd_3f43_4158_88cb_5e0047c1285b" initialAmount="0" substanceUnits="MWUSERUNIT_cell" hasOnlySubstanceUnits="true" boundaryCondition="false" constant="false">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">Number of mature antigen presenting cells in the lymph node</body>
</notes>
</species>
<species id="mw73704559_1a6a_4e49_90c7_e8649c1d73b7" name="P0" compartment="mwf7ed76cd_3f43_4158_88cb_5e0047c1285b" initialConcentration="1e-24" substanceUnits="mole" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">Concentration of free antigen (P0) in the LN compartment</body>
</notes>
<annotation>
<SimBiology xmlns="http://www.mathworks.com">
<Unit Numerator="mole" Denominator="liter"/>
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</annotation>
</species>
<species id="mwb7c54f02_3a02_497c_a2bd_6bb01949a193" name="P1" compartment="mwf7ed76cd_3f43_4158_88cb_5e0047c1285b" initialConcentration="1e-24" substanceUnits="mole" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">Concentration of free antigen (P1) in the LN compartment</body>
</notes>
<annotation>
<SimBiology xmlns="http://www.mathworks.com">
<Unit Numerator="mole" Denominator="liter"/>
</SimBiology>
</annotation>
</species>
<species id="mw2369c64a_96ba_4362_86a1_d63fe83c8e42" name="nivo" compartment="mwf7ed76cd_3f43_4158_88cb_5e0047c1285b" initialConcentration="0" substanceUnits="mole" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">Concentration of nivo in lymph node compartment</body>
</notes>
<annotation>
<SimBiology xmlns="http://www.mathworks.com">
<Unit Numerator="mole" Denominator="liter"/>
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</annotation>
</species>
<species id="mw6e060274_2daf_449c_a80b_44d9b16106c2" name="durv" compartment="mwf7ed76cd_3f43_4158_88cb_5e0047c1285b" initialConcentration="0" substanceUnits="mole" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">Concentration of durv in lymph node compartment</body>
</notes>
<annotation>
<SimBiology xmlns="http://www.mathworks.com">
<Unit Numerator="mole" Denominator="liter"/>
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</annotation>
</species>
<species id="mwd80c7730_4ed6_48b2_bb2f_3e748081d682" name="ipi" compartment="mwf7ed76cd_3f43_4158_88cb_5e0047c1285b" initialConcentration="0" substanceUnits="mole" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">Concentration of ipi in lymph node compartment</body>
</notes>
<annotation>
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<Unit Numerator="mole" Denominator="liter"/>
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<species id="mwa4006c5c_a807_4568_a3e6_d57e4a63d7fb" name="ENT" compartment="mwf7ed76cd_3f43_4158_88cb_5e0047c1285b" initialConcentration="0" substanceUnits="mole" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">Concentration of ENT in lymph node compartment</body>
</notes>
<annotation>
<SimBiology xmlns="http://www.mathworks.com">
<Unit Numerator="mole" Denominator="liter"/>
</SimBiology>
</annotation>
</species>
<species id="mw6e212437_7abd_46d3_863a_5e5a22368719" name="P0" compartment="mwfae11d7c_6828_4a44_b69a_64a0e3656d85" initialConcentration="1e-18" substanceUnits="mole" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">Concentration of antigen P0 in the APC endosomes</body>
</notes>
<annotation>
<SimBiology xmlns="http://www.mathworks.com">
<Unit Numerator="mole" Denominator="liter"/>
</SimBiology>
</annotation>
</species>
