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stress 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The mTORC1 functions as a metabolic sensor and controls protein abundance by affecting processes involved in protein production and RNA translation leading to changes in cell growth and survival.","","--NODE_NAME\\tNODE_ID\\tNODE_TYPE\\tPARENT_ID\\tPOSX\\tPOSY--","AKT3\\teWz9lexke0kY\\tGENE\\tyEOAK96Ye0j-\\t752\\t327","RPTOR\\tKHzd_YdNe0jd\\tGENE\\tJKE-mm1le0jZ\\t759\\t730","PIK3CA\\tBpH76ff7e0iw\\tGENE\\t-1\\t595\\t176","PIK3R2\\t5lBs8QfFe0i_\\tGENE\\tiK4blWyDe0i1\\t804\\t167","RHEB\\t8eeCwYTqe0jC\\tGENE\\t-1\\t599\\t619","PIK3R\\tiK4blWyDe0i1\\tFAMILY\\t-1\\t804\\t166","AKT\\tyEOAK96Ye0j-\\tFAMILY\\t-1\\t594\\t327","mTORC2\\tMMeMHe4ze0kj\\tFAMILY\\t-1\\t421\\t730","TSC\\t3b8rKMrke0jF\\tFAMILY\\t-1\\t596\\t486","AKT2\\t9o76blkNe0kR\\tGENE\\tyEOAK96Ye0j-\\t594\\t327","mTORC1\\tJKE-mm1le0jZ\\tFAMILY\\t-1\\t678\\t730","PPP2R1A\\tHY1OO1uEe0jv\\tGENE\\t-1\\t971\\t326","PIK3R3\\tGy1IflZce0i5\\tGENE\\tiK4blWyDe0i1\\t804\\t227","PTEN\\tHL_nLOSce0jV\\tGENE\\t-1\\t594\\t91","MTOR\\t_WbyV7oYe0jj\\tGENE\\tJKE-mm1le0jZ\\t597\\t730","PIK3R1\\tj_DI0z3Xe0i8\\tGENE\\tiK4blWyDe0i1\\t804\\t106","Cell growth\\t_wytH85He0jQ\\tPROCESS\\t-1\\t601\\t860","INPP4B\\t2ZOWMzsce0j4\\tGENE\\t-1\\t372\\t178","TSC1\\tx2juQzTie0jM\\tGENE\\t3b8rKMrke0jF\\t596\\t459","TSC2\\tzs4f_I93e0jJ\\tGENE\\t3b8rKMrke0jF\\t596\\t513","RICTOR\\tDg3B9H1Me0ks\\tGENE\\tMMeMHe4ze0kj\\t421\\t730","AKT1\\tTDuOMRUee0kH\\tGENE\\tyEOAK96Ye0j-\\t437\\t327","STK11\\tURGrIXe2e0kd\\tGENE\\t-1\\t336\\t483","","--EDGE_ID\\tSOURCE\\tTARGET\\tEDGE_TYPEINTERACTION_PUBMED_ID","an7n5soQe0k8\\tyEOAK96Ye0j-\\t3b8rKMrke0jF\\tINHIBITS\\t","YeQpbZw0e0lG\\t3b8rKMrke0jF\\t8eeCwYTqe0jC\\tINHIBITS\\t","wjtVfwEee0lB\\tJKE-mm1le0jZ\\t_wytH85He0jQ\\tACTIVATES\\t","6Mr0F0gAe0lD\\tURGrIXe2e0kd\\t3b8rKMrke0jF\\tACTIVATES\\t","EigHAJh7e0lI\\tHL_nLOSce0jV\\tBpH76ff7e0iw\\tINHIBITS\\t","s7B8LZsde0k-\\tBpH76ff7e0iw\\tyEOAK96Ye0j-\\tACTIVATES\\t","1T4VmG08e0lL\\tiK4blWyDe0i1\\tBpH76ff7e0iw\\tINHIBITS\\t","3yNlj0Tge0k2\\t8eeCwYTqe0jC\\tJKE-mm1le0jZ\\tACTIVATES\\t","NuGuIugXe0k6\\t2ZOWMzsce0j4\\tBpH76ff7e0iw\\tINHIBITS\\t","pYhyONrDe0lP\\tDg3B9H1Me0ks\\tURGrIXe2e0kd\\tACTIVATES\\t","h-JnEMgBe0lN\\tHY1OO1uEe0jv\\tyEOAK96Ye0j-\\tINHIBITS\\t"],"RTK-RAS":["RTK-RAS","","A signaling cascade pathway initiated by activation of RTKs followed signal transduction through Ras then Raf and then MEK family members. 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"},function(t,e){t.exports="data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAh0AAABxCAYAAABxyRHvAAAABGdBTUEAALGPC/xhBQAAQABJREFUeAHt3QeYLEdxAOBBPBtjbIxlA8YEP4GMyME2CAS2HgIEmCSRjEWQSCKDyAgEepgghIgig0GPnDMyGR6YnHMGCRBRIGOwwXlcf0Mtc3Oze7t3t3v33nV93+7szvR0V1dXV1VXV3efrQ1oNin88Ic/bPLzpS99qfnyl7/cfOtb32rOOOOM5sc//nHz05/+tPnlL3/ZZBXOdrazNec85zmb85znPM15z3ve5k//9E+b7du3NwcccEBzyUtesjn/+c/fnO985yvXffbZZ5PWuqJVKVApUClQKVApsFdSYOfZNovR8ZOf/KT5+te/3nz6059uPvKRjxQD4wc/+EExOn7xi1+sC/UZJIyOP/mTP2kufvGLN1e+8pWbK17xis3+++9fDJF1KaRmUilQKVApUClQKVApMESBjTU6vvrVrzbvf//7m7e97W3F2GB0/N///d8QonO9d9GLXrS57GUv2xx66KHNjh07mktd6lJzLa9mXilQKVApUClQKbAFKbB4o+P73/9+8/a3v7155Stf2Xz4wx9uzjrrrE1Fd1MzV7rSlZrDDz+8ud71rlemZzYVghWZSoFKgUqBSoFKgT2TAoszOr7whS80u3btal796lc3p59++qYnl/iQC17wgs0NbnCD5sgjj2yucpWrbHqcK4KVApUClQKVApUCm5gC8zc6Pve5zzUnn3xyMTYEfq4FxGSc+9znbn73d3+3+Z3f+Z3mt37rt5pt27Y1DATwv//7v83//M//NP/xH/9RAkx//vOfNz/72c/WUmR5V3m8Hve4xz3K9MuaM6wZVApUClQKVApUCmw9CszP6Pje977XPOEJT2ie//znl1Ums9D2j//4j5s/+7M/a8RaXPrSl24udrGLNRe5yEWaP/iDPxgZHec4xzma3/7t315idDA40uhgeKTR8aMf/ag57bTTGitgvvKVrzTf+c53yioYaWcBRs/Nbnaz5gEPeECJAZnl3Zq2UqBSoFKgUqBSYItTYP2NDt6GF77whc0//MM/TD2N8nu/93vN5S53ueav//qvm4MPPrisJrHUlSdjHsAIsfT2U5/6VPOud72r+cQnPtF84xvfmKooXhXLce95z3uWD0OoQqVApUClQKVApUClwIoUWF+j49vf/nbzoAc9qHn5y1++Ysm8FAceeGDxHBxyyCFlxchG7Z1x5plnNp/85Ceb17/+9c1b3vKWYpCsVIGzn/3szdWudrXmhBNOaA466KCVktfnlQKVApUClQKVAludAutndFj2KubBstdJwEtgiuI2t7lNMTo2ytAYh+N3v/vd5tRTT21e9KIXNR/4wAdGG4+NS68+xx9/fHOXu9ylYYhUqBSoFKgUqBSoFKgUGKTA+hgdT33qU5tjjz22+fd///fBUtwUp3G7292uufOd71xiNMYm3CQPxIS89a1vbdTt3e9+90SsTAPd8Y53bB772MeWmJOJievDSoFKgUqBSoFKga1JgbUZHQIxH/rQhzYnnXTSWI+A1SVHHHFE8+AHP7hsRb6n0Znx8ZrXvKY58cQTGytxxoF6Xv/612+e8YxnlO3Xx6Wr9ysFKgUqBSoFKgW2KAVWb3T853/+Z3PMMcc0z3rWs8bS7hKXuESJeTjssMPGptkTHjjbRfDpk570pObpT39682//9m+DaJteEQz7ghe8oKy2GUxUb1YKVApUClQKVApsTQqszuj47//+7+Ze97rXRIPjtre9bfEOOOdkbwErc+ym+sAHPrD5/Oc/P1itNDys4LnwhS88mKberBSoFKgUqBSoFNiCFNg581GrPBz3v//9Bw0Oy0n33XffEgdxyimnlIPV9iaiMiiue93rNm9+85vLlJG9QvrAMPnnf/7nEr9iP5AKlQKVApUClQKVApUCv6LATEaHGI4nP/nJzdOe9rRl9GNwOEqesWEVy2ZblbIM4VXeUE8bl4ndsFeHnVH7wPB473vf29zvfvdr/vVf/7X/uP6vFKgUqBSoFKgU2JIUOPvOgGlq7vTXN73pTUXRml7pAkVsKsGUAk/AVgDGxt/8zd8U4+pjH/tY06cJelk+/F//9V9l6/S6nHYrcEWtY6VApUClQKXABArsntro+PKXv9yI0/jxj3+8LD8eDvtaXOMa11j2bG++YcVKHgTnxNz+tuo8Hla8bI/dVS9zmcuMzojZm2lS61YpUClQKVApUCkwhgK7p5pesf+G80ZOHzgd9g//8A+b5zznORt6EBr8NmoaQ1yHGJe73/3ug9u2W+nyiEc8onHKboVKgUqBSoFKgUqBrUyBFY0O0wTPfe5zyy6dfUJRuI9+9KPL/hT9Z4v6z+Cw9fod7nCHQS/MIvBwCu1xxx3X3OQmN1kWy2K5LWPNWTSTNk9bBJ61jEqBSoFKgUqBSoGNpMCKRodplcc97nHLcBQoStHbYXSjgBK3OZm9M2zgZSvyoemfReDn4LfHPOYxzV/8xV8sK860yz/90z81r3jFK8ZuorbspXqjUqBSoFKgUqBSYC+jwNliJN6OqxNledRRRzUveclLliW58pWvXLwftjffCEiD4ylPecqS4m9605uW5bwbgZcYDlum/93f/V3zL//yL0vwEmx7qUtdqtDM6pcKlQLzogA+FMCM58Qd+cwDyAflgL4YEWi9qOBp3lh19fHbsn749HFyXIGDJitUCuypFMDT+p2PgT+e3sNWik7eHMxGWDe84Q1HgiUbylH0b3zjGzcscHScwZH4baThQeA96lGPKjuxEv5dMB113/vetzzfCEYhkH0mAcG9WmWhvn1B3y9LvTei7n089tb/+M9BhXnSs8MVr3nNa666TcfRibFhWbjl89rcfx+ruHj9HvnIRzZXvOIVx70+1X154SkCVr38Puc5z1mMKDzKmHJMwWmnnVb2Bzrf+c7XfOUrXylnIP30pz8dved9RtCtb33rctDkVIVvoUTTyIUkB/mg/7omoO8kyLSrlSuT8t5qz+z9ZBXpRz/60caO34cffnhz8YtffEl7bHKa7Bw7BNKZH//4xy8zODDQ0UcfvWkNDgQ31UIQPvvZzy4HzS2yERgWpnkYbBijC4Tyi1/84uZWt7pVc+lLX7r7aO6/CexPfOITzZlnnjm2LG0rMNiKnBQUYxP3HhA8VvBMCuiVpx1qh6agetnVv6uggDb+0pe+VPjva1/7WmlDnrdXvepVazYA+ugo6wc/+EExPPA1oyANWsqf0l8tyM806fve977iOfziF7/Y/OxnPyvZnetc52r222+/5qCDDmouf/nLFwPr+c9/ftkhWb+TjtEFN/mkQjz3uc/dHHzwwatFaa9975e//GWDV6bdyBD9KTv9GA98//vfLyv0su3HEeo85zlPaS8D1gqrowDe3rVrV9kr66yzzmroGvR3rtkFLnCB1WW6EW+Fch6E8GS0MZIw9bLks//++7dnnHHG4DvzvhkrQdp73/veS/Dp49f9Hx6PNpTsvNFaln+M0NpXv/rVbYyuluEa7t32Pve5Txsddtl787yBdte5znXaYNTSrmEALMPNvYte9KLtt7/97ZlQCYHThrJrz3/+8y/LU3vEyKgNN2AbAqu9+c1vPlPeNfH0FIiBQhsejiVtEEZk+4//+I/TZzJlSm0ehkX7yU9+sg3jviUXsu+F0dHu3r17ypyWJpNnGObtX/7lX7b4UR/CN6Gsygf/4ifPfv/3f7/wVXhW2ic+8Yklo1/84hdtGCnt6173ujY8PCOcwuho4xTopYXVf+23vvWtNk7ILnJBHw1vxIhm2Z6udAHZFVPE7Wtf+9pCufA4t3HOVGmjIV3hPflps6tf/ept7Fs0F4rjxTAwW20fRubUZXgvjOWZ35u6gHVOiH7hrVvSPn/7t3/bxuB2nUuaa3bHD3o6jBAEZ+YoIZinALdaKP3mghe8YN5a2HWlKZUhRHg8gEPpFhnjwe176KGHNsEQTXTQJahxGbsnAPeAAw5Y8myef8xl3+lOd2qucIUrlJGNDc3CeFwyHRKsVizn97znPWVPlmnxwSfe+eEPf7jslRA4zZWudKXi2TECFgtUYT4UCEVcph+0tT4M0P+P/uiP1r1AZZlGMYXy53/+58XDYFn9WkAclOmaMA4K/voHr6BN+IyweU8++MEPFk8mj87Pf/7zUXHwAaZfLnnJSzZhBDVWlX3kIx8Ze0Dj6OUt/INnk4te3+QdcqaUvYV4QAC6nve8522udrWrNRe72MWa7bHn0GUve9nyDG854NJCg7e97W1NGJqjFXqmUvAHebNjx47ShvZzWm/A59/97neLRwxP3P72ty+xc5PKIed48r/xjW8073rXu8phnnbR3uzeAvEbGSvFy0Qf8+DpG3sUDNk0MVdbrNOoSBlRuPqEO7MNwTD0ylzvzerhSHzzuhEeDxb3O9/5zjI6SzzyyvLfuXNny9LeCIBbnA/TXuQiFyntGoJ61M5GLLH0t+WtmRZiSqV4UdQvBP3IEpcX2nteYTEU+N73vteG4G3Dnd2GsmhjKrR4JOZZuhFv7NUzavfVeDqMUuWhb+CbME6LF6WPNw9hKIv2Nre5TfFy4DmejjgBeklS/BsGSqGBNNXTsYQ8Y/989atfbY844ohRW6JtHPewojwIQ6UN43AkT2L6q33lK185176P73i0wsgs3i/6KaaQx9YtH/zkJz9pw7htI6C/eGJi2m1m727mtcgrnuZl4jXCz7yBvIJhIC4SjbWWdfyyJbORY5k3MkcL/AesKnOm5uYWCavxcPTx4/HgWVjkclqW/oEHHlg8Hn18eDvgNCm+ov/Oev6Hm7iKy13uciX6mVcmrXxeC7EoIXymKjIMp5LWiDKmV5bs2aIcQU6s8QqLoYB2fOpTn1o8T+KKrO4y4tzMgIfCzV/mqskd/OIU66FAVHIopgDLCdaC3NPDsZnrtyfhRr7rswm8GbzEvLfjgNfAkQ+nx35E3rdfkTibmEqda9/n5Tgtgoh5OPAQwB8rAZ1is0Y8h394BvcEPtIGN77xjcvWC2K1eMytlOT92MygbXxGtkQfWYxjT4k+cFeKhF8krIfBkfhqoEXv48HVay8THbcLGiBde937i/4NrzRAuEkTGGfcpdMAA+qtb31rcatyg4f1PXoNkyWjjW7WH3OngGkFbm2fzS6QEIOhYdqE8kh3fh4vMI5YpgNsCjhpqrfy3jjqjb+PZqnAx6Xq0lX/N0g54YQTigwIL0lz0kknLWzqeBojo18PPEbu7YmgvqapyNnwVE80Bje6fnjDlN1nPvOZ5rOf/WwTHqYybbrMLHzLW94yODd/y1vecqFxESsZHOaxhiKhI7hsrHXNu7BIwwNjX/WqVx2MY2ClM4R4FjYaKCnLjLMDY5Y3v/nNZd5zJdxs8y6t0cJhhx22zMBa6f36/FcU6AryrUYTI+WPf/zjxUClEBhK+GkS6FtiPsilvlE/6b1FPNvb2zK9AuQED+dDHvKQ4nGIKa9y5EN6TRdB624ZiVf33tDvoXRD94berfemo4D4q5heKzFZ17rWtRofx4W89KUvbbbpIElwTGR5XR/23Xff5ha3uEX/9tz+T2NwCDazw+f73//+JXjwyDgHxSiIZdWHRQeXMo4IRnh2hZFAIEtMuSUtQdtIMLKxBNFSRB4YuLFOP/WpTxWjaRxu0n36058uaW145sA/B/+tFuSXH7RiBFEu3IrJo928GWzdUVnS13uCrhKkkVbeQJ6eD+Upj0zrtzTSemdaUE7ilvXIukzKhyGakHXxv+v+1UflDa+shzRZR79Bvi/dSgpcWvnKI9+Db+LsOk9AL0v/ABx42r75zW+Wk6snlWvQwZMoUNZU5nqA+nfbX56z0iL5KvNRJ+C+D36exAfJO+Wl+Oq2SZ+vu/0l8540FZJ5rvWaBoflmqZiHQbK+KArVgPq7KOuPuiTn6RnN19psj/378OtC8nH7o17Txt138u2GtdO0mc7+d3lkf47WWbyQeLhKm22V+KQ+SWfTHo/08gLSJt0/NWd3/BPP23yjvK8l/Tu45/59K/5frYDmqGDgajptWc84xllk0x0pdMZHOyLJRN1NtahaPpAIYkIXwRMY3A470W08ZCBhIC3u93tiheE8THO8EDkRezjQUhQxqz/CPIbkVD5cNsdEd8baXTAA80I7utd73pl9QAkMY5NaHhqxgFmOvXUU8v7LFkCR16zAqbV7lbU+OBDCljUvL0YuNrN43dHtDqWsmN5b+lk0nPTuy9ehdcFLhGgWOZvue/t96AsJ/5aWcRAzQ6PDiL2KTujN0YXa127Xfva1y5R+t3yh+qIHt6JZaTlIy95ilGwwiOnPCjLrvKAM8Ftsy11UBd5uVpdcOSRRzY8eFyVEZxc8FO+6awb3OAGxTPA+EO7pIP35WsagkIY8gqiD7rbp0G/N73xox/9qAgO79lB12ojqxZWqvsQPWa511Us+oVVLMrHU+OEoPv6DsW3HoAW9qtAR+5gq7HgJVbJvjpc2niGEUe4DgE+4rnxrjaRjzy1q9gafCwffK1N+nWzF4PBCH7QhskP8LBqxJy+MuAqJoGHSBn4Tn+JIMPCF3iuS9MhXFd7D16mVI499tjCO0fFrtWOo5g1dkg98CuDE83tI0RG6pOmDv7qr/6q9GX1yv7iHauWrLzDr2iVgG/ILH035ZC80JwcQ1vywvM8gFN+yjQqJwPzPfyO//pxRZ7LR9lwJlPISnXHI2SV97o8om2kHWpTutWHXLJqiD4Qp2La8LrXvW6RGVZ1eV9744fkC7yjvb2fAwu8pm3UKdOhMW/2IYccUmhKLthPyREn+Ef/x7P6uTT4TGjAOP6Bqzqpu7K8r03E86i7QQPZTG7SffS0/2RKWUkXRAy6/wpOPvnkUdRyNGT5HQW3u3btyiRzvUbjTdyHI7wG7ZOf/OQRDqJ4E8+8RnBkWXctUVS2jUouS5NpF7WqJQREG96OZXhEh2hjudrC9+xAGzipf3SuNuZjy/r2d7zjHaO9RUKolujo6MiSLwN8EwxeIsdDwLWx9KwNxi15JX2jI7ShEJa9270h8joCHtsIZi37ANh7IZi/7BeivdFo+/btbRiaS1ZhBJO30dkKvtH5RrQN4VRWbFgNEd6lQvcQCKPncMPToazaiFspK4iiI7fRAQvvxXzpkrTSwyl2mS1r+ru4d3/HZj1lz4IYcRecY4qgvBcdsazoQQu0DuOsDW9boVW+ry2s3PAO/JN+8IygvjY6daFvCLTRKqPEK04wLnR5+MMfvmy/BHQJwd2GAsyiRld1DkHWxpLUssJD2doxBMOS/TDC+7WM9qNMfv0j8U+85RHCs59s7H8r4iJwdFRv+aBVGFStlXTaMgTo2PeHHkgfm4RNtXolhHAbCqG93/3u117oQhcqbWAVFr4Jw6C1uku7hCIoKzlCYQ3io0/Y4ybOYCr8hXfxTgRitmE8lXy0CTrbb8FKixDgS9DX1vql9ujyNTzCq9OSkR/60IfaCIwv+CTN82pfFnsZhfG4JN9p/+AVvJT5aUs8lhAKrNB1x44dbWwQ1obh0YYSzsdTX9EqlroWeR6DgNL30SiMulYfVH90V44VG/gVkDnaKQYD5Z0ujfQXNNfX8qP/hVHUxkCmjZjEwg/asv+ee/mOq/wf9rCHLakP+RYDkjaM+NKm2gS/kFfKyffQXztm24ZR2EbAZ+HpbrnkG1qHAdPGgaBlNaE6JO1jmXKRjfpA7rFELudz/Eku6n8J9tcig/Sfblq8az+dMAiK/AnjtcUrmVdeY3BUZBH5OgTaQd9WH7oVDdRfG9qnKeUXufOGN7yhrKyxUpL8jJkJdDme1VwAE9hoJAvPq4wiuDSTze06jcHRXxY3zujoNoJNujba8NBRX/jCFy5RGOiLwcIKLxv0zI2wYzJGo67RIRmGjBHBiAcIzAgqHsyBUKc8MRnlH5bvzEYHg4Oy1WHlE1Z2Ua6EkQ3oYtRSOhA6eW75Jz4BFIUlySeeeOIoDZpKx8BjSGWn0LkIeoIsO7UOyUC1/FJnIOwIOXWWntLpdlrvx14kpez+F0FtwzcdXfnh0SgdPLwHraWEaGgZq7zhKP+dsWQ6+VRd4BH7yRQjQEeWTvmWAxoM6NjqwwjwLJ/HqKTwD0UYq1baWNFR8PCcANaefQWEHwkOhpd08o1ty9sYARblS6nFyLXQzHN4+++9IVCPtSyZJcwtr0Q/5eVHW8HN8ljCNEZvhcfQayWY1uiQLkbLI77XzgyxCI4ubccwUzd0RE9KQ/vivVQqcCE/tWF4WUsabRjetpYhz6ANr0fZpI0wVi8KKkaCReF064K/KRnKhNJJJaUN5Oc+Ixx/whV9/IZb0o3CjGDOJfh1y5j0e5LRkQaHpbGWY1PK45TTpDKSVhFfV+hAxzA60Ugb42X9Opf0q+/znve80ufxsvYIL3aRBxRs1htOjDl98ZhjjinG1wMf+MDSv8kTxmB4yEtfjHig8p4+9mexdDb2MCrveZfRgN8NShIYvuQRmYHWeMBy1dNOO63gbNBl40PPyJEb3ehGpd29b8sA/Y3xZuCg7eFM7pELjEltxoBheGV98BCjhP7FRxEy0OrvyRPSolPKEWWF16j0FfXQv1PeyRuNbQTHkGTwkENw6Bu4sa9SG3F6y7Z00FcsUfYcjuHZaWM/r2I8GnQx8tFf3nBkMBpQdvtJoPgbo0OjXPjCFx5VOCtutNF7Sd3WFaYxOLoejix8GqND2o32eOhkOhLGSrrmlcDQwIuGIaODFRsb/YwYNRU9/PvgfcqAoiAIwSyeDgxsBENw6viEcbgPlxSD7wgiQgG9dA5M3sVHGiOJLm3T+o7ApWIoUKZGKOrG4k/aExAEKMEdbsD2lFNOKXtDGIHaaZFgybRoYb+CPhilE1A6t/x0yNhgqZ+sGEt2zdTe8jRKiWMGlu2gyPD7+7//+5JGnuqi/oQsIwaOKUhcGUtGSgkMNkagMuAzZHTYpZeHTRp5MGjwZxfUi+DO+lMA4YrtJhn9XqvRISN4wwnOWWb3msYcJRLLBct+QTn6HSHS+TGN0YF31DsVF1rH2UhLvFCyTCV5/etfv9ALv1I+dmNNoHyf+9znjgwnitTorgv6x+tf//riIVA3SpJSGZKv7tlnpKscCXNtxbAxmMKncLALLTmdtHPlOUTTWWGc0ZH0PDj2tIC7+hvBdvvitGXRNbwVFBOlp1/lYCLzMIixl4Y641F9kVLrAj6myJNPYiqkyIJumqHfMe1ZZJf38BVaUdbjQN0ZgnCAi1F9LLhYltxOuDFFXfDRv+92t7stMQi8QGnbT0TZZCfDIVYOFt5BTwMmZeRzdMpdtfEEHktjbMjoSKQYiAYhvFHywhNoHVPPbcTeFKOaPGFwk0toh6+lRfPjjjtu2Z5c+M2gRhpGMKOTnOhCTLe02U/UQ33QpQO/MTpYJFmoTPMD8XnCNAZH38OR+ExrdEi/kuFhQ6xs3Mx/Pa+EEhdZ0jWvGG+lKYj1xCPzGjI6MDUFThjCD9MQeoREFwga7krWs7SUOpjW6PA+NzSrXTlGBkYvQ8AbwmqXDn96py8gjH4yL2kYMD1GL1nriEZMKZzlCX8ehr6L2GiaoNFRs+yYY12ikCg9BiPDSRrGy6SpSAZFbryEtrxcRtJdMCrqurd1bv/hDiedmhFitKRcBkp3tKkMI3X4qGff6EB7UwmUlzQ+aMCT0AXlEawMPWnQYcjw9856GB3qxivE26VPpOBNHLvXdLvjGbww5PlIJZm8jFb9bdCNzigGeVOA+KbP60kTZRDQabSii7bEn8AIPXZkHdGUAWNU2ccNX/JwKFM9ubnHyR3GK4UkLeVI4TOe+6BNKRCj6KST/jCUtv9u//+Q0cErJy9tk+1CMam/9LMAjwHPor4iL8oOXYeAQajO6kSJM7y7hmYfV8ocHVYCHqnsh/qI9jBtMw4YKaZoEg/eEvzVB/2QfMGf0vJS8lB0gcfDACfbSf/kVSN7KfDjjz++0Eb/JnvJE30xgXc5Zd0ko0P6OB2+NV2iLO1117vedXAremWfEoOZrkwwhYROCXBgBOb0M9xe9rKX5ePRlT5nbKfclKcBnDJ+Db/ZHMzhSsG8gd9vIDpWCVL5zZ31/RXCqgQg9Y+nz1KCUE2MopsYceWtVV/tMWI79GD2wTzmvY9HCI0S9NMvPIRSCeYJJu4/Wvj/UNgl6Cr37AgmKYFX74ktzrsAZ6txBDYKYhI8NAuoa8z3lcCpEDwlAE7A0RCEUBgd1IU/oyOU4KVuWvfhCtTBKpyhwGd5CW4SpAZC0ZRANRvHhXIv9/LLM0Fk3brhV58EwVghFEpgmXLlK6B2HCjDZj6hbAq+ITTLAYCJe/89tLExUwjI0QqaGGE2cZZKOXTRicXhMh4MEu3nlf/lGd6WJgzGUn94+x8jokxSru4rO/uLNhekNi9Ab4F46BlGZrM9tttGJ/f7EIq+CeFdgsnRJozDEjTbTzfpv/oIpBPkBkJRFD4Lo2LwNXjYNCsGDuV5GNgFh1DG5T9cw21dAvqkJbvC+7Ys4DRp7yX9wMFdAhPHQfJGKKES6NfdByff0abKCqMgb5W88edaAZ1CkTdheJR+hyeUpx8IahaMH4bA1MWEkdjEaL8E0dMvAoG1+xCEoVECKT0LhV7wOC2CLBcJ6mZreIGQQH+wJTxZ0gdtK2DcPhogBkNlk75sQ/f8zv/aNIyOElisv4WiLtu4O6E5jOFyUrPAYbojoft+3ht37aYNI7gE0JONfVA2udKVdfoYHk8QOBrGV+FX92JqZnCjUHxPtqgLiEFQ0SFhbJb/vkoINuSy84yexI+wUsqne2+9flMUiDvJ4AiLqZz1sl5lMjx0khSk/Xwtp7XsK6y6/qM1/8ekVgL0hSg6aMxwha65jPXIgPBEp8STYIxR8BKhjj4Eh07j3IahDjgJF8zsfYDhY+ReFDZa5Ccs4xLRjTcJOgIKuD/Eq+Xhr7/kMQSEpc4Sru/RY7iMM/jQIAWIFwhg5QNX0eRONAUEA6VE+I8DaQjZ7aFQgbIjfqIIp3Jj4At9uvXRPgwbu47GqGiU18CrY2/F6L8J92nZLXfHjh2NM1OspugCWlHE2hhoh1mUSzevaX8rM6Z4G/2ekA/3bTm3h7EGD7ToAj7cHcYHo9EOjXCcFtCesRJehvIKusY0y8TX8WAa5BJShHZ9BfiKgqAsGOK2GLBqSJ26kAZJ3oPztHjjg3G8CrcuX8szeTXLWs01Rt+NvZus1iAbbfyVBiql6tRs+/RMU5b+o8/geUBBWVlCWff7vfy0efYnz61OscXAIoGyJW+STxhC+nDi6wpXHzRXp1S4FK1BEl4bArzRb38Dl/BINOHdLzu6Zl5D7896ryu/+u/i3/CcjG5n/fKGvobfUwaQZSkbMk1e3defgDLRocu3xVxD0KHGtLQQkecFRhUaqTt6VJZ7PBwOl1tviODJ0tA2CcPEXSBkMdQ8gMDUwViBOl4CptN5WfDbf62M8tlGXAnFmLYqSwMtXdWZCIncTwQzRgRy2UGSQu6OrqbBV30t57J8LAGThtu5MGZ2jOzImN2zBOWffvrp+Xfmq47eN5LgNATSjutYOpE68PYAnVDb9hVjN1/5ESL4Pmkb7vzCD12F0X1nHr/VieHCu0Qg6m8J6KtuhIt2SiGTzxdxxYM8VZScpfGWC1oK6XAuQhx++ANoO/xgAGO0lgpxJTzV23K/BO3H4JkE+EYbp8xCG7yJZz0zyo04nTJoIXSTF9AUvtLxPvBurDfgLXVwHcfPqy2T4udVY9zliDcCGAtvGDAxgCd5LLJcNJeetwOgj7a0tDjbFK1SBiiLrEkw+s538968r3CAH4Av+uqzcMxP4uxKTsYUQ0mvTkb6lC7dsplBn/MZB3iLcehKJuP9cbLBcx9A1uSgIfMuRoe1ywRMH1ay/PvpZ/mvASOAqHTWCA4bNZQOvd4ejj5eRvKga3hgighKKp2rn349/mNWimV7GBZdo0PemJfwGjfFsB7lT5sHPI2ErRGnGAkwHceIjmCBa8xTFqvX2QorCep+uTomI1eegDC2hwa3dQoeZfQFJ7y0EeGeDN3Pe9r//bynfa+bDo76TeaFn6cx0HVsnpsEdTbNshEAF/1NG6ApYYkPrd3nBbD/w6KFfNIBXbU5mjKQGLe8gUbdMUdc9kHJEaS2MBKHs+mracA7lEcCYcoFPQm0MQHqY6CEl/GxEaCRIkBTfOoZmkpnWsoUBa+YUTPDqQvJQ917m+U3+vNmGn3re6aQTGnhjfSA2peGsfWEJzxhyWi5XwftxUjP/mvQZ8rbRlLawwfd+vRIhZ0Kr5/vPP8zdNILDbeIMyn7QPmdhqTffYAz/tW/1WtPB3ywPXQXPiev8D05nv0066eN3dcnAIPVjAmDJaEYHUZsfatFBzOnPW/AzMAWqSowLw9Hvx5peLDeWaI7d+4sbuZ+uvX8r9PwHhGOXcC8NobZLABPm2tFpPTINWakyUhDK/EY3LnSrAYI4lQYhDTjNpZaFYGjoybk77y677fpmI0GgqY7Fw+vbscah5906XqURj4E20YAYcjQ4EkwncGTwJCKoMsyv8sI5jpPA3GeOKID2viAvGaZ5BEDN5Y2lmmMCHxrIup+5PYmv9RjWqOD4kseVJYRGV5cCaSjfAF5RalkPnkPTY3oGefOJWIQKY/wNW/O0MspBu/06+reZgH1NR2ddYYXj60Bo0GJulEwzmoi2xzUR34MATmXXgDPKTCHw5l27rd/vt+ljf7VnwbMdPO6at/sn2gQAZTNUUcdtSQGrIsjPPK/K8/bNIOReeG/XvmSWbEyr8TY4GuDkVjNUgYDPN76pzbE94xQ3jy8Y6oxArRHNIFP6T2stz6Y35l1FNvPY9r/DA8MqYHnMaUyDg+GhzJ5eWJp0rhk63afUNMx+6CxTK+gwTSCr//+ev+HQywPKwFOsYyr4MXFyDAiPP0mPAVBrQa6dcSs28OCjrXqq8lqw94hUHSqLkwzoqGocqTnXfl0jZBufvP8TVEwMp75zGeWoGB12RHxHbH8txiB2oRrW4D5PI0O9ICLKRIC2kh6EqAXjyHlRpjrt5SCvsMVPi3Ip8uH+iBcVgLyQllAHhRsKlnPBB0K9OUFIHj1EwqaJ8/0i+kVcRFdo2OlMjf6Odp0QX0FtGoDx00wvnkweCxMi/GS6tdDgGYJjC8yhBLfzJB1gbuRO0/PIqdDNwttGB3O12FwsBnEQPLoxLLY4h13P/ajKsY2A42HUtvu1wteHWt0mLvMIJ5FVNrc7UZALDlcWLGY1zbKhF0KLoUTdjotd+NKQnc9kVVuVwh08zaqEAzHJUzoUAzOuoE75WqEshoLXnnpopanvE03UcR9Jd7FZ7P9Rodu/ID27McIDeGsvl0PiTp38xl6Z73vCQ7k1rbyhefKyJV7PNbXj0a08OQ9mEYRrwU/vMRDcWRs9U4x2/483emT8sWf3P6xbK9hGOOrDDae9F4+Y+jllIg68lbgx0kgHQMnR776s6ky/IxWPJiUMKNcP2ZsWInTVVCMjm7fn1TeZn6m78eeDcXb4YwN/ZeRyvtksGpw1ZcteJ3XxH20xHv6vt/9tJul7niK5w/gVQa46YVum24WXOeNh/YzUGd0iunh5SJHYmluoRG5pm+wG2LTs9KnGaH9tt2HdZ5zVl2kGR3TuIu779TfkymA+OIlUthlagKewppGaeU763FVrg7v0weMZR49V28QKpjLgW68YM4uWQ2ggTzToIUDl9y0S+EIbDy70YA+28MbkH0ETqYm1GcSUE4Zw8FwEVS6KI8ivOBJKZp/5+qGv+BqKy+6LnRpc4Tn9zwBb5kHFq9hefYQPw6VTwgy4oH26I+oht7Je97tLquGw0pLgvEePHOKQB7inBgwlGfsG1Joi448HKZu92blpB8fFSNZZwDhZbzFgBRYyrDtAwXunYydQUdTNF0jvP9O/scT8l+0wcYbY1oMwEG9hmYGEs/uVXp8tbcA2otHin1VSlswQGIPoWJgxAZr5Wo1qmXo4iP1gb7BgRb7jFN2Sei9hWCboR45MuoGEiZeOt4ijQ4dIju7EUcfMAshnsGt0puGojAdatQV2Plun8H6/6Vzj+HFVQfkK08xIytNT+jA5hEF43lv0dCtD8ViiWzSAe5GekMB2YmnNIIXU7lRVuJZup6Obhn53izX/vv9/0Yiu2OZafIaZc3t3wf0XZSQ1y8oLTgRWkODoD5+/hOCycMUmbnjcdCnAwVIWebUFmMQX00yGvFfrlZRjtE+F7J3To/pIcIYoCljo7sEsTyILzhvZkXUp1PiPXSVVowDL3XufaM9xAft2rVrSayL99GckZi6hXfJlK0+Pak/e4Y3chXdEC55r5+P/ysZKtKMe88A0VSSNgWMTtOSaXhmuf2rvm4wxfuFt8bBLPQel8ei7pNdvFqMa9Pvluxb1cTAsMTXNTYmLIa4th4H+7DchpZwzTJqGJd5vb+cAlx144RRLr9c/tb639HuFCSBmfEk/VJ0NC5sI7oEQrq/YU0+63fe/v9MJ18Bf0YRQKeMnfxKRDxFNwQMI8JJMGucq7JEoOm4i+i8XcGkPMZT0oJgM9q1X8Q4IUfhE0JctN7n7TGF1fUodMtAh/7/Idp003R/D71PGPLIJMCVIHU/QR5wFARpOTfo55tpXfu07//vpp30mzI2ncd1S8lMKhPf4l9eG/wp6J0g7EIXj35e+FgAY262lW3TXdHSzcv7cMp9ObwvHiGDIMnQnJ5BU7+7isn7eJjRwrhJkLaPWz4but+tU6ZzHXe/m2aa3/0y/e/f6+ZDuQgW5E5PRWNuX1wLz1VX4cKRB92omAyQ7+lhrO0KA4XsG+o32tkzx6I7NTz394EDQzXL9B8PpxHqv3fxtjibbrBv9z1pPOviSQbpI6YPyChtnFspaFd9OLazH02zKasL+JgxJT4qDnIbeTa7afL3rO3WbYt8N6+ZZ167ad3ryplMM8tVX9M/1U/eaC2OKnndAgEffQlNtQf69mEb5ZOdpfswLdfuvfp77RTA8JRVH7Jz9e+v53+Mkh2TZ4Gx4b8lkjqmES9hCkdgNG8krsNZIoe5TQWk9yNxS+bCcF0DVnk6vXls+eaIVr6xvXFZ/eJIaZ2cl8DOs1YvmQ/O9PImvI0uPMOvNrMy709IeY7Ju6NH+WF6gi3rAldpCf4UbvDzW3p1kzY7pvvdfKWVjnBSlrQEkiAqkftGueppxQ+aMdq7xhp87IAp0EpevF0C0jIYN/OXLpVV4gcP5cIN7fpCxn/8k/VLz1Xm2cUZ3l3+kxYv2Kk1BxrazFSaeAkGchqnBIz08vCBC5rAL8tEZ7j4r9xM5/40gIesTFEn/MAL1OVJeciXYrPRHx7GkwKRM8YIHaSRl98ALeCEvokTo89mXtoF37qao45jCcoUQPKCdz23aktfcT9XcIjnwCuupqoIYvzBBS+9ZeXopE3FnuAPdHQPbmjnP3yzfdFviP+kkT7pn3wgH/XygSvot4F3Mn1J0PlSVn7gov0T3FenbHd4yytBOfoBnsfTjDY46M+2PlCmvs440B/EusRhaKU/U2LowjNiMMZjYvpFvwV4S36mdBkm5JC4nwT5iRGRXlqywd4rcb5IoS+PosGMKR8etNg+vLwKF54ouMGfUWPFBX5wz5SP2BS0FmOkXCN49YEvnotznAod9BuyCE3QyvOcYiJTGWPK8izbCa5A2dpMOe5pf59+O6GntNJInzwtTzzhHhrku5lWvtJkWfjSp1uOvPt4SS+dNndVN+/IywcejC5TLYx2dNNHgbT6gb5IzrAjtLl7eKekibn5nQIEu6DSgqA2u+FBOHVHbeqggePMgxHjduu1GX5rYPtSEF5d0FhGan2F3k2zlt+YC62MsigTc/ppbOqsvAjZ2SmaZBAdm4AnMD0XQEpZZsfAgOpiH4Ld4banVOUHMD+hQWjpjIQAJtZG8iUE4tyWMhJw33MK/PQY/ciDe9Icf5yyWjq//Cyt1r7qYzShXFvYew9ts4NieB0Ew+swOhBhwBOhw1BI0uqwXPOuOg7hp04Eoq3e4zCtUX3gmPn7LW/pKSDpKSYKmvLKje90fHVBd6MeOMANHY2ElK1eppik4UI2qkvBDxe4ag/3CMycE09+UE9tS+CiVxwGVugNV3gCafymxNHJKFSdlQ1n71GUtrbmQkVbylf94Cwdo0r5vB/yRldlem5nypw2khbOBA0lxkWtvYdAWkKcDIIXSPrLVxn6hnTaEJ0YeHEOTDGM1EfsRByCVtJJQ4F4l0Gbrnvv43f1gRNFYaO2NLTwIR6lKLJt8bh64H958cDIX3trO8oTpEBmmONdZeF57QkXbapfMO5MTZoLd09e6uqqffAJYS0Pz3maLE/UTp5TMHhU/nhAHeAHZ/1TP0BLgJbSay/1GtcG8rahFXqhlRUJvAneAYmf9k7jiHGhzvL3Lt5BH3XNNoQjZc4rACdp8bB3GQo+aK5N1AHt1AGt8bk6qQ85hW4Uv110bVyYgC/g6T19Tz5op05kx64wVBh+jB4eW7QAcJfeQEZaeVCgcMf3DE8yTR8ljxmUjCH8b3sJ/IEPyTueK15BvM8LwKhkqOgjDE4DJPX2nr5iCTq5os3RCF20rf9+M+BSgWc98ZJy6A3vayc4aBt5ZD/3nnv6sTKkJZfcy7TqTo7jH30SntohTsIuXryUO+iC/+Xto99Ij75oRa6pszqRqTyAPuSwcpOPPEMfMp9eifJ3i1pnGi/5hLAYHeIVBW5amOXAt81SiWjMcspfn+bRoOXwqXnhGUxdjoIOoVYO/wnmHrxGnEI52TXxiA5RTncModUG45TDifKZazBpOWgKz4zL033Ple0I6YToMOXgOKfVhjAqaaJDlIPdgjnLIVzoEsqhnMzoUKIQDOX1EBTlNEP5DpUdgqIcUBWCvJyEGR2xHPU8lBZ+obzKwW8yVye8NS4tWoThNTp8KgRAORE0plpG9ZAmvBgFx3A/l/vRcQsOjpEPAZ5kaLVNKKVCn3FlwjGUXRsGyei9/BFCqd0Zh3LJf9z7iTNc0cTBUmE0lcOp0NgnlFg5/O2a17xmObo9BEs5nMu7IdDK4W/wiMFIqw4hYErbjCtT2ggmKwe5Ja79K3zCACp5a3NtDa8QigUn/BCejHLCZ7i5C/3UU/s6WtshdPoUwKvhEi+HiI3Dyf0wNMphWIkLXoqlw+Xk1KQhWke8RuuQP+WgDR5Fm1CC+eroqg3dd2gc3NALTV3l6ZAuB1dqq1Co5dAvuHgubzR2gmcYVOWgOPUfV4cYXbahMEvZ+Bqe49LKx0nKodRHuHZ/hOIoR557f1we2tFH/Y+Kg8/UAYQxUY5mz3cnve9dx7iHkVHedQ3jphx/ru5hEJT+jgd8QlEXfGIU3YbyLyfalhd7X2HYFN7HNyk7whgpv8O4LwcihmHUe6sth5mFd6y0lbK68iamgMopuDGdNnqPrAqF2x577LGFf9BVecrqvqvt8XxMAY8O8sOT6ObZOBp55vDGMBJGZeaPMGYKb0ziiYgta8MjVI6SD0OptNdQWfJwmBucgEPb8OZQWm0Or3BAlAPx0ADvOqBUedoMDVJ+uPqf9Ewd575DKL0bcPy2HJ2kVeUaBS0bTXWf19+rpwDrkZXfBxarkcS8wKiAZ0H5wRhji4kOVNo/E/hvQx4WO+vXSK0LwVBlqaU5dWVMgmC40Ry6dHARjMlNboTNzcpLYMTHMg+mLx4DByxZYWGEmWD0cEisrjFHPFQfZXkmHTCCNDI1qlGnIciASnUy72xb7XFpRWbnM+WbJtkVIyujJ9Y+F61RhBFRdOgyL8wFbZlhf9M9OG6PlTCWbye+ffzUJxTU4MZoyocrD9Sk9x2sheZG+LwYAi/RnKfDKI/nBk3ts8AbA9DB0trdMarDo0Ys6qpNtJPppUllkiVoPwm8Lx3vEC+WdjDCN0oTVGpUagScvIt+Rrw8Bt04Ds/lE8e8Fz4d4sekI3on4DObjqk7ehg58xwZ1Wlj+Bv1cqVz7/Ou9IHXwTMb1/EUGLkbvYbBUXC02ksbAXy8c+fO4kUzsoQzftqxY0dxVYsh0Kbj8A8FPsJBW8ILzYbSazOjdOmGQN3xpf429H6+g25wMvWZ7Z3v4suV3tWn8F+mC+U36gtG2TwiaM7zkTwq6BRNw9ArHpLEpXvFj/Z5IlN5RHhXgDqjpz4xtDpM+/NWkRF4W7yO+vHuWzrOS9GlGZy0LW9LHF9fRvO8rEbx5KL2xxemG/Cfa9YVD+gz5EDKjG4d/ObtQJ9umZlGX1QX9Rh6XxvjUV47V31WgPtQWuXoM3AC6CAuTR8bSi9v/Ah39dTW8DR9hg/QXVsCPEKOkLHkHvmnD/DK8IahARzPFsR17Ht5Kb884MoZ6lyZZjNcHb7EjdQFHZv7FRNsRtC5uVoJ1y5oQMxsU6GtDFyYlBlm5w4lYAmsPQl0Pi5RRqROrqPqnOne3Wx1ISgSz0Xjpp0ZFhQ945ZAA2hIYDE28AN3LjpS0OaQY3Q8N1ThxBjgrk9DBh/OAvAnbPXrVD6zvL/V0uLBnCJRd0pRGw8pwiHaoDdlJw+/Ke8hBd5/F9/rq+SOdlJmKtF+2u7/5E/laWd9m8Kf5t1uPnvKb/QxbWKAKGDewMSBhoxlxqd+gibaUb8xkGFM0nUGYPSxzeTCuN+5jaXWBwkWqbTNZa1mlK+CfcBEhBRGmgUw+SLqrHGGGFODsSS3Oui4PosG9Nc26wHy2ah6rAZ/itFnI4BSMYIzIu0CGhJmuQ9H99m8f8PJCHotAH9GUoXpKID/eNpWC+jNIPWZBdLQmNWITf7Eo3s7MKoMhq0aZHAcffTRxfPNm9QHA0ReEd4ZniGDBfFX9DIZy6Avq1eGXlxkh+GZ4O6dFQTX9OH0cIlyhWKKWcD0gfcWAeMYlRGlUaa17heB61YpY1Z+2Sp0qfWsFKgU2NoUyEBzU9/2WDF1NGRw9KlEz/HwGswz7rzDsNw25BFgcJjfWhTwtjA81gO4dkSNzwrcuIsAym2cu9XUS7rqFoFLLaNSoFKgUqBSoFJgEgV4K+hVQEdlnMakaW9eDcaKVTvS24hPDJkZhW0y7IOR9jjF2E+7Hv8XWdY4fBeJw5ArWyOl+2kcjvV+pUClQKVApUClwCIpYKqEh0NYgPgrsR0Cl+2HIpaF7jSYTh3GMBHQa7sBQfViRG2CKD3YZmTdh0Uq4H7ZW+G/BspG2gr1rXWsFKgUqBSoFNgzKSCI2urBWCJd9vexH4e9Oix84L2w4MRUCqNDwKmdXAWR2v9je6yOsQHfYYcdNgqkH/R0bARpVjOdIwZCRbtAmQ95Erpphn57r0KlQKVApUClQKVApcBSCojjsLmh1WWCSgWU2ureOSx0t+BROtSiEDrZ8nerWxx3YUVpVyfH742JWu9WifvGuvtZAyjtzNZf9cLiQqBZ6iV4c5rAmC7Oa/mtvL6xJL9q+KyFqvXdSoFKgUqBSoF5UcCUSmyO1hx11FFlx1iBpbm3Cn1m5ZCVaJbRMk4sbR/Sw9tElg4Fk84L8aF8bT5ia+ppIZWzTVD6AaiW6diSV72GFPu4Mha5h4LlQ33IOtWprT5l6v9KgUqBSoFKgc1AAfrJhmo+9upYDWwbmtYQCEJhpyJcTcazvAOHITxWymPoHUQRIbtII2IlPLvP0XVofxFp1GdWb0837/q7UqBSoFKgUqBSYDNTYJ+hjaooxXGKcTNVZpwnY9z9zYK7JURDYAnSkCE1lLbeqxSoFKgUqBSoFNjTKLCNV6APVrT4LEoBThr993Gb5r+YCd6aWcDc0yI8O+pqu94+KHtR9O6XXf9XClQKVApUClQKLIIC24bOFLAdt8+4nTPXGzGbgzncadapBctz+kCh744DfGaZXmGkWENs97R5A6OjH/yaZQ4ZgPlsI65wRRugbcYZZdKNe7YReNcyZ6NAN7B5UjvPlmtNXSlQKVApsJwC24bOGGBwDG0atvz19bljB1EnbM6iuKQdmqawlCfzogynAele+9rXltMap0m/ljTKGjKWCPtpDihaS9krvQu3NDhdnWHjitYMooyVEaTLM2QKzq5zfi9y9c9K9ajPJ1NAILOlbfq4a7azdnQGheVv2jg3/pHOiZF5psLk3OvTSoFKgUqB8RTYJgq1D44X9lkUUGxDUw6rKZ9AXQ3ui4phMaocOmSPYt93331XU+V1eQfN7CL3gQ98oJz4+fnPf77gSSkBB5jhFdvZ7ohjlh2d7PTA+9///s0BBxzQPP/5z18XPGom86MA3mPwWuamnZ3QbNkbo8N0qiBsRoej17WxU5y1uRNgTzrppMbx7A9/+MPnh+Ccc2ZUzzKwmTM6NftKgS1JgW3bY8ewPvAgrJcR0M976P+iFP5Q2XlvUcKI4KPc+6D8tZyy2M9v2v9iX84444yyZe1LX/rSsv7aiNbH9BpjAz8Y6TpM7x3veEc5gfMGN7hB881vfrOccyNthc1NAW1oF0FHTb/mNa8pm/tkG2c7O1/BNseMyTe96U3llMhrX/vazUc/+tFyz/43exqk907deBM30rDf02hX8a0UmAcFttnMow9GPUY/FdafAjwxFHgfCMRFGx3c5vY5eeQjH9m85z3vKdMk+MGIllFhv31udukorDe84Q3NqaeeWvC3Gx0wOuaWr7A5KUDp2ofnrW99a/PYxz62xE6ZNuGdutGNbtTY64Y3QxAzbxcPlz1z3vnOd5Ztj5/97GeXijFM8OieBAxq063vfe97i7HMgLrDHe6wJ1Wh4lopsNdRYJvdQAkhUxxd+M53vtP9O9ffubeGQgjJaYBnwOilv9EWwUhAej5tXspblECF85BBp3w7uC0KGBL2xzc9woNhua599Hfu3DkY22I6xWYwRsBc7F/84hdHQaaLwrmWMzsF8NqLX/zisoXxT37yk3Jo07Wuda3muOOOKzv39nO0ZTFjxDuPecxjihdsln7Uz2+j/ptKYijf6U53aj74wQ+W3RKvdKUrbRQ6tdxKgUqBX1Ngmzlcn/7R7kYIi4LLXOYyzYMe9KCZ9wZ53vOeV+anu3jyFhA0s4y+CSij+nkD4S2e46yzzlpWFENpEatnFGw6y+jvPve5T8O4ZPQxOIxqtcU4QFMKiYv69re/fZleGZe23t94Cpgifd3rXleMRLEcvFYOaXriE59YvBvjMLR3z1Gx1bHrfe973+bMM88cl3TT3tfX1NlUkf4N8HmFSoFKgY2lQDE6KJG+0fH1r399YZgZRfvMCu9617uWGR1W4xx//PGbUsAQfqZW+p4OXhkep0XMNxPGYjHsoc/gULZTAk2xTDI4sm0I7oMOOqh5yEMe0tzrXvcqqx/yWb1uHgqYWnA2kXalfLXbJS5xidI3hoLH+5jzfjIwv/a1rzUnnHBC//Ee8Z/3cJbBxx5RqYpkpcAeToF98pCWfj0YHWI7NjPkCKaLI6WaKy783kwAXwo/8UvcCEeKfxGeDgrocY97XJnbVz7lYp77kEMOSXRWvJr/d3rg4YcfXtJuNjqvWIG9PIH2EBxseiQ9lnjrHve4RzmIadrqkw23u93tyiqWPbGNu1OmjOsKlQKVAhtPgW06o9PjBJp1gefDqHyaUVH3vc3wO4XNZhM04k/EQvQBvg6qE1cxT1D+Zz7zmbIniXLQh2folre85czFctXf8Y53XMY3/YwYWAwdQYriSOBg9Ol9K2PsTTLk9qbkTEN5z28fRpurVReOTk6wMsOGawImcyddU4a8R0N553vdq6kIHijl8RJoE+UkjiuNmNVLPeEhbgeu2pPiVsf+cQOeZ3n9+plqs++J+/AyJecqv2k8YuKzTJ/5ALjr4wKEZ4Hkj9vc5jbN5z73uRVf7dIAvvBPGmgP9eoCGogzQa8+DdCNIQ4806xDibkAAB82SURBVMboJV9tLF+eQcZUv43VX574B05AWfiDd09+CQxoGyQO7QacAfXaVZ7ew7f2q1Gfc5zjHJlNueJ1bYV/pM2y4QdP75naVA+4SaeepoTlW6FSYCtQoCw7uOxlL7usrgwOHXQRRocOPbR3xTKkOjcIRJ22Dzq1JamESFe49NP1/w8JxX6atf6H7xe+8IVl2RBKjgOeNxCilksSekC5YjkufvGLz1x0vstgGVoyS+DaD4Ky4ub/0pe+VIxYgpnCEDR7xStesbna1a7W4D/KvQtoBVdBgBSG//CXr4DAhz70oUWxKONTn/pUWdZpzwlKnyC3vPMmN7lJKWNIoWRZlBnvk1U8H//4x5uvfvWrRcF5h+IXWGk6CY5Du/fiMQpE7IB9L+ysi//UE13Q9ipXuUrJ4yIXuchIuSn3Fa94RcFb/dRNHeXn1OUHPOABxUthVZEPHBkvgnltfsf4GAeUpFgOOADeLHVIJT7uvaH73r3GNa7R3PCGN2z233//oSQFZ8YD+icNyA91okxN6xx44IEjGqQBxzB42cte1nzyk58s7ar+Pvq2/WDuec97FiNDoLM02gedGYb45apXvWqZAtI28kRH5dqDhIfnYx/72OgEbTLmbW97W9nMLuWCchgDpgm7myTKx9JhBjq+sKJHn3FfG5iGRE88ho/l49lpp51W9qv54Q9/WIwLskgb4Jtb3epWpV0/+9nPFjwsQ2YEoc3Nb37zZkfsi9I3YgaJXW9WCuzhFChGh+VzOq1OkkBgUJA69ryBIHnuc59bOu8sZVE4fSB0LA2cpGj67xBCpgtshjQvUAbBRXn0Aa6LMDoohne/+92j4rU5hciAWA0YuYoZoCi6wDCgJJ75zGc2b3nLWwpf8eRQet5Jgf6qV72quPuPOeaY4m3pGi+EOL4gnAlxih2kcqFUKONXv/rVRdHxoqTSls4zyufkk08uhod7fUAPS0Pxnl1xKXIfBqj8GExvf/vbi9IQOCtAuWt4wNE0hnrY/8JvG2tRzjwlpihf/vKXNy95yUua61znOo16MpjUAa6UNKUmUDPrR/FQYur+lKc8pdQvR/fwp0jRcNzST7Q3WEC3BIbDavsxXCyjPvHEEwdXeKGBttAOL3jBC4rBhQYCs72LBvZ/sRrm+te/fqEBYxPPkTc8f2ig36YxzFBRR6tPtA/jU30YDv02dt/GZfqP/Bi4O2MFFsOEwifHgGfojfcS4IcntW0aHdIxkJ/znOeUJeL6LS8RGuAJeeAt9TniiCOao48+utRVOkYEfNADz0oP9ttvv2Lca2NtyniCl7aSXj0ZuEODv8S1XisF9hoKRGdpo5O04a7mc1zyCfe5x3OHEFhLyu3jsYj/T3va0+ZazxBmbSj8NoTpkrqG4GtDoLUxwp57+bGzZBtu/lH5fse02rqWG0qoDcOqjf0fSjlhULUxMm9DkLfhzWpDubShONsQ9K1n6h/etDY2HVuCR+YTSr+NFRQjvENZteGdaSM+oQ3F1l7hCldoIx6ljamDNhR6G0pkVD/5KyeUz5K8/QkF14ZB0sZItQ3PSxsjzTaMgzaUZMFRn4iRcRuKsuQX3pMWj4TSK3nBL4yM9oEPfGBp03D1t3e/+93bGBW34cVoYxTfhtFS8NTmcAmPQRsj3fI+flBWGGXlveQLuFz96ldv73znO7cxom7DW1Ou2QfCKGnDQG6VPwSh6NowgFp0yne2b9/ehgdmKPma7sEhDP82VkG1YTC24TVow7Bqw5Bo4YEGylWXMCQKncP4Ks8VjJYRqNq++c1vbu9yl7uUNHBGg/B0tGHktWHAtXEuUhvLfNvw8rThXWjDMBzVDQ/f7373a0OJt2gaxlobBkMbK9vaCHYe8Q38wkhoTznllNFn165dbRg0bXiGCh28H16z9rDDDiv0Q7cnP/nJpZ3D4CnpIni9VQf0lSe88TQIo6MNo6eNPWwKT4bhWfDEk8q+5jWv2YZnr40A3Ra/dNtHm1WoFNgCFDiea7QIZYIuO0FedXCCY94QruBlZScOi7rGqHyu1aT4KLl+fQgvAjZGZnMtn4CnVLvlUxLrrYwIfwI/y6FAKOMuUFYxYmxjRFzSUcjhfi5Ko5sufxPqMQoc5Rmu9aKAnvSkJxUhHyP7Ns6AKUo+PC9teCpKWgZNjDLbcM9nVuUKx1e+8pVtzKW3FAOlRln0ITwQbQRSjvKKKYI2Yp1KMgpGezIW1DE2Uxs9y3zU87TTTisKCD0oqbve9a7FKMk0rtJc+tKXHpVDIVFMjB51i6mWYpzJg/I+8sgj2xgld7MY/YZXjPRHtFI/hhnjYL2Bsn784x/fhielZQxR1qmAsyw0YFCHF7HghF4ME0o8QRoGWHhcRzTAm2jw9Kc/vRgC6BBeitJOsby+jfiIklb/0X6edQG/x9TciBdiWqQNL0M3yZLfcMBDjFR0ZmQyWtLIzMR4J2JlykBBOnjid+8n6MuMG+0tDf6Oabb2wQ9+cDG4GN1kq2c+DKvwiOXr9VopsDdT4PiyxWAIzcGNgrj9hqYDoqNUmJECIaya973vfcveCqFZ5oj7gYbLEq7xRgjFMp+d2XAth1Bc9wC2fjn+95djK5u7OpfocjObyhh3+i53uyA8YNqCu/tZz3pWcdU7HVjckbl1+d373vceTZNFzy2xQl2XunumQUJZFpc+GgiIlU8X4GT+3fQI8J5YDS5yz/QN00fiEsSQ3OxmN1sWM6GepmtCGRe8udvFFfTjevr1Q5tHPOIRZbdQ7x988MGlbmJCxJhkfl1883eM1gue+R+9QtGvezujgSkg7WDaQ/uYooRvF9BA21h+67dYFpvSmaZIcB+OGddj+skUzDOe8Yzmbne7WxNGU2ljUxDaSRuLEQHwCEOnTGdkfnkNgyF/lvbDi+PAVIzAW1NlibN4Jbh0IQyIMiUoFgmYUhGX4prgHfQwrQXUzYZs4nRsDaAedkc1DWcaytRX3bgsqVevezsFitGhkjoRBdgFSsAccoW1UYDCEj8gyLAPBJSgtHkDHHKOOcvS3n2hms9We5UnhSGGgxIhYMOLtiQ7uFCGGaTsv7iFruBe8kL8SYVBIQjmk/8QiIkQ+JjgPfP7CRSRlVrm1eVl5YDgzCGgTLNPwHf79u2jeA/GA8UpD3Ee42ImGPTiDRg3yQeCLfvgGVCeGACKFqgPhRVTO2UXUbEVYiPGgXwYQl2Au896AuMBHcVsyBsdBcAOARowCNUFfmJYBAj3IWkgPytTuiuUumkZ6N0+o00ZDWsBso7BgVcYFgI8GbdDoB5ppCobH/QHZ1kX7zNKL3/5y4/24RFHIkjW/ieMy4c97GElFmiorHqvUmBvo8DIjKcowlVYRg3dSjrg67a3ve1I+Hafrddvo4IUsrPkaeOivoA1urBiYFYhS8jNC4zGGBwC/PqgXLRfBBCmCYSiUXF3NJjP1nJlxOzYsaPZGcF8gkkpavzTBYoaTSijBP99pgG4MyaG2ti9DAqUl7TdOjIkbOXufQoefkPKTT4C+2584xuXtmM02LOCcjWytjGdvNXXPYZQGk1pILmiMeDNyIBQqyFWAnmjE6DkrObwmQa67Sy9+ice07w/TRrKGQ0AOlKkjMwhGihfXdAQ/RkIPFuTIGk4lEZ5aL5egO94wwQTA/TjVYI3D2Xiok18GO/qksAAOz1W2Ezbj/EWY5x3rEKlwFajwMjoSNetaPEuWAHAPZ6j0u6z9fpt6dmuXbsGlcikMo466qii2Lpp1MMx612F1n0+9JtQmWf9CC8Cuj8aIzxjLr8oviG81vMeQdc3rBhsqSTWsyzuZG3j04Usj9eHAcY934VUst17435PSttv+0xLYViabXUCcJ+B0k+fz/BEBBKW6RCja6NV71hlYXolAQ2tsAAUGAWvLArLb6sZKNt8Dgc8p03WG/CU1TcJymHs9I3zfL6aqzwZXjm6V9f0FPidNJAO7/tQysn/nq91a/W+YbWaeuQ72ui0WO5qxQmAnyk4q47UwUcaV22qHpbTJni21vpkXvVaKbC3U2BkdBC8EV09GsFlxY0AuEJvcYtb5K11vxohEeizwlAchBGlee/1FEqz4tVNTwhTsrt37+7eLr+Nki3T7Y6aliVapxsUHCWqTEISEJ6E7Tznk40CCWQC3QifK5rSFx+h7EWCtoCL9gAMiJx3H8LDc1MnYioSUsFk/AkFRaGKP5D/OGAMA3xplDsp7bg8prmvfbtTTxQlI8nAwbTNeoA6o6H9QID/DJAI+pxYr+3hVQJowDOyWQD+jKjsFwwLS1lNHU1qJwMGwMgekkWbpX4Vj0qBzUSBkdEBKcFNtk7uzoHrkEZxtrzeLIo8CUig9oGQMLLaLLiin30IbDrVBy558/WLAEYHxSfQjwIChCzcbE5Ewa4W1NEIuwtc0Eb4YicYXKZajPaVT1jjNcasDbIWBXgDDpRKQiqa/L/SNfkrR+34zAZr5uaTH1eiJY9Tn14rlTvtc/gIUKQI07vhiv7dOIhp8+umUz98NEQD+73YsG0aGqBP3+vWLWfRv+HcjXcyCLABG5k3TX3QZL0MukXXvZZXKbBoCiwxOgRPmZfsr7LwnzvZ8wqzUcBI//Wvf/3ItZxvUzqC61Zz0F3mMcuVoOfp4FHqGh2xd0cZ5XXjIGbJlxIXr2L0nqN5RqtYINNcpueMAnnRxEeYSrM6g+JPd/Ys5a0lLRrw6FHMjAYKxYjdleKYBuThfR/gv0BBqyl4GTYa4JUblOUUAIVqU7hYaltwnRVHRoYpJF4qXhSxX/gXLdERDbTxWjaamxWn9UwPf3EzCerGOM4VKnm/XisFKgXWToF9CJQEoyNL2/oCmCv8ta997URXY+ZRr7+hAGUm2NUOhn0gsO1SmUtB+8/n8d8IznbWqTDhR5FkYOWsZfJw2AEy9uEoBgZe4jnYHZ4NR6KfeuqpRaHbZtrqCyNHhgkhD5S/SFCueAceJgBf04c53TINLvqG93N5p/oy4jbLnL46mrpg5GU/ZuDxODEAVwMMCytVrLjQpvLlqUjexQdokFNOqyljI99JI8MVoJepFfWqUClQKbC+FNgnFUBmazneUGQ4N/hmEayJ62a/EtaMtdh0aAmqaI7Gsx7AtSSTVfxhbDB0ci5aFjwxtnzuB3WulD2FbR5cLIOpo4yNED9gq2dTK5STkbFVH/05766xu1JZ/ed9nu0/H5e393h07I0AGD220jf1MA1QQuqk7bb/Oj7BPUGH065I4XWYpJxXqts0eBo88CplcHS2lXaG6yyARryc9uPAxwxXyhkNMnYEDbT3tDTAcxkPMgsus6Ydxwf9fPSL9OB4xuiwuiY9gv303f/KUBd16sJ6tGM3v/q7UmBvocAyn7K16ebb+2BDoze+8Y3V29EnzJj/hJEAw1zV0E3GDe8oeWfeLBIIQp6G2Lp5NNqnVEyP2DNAYOe03gfeAWdqOFjM/gyWxaozJW5UDZTHI5Aj4m5dTct0D/mbRUhPq0y65eVvSlMcTY5qrexgUK+kBMVFqBelzYASXJp5MLTQYaWVQJ7b3wNPUGxdmKX+3feGfuMvS9Bvfetbj4KUGcBWUAn27BvBQ3m4hxcYE7Gtd/Fo4dncI0S7CoJmhGkPm6ahQTcebChfdHYeD1kyazzNUH7ujaOd+91nYr26AG/t6sroMPUHGFEMLd6d/jvd99EHLW0OljzffZ6/uzjkvXqtFNiqFFhmdBCkjrLuj0x1RCOl6u2YjlUoVYdgmV7pA/e83Rs3IgbAqM5KJMGj2cYEK8UrGNKo30h8nGKnLBknlhM6aEt8Rpx9MVqRYcSXQXmEMsMil1aig3wZLGI+urFD+GuSwTMOnz5t/Z8k5NWfF0DcA1B3CpAhMDTNolyxJ6agTBmJjbBCipdq+6+9Heorjze84Q2DXgz1koepiYc//OElxgd/dCHrl9dJdei+N+63tj0qliwzsDJegdGjD/NEOWhtkoGgTqbeHIYXW3qX+CPTZGlAMt5i6/dRHI92Z3So45ABhwamadEIDdCTITQOkg7jnnfvS9tPj368b9ob4C9tkDwmvf/aTR/VJ+2bkfXTB2J782JM9NtKfvgGXzPIHvWoRy1ZQus5SJzy+qu79btSYGtT4Ow7A/okMCf8oQ99aMleBNLopEbKovXXKhT7Za7mP2FoZN0F7nPbWqew6T5b1G+CjcA+7rjjlimy9HLYyjmVwaLwynIIY8uKjdKM3AlVQpl7nNcD/oxP932MBo1kxT8Y0QkQfepTn1oCChkcjBgjXjxBkQmczVG/d41o8RRlpL0oJ3lw0RtJK0977dixo8RcUEZo48oTAUdeFdM5yrCM9XrXu14R6t5TNlCWMvCuUSpAb7uFMjLgIZYmV06IR6Es1dFvzyjrLJfBRCGlgeWZI8r1ASN9NIsDwoqRpWz0Y5BIxzijuHlB5GE79TgrptQrzuAoU1zKQS8esTgLphj06iKIES3UFc7qMGt/kx6OPJeUI9olTtpQzAJQHjyzndVZG4n/sM27ussDL3d3evVensaLZ7yvrUxLqL8pHooZffGOKTgnszJ4BN7G+SnF05c0YMiiEcNP3rZOF5dCYau/e35nfgKgxQ4B/CzoUzCzNsn0cGIEpbGBJpaHywfvM7QZzlb78HLgUXigDVqhmbbL1Ubqo53lZ4v8Zz/72c2uXbvKu3HoXaE3GmhzOzk7oVg+8LNhoaBxvJ51KsjXr0qBrUWB3YNGB+FLaBiN6GgJOgsBZttoEewbDZvV6KBwn/jEJxY3cp9GBDUBvpodWPt5rfZ/KiQrLigcwtVVWzMsuOEpHYKVErFngU3jKCA0p7TERTA4jKYJeSBfI2BKVIwIgUtp8p4wBHg2CHoC2bkWjhQ38iXIpaUIeNIIfQLaDpGMB14IW4fLCw9S1GgsLeVkdAp3Z3qYvmCgGFUDQt5vZcBre3gnKD35UxDuecZYcfaGMk0lMkLi9NMy0pcv97sR7Y4wBoA+QhkbEdvojDKksOHJEFEHq0dMJfAWqKcYCzRzdor6oof6MdLQW/3gq25oAW8GgLIprlmBomaEW7GkfhQ6RaxsylSbahdtDFe/0e9FL3pR+ZhisN33scceWwKQtW8XkgaMCoYhOmoT9WKIJA3Qj0cAPdUlTuYtXhJ4CLLONkZ7RoM2RgMfOKMbQwaPkklw5EVMr6t38K3y4aGNGX/qr33hgj8YCzw82ouHA5+on/NdeDq8wwDxjraUH/rjC3vLMJzwLqOZx8hvRszOGLdZiSYGhJHDi6dN5QPUU9mMEWUztLoB1SVR/aoU2BoU2H226OC/Wb7SqTSBbARLaPaBVU8AUzAbCeaU++dYGMETnhuFGwFohGN5YgrFpBHlbE78BS94QRkV5f2NvGpngty5E5QtIU+4E5TqAghvCgZNKTExHIyN7qZZWQdKk3DGH5QIQSsfnhPGAWNFYKnpHeVYEWHKwm/0kUagq8DFRz/60UV4Z979K3woM2e7UBAMmVwm2k/rP2OD0UNBAIrYSFXdeVwoOcpJl4ALbwuvCgORYupvQy4d5cQQo4goFAZR5qHO8mCgU/x3uMMdSryU++hitJ8emYJQ74uSN3qPY8/HngPSe2XwLzwZlow3bc3gYCigOUMn2xle2hmdlLsjDCyxOpMM5MzbVARFTukP0YD3Rj5oYMpH3eCQU1aDiMdN7zHaGAcUN3xyR9n+O0kvRhPjQd3wQ5wWWwwPPJK8yMiwPYCpnu7meJ7zUjIqGN/6cNIp+YJxwtjF/7yqZI737HnDqGQwwkV64Dfw32DOtJQYqjTWy8P6VSmwNSiwc6zRof4MDu5kArIL3I0EoXnt7FDd54v6vdmMDkLF6EagJsOjDwQVJbnoVSt9PPr/4U15MhIYbFzMlFQKaYKSsUGQo7n9GLjux4H8GC+7w/3NW0IJEdTOMuEGN8oDSS8jYOUxIrihKWhpGJQMGEbPELhvNY64EgqGQqWYxqWnUAl8hkQCI4lXhoIxCqYI5WVkrb3UVZ1zSibf616lp6jUl0KUB6NNfShvHiX1RsMEHgceAbSe1IcYADyL3a3NM49Zr+rKI2BTNqN0o/j0cqGZOpticEAdA8uUw7QeFjQwvaROaIEGjC+8gwboiAaMiAQ04OmAxxAN8IfytTG88COZhLeG0su3Ty94aV+ryPCSMhm26ii2B08PAUODhw8PaiMGKXzwPW8NnjDNjGbAM54O9WHID+EnjelAZaIFI69CpcAWo8Bko4PgpECNzAmsLhCk3O25/LD7bFG/N5vRwTgzb29X1xw9Ji0oPN4PsRAbFcuRuKx0ZSSoCwFNUMLXyNBnbwH16isG93g/XCk7htKs4F0KSvujG6W7GQGepobgqp0BI0kbU9xrgaQBmYHvNwMN4MSQMLUxa9synhg88sAT0xpia6FhfbdSYC+lwM5fTcaPqR2BYSrF6MX8bheMih/72McWN2F35NhNM+/ffUNIeQTDRgDBzVUu+K5vcBhFGt3c4x732PQGB9pROmtVPBvRBrOU2Tc4vOveWg0reUzyAs2C4zzTwpP3ZD08KH08NyMN4MSo8pkVeCfWyhezllnTVwrsrRQY9lt3asslfswxx4zciJ1HZYrFXK7R0kYAxWi+nNHj47d7BMwigQuXESYGwTRFHwh2u3aa+61QKVApUClQKVApsFUpMNHTkUQ5KoIGzQNb1tcdxZt+OfHEE8vSR0Gni3aj3vSmNy3BYDk3yvNh/jj/J/7zvKKHuIWdEcEuELMPXLGCR8XGVKgUqBSoFKgUqBTYyhSYGEjaJYwAOTscDm0ZfcELXrCsd3euRwZWdd/dW38zOATPWQIrGLIPplWs9BA82t16vJ+u/q8UqBSoFKgUqBTYAhTYueL0ShLBvgZ2rBS53QcR8TY8sjZdcNpWAMFl1v9bcjdkcJjisSGV5XrV4NgKHFHrWClQKVApUCmwEgUGNwcb95LNkETk2xxKNHcXRP1bbil+gWGyN3s8bARlOZ0pFRsf9YHBYZrHJkhHHHHEwmNM+vjU/5UClQKVApUClQKbgALjNwcbh5ygSbsBUrhDJ5OKYbBF9dFHH93siM2F9qblZWJG1Nl2zZYL91f0oJkpFV4hHg4bYIl8r1ApUClQKVApUClQKdDsnMnTgWCUqg2ceDQo4P5qDUaJTXjsemhNvPM15rEsb9GNZ+8KG/84pdOpkqaU+pAGx/3vf/9icGz2/Tj6+Nf/lQKVApUClQKVAnOkwPDZKysVaHXIJS5xibJE1W59ec5FvmevDErZqg679Nnu106Eq9lsKfPcqCsjSj14Nxzw5L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e.forEach((function(t){i.drawEdge(t)})),this.svg.outerHTML}}),Object.defineProperty(t.prototype,"drawEdge",{enumerable:!1,configurable:!0,writable:!0,value:function(t){var e=t.sourceEndpoint(),a=t.targetEndpoint(),i=t.style("target-arrow-shape"),o=t.style("line-style"),n=t.style("curve-style"),r="segments"===n?t.segmentPoints():t.controlPoints(),l=this.createEdgeLabel(t);l&&this.svg.appendChild(l);var c={x:e.x,y:e.y},I={x:a.x,y:a.y};r&&r.length>0&&(c={x:r[r.length-1].x,y:r[r.length-1].y});var g=this.unitVector({x:a.x-c.x,y:a.y-c.y}),d=this.scale(g,-1),u=a.x,s=a.y;if("triangle"===i){u=a.x+this.TRIANGLE_ARROW_HEAD_HEIGHT*d.x,s=a.y+this.TRIANGLE_ARROW_HEAD_HEIGHT*d.y;var C=this.rotateVector(g,Math.PI/2),A=this.rotateVector(g,-Math.PI/2);C=this.scale(C,this.TRIANGLE_ARROW_HEAD_WIDTH/2),A=this.scale(A,this.TRIANGLE_ARROW_HEAD_WIDTH/2);var M=u+C.x,p=s+C.y;I={x:(M+(b=u+A.x))/2,y:(p+(y=s+A.y))/2};var N=document.createElementNS(this.SVGNameSpace,"polygon");N.setAttribute("points",M+","+p+","+b+","+y+","+a.x+","+a.y),this.svg.appendChild(N)}else if("tee"===i){u=a.x,s=a.y;C=this.rotateVector(g,Math.PI/2),A=this.rotateVector(g,-Math.PI/2);C=this.scale(C,this.T_ARROW_HEAD_HEIGHT/2),A=this.scale(A,this.T_ARROW_HEAD_HEIGHT/2);var b,y;M=u+C.x,p=s+C.y;I={x:(M+(b=u+A.x))/2,y:(p+(y=s+A.y))/2};var h=document.createElementNS(this.SVGNameSpace,"line");h.setAttribute("x1",M),h.setAttribute("y1",p),h.setAttribute("x2",b),h.setAttribute("y2",y),h.setAttribute("stroke-width",this.T_ARROW_HEAD_WIDTH.toString()),h.setAttribute("stroke","black"),this.svg.appendChild(h)}if(!r||r.length<1){var E=document.createElementNS(this.SVGNameSpace,"line");E.setAttribute("x1",e.x),E.setAttribute("y1",e.y),E.setAttribute("x2",I.x),E.setAttribute("y2",I.y),E.setAttribute("stroke-width",this.EDGE_WIDTH.toString()),E.setAttribute("stroke","black"),"dashed"===o&&E.setAttribute("stroke-dasharray",this.DASH_PARAMETERS),this.svg.appendChild(E)}else if("unbundled-bezier"===n||"bezier"===n){for(var m=document.createElementNS(this.SVGNameSpace,"path"),j=[],w=0;wa[a.length-1].value)return{lower:{value:a[a.length-1].value,color:a[a.length-1].color},upper:{value:1/0,color:a[a.length-1].color}};for(var i=0;i=a[i].value&&e0&&(d+=-1*u,u=0),g=function(t,e,a,i,o){var n=Math.log(1+i),r=Math.log(1+a),l=(Math.log(1+(o>=0?o:-1*o))-r)/(n-r)*(o>=0?.8:1.2);return{r:t.r+l*(e.r-t.r),g:t.g+l*(e.g-t.g),b:t.b+l*(e.b-t.b)}}(C,s,u,d,Number(n))}var A="";if(n){A="rgb("+Math.round(g.r)+", "+Math.round(g.g)+", 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150+35*(t>3?t-3:0)}}),Object.defineProperty(t.prototype,"updateColorScheme",{enumerable:!1,configurable:!0,writable:!0,value:function(t){this.colorScheme=t}}),Object.defineProperty(t.prototype,"showGenomicData",{enumerable:!1,configurable:!0,writable:!0,value:function(){var t=this,e=this,a=this.countVisibleGenomicDataByType();a<1?this.hideGenomicData():(this.cy.nodes('[type="GENE"]').forEach((function(e){e.data("w",t.getRequiredWidthForGenomicData(a))})),this.cy.style().selector('node[type="GENE"]').style("text-margin-y",(function(t){return t.data("name")in e.genomicDataMap?-15:0})).style("background-image",(function(t){var a=encodeURIComponent(e.generateSVGForNode(t).outerHTML);return"undefined"===a?"none":"data:image/svg+xml;utf8,"+a})).update())}}),Object.defineProperty(t.prototype,"parseGenomicData",{enumerable:!1,configurable:!0,writable:!0,value:function(t,e){this.genomicDataMap=this.genomicDataMap||{},this.visibleGenomicDataMapByType=this.visibleGenomicDataMapByType||{},this.groupedGenomicDataMap=this.groupedGenomicDataMap||{};for(var a=[],i=t.split("\n"),o=i[0].split("\t"),n=1;n12?o-12:0),c=l-10;r.setAttribute("width",l),r.setAttribute("height",n.h),r.setAttribute("xmlns",a);var I={w:c,h:25,x:l/2-c/2,y:n.h/2+12.5-18},g=0;for(var d in e[i]){var u=e[i],s=d;if(this.visibleGenomicDataMapByType[i]){var C=this.getOncoprintColors(s);void 0!==u[s]?A(I.x+g*I.w/o,I.y,I.w/o,I.h,100,r,s,C):A(I.x+g*I.w/o,I.y,I.w/o,I.h,null,r,"",null),g++}}function A(t,e,i,o,n,r,l,c){if(n){var 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r.forEach((function(t,e){var o=9*e,n=document.createElementNS(a,"g");t.forEach((function(t){return n.appendChild(Object(w.shapeToSvg)(t,o,8))})),i.appendChild(n)})),i.setAttribute("width",(9*r.length).toString()),i.setAttribute("height",31..toString()),i.setAttribute("xmlns",a),i}}),Object.defineProperty(t.prototype,"getCNADisplayString",{enumerable:!1,configurable:!0,writable:!0,value:function(t){return{"-2":"HOMODELETED","-1":"HETLOSS",1:"GAIN",2:"AMPLIFIED"}[t]}}),Object.defineProperty(t.prototype,"generateSvgIconForSample",{enumerable:!1,configurable:!0,writable:!0,value:function(t,e){return''+e+""}}),Object.defineProperty(t.prototype,"generateHTMLContentForNodeTooltip",{enumerable:!1,configurable:!0,writable:!0,value:function(t,e){var a=this,i=e.sampleColors,o=e.sampleIndex,n=e[t.data("name")],r=et()("