<species id="mwd341a5c2_449a_468b_a547_0198fcbe0903" name="p0" compartment="mwfae11d7c_6828_4a44_b69a_64a0e3656d85" initialConcentration="1e-18" substanceUnits="mole" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">Concentration of epitope P0 in the APC endosomes</body>
</notes>
<annotation>
<SimBiology xmlns="http://www.mathworks.com">
<Unit Numerator="mole" Denominator="liter"/>
</SimBiology>
</annotation>
</species>
<species id="mwc0f4f373_9723_40e8_b022_973e5611a533" name="P1" compartment="mwfae11d7c_6828_4a44_b69a_64a0e3656d85" initialConcentration="1e-18" substanceUnits="mole" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">Concentration of antigen P1 in the APC endosomes</body>
</notes>
<annotation>
<SimBiology xmlns="http://www.mathworks.com">
<Unit Numerator="mole" Denominator="liter"/>
</SimBiology>
</annotation>
</species>
<species id="mwd101a415_049d_4e9a_8c69_d54d6768a442" name="p1" compartment="mwfae11d7c_6828_4a44_b69a_64a0e3656d85" initialConcentration="1e-18" substanceUnits="mole" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">Concentration of epitope P1 in the APC endosomes</body>
</notes>
<annotation>
<SimBiology xmlns="http://www.mathworks.com">
<Unit Numerator="mole" Denominator="liter"/>
</SimBiology>
</annotation>
</species>
<species id="mwc3ece17c_334f_4435_8944_477e8e943121" name="M1" compartment="mw8e40eb56_eaaa_4cf2_9b7b_ccf6f0f37bae" initialConcentration="2185.79234972678" substanceUnits="MWBUILTINUNIT_molecule" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">Amount of MHC per area on the cell surface</body>
</notes>
<annotation>
<SimBiology xmlns="http://www.mathworks.com">
<Unit Numerator="molecule" Denominator="micrometer^2"/>
</SimBiology>
</annotation>
</species>
<species id="mw16bec048_b1a5_4c69_b34f_27d405f542f0" name="M1p0" compartment="mw8e40eb56_eaaa_4cf2_9b7b_ccf6f0f37bae" initialConcentration="1e-06" substanceUnits="MWBUILTINUNIT_molecule" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">Antigen-MHC complex</body>
</notes>
<annotation>
<SimBiology xmlns="http://www.mathworks.com">
<Unit Numerator="molecule" Denominator="micrometer^2"/>
</SimBiology>
</annotation>
</species>
<species id="mwa0c42763_5110_4f37_bd22_ee490d8aa032" name="M1p1" compartment="mw8e40eb56_eaaa_4cf2_9b7b_ccf6f0f37bae" initialConcentration="1e-06" substanceUnits="MWBUILTINUNIT_molecule" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">Antigen-MHC complex</body>
</notes>
<annotation>
<SimBiology xmlns="http://www.mathworks.com">
<Unit Numerator="molecule" Denominator="micrometer^2"/>
</SimBiology>
</annotation>
</species>
<species id="mwc2c4ce95_bb5f_45d8_946e_a2d4dee68c12" name="M1" compartment="mwb87553d5_6aac_4f53_b8c4_a288e46766fa" initialConcentration="1e-06" substanceUnits="MWBUILTINUNIT_molecule" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false">
<annotation>
<SimBiology xmlns="http://www.mathworks.com">
<Unit Numerator="molecule" Denominator="micrometer^2"/>
</SimBiology>
</annotation>
</species>
<species id="mw55e72a69_3002_4096_870f_76e134d684a9" name="M1p0" compartment="mwb87553d5_6aac_4f53_b8c4_a288e46766fa" initialConcentration="1e-06" substanceUnits="MWBUILTINUNIT_molecule" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">Antigen-MHC complex</body>
</notes>
<annotation>
<SimBiology xmlns="http://www.mathworks.com">
<Unit Numerator="molecule" Denominator="micrometer^2"/>
</SimBiology>
</annotation>
</species>
<species id="mwc7771359_cc99_4940_9323_d990493fe40d" name="M1p1" compartment="mwb87553d5_6aac_4f53_b8c4_a288e46766fa" initialConcentration="1e-06" substanceUnits="MWBUILTINUNIT_molecule" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">Antigen-MHC complex</body>
</notes>
<annotation>
<SimBiology xmlns="http://www.mathworks.com">
<Unit Numerator="molecule" Denominator="micrometer^2"/>
</SimBiology>
</annotation>
</species>
<species id="mwa285b215_0bbb_4d93_bd49_45559fbf778d" name="PD1_PDL1" compartment="mw15045a9f_a547_4e70_8547_035eaec325d3" initialConcentration="0" substanceUnits="MWBUILTINUNIT_molecule" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">concentration of PD1-PDL1 complex</body>
</notes>
<annotation>
<SimBiology xmlns="http://www.mathworks.com">
<Unit Numerator="molecule" Denominator="micrometer^2"/>
</SimBiology>
</annotation>
</species>
<species id="mw2ff9df15_19f4_4956_8c90_696dc1c42b87" name="PD1_PDL2" compartment="mw15045a9f_a547_4e70_8547_035eaec325d3" initialConcentration="0" substanceUnits="MWBUILTINUNIT_molecule" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">concentration of PD1-PDL2 complex</body>
</notes>
<annotation>
<SimBiology xmlns="http://www.mathworks.com">
<Unit Numerator="molecule" Denominator="micrometer^2"/>
</SimBiology>
</annotation>
</species>
<species id="mwf52b6036_afdb_4e09_a9fe_7a2f3b7af98c" name="PD1" compartment="mw15045a9f_a547_4e70_8547_035eaec325d3" initialConcentration="0" substanceUnits="MWBUILTINUNIT_molecule" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">concentration of PD1 in synapse</body>
</notes>
<annotation>
<SimBiology xmlns="http://www.mathworks.com">
<Unit Numerator="molecule" Denominator="micrometer^2"/>
</SimBiology>
</annotation>
</species>
<species id="mw87e73b5e_4f4a_4e1b_aad7_30c4e59228c5" name="PDL1" compartment="mw15045a9f_a547_4e70_8547_035eaec325d3" initialConcentration="0" substanceUnits="MWBUILTINUNIT_molecule" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">concentration of PDL1 in synapse</body>
</notes>
<annotation>
<SimBiology xmlns="http://www.mathworks.com">
<Unit Numerator="molecule" Denominator="micrometer^2"/>
</SimBiology>
</annotation>
</species>
<species id="mw36656e4d_d5d2_4add_b70b_574adecafe9b" name="PDL2" compartment="mw15045a9f_a547_4e70_8547_035eaec325d3" initialConcentration="0" substanceUnits="MWBUILTINUNIT_molecule" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">concentration of PDL2 in synapse</body>
</notes>
<annotation>
<SimBiology xmlns="http://www.mathworks.com">
<Unit Numerator="molecule" Denominator="micrometer^2"/>
</SimBiology>
</annotation>
</species>
<species id="mwcdf36a32_52dc_47ed_922e_22b59399f2bf" name="PD1_nivo" compartment="mw15045a9f_a547_4e70_8547_035eaec325d3" initialConcentration="0" substanceUnits="MWBUILTINUNIT_molecule" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">concentration of PD1-nivolumab complex</body>
</notes>
<annotation>
<SimBiology xmlns="http://www.mathworks.com">
<Unit Numerator="molecule" Denominator="micrometer^2"/>
</SimBiology>
</annotation>
</species>
<species id="mw2c2e61ba_da7b_47ef_a389_b004b272fcd8" name="PD1_nivo_PD1" compartment="mw15045a9f_a547_4e70_8547_035eaec325d3" initialConcentration="0" substanceUnits="MWBUILTINUNIT_molecule" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">concentration of PD1-nivolumab-PD1 complex</body>
</notes>
<annotation>
<SimBiology xmlns="http://www.mathworks.com">