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0}),Object.defineProperty(this,"svgExporter",{enumerable:!0,configurable:!0,writable:!0,value:void 0}),Object.defineProperty(this,"undoRedoManager",{enumerable:!0,configurable:!0,writable:!0,value:void 0}),Object.defineProperty(this,"isCbioPortal",{enumerable:!0,configurable:!0,writable:!0,value:void 0}),Object.defineProperty(this,"isCollaborative",{enumerable:!0,configurable:!0,writable:!0,value:void 0}),Object.defineProperty(this,"shareDBManager",{enumerable:!0,configurable:!0,writable:!0,value:void 0}),Object.defineProperty(this,"portalAccessor",{enumerable:!0,configurable:!0,writable:!0,value:void 0}),Object.defineProperty(this,"viewUtilities",{enumerable:!0,configurable:!0,writable:!0,value:void 0}),Object.defineProperty(this,"profiles",{enumerable:!0,configurable:!0,writable:!0,value:void 0}),Object.defineProperty(this,"genomicDataOverlayColorScheme",{enumerable:!0,configurable:!0,writable:!0,value:void 0}),Object.defineProperty(this,"colorSchemeChangeCallback",{enumerable:!0,configurable:!0,writable:!0,value:void 0}),Object(r.makeObservable)(this),this.cy=i,this.isCollaborative=e,this.isCbioPortal=o,this.profiles=c,this.genomicDataOverlayColorScheme=I,this.colorSchemeChangeCallback=g;var d={bendPositionsFunction:function(t){return t.data("bendPointPositions")},controlPositionsFunction:function(t){return t.data("controlPointPositions")},undoable:!0,anchorShapeSizeFactor:6,enabled:!this.isCbioPortal,handleReconnectEdge:this.isCollaborative?this.reconnectEdge.bind(this):void 0,enableMultipleAnchorRemovalOption:!0};this.edgeEditing=this.cy.edgeEditing(d),this.portalAccessor=l,this.isCollaborative&&(this.shareDBManager=a),this.FIT_CONSTANT=50,this.layoutProperties=lt.clone(t.defaultLayoutProperties),this.observers=[],this.genomicDataOverlayManager=new ot(this.cy),this.svgExporter=new _(this.edgeEditing,this),this.selectedNodeStack={},this.undoRedoManager=n,this.undoRedoManager.action("changePositions",this.doChangePosition,this.undoChangePosition),this.undoRedoManager.action("changeNodeSize",this.doChangeNodeSize,this.undoChangeNodeSize),this.undoRedoManager.action("changeCompoundSize",this.doChangeCompoundSize,this.undoChangeCompoundSize),this.undoRedoManager.action("changeName",this.doChangename,this.undoChangeName),this.undoRedoManager.action("hideNode",this.doHide,this.undoHide),this.undoRedoManager.action("showAllNodes",this.doShow,this.undoShow),this.undoRedoManager.action("highlightInvalidGenes",this.doHighlightInvalidGenes,this.undoHighlightInvalidGenes),this.undoRedoManager.action("removeHighlightInvalidGenes",this.undoHighlightInvalidGenes,this.doHighlightInvalidGenes),this.undoRedoManager.action("highlightOthers",this.doHighlight,this.undoHighlight),this.undoRedoManager.action("removeOtherHighlight",this.undoHighlight,this.doHighlight)}return Object.defineProperty(t.prototype,"setProfile",{enumerable:!1,configurable:!0,writable:!0,value:function(t,e){this.profiles[t]=e}}),Object.defineProperty(t.prototype,"addProfile",{enumerable:!1,configurable:!0,writable:!0,value:function(t){this.profiles.push(t)}}),Object.defineProperty(t.prototype,"removeProfiles",{enumerable:!1,configurable:!0,writable:!0,value:function(){this.profiles.length=0}}),Object.defineProperty(t.prototype,"setGenomicDataOverlayColorScheme",{enumerable:!1,configurable:!0,writable:!0,value:function(t){this.genomicDataOverlayColorScheme=t}}),Object.defineProperty(t.prototype,"setViewUtilities",{enumerable:!1,configurable:!0,writable:!0,value:function(t){this.viewUtilities=t}}),Object.defineProperty(t.prototype,"getGenomicDataOverlayColorScheme",{enumerable:!1,configurable:!0,writable:!0,value:function(){return this.genomicDataOverlayColorScheme}}),Object.defineProperty(t.prototype,"handleChangePositionByAlignment",{enumerable:!1,configurable:!0,writable:!0,value:function(t){this.isCollaborative?this.shareDBManager.changeElementsPositionByAlignment(t):this.undoRedoManager.do("changePositions",t)}}),Object.defineProperty(t.prototype,"doChangePosition",{enumerable:!1,configurable:!0,writable:!0,value:function(t){for(var e=[],a=0;a0&&(n.forEach((function(t){a[t.id()]=!0})),o=o.union(t(n))),o=o.union(e.remove()),i.cy.nodes().updateCompoundBounds(),o}(t);this.undoRedoManager.do("remove",o);for(var n=0;n0&&(r.data.source=I.id()),c.length>0&&(r.data.target=c.id()),!(c.length<0&&I.length<0)){var g=this.cy.filter('edge[source = "'+I.id()+'"][target = "'+c.id()+'"]'),d=!1;g.forEach((function(t){return t.data().type!=r.data.type||(d=!0,!1)})),d||(delete r.data.id,i.push(r))}}this.cy.add(i)}}),Object.defineProperty(t.prototype,"fitGraph",{enumerable:!1,configurable:!0,writable:!0,value:function(){if(this.isCollaborative){this.cy.fit(this.FIT_CONSTANT);var t={zoomLevel:this.cy.zoom(),panLevel:this.cy.pan()};this.updateGlobalOptions(t)}else this.cy.fit(this.FIT_CONSTANT)}}),Object.defineProperty(t.prototype,"loadFile",{enumerable:!1,configurable:!0,writable:!0,value:function(t,e){this.isCollaborative?this.loadfileShareDB(t,e):this.loadFileCy(t,e),this.edgeEditing.initAnchorPoints(this.cy.edges()),this.fitGraph()}}),Object.defineProperty(t.prototype,"loadFileCy",{enumerable:!1,configurable:!0,writable:!0,value:function(t,e){this.removeElementCy(this.cy.elements()),this.addNodesCy(t),this.addEdgesCy(e)}}),Object.defineProperty(t.prototype,"loadfileShareDB",{enumerable:!1,configurable:!0,writable:!0,value:function(t,e){this.shareDBManager.loadGraph(t,e)}}),Object.defineProperty(t.prototype,"removeAllElements",{enumerable:!1,configurable:!0,writable:!0,value:function(){this.isCollaborative?this.shareDBManager.removeAllElements():this.cy.remove(this.cy.elements())}}),Object.defineProperty(t.prototype,"updateHighlight",{enumerable:!1,configurable:!0,writable:!0,value:function(t,e){e?this.undoRedoManager.do("highlightOthers",t):this.undoRedoManager.do("removeOtherHighlight",t)}}),Object.defineProperty(t.prototype,"updateVisibility",{enumerable:!1,configurable:!0,writable:!0,value:function(t,e){e?this.viewUtilities.hide(t):this.viewUtilities.show(t)}}),Object.defineProperty(t.prototype,"updateElementCallback",{enumerable:!1,configurable:!0,writable:!0,value:function(t){var e=t.oi,a=e.id,i=this.cy.$("#"+a);if(this.changeNameCy(i,e.name),i.isNode())i.isParent()?(i.style("min-width",e.minWidth),i.style("min-width-bias-left",e.minWidthBiasLeft),i.style("min-width-bias-right",e.minWidthBiasRight),i.style("min-height",e.minHeight),i.style("min-height-bias-top",e.minHeightBiasTop),i.style("min-height-bias-bottom",e.minHeightBiasBottom)):(i.data("w",e.w),i.data("h",e.h),i.position({x:e.x,y:e.y})),this.updateVisibility(i,e.isHidden),this.updateHighlight(i,e.isHighlighted),e.isInvalidGene?this.doHighlightInvalidGenes(i):this.undoHighlightInvalidGenes(i);else if(i.isEdge()){var o=e.pubmedIDs;i.data("pubmedIDs",o),this.updateHighlight(i,e.isHighlighted);var n=e.anchorPoints;if(e.source!==i.source().id()||e.target!==i.target().id()){var r={source:e.source,target:e.target};i.move(r),this.edgeEditing.initAnchorPoints(i)}else{if("bezier"===e.edgeCurveStyle){var l=this.edgeEditing.getAnchorsAsArray(i);if(l&&l.length>0)for(var 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i={ele:t,oldWidth:t.width(),newWidth:e,oldHeight:t.height(),newHeight:a};n.push({name:"changeNodeSize",param:i})}})),o.do("batch",n)}this.cy.nodeEditing("get").refreshGrapples()}}),Object.defineProperty(t,"defaultLayoutProperties",{enumerable:!0,configurable:!0,writable:!0,value:{name:"fcose",nodeRepulsion:4500,idealEdgeLength:50,edgeElasticity:.45,nestingFactor:.1,gravity:.25,numIter:2500,tile:!0,animate:!0,randomize:!1,gravityRangeCompound:1.5,gravityCompound:1,gravityRange:3.8,tilingPaddingVertical:10,tilingPaddingHorizontal:10,initialEnergyOnIncremental:.5,animationDuration:2e3,animationEasing:"cubic-bezier(0.17,0.72,0.41,0.98)"}}),rt([r.observable],t.prototype,"profiles",void 0),rt([r.observable],t.prototype,"genomicDataOverlayColorScheme",void 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t=function(e,a){return(t=Object.setPrototypeOf||{__proto__:[]}instanceof Array&&function(t,e){t.__proto__=e}||function(t,e){for(var a in e)Object.prototype.hasOwnProperty.call(e,a)&&(t[a]=e[a])})(e,a)};return function(e,a){function i(){this.constructor=e}t(e,a),e.prototype=null===a?Object.create(a):(i.prototype=a.prototype,new i)}}(),st=function(t,e,a,i){var o,n=arguments.length,r=n<3?e:null===i?i=Object.getOwnPropertyDescriptor(e,a):i;if("object"==typeof Reflect&&"function"==typeof Reflect.decorate)r=Reflect.decorate(t,e,a,i);else for(var l=t.length-1;l>=0;l--)(o=t[l])&&(r=(n<3?o(r):n>3?o(e,a,r):o(e,a))||r);return n>3&&r&&Object.defineProperty(e,a,r),r},Ct=function(t){function e(e){var a=t.call(this,e)||this;return Object.defineProperty(a,"pathwayInfo",{enumerable:!0,configurable:!0,writable:!0,value:void 0}),a}return ut(e,t),Object.defineProperty(e.prototype,"render",{enumerable:!1,configurable:!0,writable:!0,value:function(){var t=this;return 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Number(t.value)-Number(e.value)}))}}),Object.defineProperty(e.prototype,"handleColorChange",{enumerable:!1,configurable:!0,writable:!0,value:function(t,e){this.colorMappings[t].color=e}}),Object.defineProperty(e.prototype,"handleValueChange",{enumerable:!1,configurable:!0,writable:!0,value:function(t,e){this.colorMappings[t].value=e}}),Object.defineProperty(e.prototype,"addDefaultColorMapping",{enumerable:!1,configurable:!0,writable:!0,value:function(){this.colorMappings.push({value:"0",color:"#ffffff"})}}),Object.defineProperty(e.prototype,"removeColorMapping",{enumerable:!1,configurable:!0,writable:!0,value:function(t){this.colorMappings.splice(t,1)}}),Object.defineProperty(e.prototype,"setDefaultColorMapping",{enumerable:!1,configurable:!0,writable:!0,value:function(){this.colorMappings=[{value:"-100",color:"#0000ff"},{value:"0",color:"#ffffff"},{value:"100",color:"#ff0000"}]}}),Object.defineProperty(e.prototype,"setShowUniqueValuesWarningModal",{enumerable:!1,configurable:!0,writable:!0,value:function(t){this.showUniqueValuesWarningModal=t}}),Object.defineProperty(e.prototype,"handleSaveColorScheme",{enumerable:!1,configurable:!0,writable:!0,value:function(){var t={};return this.colorMappings.forEach((function(e){t[e.value]=e.color})),Object.keys(t).length<2?(this.setShowUniqueValuesWarningModal(!0),!1):(this.props.handleColorMappingChange(t),!0)}}),Object.defineProperty(e.prototype,"close",{enumerable:!1,configurable:!0,writable:!0,value:function(){this.props.handleClose($e.PROFILES_COLOR_SCHEME)}}),Object.defineProperty(e.prototype,"render",{enumerable:!1,configurable:!0,writable:!0,value:function(){var t=this,e=this.colorMappings.map((function(e,a){return I.a.createElement(g.Row,{style:{padding:"10px"}},I.a.createElement(g.Col,{md:2}),I.a.createElement(g.Col,{md:3},I.a.createElement("input",{value:e.value,style:{width:"50px"},onChange:function(e){var i=e.target.value;t.handleValueChange(a,i)}})),I.a.createElement(g.Col,{md:3},I.a.createElement("input",{type:"color",value:e.color,onChange:function(e){var i=e.target.value;t.handleColorChange(a,i)}})),I.a.createElement(g.Col,{md:1},I.a.createElement("img",{src:Nt,className:"icon-small 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i(){this.constructor=e}t(e,a),e.prototype=null===a?Object.create(a):(i.prototype=a.prototype,new i)}}(),jt=function(t){function e(e){return t.call(this,e)||this}return mt(e,t),Object.defineProperty(e.prototype,"render",{enumerable:!1,configurable:!0,writable:!0,value:function(){var t=this;return I.a.createElement(g.Modal,{id:"quickHelpModal",show:this.props.show,onHide:function(){t.props.handleClose($e.HELP)}},I.a.createElement(g.Modal.Header,{closeButton:!0},I.a.createElement(g.Modal.Title,null,"Quick Help")),I.a.createElement(g.Modal.Body,null,I.a.createElement("ul",{className:"leftText"},I.a.createElement("li",null,I.a.createElement("strong",null,"To add a node:")," Drag and drop from node palette"),I.a.createElement("li",null,I.a.createElement("strong",null,"To add an interaction:")," Click on interaction type; then click on small circle on source node and release on target node"),I.a.createElement("li",null,I.a.createElement("strong",null,"To add a node into a container (family, complex, compartment or process):"),' Drag the node into its container node or select nodes to be contained and right click on container node and choose "Add Selected Into This"'),I.a.createElement("li",null,I.a.createElement("strong",null,"To delete nodes/interactions:")," Select and perform Edit > Delete Selected"),I.a.createElement("li",null,I.a.createElement("strong",null,"To overlay experiment data:")," Select Alteration % > Load From cBioPortal..."))))}}),e}(I.a.Component),wt=function(){function t(){}return Object.defineProperty(t.prototype,"getDataTypes",{enumerable:!1,configurable:!0,writable:!0,value:function(){return[t.MUTATION,t.GENE_EXPRESSION,t.CNA]}}),Object.defineProperty(t.prototype,"fetchCancerStudies",{enumerable:!1,configurable:!0,writable:!0,value:function(e){var a={},i=new XMLHttpRequest;i.onreadystatechange=function(){if(i.readyState===XMLHttpRequest.DONE&&200===i.status){for(var t=i.responseText.split(/\r?\n|\r/),o=1;o=t.Z_SCORE_UPPER_THRESHOLD||parseFloat(g[u])<=t.Z_SCORE_LOWER_THRESHOLD)&&d++:d++);c[a][g[1]]=d/l*100}i(c)}}),Object.defineProperty(t.prototype,"getProfileData",{enumerable:!1,configurable:!0,writable:!0,value:function(e,a){var i=new XMLHttpRequest,o=this;i.onreadystatechange=function(){i.readyState===XMLHttpRequest.DONE&&200===i.status&&(o.calcAlterationPercentages(i.responseText,e.geneticProfileId,a),d.toast.success(e.geneticProfileId+" has been succesfully loaded from cBioPortal."))};var n=t.GET_PROFILE_DATA_URL;n+="&case_set_id="+e.caseSetId+"_sequenced",n+="&genetic_profile_id="+e.geneticProfileId,n+="&gene_list=";for(var r=!0,l=0,c=e.genes;l=0;l--)(o=t[l])&&(r=(n<3?o(r):n>3?o(e,a,r):o(e,a))||r);return n>3&&r&&Object.defineProperty(e,a,r),r},ft=function(t){function e(e){var a=t.call(this,e)||this;return Object.defineProperty(a,"dataTypes",{enumerable:!0,configurable:!0,writable:!0,value:{}}),Object.defineProperty(a,"dataTypeFetchResultsReady",{enumerable:!0,configurable:!0,writable:!0,value:!1}),Object.defineProperty(a,"currentlySelectedItemIndex",{enumerable:!0,configurable:!0,writable:!0,value:-1}),Object.defineProperty(a,"selectedStudies",{enumerable:!0,configurable:!0,writable:!0,value:[]}),Object.defineProperty(a,"checkboxModalPosition",{enumerable:!0,configurable:!0,writable:!0,value:{bottom:0}}),Object.defineProperty(a,"selectedDataTypesPerStudy",{enumerable:!0,configurable:!0,writable:!0,value:[]}),Object.defineProperty(a,"itemArray",{enumerable:!0,configurable:!0,writable:!0,value:[]}),Object.defineProperty(a,"searchQuery",{enumerable:!0,configurable:!0,writable:!0,value:""}),Object.defineProperty(a,"showDataTypeSelectionModal",{enumerable:!0,configurable:!0,writable:!0,value:!1}),Object.defineProperty(a,"studyListItemCheckboxChecked",{enumerable:!0,configurable:!0,writable:!0,value:[]}),Object.defineProperty(a,"selectedStudyData",{enumerable:!0,configurable:!0,writable:!0,value:void 0}),Object.defineProperty(a,"portalAccessor",{enumerable:!0,configurable:!0,writable:!0,value:void 0}),Object(r.makeObservable)(a),a.selectedStudyData=[],a.portalAccessor=new wt,a.fetchStudy(),a}return Dt(e,t),Object.defineProperty(e.prototype,"setDataTypeFetchResultsReady",{enumerable:!1,configurable:!0,writable:!0,value:function(t){this.dataTypeFetchResultsReady=t}}),Object.defineProperty(e.prototype,"setItemArray",{enumerable:!1,configurable:!0,writable:!0,value:function(t){this.itemArray=t}}),Object.defineProperty(e.prototype,"setSearchQuery",{enumerable:!1,configurable:!0,writable:!0,value:function(t){this.searchQuery=t}}),Object.defineProperty(e.prototype,"setSelectedStudyData",{enumerable:!1,configurable:!0,writable:!0,value:function(t){this.selectedStudyData=t}}),Object.defineProperty(e.prototype,"setDataTypeProperties",{enumerable:!1,configurable:!0,writable:!0,value:function(t,e){this.dataTypes[t]=e}}),Object.defineProperty(e.prototype,"initStudyListItemCheckboxChecked",{enumerable:!1,configurable:!0,writable:!0,value:function(t){this.studyListItemCheckboxChecked=Array(t).fill(!1)}}),Object.defineProperty(e.prototype,"initSelectedDataTypesPerStudy",{enumerable:!1,configurable:!0,writable:!0,value:function(t){this.selectedDataTypesPerStudy=Array(t).fill("")}}),Object.defineProperty(e.prototype,"toggleStudyListItemCheckboxChecked",{enumerable:!1,configurable:!0,writable:!0,value:function(t){this.studyListItemCheckboxChecked[t]=!this.studyListItemCheckboxChecked[t]}}),Object.defineProperty(e.prototype,"addSelectedStudy",{enumerable:!1,configurable:!0,writable:!0,value:function(t){this.selectedStudies.push(t)}}),Object.defineProperty(e.prototype,"removeSelectedStudy",{enumerable:!1,configurable:!0,writable:!0,value:function(t){this.selectedStudies=this.selectedStudies.filter((function(e){return e.data[0]!=t[0]}))}}),Object.defineProperty(e.prototype,"clearSelectedStudies",{enumerable:!1,configurable:!0,writable:!0,value:function(){this.selectedStudies=[]}}),Object.defineProperty(e.prototype,"setShowDataTypeSelectionModal",{enumerable:!1,configurable:!0,writable:!0,value:function(t){this.showDataTypeSelectionModal=t}}),Object.defineProperty(e.prototype,"clearStudyCheckboxesChecked",{enumerable:!1,configurable:!0,writable:!0,value:function(){var t=this.studyListItemCheckboxChecked.length;this.studyListItemCheckboxChecked=Array(t).fill(!1)}}),Object.defineProperty(e.prototype,"clearSelectedDataTypesPerStudy",{enumerable:!1,configurable:!0,writable:!0,value:function(){var t=this.studyListItemCheckboxChecked.length;this.selectedDataTypesPerStudy=Array(t).fill("")}}),Object.defineProperty(e.prototype,"unselectDataTypesForStudy",{enumerable:!1,configurable:!0,writable:!0,value:function(t){this.selectedDataTypesPerStudy[t]=""}}),Object.defineProperty(e.prototype,"preparePortalAccess",{enumerable:!1,configurable:!0,writable:!0,value:function(t){var e=this;this.setDataTypeFetchResultsReady(!1),this.portalAccessor.getSupportedGeneticProfiles(t,(function(t){e.disableAllDataTypes();for(var a=0,i=Object.keys(t);a1&&this.selectedStudyData[1]||"Choose study"},enumerable:!1,configurable:!0}),Object.defineProperty(e.prototype,"render",{enumerable:!1,configurable:!0,writable:!0,value:function(){var t=this;return I.a.createElement(g.Modal,{id:"cbioPortalModal",show:this.props.show,onHide:function(){t.props.handleClose($e.STUDY),t.resetModal()}},I.a.createElement(g.Modal.Header,{closeButton:!0},I.a.createElement(g.Modal.Title,null,"Profile Data from cBioPortal")),I.a.createElement(g.Modal.Body,null,I.a.createElement("div",{id:"cancerDropDown",style:{textAlign:"left"}},I.a.createElement("h4",null,"Select Cancer Study"),I.a.createElement("form",null,I.a.createElement(g.FormControl,{type:"text",placeholder:"Search studies",onChange:function(e){return t.setSearchQuery(e.target.value)}})),I.a.createElement(g.ListGroup,{style:{maxHeight:"200px",overflow:"auto",marginTop:"10px",border:"1px solid #ccc",borderRadius:"4px"}},this.itemArray.length<1?I.a.createElement("span",null,"Fetching studies from cBioPortal..."):this.itemArray.map((function(t,e){return{item:t,index:e}})).filter((function(e){return e.item[1].toLowerCase().includes(t.searchQuery.toLowerCase())})).map((function(e){var a=e.item,i=e.index,o=a[1],n=a[0];return I.a.createElement(g.ListGroupItem,{id:"listgroupitem"+i,key:n,style:{padding:"5px 5px"}},I.a.createElement(g.Checkbox,{checked:t.studyListItemCheckboxChecked[i],style:{marginTop:"0px",marginBottom:"0px"},onClick:function(){var e=document.getElementById("listgroupitem"+i).getBoundingClientRect();t.checkboxModalPosition={bottom:e.bottom-30},t.setSelectedStudyData(a),t.preparePortalAccess(n),t.toggleStudyListItemCheckboxChecked(i),t.currentlySelectedItemIndex=i,t.studyListItemCheckboxChecked[i]?t.setShowDataTypeSelectionModal(!0):(t.removeSelectedStudy(a),t.unselectDataTypesForStudy(i))}},o),""!=t.selectedDataTypesPerStudy[i]&&I.a.createElement("span",{style:{fontSize:"12px",marginLeft:"25px"}},t.selectedDataTypesPerStudy[i]))})))),I.a.createElement("div",{style:{marginTop:"10px"}},I.a.createElement("p",{style:{textAlign:"left"}},I.a.createElement("b",null,"Warning:"),' At most six different data sets will be overlayed on the genes. You can toggle which ones are to be displayed via "Alteration %" ',">",' "View Settings" menu.')),I.a.createElement(g.Modal,{style:{position:"absolute",top:this.checkboxModalPosition.bottom+"px"},dialogClassName:"fitContent",show:this.showDataTypeSelectionModal,onHide:function(){t.setShowDataTypeSelectionModal(!1)}},I.a.createElement(g.Modal.Body,null,!1===this.dataTypeFetchResultsReady?I.a.createElement("span",null,"Fetching data types from cBioPortal..."):Object.keys(this.dataTypes).map((function(e){return I.a.createElement(g.Checkbox,{inline:!0,key:e,disabled:!t.dataTypes[e].enabled,onClick:function(){t.handleCheckboxClick(e)},checked:t.dataTypes[e].checked},e)}))),I.a.createElement(g.Modal.Footer,null,I.a.createElement(g.Button,{onClick:function(){var e=Tt({},t.dataTypes);0==Object.keys(e).filter((function(t){return e[t].checked})).length&&(t.studyListItemCheckboxChecked[t.currentlySelectedItemIndex]=!1),t.setShowDataTypeSelectionModal(!1)}},"Cancel"),I.a.createElement(g.Button,{onClick:function(){var e=Tt({},t.dataTypes);t.addSelectedStudy({data:t.selectedStudyData,dataTypes:e}),t.selectedDataTypesPerStudy[t.currentlySelectedItemIndex]=Object.keys(e).filter((function(t){return e[t].checked})).join(", "),t.setShowDataTypeSelectionModal(!1)}},"Add")))),I.a.createElement(g.Modal.Footer,null,I.a.createElement(g.Button,{bsClass:"success",onClick:function(){t.selectedStudies.forEach((function(e){t.props.loadFromCBio(e.dataTypes,e.data)})),t.props.handleClose($e.STUDY),t.resetModal()}},"Load Data")))}}),Lt([r.observable],e.prototype,"dataTypes",void 0),Lt([r.observable],e.prototype,"dataTypeFetchResultsReady",void 0),Lt([r.observable],e.prototype,"selectedStudies",void 0),Lt([r.observable],e.prototype,"selectedDataTypesPerStudy",void 0),Lt([r.observable],e.prototype,"itemArray",void 0),Lt([r.observable],e.prototype,"searchQuery",void 0),Lt([r.observable],e.prototype,"showDataTypeSelectionModal",void 0),Lt([r.observable],e.prototype,"studyListItemCheckboxChecked",void 0),Lt([r.observable],e.prototype,"selectedStudyData",void 0),Lt([r.observable],e.prototype,"portalAccessor",void 0),Lt([r.action.bound],e.prototype,"setDataTypeFetchResultsReady",null),Lt([r.action.bound],e.prototype,"setItemArray",null),Lt([r.action.bound],e.prototype,"setSearchQuery",null),Lt([r.action.bound],e.prototype,"setSelectedStudyData",null),Lt([r.action.bound],e.prototype,"setDataTypeProperties",null),Lt([r.action.bound],e.prototype,"initStudyListItemCheckboxChecked",null),Lt([r.action.bound],e.prototype,"initSelectedDataTypesPerStudy",null),Lt([r.action.bound],e.prototype,"toggleStudyListItemCheckboxChecked",null),Lt([r.action.bound],e.prototype,"addSelectedStudy",null),Lt([r.action.bound],e.prototype,"removeSelectedStudy",null),Lt([r.action.bound],e.prototype,"clearSelectedStudies",null),Lt([r.action.bound],e.prototype,"setShowDataTypeSelectionModal",null),Lt([r.action.bound],e.prototype,"clearStudyCheckboxesChecked",null),Lt([r.action.bound],e.prototype,"clearSelectedDataTypesPerStudy",null),Lt([r.action.bound],e.prototype,"unselectDataTypesForStudy",null),Lt([n.a],e.prototype,"resetModal",null),Lt([n.a],e.prototype,"handleCheckboxClick",null),Lt([r.computed],e.prototype,"selectedStudyDataTitle",null),e=Lt([l.observer],e)}(I.a.Component),Ot=function(){var t=function(e,a){return(t=Object.setPrototypeOf||{__proto__:[]}instanceof Array&&function(t,e){t.