<Unit Numerator="molecule" Denominator="micrometer^2"/>
</SimBiology>
</annotation>
</species>
<species id="mw8dba18a6_e88c_4c9d_ae32_8218f2427afc" name="PDL1_durv" compartment="mw15045a9f_a547_4e70_8547_035eaec325d3" initialConcentration="0" substanceUnits="MWBUILTINUNIT_molecule" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">concentration of PDL1-durvalumab complex</body>
</notes>
<annotation>
<SimBiology xmlns="http://www.mathworks.com">
<Unit Numerator="molecule" Denominator="micrometer^2"/>
</SimBiology>
</annotation>
</species>
<species id="mwb12b733c_212a_4352_9c20_f3e6365f7356" name="PDL1_durv_PDL1" compartment="mw15045a9f_a547_4e70_8547_035eaec325d3" initialConcentration="0" substanceUnits="MWBUILTINUNIT_molecule" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">concentration of PDL1-durvalumab-PDL1 complex</body>
</notes>
<annotation>
<SimBiology xmlns="http://www.mathworks.com">
<Unit Numerator="molecule" Denominator="micrometer^2"/>
</SimBiology>
</annotation>
</species>
<species id="mwf74be379_9b70_4aeb_88d5_8dc63cb481a0" name="TPDL1" compartment="mw15045a9f_a547_4e70_8547_035eaec325d3" initialConcentration="0" substanceUnits="MWBUILTINUNIT_molecule" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">concentration of PDL1 in synapse of T cell</body>
</notes>
<annotation>
<SimBiology xmlns="http://www.mathworks.com">
<Unit Numerator="molecule" Denominator="micrometer^2"/>
</SimBiology>
</annotation>
</species>
<species id="mw927433f0_22fe_4de1_b2e7_3988f53dafd4" name="TPDL1_durv" compartment="mw15045a9f_a547_4e70_8547_035eaec325d3" initialConcentration="0" substanceUnits="MWBUILTINUNIT_molecule" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">concentration of TPDL1-durvalumab complex</body>
</notes>
<annotation>
<SimBiology xmlns="http://www.mathworks.com">
<Unit Numerator="molecule" Denominator="micrometer^2"/>
</SimBiology>
</annotation>
</species>
<species id="mw08b60496_630a_4840_bf49_028afa3203db" name="TPDL1_durv_TPDL1" compartment="mw15045a9f_a547_4e70_8547_035eaec325d3" initialConcentration="0" substanceUnits="MWBUILTINUNIT_molecule" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">concentration of TPDL1-durvalumab-TPDL1 complex</body>
</notes>
<annotation>
<SimBiology xmlns="http://www.mathworks.com">
<Unit Numerator="molecule" Denominator="micrometer^2"/>
</SimBiology>
</annotation>
</species>
<species id="mw47782763_66ef_4a9b_bfe3_0e7e0873913e" name="CD28_CD80" compartment="mw15045a9f_a547_4e70_8547_035eaec325d3" initialConcentration="0" substanceUnits="MWBUILTINUNIT_molecule" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">concentration of CD28-CD80 complex</body>
</notes>
<annotation>
<SimBiology xmlns="http://www.mathworks.com">
<Unit Numerator="molecule" Denominator="micrometer^2"/>
</SimBiology>
</annotation>
</species>
<species id="mw74f8e7f0_b3a9_42af_9164_3fc4686247a0" name="CD28_CD80_CD28" compartment="mw15045a9f_a547_4e70_8547_035eaec325d3" initialConcentration="0" substanceUnits="MWBUILTINUNIT_molecule" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">concentration of CD28-CD80-CD28 complex</body>
</notes>
<annotation>
<SimBiology xmlns="http://www.mathworks.com">
<Unit Numerator="molecule" Denominator="micrometer^2"/>
</SimBiology>
</annotation>
</species>
<species id="mw46989c2c_5a12_474f_987a_3e480a442f78" name="CD28_CD86" compartment="mw15045a9f_a547_4e70_8547_035eaec325d3" initialConcentration="0" substanceUnits="MWBUILTINUNIT_molecule" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">concentration of CD28-CD86 complex</body>