__proto__=e}||function(t,e){for(var a in e)Object.prototype.hasOwnProperty.call(e,a)&&(t[a]=e[a])})(e,a)};return function(e,a){function i(){this.constructor=e}t(e,a),e.prototype=null===a?Object.create(a):(i.prototype=a.prototype,new i)}}(),vt=function(t,e,a,i){var o,n=arguments.length,r=n<3?e:null===i?i=Object.getOwnPropertyDescriptor(e,a):i;if("object"==typeof Reflect&&"function"==typeof Reflect.decorate)r=Reflect.decorate(t,e,a,i);else for(var l=t.length-1;l>=0;l--)(o=t[l])&&(r=(n<3?o(r):n>3?o(e,a,r):o(e,a))||r);return n>3&&r&&Object.defineProperty(e,a,r),r},Gt=["Cell Cycle","HIPPO","MYC","NOTCH","NRF2","PI3K","RTK-RAS","TGF-Beta","TP53","WNT"],St=function(t){function e(e){var a=t.call(this,e)||this;return Object.defineProperty(a,"bestPathways",{enumerable:!0,configurable:!0,writable:!0,value:void 0}),Object.defineProperty(a,"shownPathways",{enumerable:!0,configurable:!0,writable:!0,value:void 0}),Object.defineProperty(a,"dropDownTitle",{enumerable:!0,configurable:!0,writable:!0,value:void 0}),Object.defineProperty(a,"selectedPathway",{enumerable:!0,configurable:!0,writable:!0,value:void 0}),Object.defineProperty(a,"isPercentageMatch",{enumerable:!0,configurable:!0,writable:!0,value:void 0}),Object.defineProperty(a,"isAlterationEnabled",{enumerable:!0,configurable:!0,writable:!0,value:void 0}),Object.defineProperty(a,"considerOnlyTCGAPanPathways",{enumerable:!0,configurable:!0,writable:!0,value:void 0}),Object.defineProperty(a,"isExpanded",{enumerable:!0,configurable:!0,writable:!0,value:void 0}),Object.defineProperty(a,"COUNT_PERC_EXPLANATION",{enumerable:!0,configurable:!0,writable:!0,value:"Whether we should favor the number of genes of interest matching the ones in a pathway or the percentage of such genes in that pathway. For instance, suppose genes of interest are A, B, and C, and the pathway contains genes B, C, D, and E. When we consider count, the score is 2 (for the two genes that match). However, when we consider percentage the score will be 50% as 2 of the 4 genes in the pathway are among genes of interest."}),Object.defineProperty(a,"ALTERATION_EXPLANATION",{enumerable:!0,configurable:!0,writable:!0,value:"When this is checked, each matching gene will not directly contribute to the score as 1 unit but with the alteration frequency percentage of that gene. For instance, suppose genes of interest are A, B, and C with alteration frequencies of 0.5, 0.2, and 0.3, respectively, and the pathway contains genes B, C, D, and E. When this is option isn't checked, the score will be 2 for match count and 50% for the match percentage. However, when this option is checked, the scores will be 0.2+0.3=0.5 and (0.2+0.3)/4=12.5% for match count and percentage, respectively."}),Object.defineProperty(a,"TCGA_PANCAN_EXPLANATION",{enumerable:!0,configurable:!0,writable:!0,value:"The pathways listed above were retrieved from PathwayMapper. When this option is checked, only the pathways under TCGA > PanCanAtlas will be shown. Uncheck to show all."}),Object(r.makeObservable)(a),a.isPercentageMatch=0,a.isAlterationEnabled=0,a.considerOnlyTCGAPanPathways=!0,a.dropDownTitle="Match count",a.isExpanded=!1,a.setBestPathwayMethod(0),a.selectedPathway=a.shownPathways[0].pathwayName,a}return Ot(e,t),Object.defineProperty(e.prototype,"setBestPathwayMethod",{enumerable:!1,configurable:!0,writable:!0,value:function(t){this.bestPathways=this.props.bestPathwaysAlgos[t],this.filterBestPathwaysByTCGAPanPathways()}}),Object.defineProperty(e.prototype,"onPathwayClick",{enumerable:!1,configurable:!0,writable:!0,value:function(t){this.selectedPathway=t,this.props.pathwayActions.changePathway(this.selectedPathway)}}),Object.defineProperty(e.prototype,"onApplyClick",{enumerable:!1,configurable:!0,writable:!0,value:function(){this.setBestPathwayMethod(2*this.isAlterationEnabled+this.isPercentageMatch)}}),Object.defineProperty(e.prototype,"filterBestPathwaysByTCGAPanPathways",{enumerable:!1,configurable:!0,writable:!0,value:function(){var t=this;this.shownPathways=this.bestPathways.filter((function(e){return!t.considerOnlyTCGAPanPathways||Gt.indexOf(e.pathwayName)>-1})),this.considerOnlyTCGAPanPathways&&Gt.indexOf(this.selectedPathway)<0&&(this.selectedPathway=this.shownPathways[0].pathwayName,this.props.pathwayActions.changePathway(this.selectedPathway))}}),Object.defineProperty(e.prototype,"toggleConsiderOnlyTCGAPanPathways",{enumerable:!1,configurable:!0,writable:!0,value:function(){this.considerOnlyTCGAPanPathways=!this.considerOnlyTCGAPanPathways,this.filterBestPathwaysByTCGAPanPathways()}}),Object.defineProperty(e.prototype,"componentDidMount",{enumerable:!1,configurable:!0,writable:!0,value:function(){this.props.pathwayActions.changePathway(this.selectedPathway)}}),Object.defineProperty(e.prototype,"render",{enumerable:!1,configurable:!0,writable:!0,value:function(){var t=this;return I.a.createElement("div",{id:"ranking-bar"},this.props.tableComponent&&this.props.tableComponent(this.shownPathways.map((function(t){return{name:t.pathwayName,score:t.score,genes:t.genesMatched}})),this.selectedPathway,this.onPathwayClick),I.a.createElement("div",{className:"indent"},I.a.createElement(g.Checkbox,{checked:this.considerOnlyTCGAPanPathways,id:"tcgaPathwaysCheckbox",onClick:this.toggleConsiderOnlyTCGAPanPathways,style:{fontSize:"13px"}},"Show TCGA PanCancer Atlas pathways only ",I.a.createElement("span",{"data-tip":this.TCGA_PANCAN_EXPLANATION,"data-border":"true","data-type":"light","data-place":"left","data-effect":"solid","data-html":"true","data-delay-hide":"500",className:"fa fa-question-circle styles-module__infoIcon__zMiog"}))),!this.props.patientView&&I.a.createElement("div",{className:"info-entry"},I.a.createElement("div",{id:"criteria-title",className:"info-title"},I.a.createElement("b",{style:{display:"inline-block"}}," Ranking options")),I.a.createElement("div",{className:"indent"},I.a.createElement(g.DropdownButton,{title:this.dropDownTitle,id:"0",style:{fontSize:"13px"}},I.a.createElement(g.MenuItem,{style:{fontSize:"13px"},onClick:function(){t.isPercentageMatch=0,t.dropDownTitle="Match count",t.onApplyClick()}},"Match count"),I.a.createElement(g.MenuItem,{style:{fontSize:"13px"},onClick:function(){t.isPercentageMatch=1,t.dropDownTitle="Match percentage",t.onApplyClick()}},"Match percentage"))," ",I.a.createElement("div",{"data-tip":this.COUNT_PERC_EXPLANATION,"data-border":"true","data-type":"light","data-place":"left","data-effect":"solid",className:"fa fa-question-circle styles-module__infoIcon__zMiog"}),I.a.createElement(g.Checkbox,{id:"alterationCheckBox",onClick:function(){t.isAlterationEnabled=1===t.isAlterationEnabled?0:1,t.onApplyClick()},style:{fontSize:"13px",marginTop:"18px",bottom:"4px"}},"Consider alteration frequency ",I.a.createElement("span",{"data-tip":this.ALTERATION_EXPLANATION,"data-border":"true","data-type":"light","data-place":"left","data-effect":"solid",className:"fa fa-question-circle styles-module__infoIcon__zMiog"})))))}}),vt([r.observable],e.prototype,"bestPathways",void 0),vt([r.observable],e.prototype,"shownPathways",void 0),vt([r.observable],e.prototype,"dropDownTitle",void 0),vt([r.observable],e.prototype,"selectedPathway",void 0),vt([r.observable],e.prototype,"considerOnlyTCGAPanPathways",void 0),vt([r.observable],e.prototype,"isExpanded",void 0),vt([n.a],e.prototype,"setBestPathwayMethod",null),vt([n.a],e.prototype,"onPathwayClick",null),vt([n.a],e.prototype,"onApplyClick",null),vt([r.action.bound],e.prototype,"filterBestPathwaysByTCGAPanPathways",null),vt([r.action.bound],e.prototype,"toggleConsiderOnlyTCGAPanPathways",null),e=vt([l.observer],e)}(I.a.Component),Pt=function(){var t=function(e,a){return(t=Object.setPrototypeOf||{__proto__:[]}instanceof 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Pt(e,t),Object.defineProperty(e.prototype,"render",{enumerable:!1,configurable:!0,writable:!0,value:function(){var t=this,e="q="+JSON.stringify(this.props.alterationData)+"&g="+this.props.genes.map((function(t){return t.hugoGeneSymbol})).join("+");return I.a.createElement("div",{id:"toolbar",style:{marginLeft:"0px"}},I.a.createElement("img",{height:"22px",width:"22px","data-border":"true","data-type":"light","data-tip":"Save as PNG","data-place":"right","data-effect":"solid",src:v.a,onClick:function(){t.props.pathwayActions.saveAs("PNG")}}),I.a.createElement("img",{height:"22px",width:"22px","data-border":"true","data-type":"light","data-tip":"Save as SVG","data-place":"right","data-effect":"solid",src:S.a,onClick:function(){t.props.pathwayActions.saveAs("SVG")}}),I.a.createElement("img",{height:"22px",width:"22px","data-border":"true","data-type":"light","data-tip":"Perform 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t=this.editor.cy.elements(":selected");this.editor.removeElement(t)}}),Object.defineProperty(t.prototype,"addEdge",{enumerable:!1,configurable:!0,writable:!0,value:function(t){if(window.edgeAddingMode=t+1,-1===t)return this.eh.disable(),void this.eh.hide();this.eh.enable()}}),Object.defineProperty(t.prototype,"changeNodeName",{enumerable:!1,configurable:!0,writable:!0,value:function(t,e){var a=this.editor.cy.$('[name="'+t+'"]')[0];this.editor.changeName(a,e)}}),Object.defineProperty(t.prototype,"addNode",{enumerable:!1,configurable:!0,writable:!0,value:function(t){var e={type:t.toUpperCase(),name:"New "+t,w:"150",h:"52"},a=this.editor.cy.extent(),i={x:(a.x1+a.x2)/2,y:(a.y1+a.y2)/2};this.editor.addNode(e,i),this.pathwayHandler("Additional Pathway")}}),Object.defineProperty(t.prototype,"searchGene",{enumerable:!1,configurable:!0,writable:!0,value:function(t){var e="node[name @*= 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t=function(e,a){return(t=Object.setPrototypeOf||{__proto__:[]}instanceof Array&&function(t,e){t.__proto__=e}||function(t,e){for(var a in e)Object.prototype.hasOwnProperty.call(e,a)&&(t[a]=e[a])})(e,a)};return function(e,a){function i(){this.constructor=e}t(e,a),e.prototype=null===a?Object.create(a):(i.prototype=a.prototype,new i)}}(),ve=function(t,e,a,i){var o,n=arguments.length,r=n<3?e:null===i?i=Object.getOwnPropertyDescriptor(e,a):i;if("object"==typeof Reflect&&"function"==typeof Reflect.decorate)r=Reflect.decorate(t,e,a,i);else for(var l=t.length-1;l>=0;l--)(o=t[l])&&(r=(n<3?o(r):n>3?o(e,a,r):o(e,a))||r);return n>3&&r&&Object.defineProperty(e,a,r),r},Ge=function(t){function e(e){var a=t.call(this,e)||this;return Object.defineProperty(a,"searchedGene",{enumerable:!0,configurable:!0,writable:!0,value:void 0}),Object(r.makeObservable)(a),a.searchedGene="",a.props.pathwayActions.enabledType=R.NONE,a}return 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I.a.createElement(g.Navbar,{fluid:!0,style:{backgroundColor:"#eff0f2",minHeight:"0px"},className:"pathway-toolbar"},I.a.createElement(g.ButtonToolbar,{className:"toolbar pathway-toolbar",style:{marginBottom:"0px",paddingBottom:"0px"}},l.map((function(t,e){return I.a.createElement(g.ButtonGroup,{key:e},t.map((function(t,e){return I.a.createElement(g.Button,{key:e,className:"toolbar-button"+(t.isFocused?" toolbar-button-focused":""),style:{padding:0}},I.a.createElement("img",{height:"22px",width:"22px",src:t.svg,"data-tip":t.tooltip,"data-place":"bottom","data-effect":"solid",onClick:t.function}))})))})),I.a.createElement(g.ButtonGroup,{id:"searchGeneToolbar"},I.a.createElement(g.FormGroup,null,I.a.createElement(g.InputGroup,null,I.a.createElement(g.FormControl,{id:"searchGene",type:"text",style:{maxHeight:"32px",borderTopRightRadius:0,borderBottomRightRadius:0},onChange:function(e){t.searchedGene=e.target.value},placeholder:"Search 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wt,this.initCyJS(),this.initCyHandlers(),this.initKeyboardHandlers(),this.initUndoRedoFunctionality(),this.initCBioPortalFunctionalities(),this.placePanzoomAndOverlay()}}),Object.defineProperty(e.prototype,"placePanzoomAndOverlay",{enumerable:!1,configurable:!0,writable:!0,value:function(){var 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e||15},getCompoundMinWidth:function(t){return t.style("min-width")},getCompoundMinHeight:function(t){return t.style("min-height")},getCompoundMinWidthBiasRight:function(t){return t.style("min-width-bias-right")},getCompoundMinWidthBiasLeft:function(t){return t.style("min-width-bias-left")},getCompoundMinHeightBiasTop:function(t){return t.style("min-height-bias-top")},getCompoundMinHeightBiasBottom:function(t){return t.style("min-height-bias-bottom")},isFixedAspectRatioResizeMode:function(t){return t.is(".fixedAspectRatioResizeMode")},isNoResizeMode:function(t){},setWidth:function(t,e){t.style("width",e)},setHeight:function(t,e){t.style("height",e)},setCompoundMinWidth:function(t,e){t.style("min-width",e)},setCompoundMinHeight:function(t,e){t.style("min-height",e)},setCompoundMinWidthBiasLeft:function(t,e){t.style("min-width-bias-left",e)},setCompoundMinWidthBiasRight:function(t,e){t.style("min-width-bias-right",e)},setCompoundMinHeightBiasTop:function(t,e){t.style("min-height-bias-top",e)},setCompoundMinHeightBiasBottom:function(t,e){t.style("min-height-bias-bottom",e)},cursors:{default:"default",inactive:"not-allowed",nw:"nw-resize",n:"n-resize",ne:"ne-resize",e:"e-resize",se:"se-resize",s:"s-resize",sw:"sw-resize",w:"w-resize"},resizeToContentCueImage:Ke.a,resizeToContentFunction:this.editor.resizeNodesToContent.bind(this.editor)});this.cy.navigator({container:".cytoscape-navigator-wrapper",viewLiveFramerate:0,thumbnailEventFramerate:10,thumbnailLiveFramerate:!1,dblClickDelay:200,removeCustomContainer:!0,rerenderDelay:100});this.viewUtilities=this.cy.viewUtilities({node:{highlighted:{"border-width":2,"border-color":"#bc1142"},unhighlighted:{opacity:function(t){return t.css("opacity")}}},edge:{highlighted:{},unhighlighted:{opacity:function(t){return t.css("opacity")}}},setVisibilityOnHide:!1,setDisplayOnHide:!0,neighbor:function(){return!1},neighborSelectTime:500}),this.editor.setViewUtilities(this.viewUtilities),this.placePanzoomAndOverlay()}}),Object.defineProperty(e.prototype,"getGlobalEdgeType",{enumerable:!1,configurable:!0,writable:!0,value:function(){var t="NONE";return 1===window.edgeAddingMode?t="ACTIVATES":2===window.edgeAddingMode?t="INHIBITS":3===window.edgeAddingMode?t="INDUCES":4===window.edgeAddingMode?t="REPRESSES":5===window.edgeAddingMode&&(t="BINDS"),t}}),Object.defineProperty(e.prototype,"initCyHandlers",{enumerable:!1,configurable:!0,writable:!0,value:function(){var t,e,a=this,i=this;this.cy.on("tap",(function(a){var i=a.target;-1!==e&&-1!==t&&clearTimeout(e),t===i?(i.trigger("doubleTap"),t=-1):(e=setTimeout((function(){t=-1}),300),t=i)})),this.cy.on("doubleTap","node",(function(t){i.props.isCbioPortal||t.target===this&&(i.qtipManager.addQtipToElements(t.target),t.target.trigger("showqtipevent"))})),this.cy.on("doubleTap","edge",(function(t){i.props.isCbioPortal||t.target===this&&(i.qtipManager.addQtipToElements(t.target),t.target.trigger("showqtipevent"))})),this.cy.on("select","node",(function(t){a.editor.pushSelectedNodeStack(t.target)})),this.cy.on("unselect","node",(function(t){a.editor.removeElementFromSelectedNodeStack(t.target)})),this.cy.on("free","node",(function(t){var e=a.cy.nodes(":selected"),i=t.target;i=(i=i.union(i.descendants())).union(e),a.editor.moveElements(i)})),this.cy.on("layoutstop",(function(){a.editor.postLayout()})),this.cy.on("nodeediting.resizeend",(function(t,e,i){i.data("w",i.width()),i.data("h",i.height()),a.editor.resizeElements(i)})),this.cy.on("select","edge",(function(t){a.lastSelectedEdge=t.target})),this.cy.on("bendPointMovement",(function(){a.editor.updateEdgeAnchorPoints(a.lastSelectedEdge)})),this.cy.on("nodeediting.moveend",(function(){a.editor.changeNodePositionsByArrows(a.cy.nodes(":selected"))}))}}),Object.defineProperty(e.prototype,"initKeyboardHandlers",{enumerable:!1,configurable:!0,writable:!0,value:function(){var t=this;this.isCollaborative||this.isCbioPortal?(et()('a[role="redo"]').hide(),et()('a[role="undo"]').hide()):et()(document).keydown((function(e){89===e.which&&(e.ctrlKey||e.metaKey)?t.undoRedoManager.redo():90===e.which&&(e.ctrlKey||e.metaKey)&&t.undoRedoManager.undo()})),et()(document).keydown((function(e){if(65===e.which&&(e.ctrlKey||e.metaKey))"TEXTAREA"!=(a=document.activeElement.tagName)&&"INPUT"!=a&&(e.preventDefault(),t.cy.elements().select());else if(8===e.which||46===e.which){var a;if("TEXTAREA"!=(a=document.activeElement.tagName)&&"INPUT"!=a){var i=t.cy.$(":selected");t.editor.removeElement(i)}}}))}}),Object.defineProperty(e.prototype,"initUndoRedoFunctionality",{enumerable:!1,configurable:!0,writable:!0,value:function(){(this.isCollaborative||this.isCbioPortal)&&(et()('[role="undo"]').hide(),et()('[role="redo"]').hide())}}),Object.defineProperty(e.prototype,"initCBioPortalFunctionalities",{enumerable:!1,configurable:!0,writable:!0,value:function(){this.isCbioPortal&&this.cy.contextMenus("get").destroy()}}),_e([n.a],e.prototype,"cyDivHandler",null),e=_e([l.observer],e)}(I.a.Component),Ma=function(){var t=function(e,a){return(t=Object.setPrototypeOf||{__proto__:[]}instanceof Array&&function(t,e){t.__proto__=e}||function(t,e){for(var a in e)Object.prototype.hasOwnProperty.call(e,a)&&(t[a]=e[a])})(e,a)};return function(e,a){function i(){this.constructor=e}t(e,a),e.prototype=null===a?Object.create(a):(i.prototype=a.prototype,new i)}}(),pa=function(t){function e(e){return t.call(this,e)||this}return 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t=this,e=[ba.a,wa.a,ma.a,Ta.a,ha.a];return I.a.createElement("div",{id:"pathway-sidebar",className:"sideBarWrapper"},I.a.createElement(g.Panel,{className:"pnl"},I.a.createElement(g.Panel.Heading,{className:"pnl-header"},"Network"),I.a.createElement(g.Panel.Body,{className:"pnl-body pathwayPanel"},I.a.createElement("div",{className:"buttonContainer"},I.a.createElement(g.Button,{onClick:function(){t.props.handleOpen($e.PW_DETAILS)}},"Properties")),I.a.createElement("div",{className:"buttonContainer"},I.a.createElement(g.Button,{onClick:function(){t.props.pathwayActions.upload()}},"Import")),I.a.createElement("div",{className:"buttonContainer"},I.a.createElement(g.Button,{onClick:function(){t.props.pathwayActions.export(!1)}},"Export")))),I.a.createElement(g.Panel,{className:"pnl"},I.a.createElement(g.Panel.Heading,{className:"pnl-header"},"Node Palette"),I.a.createElement(g.Panel.Body,{className:"pnl-body"},["simpleNodeDiv","familyNodeDiv","complexNodeDiv","compartmentNodeDiv","processNodeDiv"].map((function(t){return I.a.createElement("div",{key:t,id:t,"data-tip":"Click on this and drag to the location on drawing canvas and release!","data-effect":"solid","data-place":"bottom","data-delay-show":"1000",className:"dragButtonContainer"})})))),I.a.createElement(g.Panel,{className:"pnl edgePanel"},I.a.createElement(g.Panel.Heading,{className:"pnl-header"},"Interaction Palette"),I.a.createElement(g.Panel.Body,{className:"pnl-body edgePaletteWrapper"},I.a.createElement("div",{className:"list-group edge-palette"},["Activates","Inhibits","Induces","Represses","Binds"].map((function(a,i){return I.a.createElement("div",{key:i,"data-tip":"Click to activate; then, start the interaction from the little circle on the source 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Reflect.decorate)r=Reflect.decorate(t,e,a,i);else for(var l=t.length-1;l>=0;l--)(o=t[l])&&(r=(n<3?o(r):n>3?o(e,a,r):o(e,a))||r);return n>3&&r&&Object.defineProperty(e,a,r),r},Sa=a(79),Pa=Sa();!function(t){t[t.STUDY=0]="STUDY",t[t.CONFIRMATION=1]="CONFIRMATION",t[t.PROFILES=2]="PROFILES",t[t.ABOUT=3]="ABOUT",t[t.PW_DETAILS=4]="PW_DETAILS",t[t.GRID=5]="GRID",t[t.HELP=6]="HELP",t[t.LAYOUT=7]="LAYOUT",t[t.CHELP=8]="CHELP",t[t.PROFILES_COLOR_SCHEME=9]="PROFILES_COLOR_SCHEME"}($e||($e={}));var za=function(t){function e(e){var i=t.call(this,e)||this;return Object.defineProperty(i,"MAX_ALLOWED_PROFILES_ENABLED",{enumerable:!0,configurable:!0,writable:!0,value:6}),Object.defineProperty(i,"selectedPathway",{enumerable:!0,configurable:!0,writable:!0,value:void 0}),Object.defineProperty(i,"fileManager",{enumerable:!0,configurable:!0,writable:!0,value:void 0}),Object.defineProperty(i,"editor",{enumerable:!0,configurable:!0,writable:!0,value:void 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Wt(i.pathwayHandler,i.profiles,i.fileManager,i.handleOpen,i.props.isCBioPortal,i.props.isCollaborative),i.selectedPathway="",i.props.pathwayName&&i.pathwayActions.changePathway(i.props.pathwayName),i.isModalShown=[!1,!1,!1,!1,!1,!1,!1,!1,!1,!1],i.alterationData={},i.extractAllGenes(),i.colorValueMap={"-100":"#0000ff",0:"#ffffff",100:"#ff0000"},i.props.isCBioPortal&&(i.props.cBioAlterationData&&(i.props.patientView?(i.calculatePatientData(i.props.cBioAlterationData),i.addSampleIconData(i.props.sampleIconData)):i.calculateAlterationData(i.props.cBioAlterationData)),i.props.addGenomicDataHandler&&i.props.addGenomicDataHandler(i.addGenomicData),i.profiles.push({profileId:a.CBIO_PROFILE_NAME,enabled:!0}),i.getBestPathway(0),i.getBestPathway(1),i.getBestPathway(2),i.getBestPathway(3)),i}var a;return va(e,t),a=e,Object.defineProperty(e.prototype,"setColorMapping",{enumerable:!1,configurable:!0,writable:!0,value:function(t){this.colorValueMap=t,this.editor.updateGenomicDataColorScheme(this.colorValueMap)}}),Object.defineProperty(e.prototype,"setSelectedPathway",{enumerable:!1,configurable:!0,writable:!0,value:function(t){this.selectedPathway=t}}),Object.defineProperty(e.prototype,"setEditor",{enumerable:!1,configurable:!0,writable:!0,value:function(t){this.editor=t}}),Object.defineProperty(e.prototype,"addProfile",{enumerable:!1,configurable:!0,writable:!0,value:function(t){this.profiles.push(t)}}),Object.defineProperty(e.prototype,"toggleProfileEnabled",{enumerable:!1,configurable:!0,writable:!0,value:function(t){this.profiles[t].enabled=!this.profiles[t].enabled}}),Object.defineProperty(e.prototype,"calculateAlterationData",{enumerable:!1,configurable:!0,writable:!0,value:function(t){var e=this;this.alterationData[a.CBIO_PROFILE_NAME]={},t.forEach((function(t){var i=t.altered/t.sequenced*100;e.alterationData[a.CBIO_PROFILE_NAME][t.gene]=Object.is(i,NaN)?-101:i}))}}),Object.defineProperty(e.prototype,"calculatePatientData",{enumerable:!1,configurable:!0,writable:!0,value:function(t){var e=this;this.alterationData[a.CBIO_PROFILE_NAME]={};var i=t.map((function(t){return t.gene})).filter((function(t,e,a){return a.indexOf(t)==e}));this.patientData.PatientView=1,i.forEach((function(t){e.patientData[t]={}})),t.forEach((function(t){var 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E=document.createElementNS(this.SVGNameSpace,"line");E.setAttribute("x1",e.x),E.setAttribute("y1",e.y),E.setAttribute("x2",g.x),E.setAttribute("y2",g.y),E.setAttribute("stroke-width",this.EDGE_WIDTH.toString()),E.setAttribute("stroke","black"),"dashed"===o&&E.setAttribute("stroke-dasharray",this.DASH_PARAMETERS),this.svg.appendChild(E)}else if("unbundled-bezier"===n||"bezier"===n){for(var m=document.createElementNS(this.SVGNameSpace,"path"),j=[],w=0;wa[a.length-1].value)return{lower:{value:a[a.length-1].value,color:a[a.length-1].color},upper:{value:1/0,color:a[a.length-1].color}};for(var i=0;i=a[i].value&&e0&&(d+=-1*u,u=0),I=function(t,e,a,i,o){var n=Math.log(1+i),r=Math.log(1+a),l=(Math.log(1+(o>=0?o:-1*o))-r)/(n-r)*(o>=0?.8:1.2);return{r:t.r+l*(e.r-t.r),g:t.g+l*(e.g-t.g),b:t.b+l*(e.b-t.b)}}(C,s,u,d,Number(n))}var A="";if(n){A="rgb("+Math.round(I.r)+", "+Math.round(I.g)+", 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150+35*(t>3?t-3:0)}}),Object.defineProperty(t.prototype,"updateColorScheme",{enumerable:!1,configurable:!0,writable:!0,value:function(t){this.colorScheme=t}}),Object.defineProperty(t.prototype,"showGenomicData",{enumerable:!1,configurable:!0,writable:!0,value:function(){var t=this,e=this,a=this.countVisibleGenomicDataByType();a<1?this.hideGenomicData():(this.cy.nodes('[type="GENE"]').forEach((function(e){e.data("w",t.getRequiredWidthForGenomicData(a))})),this.cy.style().selector('node[type="GENE"]').style("text-margin-y",(function(t){return t.data("name")in e.genomicDataMap?-15:0})).style("background-image",(function(t){var a=encodeURIComponent(e.generateSVGForNode(t).outerHTML);return"undefined"===a?"none":"data:image/svg+xml;utf8,"+a})).update())}}),Object.defineProperty(t.prototype,"parseGenomicData",{enumerable:!1,configurable:!0,writable:!0,value:function(t,e){this.genomicDataMap=this.genomicDataMap||{},this.visibleGenomicDataMapByType=this.visibleGenomicDataMapByType||{},this.groupedGenomicDataMap=this.groupedGenomicDataMap||{};for(var a=[],i=t.split("\n"),o=i[0].split("\t"),n=1;n12?o-12:0),c=l-10;r.setAttribute("width",l),r.setAttribute("height",n.h),r.setAttribute("xmlns",a);var g={w:c,h:25,x:l/2-c/2,y:n.h/2+12.5-18},I=0;for(var d in e[i]){var u=e[i],s=d;if(this.visibleGenomicDataMapByType[i]){var C=this.getOncoprintColors(s);void 0!==u[s]?A(g.x+I*g.w/o,g.y,g.w/o,g.h,100,r,s,C):A(g.x+I*g.w/o,g.y,g.w/o,g.h,null,r,"",null),I++}}function A(t,e,i,o,n,r,l,c){if(n){var g=document.createElementNS(a,"rect");g.setAttribute("x",t),g.setAttribute("y",e),g.setAttribute("width",i),g.setAttribute("height",o),g.setAttribute("style","stroke-width:1;stroke:rgb(0,0,0);opacity:1;fill:"+c+";");var I=i/2-16,d=document.createElementNS(a,"text");"rgb(0,0,0)"===c&&d.setAttribute("fill","white"),d.setAttribute("x",t+I),d.setAttribute("y",e+o/2+14/3),d.setAttribute("font-family","Arial"),d.setAttribute("font-size","14"),d.innerHTML=l.substring(0,4),r.appendChild(g),r.appendChild(d)}else c="rgb(210,210,210)"}return r}}),Object.defineProperty(t.prototype,"generateOncoprintForPatientNode",{enumerable:!1,configurable:!0,writable:!0,value:function(t){var e=this.patientData[t.data("name")],a="http://www.w3.org/2000/svg",i=document.createElementNS(a,"svg");if(!e)return{outerHTML:""};var o=new w.GeneticAlterationRuleSet(e.geneticTrackRuleSetParams),n=o.getUniversalShapes(6,23),r=o.getSpecificShapesForDatum(e.geneticTrackData,6,23).map((function(t){return n.concat(t)}));return r.forEach((function(t,e){var o=9*e,n=document.createElementNS(a,"g");t.forEach((function(t){return n.appendChild(Object(w.shapeToSvg)(t,o,8))})),i.appendChild(n)})),i.setAttribute("width",(9*r.length).toString()),i.setAttribute("height",31..toString()),i.setAttribute("xmlns",a),i}}),Object.defineProperty(t.prototype,"getCNADisplayString",{enumerable:!1,configurable:!0,writable:!0,value:function(t){return{"-2":"HOMODELETED","-1":"HETLOSS",1:"GAIN",2:"AMPLIFIED"}[t]}}),Object.defineProperty(t.prototype,"generateSvgIconForSample",{enumerable:!1,configurable:!0,writable:!0,value:function(t,e){return''+e+""}}),Object.defineProperty(t.prototype,"generateHTMLContentForNodeTooltip",{enumerable:!1,configurable:!0,writable:!0,value:function(t,e){var a=this,i=e.sampleColors,o=e.sampleIndex,n=e[t.data("name")],r=et()("
");return r.css({"max-width":"200px","max-height":"200px","word-wrap":"break-word","overflow-y":"auto"}),n.geneticTrackData.forEach((function(t,e){var n=t.sample,l=i[n],c=(o[n]+1).toString(),g=a.generateSvgIconForSample(l,c),I=e>0?"10px":"0px",d=et()("
");d.css({"margin-top":I});var u=t.data,s=[],C=[],A=[];u.forEach((function(e){var i=e.gene.hugoGeneSymbol;if(t.disp_mut&&e.proteinChange&&"Fusion"!==e.mutationType){var o=e.proteinChange;s.push({gene:i,proteinChange:o})}if(t.disp_cna&&e.alteration){var n=e.alteration,r=a.getCNADisplayString(n);C.push({gene:i,cnaLabel:r})}if(t.disp_fusion&&e.proteinChange&&"Fusion"===e.mutationType){o=e.proteinChange;A.push({gene:i,proteinChange:o})}}));var M=s.length>0?"Mutation: ":"",p=C.length>0?"CNA: ":"",N=A.length>0?"Fusion: ":"";s.forEach((function(t,e){M+=""+t.gene+" "+t.proteinChange+"",e!==s.length-1?M+=", ":M+="
"})),C.forEach((function(t,e){p+=""+t.gene+" "+t.cnaLabel+"",e!==C.length-1?p+=", ":p+="
"})),A.forEach((function(t,e){N+=""+t.gene+" "+t.proteinChange+"",e!==A.length-1?N+=", ":N+="
"}));var b=" "+n+"
";d.append(et()("
"+g+b+M+p+N+NaN)),r.append(d)})),r}}),t}()),nt=function(){return(nt=Object.assign||function(t){for(var e,a=1,i=arguments.length;a=0;l--)(o=t[l])&&(r=(n<3?o(r):n>3?o(e,a,r):o(e,a))||r);return n>3&&r&&Object.defineProperty(e,a,r),r},lt=a(6),ct=function(){function t(e,a,i,o,n,l,c,g,I){Object.defineProperty(this,"cy",{enumerable:!0,configurable:!0,writable:!0,value:void 0}),Object.defineProperty(this,"genomicDataOverlayManager",{enumerable:!0,configurable:!0,writable:!0,value:void 0}),Object.defineProperty(this,"edgeEditing",{enumerable:!0,configurable:!0,writable:!0,value:void 0}),Object.defineProperty(this,"selectedNodeStack",{enumerable:!0,configurable:!0,writable:!0,value:void 0}),Object.defineProperty(this,"layoutProperties",{enumerable:!0,configurable:!0,writable:!0,value:void 0}),Object.defineProperty(this,"FIT_CONSTANT",{enumerable:!0,configurable:!0,writable:!0,value:void 0}),Object.defineProperty(this,"observers",{enumerable:!0,configurable:!0,writable:!0,value:void 0}),Object.defineProperty(this,"svgExporter",{enumerable:!0,configurable:!0,writable:!0,value:void 0}),Object.defineProperty(this,"undoRedoManager",{enumerable:!0,configurable:!0,writable:!0,value:void 0}),Object.defineProperty(this,"isCbioPortal",{enumerable:!0,configurable:!0,writable:!0,value:void 0}),Object.defineProperty(this,"isCollaborative",{enumerable:!0,configurable:!0,writable:!0,value:void 0}),Object.defineProperty(this,"shareDBManager",{enumerable:!0,configurable:!0,writable:!0,value:void 0}),Object.defineProperty(this,"portalAccessor",{enumerable:!0,configurable:!0,writable:!0,value:void 0}),Object.defineProperty(this,"viewUtilities",{enumerable:!0,configurable:!0,writable:!0,value:void 0}),Object.defineProperty(this,"profiles",{enumerable:!0,configurable:!0,writable:!0,value:void 0}),Object.defineProperty(this,"genomicDataOverlayColorScheme",{enumerable:!0,configurable:!0,writable:!0,value:void 0}),Object.defineProperty(this,"colorSchemeChangeCallback",{enumerable:!0,configurable:!0,writable:!0,value:void 0}),Object(r.makeObservable)(this),this.cy=i,this.isCollaborative=e,this.isCbioPortal=o,this.profiles=c,this.genomicDataOverlayColorScheme=g,this.colorSchemeChangeCallback=I;var d={bendPositionsFunction:function(t){return t.data("bendPointPositions")},controlPositionsFunction:function(t){return t.data("controlPointPositions")},undoable:!0,anchorShapeSizeFactor:6,enabled:!this.isCbioPortal,handleReconnectEdge:this.isCollaborative?this.reconnectEdge.bind(this):void 0,enableMultipleAnchorRemovalOption:!0};this.edgeEditing=this.cy.edgeEditing(d),this.portalAccessor=l,this.isCollaborative&&(this.shareDBManager=a),this.FIT_CONSTANT=50,this.layoutProperties=lt.clone(t.defaultLayoutProperties),this.observers=[],this.genomicDataOverlayManager=new ot(this.cy),this.svgExporter=new _(this.edgeEditing,this),this.selectedNodeStack={},this.undoRedoManager=n,this.undoRedoManager.action("changePositions",this.doChangePosition,this.undoChangePosition),this.undoRedoManager.action("changeNodeSize",this.doChangeNodeSize,this.undoChangeNodeSize),this.undoRedoManager.action("changeCompoundSize",this.doChangeCompoundSize,this.undoChangeCompoundSize),this.undoRedoManager.action("changeName",this.doChangename,this.undoChangeName),this.undoRedoManager.action("hideNode",this.doHide,this.undoHide),this.undoRedoManager.action("showAllNodes",this.doShow,this.undoShow),this.undoRedoManager.action("highlightInvalidGenes",this.doHighlightInvalidGenes,this.undoHighlightInvalidGenes),this.undoRedoManager.action("removeHighlightInvalidGenes",this.undoHighlightInvalidGenes,this.doHighlightInvalidGenes),this.undoRedoManager.action("highlightOthers",this.doHighlight,this.undoHighlight),this.undoRedoManager.action("removeOtherHighlight",this.undoHighlight,this.doHighlight)}return Object.defineProperty(t.prototype,"setProfile",{enumerable:!1,configurable:!0,writable:!0,value:function(t,e){this.profiles[t]=e}}),Object.defineProperty(t.prototype,"addProfile",{enumerable:!1,configurable:!0,writable:!0,value:function(t){this.profiles.push(t)}}),Object.defineProperty(t.prototype,"removeProfiles",{enumerable:!1,configurable:!0,writable:!0,value:function(){this.profiles.length=0}}),Object.defineProperty(t.prototype,"setGenomicDataOverlayColorScheme",{enumerable:!1,configurable:!0,writable:!0,value:function(t){this.genomicDataOverlayColorScheme=t}}),Object.defineProperty(t.prototype,"setViewUtilities",{enumerable:!1,configurable:!0,writable:!0,value:function(t){this.viewUtilities=t}}),Object.defineProperty(t.prototype,"getGenomicDataOverlayColorScheme",{enumerable:!1,configurable:!0,writable:!0,value:function(){return this.genomicDataOverlayColorScheme}}),Object.defineProperty(t.prototype,"handleChangePositionByAlignment",{enumerable:!1,configurable:!0,writable:!0,value:function(t){this.isCollaborative?this.shareDBManager.changeElementsPositionByAlignment(t):this.undoRedoManager.do("changePositions",t)}}),Object.defineProperty(t.prototype,"doChangePosition",{enumerable:!1,configurable:!0,writable:!0,value:function(t){for(var e=[],a=0;a0&&(n.forEach((function(t){a[t.id()]=!0})),o=o.union(t(n))),o=o.union(e.remove()),i.cy.nodes().updateCompoundBounds(),o}(t);this.undoRedoManager.do("remove",o);for(var n=0;n0&&(r.data.source=g.id()),c.length>0&&(r.data.target=c.id()),!(c.length<0&&g.length<0)){var I=this.cy.filter('edge[source = "'+g.id()+'"][target = "'+c.id()+'"]'),d=!1;I.forEach((function(t){return t.data().type!=r.data.type||(d=!0,!1)})),d||(delete r.data.id,i.push(r))}}this.cy.add(i)}}),Object.defineProperty(t.prototype,"fitGraph",{enumerable:!1,configurable:!0,writable:!0,value:function(){if(this.isCollaborative){this.cy.fit(this.FIT_CONSTANT);var t={zoomLevel:this.cy.zoom(),panLevel:this.cy.pan()};this.updateGlobalOptions(t)}else this.cy.fit(this.FIT_CONSTANT)}}),Object.defineProperty(t.prototype,"loadFile",{enumerable:!1,configurable:!0,writable:!0,value:function(t,e){this.isCollaborative?this.loadfileShareDB(t,e):this.loadFileCy(t,e),this.edgeEditing.initAnchorPoints(this.cy.edges()),this.fitGraph()}}),Object.defineProperty(t.prototype,"loadFileCy",{enumerable:!1,configurable:!0,writable:!0,value:function(t,e){this.removeElementCy(this.cy.elements()),this.addNodesCy(t),this.addEdgesCy(e)}}),Object.defineProperty(t.prototype,"loadfileShareDB",{enumerable:!1,configurable:!0,writable:!0,value:function(t,e){this.shareDBManager.loadGraph(t,e)}}),Object.defineProperty(t.prototype,"removeAllElements",{enumerable:!1,configurable:!0,writable:!0,value:function(){this.isCollaborative?this.shareDBManager.removeAllElements():this.cy.remove(this.cy.elements())}}),Object.defineProperty(t.prototype,"updateHighlight",{enumerable:!1,configurable:!0,writable:!0,value:function(t,e){e?this.undoRedoManager.do("highlightOthers",t):this.undoRedoManager.do("removeOtherHighlight",t)}}),Object.defineProperty(t.prototype,"updateVisibility",{enumerable:!1,configurable:!0,writable:!0,value:function(t,e){e?this.viewUtilities.hide(t):this.viewUtilities.show(t)}}),Object.defineProperty(t.prototype,"updateElementCallback",{enumerable:!1,configurable:!0,writable:!0,value:function(t){var e=t.oi,a=e.id,i=this.cy.$("#"+a);if(this.changeNameCy(i,e.name),i.isNode())i.isParent()?(i.style("min-width",e.minWidth),i.style("min-width-bias-left",e.minWidthBiasLeft),i.style("min-width-bias-right",e.minWidthBiasRight),i.style("min-height",e.minHeight),i.style("min-height-bias-top",e.minHeightBiasTop),i.style("min-height-bias-bottom",e.minHeightBiasBottom)):(i.data("w",e.w),i.data("h",e.h),i.position({x:e.x,y:e.y})),this.updateVisibility(i,e.isHidden),this.updateHighlight(i,e.isHighlighted),e.isInvalidGene?this.doHighlightInvalidGenes(i):this.undoHighlightInvalidGenes(i);else if(i.isEdge()){var o=e.pubmedIDs;i.data("pubmedIDs",o),this.updateHighlight(i,e.isHighlighted);var n=e.anchorPoints;if(e.source!==i.source().id()||e.target!==i.target().id()){var r={source:e.source,target:e.target};i.move(r),this.edgeEditing.initAnchorPoints(i)}else{if("bezier"===e.edgeCurveStyle){var l=this.edgeEditing.getAnchorsAsArray(i);if(l&&l.length>0)for(var c=0;c=6?a.visibilityMap[t]=!1:a.visibilityMap[t]&&i++})),this.shareDBManager.addGenomicVisibilityData(a.visibilityMap)}else this.genomicDataOverlayManager.addGenomicDataLocally(t,e)}}),Object.defineProperty(t.prototype,"adjustVisibilityShareDB",{enumerable:!1,configurable:!0,writable:!0,value:function(t,e){var a=this.profiles.map((function(t){return t.profileId})).indexOf(t);this.setProfile(a,nt(nt({},this.profiles[a]),{enabled:e}))}}),Object.defineProperty(t.prototype,"addToProfiles",{enumerable:!1,configurable:!0,writable:!0,value:function(t){this.profiles.map((function(t){return t.profileId})).includes(t)||this.addProfile({profileId:t,enabled:!0})}}),Object.defineProperty(t.prototype,"addPortalGenomicData",{enumerable:!1,configurable:!0,writable:!0,value:function(t,e){if(this.isCollaborative){var a=this.genomicDataOverlayManager.preparePortalGenomicDataShareDB(t);this.shareDBManager.addGenomicData(a.genomicDataMap),this.shareDBManager.groupGenomicData(Object.keys(a.visibilityMap),e),this.shareDBManager.addGenomicVisibilityData(a.visibilityMap)}else this.genomicDataOverlayManager.addPortalGenomicData(t,e)}}),Object.defineProperty(t.prototype,"shareDBGenomicDataHandler",{enumerable:!1,configurable:!0,writable:!0,value:function(t){var e="od"===Object.keys(t)[1],a=t.oi,i=t.p[1];e?this.genomicDataOverlayManager.removeGenomicDataWithGeneSymbol(i):this.genomicDataOverlayManager.addGenomicDataWithGeneSymbol(i,a)}}),Object.defineProperty(t.prototype,"shareDBGenomicDataGroupChangeHandler",{enumerable:!1,configurable:!0,writable:!0,value:function(t){var e=this,a="od"===Object.keys(t)[1],i=t.oi,o=t.p[1];a||(this.genomicDataOverlayManager.addGenomicGroupData(o,i),1!==i.length&&console.log("Grouped genomic data expected to be of length 1"),i.forEach((function(t){e.addToProfiles(t)}))),this.genomicDataOverlayManager.showGenomicData(),this.genomicDataOverlayManager.notifyObservers()}}),Object.defineProperty(t.prototype,"shareDBGenomicDataVisibilityHandler",{enumerable:!1,configurable:!0,writable:!0,value:function(t){var e=t.oi,a=t.p[1];"od"===Object.keys(t)[1]?(this.genomicDataOverlayManager.removeGenomicVisData(),this.removeProfiles()):(this.genomicDataOverlayManager.addGenomicVisData(a,e),this.adjustVisibilityShareDB(a,e)),this.genomicDataOverlayManager.showGenomicData(),this.genomicDataOverlayManager.notifyObservers()}}),Object.defineProperty(t.prototype,"updateGenomicDataColorSchemeHandler",{enumerable:!1,configurable:!0,writable:!0,value:function(t){var e=t.li;this.setGenomicDataOverlayColorScheme(e),this.colorSchemeChangeCallback(e),this.genomicDataOverlayManager.updateColorScheme(e),this.genomicDataOverlayManager.showGenomicData(),this.genomicDataOverlayManager.notifyObservers()}}),Object.defineProperty(t.prototype,"resizeNodesToContent",{enumerable:!1,configurable:!0,writable:!0,value:function(t){if(this.isCollaborative){var e=this.genomicDataOverlayManager.countVisibleGenomicDataByType(),a=148+36*(e-3),i=this.shareDBManager;t.forEach((function(t){if(t.isParent())i.resizeCompound(t,0,0,0,0,0,0);else{var o=150,n=52;if(""!=t.data("name"))o=10*t.style("label").length+6,n=24;"PROCESS"!==t.data("type")&&e>0&&(n=52,e<4?150>o&&(o=150):a>o&&(o=a)),i.setSizeOfElement(t,o,n)}}))}else{var o=this.cy.undoRedo(),n=[],r=this.genomicDataOverlayManager.countVisibleGenomicDataByType(),l=150+36*(r-3);t.forEach((function(t){if(t.isParent()){i={ele:t,oldMinWidth:t.style("min-width"),newMinWidth:0,oldMinWidthBiasLeft:t.style("min-width-bias-left"),newMinWidthBiasLeft:0,oldMinWidthBiasRight:t.style("min-width-bias-right"),newMinWidthBiasRight:0,oldMinHeight:t.style("min-height"),newMinHeight:0,oldMinHeightBiasTop:t.style("min-height-bias-top"),newMinHeightBiasTop:0,oldMinHeightBiasBottom:t.style("min-height-bias-bottom"),newMinHeightBiasBottom:0};n.push({name:"changeCompoundSize",param:i})}else{var e=150,a=52;if(""!