</notes>
<annotation>
<SimBiology xmlns="http://www.mathworks.com">
<Unit Numerator="molecule" Denominator="micrometer^2"/>
</SimBiology>
</annotation>
</species>
<species id="mw8885eb49_c385_444f_8b0a_6fe53ee7283f" name="CD80_CTLA4" compartment="mw15045a9f_a547_4e70_8547_035eaec325d3" initialConcentration="0" substanceUnits="MWBUILTINUNIT_molecule" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">concentration of CD80-CTLA4 complex</body>
</notes>
<annotation>
<SimBiology xmlns="http://www.mathworks.com">
<Unit Numerator="molecule" Denominator="micrometer^2"/>
</SimBiology>
</annotation>
</species>
<species id="mw6322ed31_01e3_4e93_af12_f35af304a5d2" name="CD80_CTLA4_CD80" compartment="mw15045a9f_a547_4e70_8547_035eaec325d3" initialConcentration="0" substanceUnits="MWBUILTINUNIT_molecule" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">concentration of CD80-CTLA4-CD80 complex</body>
</notes>
<annotation>
<SimBiology xmlns="http://www.mathworks.com">
<Unit Numerator="molecule" Denominator="micrometer^2"/>
</SimBiology>
</annotation>
</species>
<species id="mw3254bf69_8762_4c12_935e_6bb9dabd1491" name="CTLA4_CD80_CTLA4" compartment="mw15045a9f_a547_4e70_8547_035eaec325d3" initialConcentration="0" substanceUnits="MWBUILTINUNIT_molecule" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">concentration of CTLA4-CD80-CTLA4 complex</body>
</notes>
<annotation>
<SimBiology xmlns="http://www.mathworks.com">
<Unit Numerator="molecule" Denominator="micrometer^2"/>
</SimBiology>
</annotation>
</species>
<species id="mw5952b0f0_ea30_47e2_87a9_0522377b13bd" name="CD80_CTLA4_CD80_CTLA4" compartment="mw15045a9f_a547_4e70_8547_035eaec325d3" initialConcentration="0" substanceUnits="MWBUILTINUNIT_molecule" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">concentration of CD80-CTLA4-CD80-CTLA4 complex</body>
</notes>
<annotation>
<SimBiology xmlns="http://www.mathworks.com">
<Unit Numerator="molecule" Denominator="micrometer^2"/>
</SimBiology>
</annotation>
</species>
<species id="mw0a4c4a3d_d2b1_4a3e_a0d7_5f6fb1eb111d" name="CD86_CTLA4" compartment="mw15045a9f_a547_4e70_8547_035eaec325d3" initialConcentration="0" substanceUnits="MWBUILTINUNIT_molecule" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">concentration of CD86-CTLA4 complex</body>
</notes>
<annotation>
<SimBiology xmlns="http://www.mathworks.com">
<Unit Numerator="molecule" Denominator="micrometer^2"/>
</SimBiology>
</annotation>
</species>
<species id="mw76d61402_92cc_4953_93d9_124a45b5dc93" name="CD86_CTLA4_CD86" compartment="mw15045a9f_a547_4e70_8547_035eaec325d3" initialConcentration="0" substanceUnits="MWBUILTINUNIT_molecule" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">concentration of CD86-CTLA4-CD86 complex</body>
</notes>
<annotation>
<SimBiology xmlns="http://www.mathworks.com">
<Unit Numerator="molecule" Denominator="micrometer^2"/>
</SimBiology>
</annotation>
</species>
<species id="mwdd30eae0_06ac_43b0_878f_3897ebfee6c5" name="TPDL1_CD80" compartment="mw15045a9f_a547_4e70_8547_035eaec325d3" initialConcentration="0" substanceUnits="MWBUILTINUNIT_molecule" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">concentration of TPDL1-CD80 complex</body>
</notes>
<annotation>
<SimBiology xmlns="http://www.mathworks.com">
<Unit Numerator="molecule" Denominator="micrometer^2"/>
</SimBiology>
</annotation>