=t.data("name"))e=6*t.style("label").length+24,a=24;"PROCESS"!==t.data("type")&&r>0&&(a=52,r<4?150>e&&(e=150):l>e&&(e=l));var i={ele:t,oldWidth:t.width(),newWidth:e,oldHeight:t.height(),newHeight:a};n.push({name:"changeNodeSize",param:i})}})),o.do("batch",n)}this.cy.nodeEditing("get").refreshGrapples()}}),Object.defineProperty(t,"defaultLayoutProperties",{enumerable:!0,configurable:!0,writable:!0,value:{name:"fcose",nodeRepulsion:4500,idealEdgeLength:50,edgeElasticity:.45,nestingFactor:.1,gravity:.25,numIter:2500,tile:!0,animate:!0,randomize:!1,gravityRangeCompound:1.5,gravityCompound:1,gravityRange:3.8,tilingPaddingVertical:10,tilingPaddingHorizontal:10,initialEnergyOnIncremental:.5,animationDuration:2e3,animationEasing:"cubic-bezier(0.17,0.72,0.41,0.98)"}}),rt([r.observable],t.prototype,"profiles",void 0),rt([r.observable],t.prototype,"genomicDataOverlayColorScheme",void 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t={};return this.colorMappings.forEach((function(e){t[e.value]=e.color})),Object.keys(t).length<2?(this.setShowUniqueValuesWarningModal(!0),!1):(this.props.handleColorMappingChange(t),!0)}}),Object.defineProperty(e.prototype,"close",{enumerable:!1,configurable:!0,writable:!0,value:function(){this.props.handleClose($e.PROFILES_COLOR_SCHEME)}}),Object.defineProperty(e.prototype,"render",{enumerable:!1,configurable:!0,writable:!0,value:function(){var t=this,e=this.colorMappings.map((function(e,a){return g.a.createElement(I.Row,{style:{padding:"10px"}},g.a.createElement(I.Col,{md:2}),g.a.createElement(I.Col,{md:3},g.a.createElement("input",{value:e.value,style:{width:"50px"},onChange:function(e){var i=e.target.value;t.handleValueChange(a,i)}})),g.a.createElement(I.Col,{md:3},g.a.createElement("input",{type:"color",value:e.color,onChange:function(e){var i=e.target.value;t.handleColorChange(a,i)}})),g.a.createElement(I.Col,{md:1},g.a.createElement("img",{src:Nt,className:"icon-small 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i(){this.constructor=e}t(e,a),e.prototype=null===a?Object.create(a):(i.prototype=a.prototype,new i)}}(),jt=function(t){function e(e){return t.call(this,e)||this}return mt(e,t),Object.defineProperty(e.prototype,"render",{enumerable:!1,configurable:!0,writable:!0,value:function(){var t=this;return g.a.createElement(I.Modal,{id:"quickHelpModal",show:this.props.show,onHide:function(){t.props.handleClose($e.HELP)}},g.a.createElement(I.Modal.Header,{closeButton:!0},g.a.createElement(I.Modal.Title,null,"Quick Help")),g.a.createElement(I.Modal.Body,null,g.a.createElement("ul",{className:"leftText"},g.a.createElement("li",null,g.a.createElement("strong",null,"To add a node:")," Drag and drop from node palette"),g.a.createElement("li",null,g.a.createElement("strong",null,"To add an interaction:")," Click on interaction type; then click on small circle on source node and release on target node"),g.a.createElement("li",null,g.a.createElement("strong",null,"To add a node into a container (family, 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t=i.responseText.split(/\r?\n|\r/),o=1;o=t.Z_SCORE_UPPER_THRESHOLD||parseFloat(I[u])<=t.Z_SCORE_LOWER_THRESHOLD)&&d++:d++);c[a][I[1]]=d/l*100}i(c)}}),Object.defineProperty(t.prototype,"getProfileData",{enumerable:!1,configurable:!0,writable:!0,value:function(e,a){var i=new XMLHttpRequest,o=this;i.onreadystatechange=function(){i.readyState===XMLHttpRequest.DONE&&200===i.status&&(o.calcAlterationPercentages(i.responseText,e.geneticProfileId,a),d.toast.success(e.geneticProfileId+" has been succesfully loaded from cBioPortal."))};var n=t.GET_PROFILE_DATA_URL;n+="&case_set_id="+e.caseSetId+"_sequenced",n+="&genetic_profile_id="+e.geneticProfileId,n+="&gene_list=";for(var r=!0,l=0,c=e.genes;l=0;l--)(o=t[l])&&(r=(n<3?o(r):n>3?o(e,a,r):o(e,a))||r);return n>3&&r&&Object.defineProperty(e,a,r),r},ft=function(t){function e(e){var a=t.call(this,e)||this;return Object.defineProperty(a,"dataTypes",{enumerable:!0,configurable:!0,writable:!0,value:{}}),Object.defineProperty(a,"dataTypeFetchResultsReady",{enumerable:!0,configurable:!0,writable:!0,value:!1}),Object.defineProperty(a,"currentlySelectedItemIndex",{enumerable:!0,configurable:!0,writable:!0,value:-1}),Object.defineProperty(a,"selectedStudies",{enumerable:!0,configurable:!0,writable:!0,value:[]}),Object.defineProperty(a,"checkboxModalPosition",{enumerable:!0,configurable:!0,writable:!0,value:{bottom:0}}),Object.defineProperty(a,"selectedDataTypesPerStudy",{enumerable:!0,configurable:!0,writable:!0,value:[]}),Object.defineProperty(a,"itemArray",{enumerable:!0,configurable:!0,writable:!0,value:[]}),Object.defineProperty(a,"searchQuery",{enumerable:!0,configurable:!0,writable:!0,value:""}),Object.defineProperty(a,"showDataTypeSelectionModal",{enumerable:!0,configurable:!0,writable:!0,value:!1}),Object.defineProperty(a,"studyListItemCheckboxChecked",{enumerable:!0,configurable:!0,writable:!0,value:[]}),Object.defineProperty(a,"selectedStudyData",{enumerable:!0,configurable:!0,writable:!0,value:void 0}),Object.defineProperty(a,"portalAccessor",{enumerable:!0,configurable:!0,writable:!0,value:void 0}),Object(r.makeObservable)(a),a.selectedStudyData=[],a.portalAccessor=new wt,a.fetchStudy(),a}return Dt(e,t),Object.defineProperty(e.prototype,"setDataTypeFetchResultsReady",{enumerable:!1,configurable:!0,writable:!0,value:function(t){this.dataTypeFetchResultsReady=t}}),Object.defineProperty(e.prototype,"setItemArray",{enumerable:!1,configurable:!0,writable:!0,value:function(t){this.itemArray=t}}),Object.defineProperty(e.prototype,"setSearchQuery",{enumerable:!1,configurable:!0,writable:!0,value:function(t){this.searchQuery=t}}),Object.defineProperty(e.prototype,"setSelectedStudyData",{enumerable:!1,configurable:!0,writable:!0,value:function(t){this.selectedStudyData=t}}),Object.defineProperty(e.prototype,"setDataTypeProperties",{enumerable:!1,configurable:!0,writable:!0,value:function(t,e){this.dataTypes[t]=e}}),Object.defineProperty(e.prototype,"initStudyListItemCheckboxChecked",{enumerable:!1,configurable:!0,writable:!0,value:function(t){this.studyListItemCheckboxChecked=Array(t).fill(!1)}}),Object.defineProperty(e.prototype,"initSelectedDataTypesPerStudy",{enumerable:!1,configurable:!0,writable:!0,value:function(t){this.selectedDataTypesPerStudy=Array(t).fill("")}}),Object.defineProperty(e.prototype,"toggleStudyListItemCheckboxChecked",{enumerable:!1,configurable:!0,writable:!0,value:function(t){this.studyListItemCheckboxChecked[t]=!this.studyListItemCheckboxChecked[t]}}),Object.defineProperty(e.prototype,"addSelectedStudy",{enumerable:!1,configurable:!0,writable:!0,value:function(t){this.selectedStudies.push(t)}}),Object.defineProperty(e.prototype,"removeSelectedStudy",{enumerable:!1,configurable:!0,writable:!0,value:function(t){this.selectedStudies=this.selectedStudies.filter((function(e){return e.data[0]!=t[0]}))}}),Object.defineProperty(e.prototype,"clearSelectedStudies",{enumerable:!1,configurable:!0,writable:!0,value:function(){this.selectedStudies=[]}}),Object.defineProperty(e.prototype,"setShowDataTypeSelectionModal",{enumerable:!1,configurable:!0,writable:!0,value:function(t){this.showDataTypeSelectionModal=t}}),Object.defineProperty(e.prototype,"clearStudyCheckboxesChecked",{enumerable:!1,configurable:!0,writable:!0,value:function(){var t=this.studyListItemCheckboxChecked.length;this.studyListItemCheckboxChecked=Array(t).fill(!1)}}),Object.defineProperty(e.prototype,"clearSelectedDataTypesPerStudy",{enumerable:!1,configurable:!0,writable:!0,value:function(){var t=this.studyListItemCheckboxChecked.length;this.selectedDataTypesPerStudy=Array(t).fill("")}}),Object.defineProperty(e.prototype,"unselectDataTypesForStudy",{enumerable:!1,configurable:!0,writable:!0,value:function(t){this.selectedDataTypesPerStudy[t]=""}}),Object.defineProperty(e.prototype,"preparePortalAccess",{enumerable:!1,configurable:!0,writable:!0,value:function(t){var e=this;this.setDataTypeFetchResultsReady(!1),this.portalAccessor.getSupportedGeneticProfiles(t,(function(t){e.disableAllDataTypes();for(var a=0,i=Object.keys(t);a1&&this.selectedStudyData[1]||"Choose study"},enumerable:!1,configurable:!0}),Object.defineProperty(e.prototype,"render",{enumerable:!1,configurable:!0,writable:!0,value:function(){var t=this;return g.a.createElement(I.Modal,{id:"cbioPortalModal",show:this.props.show,onHide:function(){t.props.handleClose($e.STUDY),t.resetModal()}},g.a.createElement(I.Modal.Header,{closeButton:!0},g.a.createElement(I.Modal.Title,null,"Profile Data from cBioPortal")),g.a.createElement(I.Modal.Body,null,g.a.createElement("div",{id:"cancerDropDown",style:{textAlign:"left"}},g.a.createElement("h4",null,"Select Cancer Study"),g.a.createElement("form",null,g.a.createElement(I.FormControl,{type:"text",placeholder:"Search studies",onChange:function(e){return t.setSearchQuery(e.target.value)}})),g.a.createElement(I.ListGroup,{style:{maxHeight:"200px",overflow:"auto",marginTop:"10px",border:"1px solid #ccc",borderRadius:"4px"}},this.itemArray.length<1?g.a.createElement("span",null,"Fetching studies from cBioPortal..."):this.itemArray.map((function(t,e){return{item:t,index:e}})).filter((function(e){return e.item[1].toLowerCase().includes(t.searchQuery.toLowerCase())})).map((function(e){var a=e.item,i=e.index,o=a[1],n=a[0];return g.a.createElement(I.ListGroupItem,{id:"listgroupitem"+i,key:n,style:{padding:"5px 5px"}},g.a.createElement(I.Checkbox,{checked:t.studyListItemCheckboxChecked[i],style:{marginTop:"0px",marginBottom:"0px"},onClick:function(){var e=document.getElementById("listgroupitem"+i).getBoundingClientRect();t.checkboxModalPosition={bottom:e.bottom-30},t.setSelectedStudyData(a),t.preparePortalAccess(n),t.toggleStudyListItemCheckboxChecked(i),t.currentlySelectedItemIndex=i,t.studyListItemCheckboxChecked[i]?t.setShowDataTypeSelectionModal(!0):(t.removeSelectedStudy(a),t.unselectDataTypesForStudy(i))}},o),""!=t.selectedDataTypesPerStudy[i]&&g.a.createElement("span",{style:{fontSize:"12px",marginLeft:"25px"}},t.selectedDataTypesPerStudy[i]))})))),g.a.createElement("div",{style:{marginTop:"10px"}},g.a.createElement("p",{style:{textAlign:"left"}},g.a.createElement("b",null,"Warning:"),' At most six different data sets will be overlayed on the genes. You can toggle which ones are to be displayed via "Alteration %" ',">",' "View Settings" menu.')),g.a.createElement(I.Modal,{style:{position:"absolute",top:this.checkboxModalPosition.bottom+"px"},dialogClassName:"fitContent",show:this.showDataTypeSelectionModal,onHide:function(){t.setShowDataTypeSelectionModal(!1)}},g.a.createElement(I.Modal.Body,null,!1===this.dataTypeFetchResultsReady?g.a.createElement("span",null,"Fetching data types from cBioPortal..."):Object.keys(this.dataTypes).map((function(e){return g.a.createElement(I.Checkbox,{inline:!0,key:e,disabled:!t.dataTypes[e].enabled,onClick:function(){t.handleCheckboxClick(e)},checked:t.dataTypes[e].checked},e)}))),g.a.createElement(I.Modal.Footer,null,g.a.createElement(I.Button,{onClick:function(){var e=Tt({},t.dataTypes);0==Object.keys(e).filter((function(t){return e[t].checked})).length&&(t.studyListItemCheckboxChecked[t.currentlySelectedItemIndex]=!1),t.setShowDataTypeSelectionModal(!1)}},"Cancel"),g.a.createElement(I.Button,{onClick:function(){var e=Tt({},t.dataTypes);t.addSelectedStudy({data:t.selectedStudyData,dataTypes:e}),t.selectedDataTypesPerStudy[t.currentlySelectedItemIndex]=Object.keys(e).filter((function(t){return e[t].checked})).join(", "),t.setShowDataTypeSelectionModal(!1)}},"Add")))),g.a.createElement(I.Modal.Footer,null,g.a.createElement(I.Button,{bsClass:"success",onClick:function(){t.selectedStudies.forEach((function(e){t.props.loadFromCBio(e.dataTypes,e.data)})),t.props.handleClose($e.STUDY),t.resetModal()}},"Load Data")))}}),Lt([r.observable],e.prototype,"dataTypes",void 0),Lt([r.observable],e.prototype,"dataTypeFetchResultsReady",void 0),Lt([r.observable],e.prototype,"selectedStudies",void 0),Lt([r.observable],e.prototype,"selectedDataTypesPerStudy",void 0),Lt([r.observable],e.prototype,"itemArray",void 0),Lt([r.observable],e.prototype,"searchQuery",void 0),Lt([r.observable],e.prototype,"showDataTypeSelectionModal",void 0),Lt([r.observable],e.prototype,"studyListItemCheckboxChecked",void 0),Lt([r.observable],e.prototype,"selectedStudyData",void 0),Lt([r.observable],e.prototype,"portalAccessor",void 0),Lt([r.action.bound],e.prototype,"setDataTypeFetchResultsReady",null),Lt([r.action.bound],e.prototype,"setItemArray",null),Lt([r.action.bound],e.prototype,"setSearchQuery",null),Lt([r.action.bound],e.prototype,"setSelectedStudyData",null),Lt([r.action.bound],e.prototype,"setDataTypeProperties",null),Lt([r.action.bound],e.prototype,"initStudyListItemCheckboxChecked",null),Lt([r.action.bound],e.prototype,"initSelectedDataTypesPerStudy",null),Lt([r.action.bound],e.prototype,"toggleStudyListItemCheckboxChecked",null),Lt([r.action.bound],e.prototype,"addSelectedStudy",null),Lt([r.action.bound],e.prototype,"removeSelectedStudy",null),Lt([r.action.bound],e.prototype,"clearSelectedStudies",null),Lt([r.action.bound],e.prototype,"setShowDataTypeSelectionModal",null),Lt([r.action.bound],e.prototype,"clearStudyCheckboxesChecked",null),Lt([r.action.bound],e.prototype,"clearSelectedDataTypesPerStudy",null),Lt([r.action.bound],e.prototype,"unselectDataTypesForStudy",null),Lt([n.a],e.prototype,"resetModal",null),Lt([n.a],e.prototype,"handleCheckboxClick",null),Lt([r.computed],e.prototype,"selectedStudyDataTitle",null),e=Lt([l.observer],e)}(g.a.Component),Ot=function(){var t=function(e,a){return(t=Object.setPrototypeOf||{__proto__:[]}instanceof Array&&function(t,e){t.__proto__=e}||function(t,e){for(var a in e)Object.prototype.hasOwnProperty.call(e,a)&&(t[a]=e[a])})(e,a)};return function(e,a){function i(){this.constructor=e}t(e,a),e.prototype=null===a?Object.create(a):(i.prototype=a.prototype,new i)}}(),vt=function(t,e,a,i){var o,n=arguments.length,r=n<3?e:null===i?i=Object.getOwnPropertyDescriptor(e,a):i;if("object"==typeof Reflect&&"function"==typeof Reflect.decorate)r=Reflect.decorate(t,e,a,i);else for(var l=t.length-1;l>=0;l--)(o=t[l])&&(r=(n<3?o(r):n>3?o(e,a,r):o(e,a))||r);return n>3&&r&&Object.defineProperty(e,a,r),r},Gt=["Cell Cycle","HIPPO","MYC","NOTCH","NRF2","PI3K","RTK-RAS","TGF-Beta","TP53","WNT"],St=function(t){function e(e){var a=t.call(this,e)||this;return Object.defineProperty(a,"bestPathways",{enumerable:!0,configurable:!0,writable:!0,value:void 0}),Object.defineProperty(a,"shownPathways",{enumerable:!0,configurable:!0,writable:!0,value:void 0}),Object.defineProperty(a,"dropDownTitle",{enumerable:!0,configurable:!0,writable:!0,value:void 0}),Object.defineProperty(a,"selectedPathway",{enumerable:!0,configurable:!0,writable:!0,value:void 0}),Object.defineProperty(a,"isPercentageMatch",{enumerable:!0,configurable:!0,writable:!0,value:void 0}),Object.defineProperty(a,"isAlterationEnabled",{enumerable:!0,configurable:!0,writable:!0,value:void 0}),Object.defineProperty(a,"considerOnlyTCGAPanPathways",{enumerable:!0,configurable:!0,writable:!0,value:void 0}),Object.defineProperty(a,"isExpanded",{enumerable:!0,configurable:!0,writable:!0,value:void 0}),Object.defineProperty(a,"COUNT_PERC_EXPLANATION",{enumerable:!0,configurable:!0,writable:!0,value:"Whether we should favor the number of genes of interest matching the ones in a pathway or the percentage of such genes in that pathway. For instance, suppose genes of interest are A, B, and C, and the pathway contains genes B, C, D, and E. When we consider count, the score is 2 (for the two genes that match). However, when we consider percentage the score will be 50% as 2 of the 4 genes in the pathway are among genes of interest."}),Object.defineProperty(a,"ALTERATION_EXPLANATION",{enumerable:!0,configurable:!0,writable:!0,value:"When this is checked, each matching gene will not directly contribute to the score as 1 unit but with the alteration frequency percentage of that gene. For instance, suppose genes of interest are A, B, and C with alteration frequencies of 0.5, 0.2, and 0.3, respectively, and the pathway contains genes B, C, D, and E. When this is option isn't checked, the score will be 2 for match count and 50% for the match percentage. However, when this option is checked, the scores will be 0.2+0.3=0.5 and (0.2+0.3)/4=12.5% for match count and percentage, respectively."}),Object.defineProperty(a,"TCGA_PANCAN_EXPLANATION",{enumerable:!0,configurable:!0,writable:!0,value:"The pathways listed above were retrieved from PathwayMapper. When this option is checked, only the pathways under TCGA > PanCanAtlas will be shown. Uncheck to show all."}),Object(r.makeObservable)(a),a.isPercentageMatch=0,a.isAlterationEnabled=0,a.considerOnlyTCGAPanPathways=!0,a.dropDownTitle="Match count",a.isExpanded=!1,a.setBestPathwayMethod(0),a.selectedPathway=a.shownPathways[0].pathwayName,a}return Ot(e,t),Object.defineProperty(e.prototype,"setBestPathwayMethod",{enumerable:!1,configurable:!0,writable:!0,value:function(t){this.bestPathways=this.props.bestPathwaysAlgos[t],this.filterBestPathwaysByTCGAPanPathways()}}),Object.defineProperty(e.prototype,"onPathwayClick",{enumerable:!1,configurable:!0,writable:!0,value:function(t){this.selectedPathway=t,this.props.pathwayActions.changePathway(this.selectedPathway)}}),Object.defineProperty(e.prototype,"onApplyClick",{enumerable:!1,configurable:!0,writable:!0,value:function(){this.setBestPathwayMethod(2*this.isAlterationEnabled+this.isPercentageMatch)}}),Object.defineProperty(e.prototype,"filterBestPathwaysByTCGAPanPathways",{enumerable:!1,configurable:!0,writable:!0,value:function(){var t=this;this.shownPathways=this.bestPathways.filter((function(e){return!t.considerOnlyTCGAPanPathways||Gt.indexOf(e.pathwayName)>-1})),this.considerOnlyTCGAPanPathways&&Gt.indexOf(this.selectedPathway)<0&&(this.selectedPathway=this.shownPathways[0].pathwayName,this.props.pathwayActions.changePathway(this.selectedPathway))}}),Object.defineProperty(e.prototype,"toggleConsiderOnlyTCGAPanPathways",{enumerable:!1,configurable:!0,writable:!0,value:function(){this.considerOnlyTCGAPanPathways=!this.considerOnlyTCGAPanPathways,this.filterBestPathwaysByTCGAPanPathways()}}),Object.defineProperty(e.prototype,"componentDidMount",{enumerable:!1,configurable:!0,writable:!0,value:function(){this.props.pathwayActions.changePathway(this.selectedPathway)}}),Object.defineProperty(e.prototype,"render",{enumerable:!1,configurable:!0,writable:!0,value:function(){var t=this;return g.a.createElement("div",{id:"ranking-bar"},this.props.tableComponent&&this.props.tableComponent(this.shownPathways.map((function(t){return{name:t.pathwayName,score:t.score,genes:t.genesMatched}})),this.selectedPathway,this.onPathwayClick),g.a.createElement("div",{className:"indent"},g.a.createElement(I.Checkbox,{checked:this.considerOnlyTCGAPanPathways,id:"tcgaPathwaysCheckbox",onClick:this.toggleConsiderOnlyTCGAPanPathways,style:{fontSize:"13px"}},"Show TCGA PanCancer Atlas pathways only ",g.a.createElement("span",{"data-tip":this.TCGA_PANCAN_EXPLANATION,"data-border":"true","data-type":"light","data-place":"left","data-effect":"solid","data-html":"true","data-delay-hide":"500",className:"fa fa-question-circle styles-module__infoIcon__zMiog"}))),!this.props.patientView&&g.a.createElement("div",{className:"info-entry"},g.a.createElement("div",{id:"criteria-title",className:"info-title"},g.a.createElement("b",{style:{display:"inline-block"}}," Ranking options")),g.a.createElement("div",{className:"indent"},g.a.createElement(I.DropdownButton,{title:this.dropDownTitle,id:"0",style:{fontSize:"13px"}},g.a.createElement(I.MenuItem,{style:{fontSize:"13px"},onClick:function(){t.isPercentageMatch=0,t.dropDownTitle="Match count",t.onApplyClick()}},"Match count"),g.a.createElement(I.MenuItem,{style:{fontSize:"13px"},onClick:function(){t.isPercentageMatch=1,t.dropDownTitle="Match percentage",t.onApplyClick()}},"Match percentage"))," ",g.a.createElement("div",{"data-tip":this.COUNT_PERC_EXPLANATION,"data-border":"true","data-type":"light","data-place":"left","data-effect":"solid",className:"fa fa-question-circle styles-module__infoIcon__zMiog"}),g.a.createElement(I.Checkbox,{id:"alterationCheckBox",onClick:function(){t.isAlterationEnabled=1===t.isAlterationEnabled?0:1,t.onApplyClick()},style:{fontSize:"13px",marginTop:"18px",bottom:"4px"}},"Consider alteration frequency ",g.a.createElement("span",{"data-tip":this.ALTERATION_EXPLANATION,"data-border":"true","data-type":"light","data-place":"left","data-effect":"solid",className:"fa fa-question-circle styles-module__infoIcon__zMiog"})))))}}),vt([r.observable],e.prototype,"bestPathways",void 0),vt([r.observable],e.prototype,"shownPathways",void 0),vt([r.observable],e.prototype,"dropDownTitle",void 0),vt([r.observable],e.prototype,"selectedPathway",void 0),vt([r.observable],e.prototype,"considerOnlyTCGAPanPathways",void 0),vt([r.observable],e.prototype,"isExpanded",void 0),vt([n.a],e.prototype,"setBestPathwayMethod",null),vt([n.a],e.prototype,"onPathwayClick",null),vt([n.a],e.prototype,"onApplyClick",null),vt([r.action.bound],e.prototype,"filterBestPathwaysByTCGAPanPathways",null),vt([r.action.bound],e.prototype,"toggleConsiderOnlyTCGAPanPathways",null),e=vt([l.observer],e)}(g.a.Component),Pt=function(){var t=function(e,a){return(t=Object.setPrototypeOf||{__proto__:[]}instanceof 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Pt(e,t),Object.defineProperty(e.prototype,"render",{enumerable:!1,configurable:!0,writable:!0,value:function(){var t=this,e="q="+JSON.stringify(this.props.alterationData)+"&g="+this.props.genes.map((function(t){return t.hugoGeneSymbol})).join("+");return g.a.createElement("div",{id:"toolbar",style:{marginLeft:"0px"}},g.a.createElement("img",{height:"22px",width:"22px","data-border":"true","data-type":"light","data-tip":"Save as PNG","data-place":"right","data-effect":"solid",src:v.a,onClick:function(){t.props.pathwayActions.saveAs("PNG")}}),g.a.createElement("img",{height:"22px",width:"22px","data-border":"true","data-type":"light","data-tip":"Save as SVG","data-place":"right","data-effect":"solid",src:S.a,onClick:function(){t.props.pathwayActions.saveAs("SVG")}}),g.a.createElement("img",{height:"22px",width:"22px","data-border":"true","data-type":"light","data-tip":"Perform 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"),t.selectedGenes.forEach((function(e){t.props.validGenes.hasOwnProperty(e)||a.push(e)})),0===a.length?t.selectedGenes.length>0&&0===e.length&&t.props.onAddGenes(t.selectedGenes):i+="Following gene symbols are invalid or already in gene list: "+a.join(", ")+".",i.length>0&&t.props.showMessage(i)}}),g.a.createElement("img",{height:"22px",width:"22px","data-border":"true","data-type":"light","data-tip":"Add all valid genes to query","data-place":"right","data-effect":"solid",src:Zt,onClick:function(){t.selectedGenes=t.props.pathwayGenes.filter((function(e){return t.props.validGenes.hasOwnProperty(e)})),t.selectedGenes.length>0&&t.props.onAddGenes(t.selectedGenes)}}),g.a.createElement("img",{height:"22px",width:"22px","data-border":"true","data-type":"light","data-tip":"Edit 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t=this.editor.cy.elements(":selected");this.editor.removeElement(t)}}),Object.defineProperty(t.prototype,"addEdge",{enumerable:!1,configurable:!0,writable:!0,value:function(t){if(window.edgeAddingMode=t+1,-1===t)return this.eh.disable(),void this.eh.hide();this.eh.enable()}}),Object.defineProperty(t.prototype,"changeNodeName",{enumerable:!1,configurable:!0,writable:!0,value:function(t,e){var a=this.editor.cy.$('[name="'+t+'"]')[0];this.editor.changeName(a,e)}}),Object.defineProperty(t.prototype,"addNode",{enumerable:!1,configurable:!0,writable:!0,value:function(t){var e={type:t.toUpperCase(),name:"New "+t,w:"150",h:"52"},a=this.editor.cy.extent(),i={x:(a.x1+a.x2)/2,y:(a.y1+a.y2)/2};this.editor.addNode(e,i),this.pathwayHandler("Additional Pathway")}}),Object.defineProperty(t.prototype,"searchGene",{enumerable:!1,configurable:!0,writable:!0,value:function(t){var e="node[name @*= 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t=function(e,a){return(t=Object.setPrototypeOf||{__proto__:[]}instanceof Array&&function(t,e){t.__proto__=e}||function(t,e){for(var a in e)Object.prototype.hasOwnProperty.call(e,a)&&(t[a]=e[a])})(e,a)};return function(e,a){function i(){this.constructor=e}t(e,a),e.prototype=null===a?Object.create(a):(i.prototype=a.prototype,new i)}}(),ve=function(t,e,a,i){var o,n=arguments.length,r=n<3?e:null===i?i=Object.getOwnPropertyDescriptor(e,a):i;if("object"==typeof Reflect&&"function"==typeof Reflect.decorate)r=Reflect.decorate(t,e,a,i);else for(var l=t.length-1;l>=0;l--)(o=t[l])&&(r=(n<3?o(r):n>3?o(e,a,r):o(e,a))||r);return n>3&&r&&Object.defineProperty(e,a,r),r},Ge=function(t){function e(e){var a=t.call(this,e)||this;return Object.defineProperty(a,"searchedGene",{enumerable:!0,configurable:!0,writable:!0,value:void 0}),Object(r.makeObservable)(a),a.searchedGene="",a.props.pathwayActions.enabledType=R.NONE,a}return 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"+(this.isCbioPortal?"#4389c0":"#1abc9c")}},g.a.createElement("div",{ref:this.cyDivHandler,id:"cy",style:{height:this.isCbioPortal?"800px":"100%",borderRadius:"6px",marginTop:"0px"}}),g.a.createElement("div",{className:"cytoscape-navigator-wrapper"}))}}),Object.defineProperty(e.prototype,"componentDidMount",{enumerable:!1,configurable:!0,writable:!0,value:function(){this.isMountedFirst&&(this.init(),this.isMountedFirst=!1),this.getPathway(this.props.selectedPathway)}}),Object.defineProperty(e.prototype,"cyDivHandler",{enumerable:!1,configurable:!0,writable:!0,value:function(t){this.cyDiv=t}}),Object.defineProperty(e.prototype,"init",{enumerable:!1,configurable:!0,writable:!0,value:function(){this.portalAccessor=new wt,this.initCyJS(),this.initCyHandlers(),this.initKeyboardHandlers(),this.initUndoRedoFunctionality(),this.initCBioPortalFunctionalities(),this.placePanzoomAndOverlay()}}),Object.defineProperty(e.prototype,"placePanzoomAndOverlay",{enumerable:!1,configurable:!0,writable:!0,value:function(){var t=et()(this.cyDiv).offset().top,e=et()(this.cyDiv).offset().left,a=et()(this.cyDiv).outerHeight(),i=et()(this.cyDiv).outerWidth(),o=et()(".cytoscape-navigator-wrapper").outerHeight(),n=et()(".cytoscape-navigator-wrapper").outerWidth();this.isCbioPortal?(et()(".cytoscape-navigator-wrapper").css("bottom",10.5),et()(".cytoscape-navigator-wrapper").css("right",0)):(et()(".cytoscape-navigator-wrapper").css("top",a+t-o-5+16),et()(".cytoscape-navigator-wrapper").css("left",i+e-n-5+24-.5+.35)),et()(".cytoscape-navigator-wrapper").css("z-index",1039),et()(".cy-panzoom").css("position","relative"),et()(".cy-panzoom").css("top",2),et()(".cy-panzoom").css("left",i-51),et()(".cy-panzoom").css("z-index",1039),et()(".cy-panzoom").css("width",200)}}),Object.defineProperty(e.prototype,"getPathwayData",{enumerable:!1,configurable:!0,writable:!0,value:function(){return this.pathwayDetailsView.getPathwayData()}}),Object.defineProperty(e.prototype,"initCyJS",{enumerable:!1,configurable:!0,writable:!0,value:function(){var t=this;try{na(Pe.a,et.a)}catch(t){console.log(t)}try{ca(Pe.a)}catch(t){console.log(t)}try{ua(Pe.a,et.a)}catch(t){console.log(t)}try{oa(Pe.a)}catch(t){console.log(t)}try{ga(Pe.a,et.a)}catch(t){console.log(t)}try{ia(Pe.a,et.a,Ia)}catch(t){console.log(t)}try{ea(Pe.a,et.a,Ia)}catch(t){console.log(t)}try{da(Pe.a,et.a)}catch(t){console.log(t)}try{ta(Pe.a,et.a)}catch(t){console.log(t)}try{sa(Pe.a)}catch(t){console.log(t)}try{aa(Pe.a)}catch(t){console.log(t)}try{Ca(Pe.a)}catch(t){console.log(t)}this.cy=Pe()({container:this.cyDiv,boxSelectionEnabled:!0,autounselectify:!1,wheelSensitivity:.1,style:ra,textureOnViewport:!1,motionBlur:!0,layout:{name:"preset"}}),this.edgeAddingMode=0,this.undoRedoManager=this.cy.undoRedo(),this.shareDBManager=new Fe((function(){t.shareDBManager.getDoc()})),this.editor=new ct(this.isCollaborative,this.shareDBManager,this.cy,this.isCbioPortal,this.undoRedoManager,this.portalAccessor,this.props.profiles,this.props.genomicDataOverlayColorScheme,this.props.colorSchemeChangeCallback),this.shareDBManager.setEditor(this.editor),this.isCollaborative&&this.shareDBManager.initShareDB(),this.qtipManager=new Ve(this.cy,this.editor),this.cxtMenuManager=new Xe(this.cy,this.editor,this.props.handleOpen,this.undoRedoManager,this.props.isCollaborative),this.dragDropNodeAddManager=new Je(this.editor,this.cy,this.props.pathwayHandler),this.cy.panzoom(la),this.cy.layoutUtilities({desiredAspectRatio:this.cy.width()/this.cy.height()}),this.cy.nodeadd({components:[{container:et()("#simpleNodeDiv"),nodeType:"Gene",icon:ke.a},{container:et()("#familyNodeDiv"),nodeType:"Family",icon:xe.a},{container:et()("#complexNodeDiv"),nodeType:"Complex",icon:Re.a},{container:et()("#compartmentNodeDiv"),nodeType:"Compartment",icon:Ye.a},{container:et()("#processNodeDiv"),nodeType:"Process",icon:He.a}]});var e=this,a={preview:!0,stackOrder:4,handleSize:10,handleColor:"#1abc9c",handleLineType:"ghost",handleLineWidth:1,handleNodes:"node",hoverDelay:1,cxt:!1,enabled:!1,toggleOffOnLeave:!0,edgeType:function(t,e){return"flat"},handlePosition:function(t){return"middle 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e||15},getCompoundMinWidth:function(t){return t.style("min-width")},getCompoundMinHeight:function(t){return t.style("min-height")},getCompoundMinWidthBiasRight:function(t){return t.style("min-width-bias-right")},getCompoundMinWidthBiasLeft:function(t){return t.style("min-width-bias-left")},getCompoundMinHeightBiasTop:function(t){return t.style("min-height-bias-top")},getCompoundMinHeightBiasBottom:function(t){return t.style("min-height-bias-bottom")},isFixedAspectRatioResizeMode:function(t){return t.is(".fixedAspectRatioResizeMode")},isNoResizeMode:function(t){},setWidth:function(t,e){t.data("w",e)},setHeight:function(t,e){t.data("h",e)},setCompoundMinWidth:function(t,e){t.style("min-width",e)},setCompoundMinHeight:function(t,e){t.style("min-height",e)},setCompoundMinWidthBiasLeft:function(t,e){t.style("min-width-bias-left",e)},setCompoundMinWidthBiasRight:function(t,e){t.style("min-width-bias-right",e)},setCompoundMinHeightBiasTop:function(t,e){t.style("min-height-bias-top",e)},setCompoundMinHeightBiasBottom:function(t,e){t.style("min-height-bias-bottom",e)},cursors:{default:"default",inactive:"not-allowed",nw:"nw-resize",n:"n-resize",ne:"ne-resize",e:"e-resize",se:"se-resize",s:"s-resize",sw:"sw-resize",w:"w-resize"},resizeToContentCueImage:Ke.a,resizeToContentFunction:this.editor.resizeNodesToContent.bind(this.editor)});this.cy.navigator({container:".cytoscape-navigator-wrapper",viewLiveFramerate:0,thumbnailEventFramerate:10,thumbnailLiveFramerate:!1,dblClickDelay:200,removeCustomContainer:!0,rerenderDelay:100});this.viewUtilities=this.cy.viewUtilities({node:{highlighted:{"border-width":2,"border-color":"#bc1142"},unhighlighted:{opacity:function(t){return t.css("opacity")}}},edge:{highlighted:{},unhighlighted:{opacity:function(t){return t.css("opacity")}}},setVisibilityOnHide:!1,setDisplayOnHide:!0,neighbor:function(){return!1},neighborSelectTime:500}),this.editor.setViewUtilities(this.viewUtilities),this.placePanzoomAndOverlay()}}),Object.defineProperty(e.prototype,"getGlobalEdgeType",{enumerable:!1,configurable:!0,writable:!0,value:function(){var t="NONE";return 1===window.edgeAddingMode?t="ACTIVATES":2===window.edgeAddingMode?t="INHIBITS":3===window.edgeAddingMode?t="INDUCES":4===window.edgeAddingMode?t="REPRESSES":5===window.edgeAddingMode&&(t="BINDS"),t}}),Object.defineProperty(e.prototype,"initCyHandlers",{enumerable:!1,configurable:!0,writable:!0,value:function(){var t,e,a=this,i=this;this.cy.on("tap",(function(a){var i=a.target;-1!==e&&-1!==t&&clearTimeout(e),t===i?(i.trigger("doubleTap"),t=-1):(e=setTimeout((function(){t=-1}),300),t=i)})),this.cy.on("doubleTap","node",(function(t){i.props.isCbioPortal||t.target===this&&(i.qtipManager.addQtipToElements(t.target),t.target.trigger("showqtipevent"))})),this.cy.on("doubleTap","edge",(function(t){i.props.isCbioPortal||t.target===this&&(i.qtipManager.addQtipToElements(t.target),t.target.trigger("showqtipevent"))})),this.cy.on("select","node",(function(t){a.editor.pushSelectedNodeStack(t.target)})),this.cy.on("unselect","node",(function(t){a.editor.removeElementFromSelectedNodeStack(t.target)})),this.cy.on("free","node",(function(t){var e=a.cy.nodes(":selected"),i=t.target;i=(i=i.union(i.descendants())).union(e),a.editor.moveElements(i)})),this.cy.on("layoutstop",(function(){a.editor.postLayout()})),this.cy.on("nodeediting.resizeend",(function(t,e,i){i.data("w",i.width()),i.data("h",i.height()),a.editor.resizeElements(i)})),this.cy.on("select","edge",(function(t){a.lastSelectedEdge=t.target})),this.cy.on("bendPointMovement",(function(){a.editor.updateEdgeAnchorPoints(a.lastSelectedEdge)})),this.cy.on("nodeediting.moveend",(function(){a.editor.changeNodePositionsByArrows(a.cy.nodes(":selected"))}))}}),Object.defineProperty(e.prototype,"initKeyboardHandlers",{enumerable:!1,configurable:!0,writable:!0,value:function(){var t=this;this.isCollaborative||this.isCbioPortal?(et()('a[role="redo"]').hide(),et()('a[role="undo"]').hide()):et()(document).keydown((function(e){89===e.which&&(e.ctrlKey||e.metaKey)?t.undoRedoManager.redo():90===e.which&&(e.ctrlKey||e.metaKey)&&t.undoRedoManager.undo()})),et()(document).keydown((function(e){if(65===e.which&&(e.ctrlKey||e.metaKey))"TEXTAREA"!=(a=document.activeElement.tagName)&&"INPUT"!=a&&(e.preventDefault(),t.cy.elements().select());else if(8===e.which||46===e.which){var a;if("TEXTAREA"!=(a=document.activeElement.tagName)&&"INPUT"!=a){var i=t.cy.$(":selected");t.editor.removeElement(i)}}}))}}),Object.defineProperty(e.prototype,"initUndoRedoFunctionality",{enumerable:!1,configurable:!0,writable:!0,value:function(){(this.isCollaborative||this.isCbioPortal)&&(et()('[role="undo"]').hide(),et()('[role="redo"]').hide())}}),Object.defineProperty(e.prototype,"initCBioPortalFunctionalities",{enumerable:!1,configurable:!0,writable:!0,value:function(){this.isCbioPortal&&this.cy.contextMenus("get").destroy()}}),_e([n.a],e.prototype,"cyDivHandler",null),e=_e([l.observer],e)}(g.a.Component),Ma=function(){var t=function(e,a){return(t=Object.setPrototypeOf||{__proto__:[]}instanceof Array&&function(t,e){t.__proto__=e}||function(t,e){for(var a in e)Object.prototype.hasOwnProperty.call(e,a)&&(t[a]=e[a])})(e,a)};return function(e,a){function i(){this.constructor=e}t(e,a),e.prototype=null===a?Object.create(a):(i.prototype=a.prototype,new i)}}(),pa=function(t){function e(e){return t.call(this,e)||this}return Ma(e,t),Object.defineProperty(e.prototype,"render",{enumerable:!1,configurable:!0,writable:!0,value:function(){for(var t=this,e={},a=0,i=Object.keys(C);a=0;l--)(o=t[l])&&(r=(n<3?o(r):n>3?o(e,a,r):o(e,a))||r);return n>3&&r&&Object.defineProperty(e,a,r),r},Oa=function(t){function e(e){var a=t.call(this,e)||this;return Object.defineProperty(a,"activeEdge",{enumerable:!0,configurable:!0,writable:!0,value:-1}),Object(r.makeObservable)(a),e.setActiveEdgeHandler(a.setActiveEdge),a}return La(e,t),Object.defineProperty(e.prototype,"addEdge",{enumerable:!1,configurable:!0,writable:!0,value:function(t){if(t===this.activeEdge)return this.setActiveEdge(-1),void this.props.pathwayActions.addEdge(-1);this.setActiveEdge(t),this.props.pathwayActions.addEdge(t)}}),Object.defineProperty(e.prototype,"setActiveEdge",{enumerable:!1,configurable:!0,writable:!0,value:function(t){this.activeEdge=t}}),Object.defineProperty(e.prototype,"render",{enumerable:!1,configurable:!0,writable:!0,value:function(){var t=this,e=[ba.a,wa.a,ma.a,Ta.a,ha.a];return g.a.createElement("div",{id:"pathway-sidebar",className:"sideBarWrapper"},g.a.createElement(I.Panel,{className:"pnl"},g.a.createElement(I.Panel.Heading,{className:"pnl-header"},"Network"),g.a.createElement(I.Panel.Body,{className:"pnl-body pathwayPanel"},g.a.createElement("div",{className:"buttonContainer"},g.a.createElement(I.Button,{onClick:function(){t.props.handleOpen($e.PW_DETAILS)}},"Properties")),g.a.createElement("div",{className:"buttonContainer"},g.a.createElement(I.Button,{onClick:function(){t.props.pathwayActions.upload()}},"Import")),g.a.createElement("div",{className:"buttonContainer"},g.a.createElement(I.Button,{onClick:function(){t.props.pathwayActions.export(!1)}},"Export")))),g.a.createElement(I.Panel,{className:"pnl"},g.a.createElement(I.Panel.Heading,{className:"pnl-header"},"Node Palette"),g.a.createElement(I.Panel.Body,{className:"pnl-body"},["simpleNodeDiv","familyNodeDiv","complexNodeDiv","compartmentNodeDiv","processNodeDiv"].map((function(t){return g.a.createElement("div",{key:t,id:t,"data-tip":"Click on this and drag to the location on drawing canvas and release!","data-effect":"solid","data-place":"bottom","data-delay-show":"1000",className:"dragButtonContainer"})})))),g.a.createElement(I.Panel,{className:"pnl edgePanel"},g.a.createElement(I.Panel.Heading,{className:"pnl-header"},"Interaction Palette"),g.a.createElement(I.Panel.Body,{className:"pnl-body edgePaletteWrapper"},g.a.createElement("div",{className:"list-group edge-palette"},["Activates","Inhibits","Induces","Represses","Binds"].map((function(a,i){return g.a.createElement("div",{key:i,"data-tip":"Click to activate; then, start the interaction from the little circle on the source node!","data-effect":"solid","data-place":"bottom","data-delay-show":"1000"},g.a.createElement("a",{style:{marginBottom:"5px"},className:"list-group-item "+(t.activeEdge===i?"active":""),onClick:function(){t.addEdge(i)},href:"#"},g.a.createElement("img",{style:{width:"30px"},className:"pull-left",src:e[i]})," ",a))}))))))}}),fa([r.observable],e.prototype,"activeEdge",void 0),fa([r.action.bound],e.prototype,"setActiveEdge",null),e=fa([l.observer],e)}(g.a.Component),va=function(){var t=function(e,a){return(t=Object.setPrototypeOf||{__proto__:[]}instanceof Array&&function(t,e){t.__proto__=e}||function(t,e){for(var a in e)Object.prototype.hasOwnProperty.call(e,a)&&(t[a]=e[a])})(e,a)};return function(e,a){function i(){this.constructor=e}t(e,a),e.prototype=null===a?Object.create(a):(i.prototype=a.prototype,new i)}}(),Ga=function(t,e,a,i){var o,n=arguments.length,r=n<3?e:null===i?i=Object.getOwnPropertyDescriptor(e,a):i;if("object"==typeof Reflect&&"function"==typeof Reflect.decorate)r=Reflect.decorate(t,e,a,i);else for(var l=t.length-1;l>=0;l--)(o=t[l])&&(r=(n<3?o(r):n>3?o(e,a,r):o(e,a))||r);return n>3&&r&&Object.defineProperty(e,a,r),r},Sa=a(79),Pa=Sa();!function(t){t[t.STUDY=0]="STUDY",t[t.CONFIRMATION=1]="CONFIRMATION",t[t.PROFILES=2]="PROFILES",t[t.ABOUT=3]="ABOUT",t[t.PW_DETAILS=4]="PW_DETAILS",t[t.GRID=5]="GRID",t[t.HELP=6]="HELP",t[t.LAYOUT=7]="LAYOUT",t[t.CHELP=8]="CHELP",t[t.PROFILES_COLOR_SCHEME=9]="PROFILES_COLOR_SCHEME"}($e||($e={}));var za=function(t){function e(e){var i=t.call(this,e)||this;return Object.defineProperty(i,"MAX_ALLOWED_PROFILES_ENABLED",{enumerable:!0,configurable:!0,writable:!0,value:6}),Object.defineProperty(i,"selectedPathway",{enumerable:!0,configurable:!0,writable:!0,value:void 0}),Object.defineProperty(i,"fileManager",{enumerable:!0,configurable:!0,writable:!0,value:void 0}),Object.defineProperty(i,"editor",{enumerable:!0,configurable:!0,writable:!0,value:void 0}),Object.defineProperty(i,"pathwayActions",{enumerable:!0,configurable:!0,writable:!0,value:void 0}),Object.defineProperty(i,"isModalShown",{enumerable:!0,configurable:!0,writable:!0,value:void 0}),Object.defineProperty(i,"colorValueMap",{enumerable:!0,configurable:!0,writable:!0,value:void 0}),Object.defineProperty(i,"portalAccessor",{enumerable:!0,configurable:!0,writable:!0,value:void 0}),Object.defineProperty(i,"alterationData",{enumerable:!0,configurable:!0,writable:!0,value:void 0}),Object.defineProperty(i,"patientData",{enumerable:!0,configurable:!0,writable:!0,value:[]}),Object.defineProperty(i,"pathwayGeneMap",{enumerable:!0,configurable:!0,writable:!0,value:{}}),Object.defineProperty(i,"bestPathwaysAlgos",{enumerable:!0,configurable:!0,writable:!0,value:[]}),Object.defineProperty(i,"oldName",{enumerable:!0,configurable:!0,writable:!0,value:""}),Object.defineProperty(i,"profiles",{enumerable:!0,configurable:!0,writable:!0,value:[]}),Object.defineProperty(i,"setActiveEdge",{enumerable:!0,configurable:!0,writable:!0,value:void 0}),Object.defineProperty(i,"viewOperationsManager",{enumerable:!0,configurable:!0,writable:!0,value:void 0}),Object.defineProperty(i,"gridOptionsManager",{enumerable:!0,configurable:!0,writable:!0,value:void 0}),Object(r.makeObservable)(i),i.fileManager=new N,i.pathwayActions=new Wt(i.pathwayHandler,i.profiles,i.fileManager,i.handleOpen,i.props.isCBioPortal,i.props.isCollaborative),i.selectedPathway="",i.props.pathwayName&&i.pathwayActions.changePathway(i.props.pathwayName),i.isModalShown=[!1,!1,!1,!1,!1,!1,!1,!1,!1,!1],i.alterationData={},i.extractAllGenes(),i.colorValueMap={"-100":"#0000ff",0:"#ffffff",100:"#ff0000"},i.props.isCBioPortal&&(i.props.cBioAlterationData&&(i.props.patientView?(i.calculatePatientData(i.props.cBioAlterationData),i.addSampleIconData(i.props.sampleIconData)):i.calculateAlterationData(i.props.cBioAlterationData)),i.props.addGenomicDataHandler&&i.props.addGenomicDataHandler(i.addGenomicData),i.profiles.push({profileId:a.CBIO_PROFILE_NAME,enabled:!0}),i.getBestPathway(0),i.getBestPathway(1),i.getBestPathway(2),i.getBestPathway(3)),i}var a;return va(e,t),a=e,Object.defineProperty(e.prototype,"setColorMapping",{enumerable:!1,configurable:!0,writable:!0,value:function(t){this.colorValueMap=t,this.editor.updateGenomicDataColorScheme(this.colorValueMap)}}),Object.defineProperty(e.prototype,"setSelectedPathway",{enumerable:!1,configurable:!0,writable:!0,value:function(t){this.selectedPathway=t}}),Object.defineProperty(e.prototype,"setEditor",{enumerable:!1,configurable:!0,writable:!0,value:function(t){this.editor=t}}),Object.defineProperty(e.prototype,"addProfile",{enumerable:!1,configurable:!0,writable:!0,value:function(t){this.profiles.push(t)}}),Object.defineProperty(e.prototype,"toggleProfileEnabled",{enumerable:!1,configurable:!0,writable:!0,value:function(t){this.profiles[t].enabled=!this.profiles[t].enabled}}),Object.defineProperty(e.prototype,"calculateAlterationData",{enumerable:!1,configurable:!0,writable:!0,value:function(t){var e=this;this.alterationData[a.CBIO_PROFILE_NAME]={},t.forEach((function(t){var i=t.altered/t.sequenced*100;e.alterationData[a.CBIO_PROFILE_NAME][t.gene]=Object.is(i,NaN)?-101:i}))}}),Object.defineProperty(e.prototype,"calculatePatientData",{enumerable:!1,configurable:!0,writable:!0,value:function(t){var e=this;this.alterationData[a.CBIO_PROFILE_NAME]={};var i=t.map((function(t){return t.gene})).filter((function(t,e,a){return a.indexOf(t)==e}));this.patientData.PatientView=1,i.forEach((function(t){e.patientData[t]={}})),t.forEach((function(t){var i=t.altered/t.sequenced*100;e.alterationData[a.CBIO_PROFILE_NAME][t.gene]=Object.is(i,NaN)?-101:i,e.patientData[t.gene][t.percentAltered]=Object.is(i,NaN)?-101:i,e.patientData[t.gene].geneticTrackData=t.geneticTrackData,e.patientData[t.gene].geneticTrackRuleSetParams=t.geneticTrackRuleSetParams}))}}),Object.defineProperty(e.prototype,"addSampleIconData",{enumerable:!1,configurable:!0,writable:!0,value:function(t){t&&(this.patientData.sampleColors=t.sampleColors,this.patientData.sampleIndex=t.sampleIndex)}}),Object.defineProperty(e.prototype,"getGeneStudyMap",{enumerable:!1,configurable:!0,writable:!0,value:function(t){for(var e={},a=0,i=Object.keys(t);a0;){var C=Pa.extractMax();n=C.getValue().pathwayName;o.push({score:C.getKey(),genesMatched:i[n],pathwayName:n})}0===this.bestPathwaysAlgos.length&&this.setSelectedPathway(o[0].pathwayName),this.bestPathwaysAlgos.push(o)}}),Object.defineProperty(e.prototype,"includePathway",{enumerable:!1,configurable:!0,writable:!0,value:function(t,e){for(var a={},i=0,o=t.nodes;i 4) ? lineData[4] : \"0\";\n var posY = (lineData.length > 5) ? lineData[5] : \"0\";\n var nodeW = (lineData.length > 7) ? lineData[6] : (nodeType === 'PROCESS') ? (nodeName.length * 6 + 24) : \"150\";\n var nodeH = (lineData.length > 7) ? lineData[7] : (nodeType === 'PROCESS') ? \"24\" : \"52\";\n\n if(nodeName === \" \" || nodeName === \"\"){\n //nodeName = \"No Name \" + (i + 1);\n }\n\n\n var newNode = {\n group: 'nodes',\n data:\n {\n id: nodeID,\n name: nodeName,\n type: nodeType,\n w: nodeW,\n h: nodeH,\n parent: -1\n },\n position:\n {\n x: parseInt(posX),\n y: parseInt(posY)\n }\n };\n\n if (parentID != '-1') {\n newNode.data.parent = parentID;\n }\n nodes.push(newNode);\n }\n //Read edges\n for (let i = edgesStartIndex; i < lines.length; i++) {\n //If we reach EOF we break loop\n if (lines[i].length == 0) {\n break;\n }\n\n var lineData = lines[i].split('\\t');\n var edgeID = lineData[0];\n var edgeSource = lineData[1];\n var edgeTarget = lineData[2];\n var edgeType = lineData[3];\n var pubmedIDs = (lineData.length > 4) ? lineData[4].split(';') : [];\n var label = (lineData.length > 5) ? lineData[5] : '';\n var anchorPoints = (lineData.length > 6) ? lineData[6] : '';\n var edgeCurveStyle = (lineData.length > 7) ? lineData[7] : '';\n\n var anchorPointPositions = [];\n if (anchorPoints) {\n var anchorPair = anchorPoints.split(')'); //The last element of anchorPair array is \"\"\n for (var j = 0; j < anchorPair.length - 1; j++) {\n var separatorIndex = anchorPair[j].indexOf(\";\");\n var x = anchorPair[j].substring(1, separatorIndex);\n var y = anchorPair[j].substring(separatorIndex + 1, anchorPair[j].length);\n anchorPointPositions.push({x: parseFloat(x), y: parseFloat(y)});\n }\n }\n\n var edgeData = {\n id: edgeID,//((isFound) ? edgeID : i - edgesStartIndex),\n type: edgeType,//((isFound) ? edgeType : edgeTarget),\n source: edgeSource,//((isFound) ? edgeSource : edgeID),\n target: edgeTarget,//((isFound) ? edgeTarget : edgeSource),\n pubmedIDs: pubmedIDs,\n name: label,\n }\n\n if (edgeCurveStyle === \"unbundled-bezier\") {\n edgeData['controlPointPositions'] = anchorPointPositions;\n }\n else {\n edgeData['bendPointPositions'] = anchorPointPositions;\n }\n\n const newEdge = {\n group: 'edges', \n data: edgeData\n };\n edges.push(newEdge);\n }\n return {title: title, description: description, nodes: nodes, edges: edges};\n }\n}\n","import { saveAs } from 'file-saver';\nimport { action, computed, makeObservable, observable } from 'mobx';\nimport SaveLoadUtility from '../utils/SaveLoadUtility';\nimport EditorActionsManager from './EditorActionsManager.js';\n\nexport interface IPathwayInfo{\n pathwayTitle: string;\n pathwayDetails: string;\n}\n\nexport default class FileOperationsManager{\n\n @observable\n pathwayInfo: IPathwayInfo;\n\n constructor(){\n makeObservable(this);\n this.pathwayInfo = {pathwayTitle: \"New Pathway\", pathwayDetails: \"\"};\n }\n\n\n @computed get\n getPathwayInfo(){\n return this.pathwayInfo;\n }\n\n @action\n setPathwayInfo(other: IPathwayInfo){\n this.pathwayInfo = other;\n }\n \n // see http://stackoverflow.com/questions/16245767/creating-a-blob-from-a-base64-string-in-javascript\n b64toBlob(b64Data, contentType, sliceSize = 512)\n {\n contentType = contentType || '';\n\n var byteCharacters = atob(b64Data);\n var byteArrays = [];\n\n for (var offset = 0; offset < byteCharacters.length; offset += sliceSize) {\n var slice = byteCharacters.slice(offset, offset + sliceSize);\n\n var byteNumbers = new Array(slice.length);\n for (var i = 0; i < slice.length; i++) {\n byteNumbers[i] = slice.charCodeAt(i);\n }\n\n var byteArray = new Uint8Array(byteNumbers);\n\n byteArrays.push(byteArray);\n }\n\n var blob = new Blob(byteArrays, {type: contentType});\n return blob;\n };\n\n saveAsJPEG(cy: any)\n {\n const graphData = cy.jpeg();\n // this is to remove the beginning of the pngContent: data:img/png;base64,\n const b64data = graphData.substr(graphData.indexOf(\",\") + 1);\n const imageData = this.b64toBlob(b64data, \"image/jpeg\");\n const blob = new Blob([imageData]);\n const fileName = this.pathwayInfo.pathwayTitle + \".jpg\"\n saveAs(blob, fileName);\n };\n\n saveAsSVG(editor: EditorActionsManager){\n const returnString: any = editor.exportSVG();\n const fileName = this.pathwayInfo.pathwayTitle + \".svg\"\n const blob = new Blob([returnString], {type: \"text/plain;charset=utf-8\"});\n saveAs(blob, fileName);\n }\n\n saveAsPNG(cy: any)\n {\n const graphData = cy.png();\n // this is to remove the beginning of the pngContent: data:img/png;base64,\n const b64data = graphData.substr(graphData.indexOf(\",\") + 1);\n const imageData = this.b64toBlob(b64data, \"image/png\");\n const blob = new Blob([imageData]);\n const fileName = this.pathwayInfo.pathwayTitle + \".png\"\n saveAs(blob, fileName);\n };\n \n\n saveGraph(isSIFNX: boolean, editor: EditorActionsManager)\n {\n const pathwayData = this.pathwayInfo;\n const returnString = (isSIFNX) ? SaveLoadUtility.exportAsSIFNX(editor.cy):\n SaveLoadUtility.exportGraph(pathwayData, editor.cy, editor.edgeEditing);\n const blob = new Blob([returnString], {type: \"text/plain;charset=utf-8\"});\n const fileName = pathwayData.pathwayTitle + \".txt\";\n saveAs(blob, fileName);\n };\n}","import _ from \"lodash\";\n\nexport default class GridOptionsManager\n{\n\n static defaultGridGuideOptions = \n {\n // On/Off Modules\n /* From the following four snap options, at most one should be true at a given time */\n snapToGridOnRelease: false, // Snap to grid on release\n snapToGridDuringDrag: false, // Snap to grid during drag\n snapToAlignmentLocationOnRelease: false, // Snap to alignment location on release\n snapToAlignmentLocationDuringDrag: false, // Snap to alignment location during drag\n distributionGuidelines: false, // Distribution guidelines\n geometricGuideline: false, // Geometric guidelines\n initPosAlignment: false, // Guideline to initial mouse position\n centerToEdgeAlignment: false, // Center to edge alignment\n resize: false, // Adjust node sizes to cell sizes\n parentPadding: false, // Adjust parent sizes to cell sizes by padding\n drawGrid: false, // Draw grid background\n\n // General\n gridSpacing: 20, // Distance between the lines of the grid.\n\n // Draw Grid\n zoomDash: true, // Determines whether the size of the dashes should change when the drawing is zoomed in and out if grid is drawn.\n panGrid: true, // Determines whether the grid should move then the user moves the graph if grid is drawn.\n gridStackOrder: -1, // Namely z-index\n gridColor: '#dedede', // Color of grid lines\n lineWidth: 1.0, // Width of grid lines\n\n // Guidelines\n guidelinesStackOrder: 4, // z-index of guidelines\n guidelinesTolerance: 5.00, // Tolerance distance for rendered positions of nodes' interaction.\n guidelinesStyle: { // Set ctx properties of line. Properties are here:\n strokeStyle: \"#4286f4\", // color of geometric guidelines\n geometricGuidelineRange: 750, // range of geometric guidelines\n range: 500, // max range of distribution guidelines\n minDistRange: 10, // min range for distribution guidelines\n distGuidelineOffset: 10, // shift amount of distribution guidelines\n horizontalDistColor: \"#4286f4\", // color of horizontal distribution alignment\n verticalDistColor: \"#4286f4\", // color of vertical distribution alignment\n initPosAlignmentColor: \"#34495E\", // color of alignment to initial mouse location\n lineDash: [6, 8], // line style of geometric guidelines\n horizontalDistLine: [0, 0], // line style of horizontal distribution guidelines\n verticalDistLine: [0, 0], // line style of vertical distribution guidelines\n initPosAlignmentLine: [0, 0], // line style of alignment to initial mouse position\n },\n\n // Parent Padding\n parentSpacing: -1 // -1 to set paddings of parents to gridSpacing\n };\n currentProperties: any;\n cy: any;\n constructor(cy: any)\n {\n this.cy = cy;\n\n this.currentProperties = {};\n this.changeParameters(GridOptionsManager.defaultGridGuideOptions);\n\n }\n\n changeParameters(params)\n {\n this.currentProperties = _.clone(params);\n this.refreshGridOptionsExtension();\n }\n\n getCurrentOptions()\n {\n return this.currentProperties;\n }\n\n getDefaultOptions()\n {\n return GridOptionsManager.defaultGridGuideOptions;\n }\n\n setSnapToGuidelines(state)\n {\n this.currentProperties.geometricGuideline = state;\n this.currentProperties.snapToAlignmentLocationDuringDrag = state;\n this.currentProperties.distributionGuidelines = state;\n this.refreshGridOptionsExtension();\n //this.appManager.gridOptionsView.changeParameters();\n }\n\n setShowGrid(state)\n {\n this.currentProperties.drawGrid = state;\n this.currentProperties.snapToGridDuringDrag = state;\n this.refreshGridOptionsExtension();\n }\n\n refreshGridOptionsExtension()\n {\n this.cy.gridGuide(this.currentProperties);\n }\n\n //TODO expose individual functions related for changing parameters from toolbar here\n\n}\n","import EditorActionsManager from \"./EditorActionsManager\";\n\nexport default class ViewOperationsManager{\n movedNodes: any[];\n editor: EditorActionsManager;\n cy: any;\n\n constructor(editor: EditorActionsManager,cy: any)\n {\n this.cy = cy;\n this.editor = editor;\n this.movedNodes = [];\n }\n\n //TODO use align function from cytoscape.js-grid-guide extension\n handleNodeAlignment(param)\n {\n var tmpNodes = this.editor.selectedNodeStack;\n var nodes = this.cy.collection();\n var nodeMap = {};\n this.movedNodes = [];\n\n for (const key in tmpNodes)\n {\n nodes = nodes.add(tmpNodes[key]);\n }\n\n nodes.forEach(function(node)\n {\n if (node.isParent())\n {\n nodeMap[node.id()] = node;\n }\n });\n\n\n if (nodes.length > 0)\n {\n var firstSelected = nodes[0];\n var firstBbox = firstSelected.boundingBox();\n //OuterHeight variable added due to miscalculation of boundingBox function in pathwaymapper\n var firstOuterHeight = firstSelected.outerHeight();\n var self = this;\n nodes.forEach(function(node,index)\n {\n if (index == 0)\n {\n return ;\n }\n\n //If parent of selected node is in selection do nothing !\n if (nodeMap[node.parent().id()] == null)\n {\n var newPosition = self.calculateNewPosition(param, node, firstBbox, firstOuterHeight);\n //Recursively traverse leaf nodes\n self.changePosition(node,0,0,newPosition);\n }\n });\n this.editor.handleChangePositionByAlignment(self.movedNodes);\n }\n }\n\n /*\n Determine new position according to the alignment\n node that node.position works on center positions thats why all calculations\n are performed accordingly\n */\n calculateNewPosition(param, node, referenceBbox, referenceOuterHeight)\n {\n var currentPos = node.position();\n var currentBbox = node.boundingBox();\n var newPosition;\n //This parameter is used to move the compounds less upwards when they contain label\n var moveParam = node.isParent() ? node.outerHeight() - ((currentBbox.h - node.outerHeight())/2) - ((node.outerHeight() - node.height())/2) : node.height();\n //This param is used only when the node is parent, for simple nodes is 0\n var labelHeight = node.isParent()? currentBbox.h - node.outerHeight(): 0;\n\n if (param === 'vLeft')\n {\n newPosition = {x: referenceBbox.x1+currentBbox.w/2, y: currentPos.y};\n }\n else if (param === 'vCen')\n {\n newPosition = {x: referenceBbox.x1+referenceBbox.w/2, y: currentPos.y};\n }\n else if (param === 'vRight')\n {\n newPosition = {x: referenceBbox.x2-currentBbox.w/2, y: currentPos.y};\n }\n else if (param === 'hTop')\n {\n newPosition = {x: currentPos.x, y: referenceBbox.y1 + currentBbox.h/2};\n }\n //Checks for the case where compounds don't have names (name isn't taken in consideration in that case)\n else if (param === 'hMid' && node.isParent() && node.data('name') == \"\")\n {\n newPosition = {x: currentPos.x, y: referenceBbox.y1 + referenceBbox.h/2};\n }\n else if (param === 'hMid' )\n {\n newPosition = {x: currentPos.x, y: referenceBbox.y1 + referenceOuterHeight/2 + labelHeight/2};\n }\n //Checks for the case where compounds don't have names (name isn't taken in consideration in that case)\n else if (param === 'hBot' && node.isParent() && node.data('name') == \"\")\n {\n newPosition = {x: currentPos.x, y: referenceBbox.y2 - currentBbox.h/2};\n }\n else if (param === 'hBot')\n {\n newPosition = {x: currentPos.x, y: referenceBbox.y1 + referenceOuterHeight - moveParam/2};\n }\n else {\n console.log('Error: wrong alignment name ' + param);\n return;\n }\n\n return newPosition;\n }\n\n //Recursively move leaf nodes\n changePosition(node, dx, dy, newPos)\n {\n if (node.isParent())\n {\n var childNodes = node.children();\n var parentBbox = node.boundingBox();\n var self = this;\n childNodes.forEach(function(childNode, index)\n {\n var childBbox = childNode.boundingBox();\n var _dx = -(parentBbox.x1 - childBbox.x1)-parentBbox.w/2+childBbox.w/2;\n var _dy = -(parentBbox.y1 - childBbox.y1)-parentBbox.h/2+childBbox.h/2;\n\n //If further compound node is found, set position accordingly\n if (childNode.isParent())\n {\n self.changePosition(childNode, 0, 0, {x: newPos.x+_dx, y:newPos.y+_dy});\n }\n else\n {\n self.changePosition(childNode, _dx, _dy, newPos);\n }\n\n });\n }\n else\n {\n //Move locally and let editor actions manager know a move happened\n //If in collaborative mode editor actions manager will update collaborative model\n var position =\n {\n x: newPos.x+dx,\n y: newPos.y+dy\n };\n\n this.movedNodes.push({node: node, nextPosition: position, oldPosition: null});\n }\n }\n\n}\n","import React from 'react';\nimport { Modal } from 'react-bootstrap';\nimport { EModalType } from '../ui/react-pathway-mapper';\ninterface IAboutModalProps{\n show: boolean;\n handleClose: Function;\n}\n\nexport default class AboutModal extends React.Component {\n\n constructor(props: IAboutModalProps){\n super(props);\n }\n\n render(){\n\n\n return(\n \n {this.props.handleClose(EModalType.ABOUT)}}\n >\n \n About\n \n \n

PathwayMapper 2.2

\n
\n \"\"\n
\n
\n \"\"\n
\n
\n

i-Vis information Visualization Lab

\n

Bilkent University, Ankara, Turkey

\n
\n
\n

Memorial Sloan-Kettering Cancer Center

\n

New York, USA

\n
\n
\n \n https://github.com/iVis-at-Bilkent/pathway-mapper\n \n \n\n )\n\n\n }\n\n}\n","import { RGBAColor, shapeToSvg } from 'oncoprintjs';\nimport React from 'react';\nimport { Modal } from 'react-bootstrap';\n// @ts-ignore\nimport openImage from \"../images/toolbar/edit.svg\";\n// @ts-ignore\nimport layoutImage from \"../images/toolbar/layout-cose.svg\";\n// @ts-ignore\nimport savePNGImage from \"../images/toolbar/save_png.svg\";\n// @ts-ignore\nimport saveSVGImage from \"../images/toolbar/save_svg.svg\";\nimport { EModalType } from '../ui/react-pathway-mapper';\n// @ts-ignore\nconst addSelImage = require(\"../images/toolbar/add-selected.svg\");\n// @ts-ignore\nconst addAllImage = require(\"../images/toolbar/add-all.svg\");\n\n\ninterface ICBioHelpModalProps{\n show: boolean;\n handleClose: (modalId: EModalType) => void;\n patientView ?: boolean;\n}\n\n// https://github.com/cBioPortal/cbioportal-frontend/blob/29a93c5e992ca1affd3d027355015164ae3602bd/src/shared/lib/Colors.ts\nconst CNA_COLOR_AMP = '#ff0000';\nconst CNA_COLOR_HOMDEL = '#0000ff';\nconst DEFAULT_GREY = '#bebebe';\nconst MUT_COLOR_MISSENSE = '#008000';\nconst MUT_COLOR_MISSENSE_PASSENGER = '#53D400';\nconst MUT_COLOR_INFRAME = '#993404';\nconst MUT_COLOR_INFRAME_PASSENGER = '#a68028';\nconst MUT_COLOR_TRUNC = '#000000';\nconst MUT_COLOR_TRUNC_PASSENGER = '#708090';\nconst MUT_COLOR_FUSION = '#8B00C9';\nconst MUT_COLOR_PROMOTER = '#00B7CE';\nconst MUT_COLOR_OTHER = '#cf58bc';\nconst MUT_COLOR_GERMLINE = '#FFFFFF';\n\nexport function hexToRGBA(str: string): [number, number, number, number] {\n const r = parseInt(str[1] + str[2], 16);\n const g = parseInt(str[3] + str[4], 16);\n const b = parseInt(str[5] + str[6], 16);\n return [r, g, b, 1];\n}\n\n// always used shape\nconst defaultShape = {\n type: 'rectangle',\n fill: hexToRGBA(DEFAULT_GREY),\n x: 0,\n y: 0,\n width: 6,\n height: 20,\n stroke: [0,0,0,0] as RGBAColor,\n 'stroke-width': 0\n};\n\nconst labels = [\n 'Amplification',\n 'Deep Deletion',\n 'Fusion',\n 'Germline Mutation',\n 'Missense Mutation (putative driver)',\n 'Missense Mutation (unknown significance)',\n 'Other Mutation',\n 'Promoter Mutation',\n 'Truncating Mutation (putative driver)',\n 'Truncating Mutation (unknown significance)',\n 'Inframe Mutation (putative driver)',\n 'Inframe Mutation (unknown significance)'\n];\n\n// conditional shapes\nconst shapeBank = [\n {\n type: 'rectangle',\n fill: hexToRGBA(CNA_COLOR_AMP),\n x: 0,\n y: 0,\n width: 6,\n height: 20\n },\n {\n type: 'rectangle',\n fill: hexToRGBA(CNA_COLOR_HOMDEL),\n x: 0,\n y: 0,\n width: 6,\n height: 20\n },\n {\n type: 'rectangle',\n fill: hexToRGBA(MUT_COLOR_FUSION),\n x: 0,\n y: 4,\n width: 6,\n height: 12\n },\n {\n type: 'rectangle',\n fill: hexToRGBA(MUT_COLOR_GERMLINE),\n x: 0,\n y: 8.75,\n width: 6,\n height: 1.6\n },\n {\n type: 'rectangle',\n fill: hexToRGBA(MUT_COLOR_MISSENSE),\n x: 0,\n y: 6.66,\n width: 6,\n height: 6.66\n },\n {\n type: 'rectangle',\n fill: hexToRGBA(MUT_COLOR_MISSENSE_PASSENGER),\n x: 0,\n y: 6.66,\n width: 6,\n height: 6.66\n },\n {\n type: 'rectangle',\n fill: hexToRGBA(MUT_COLOR_OTHER),\n x: 0,\n y: 6.66,\n width: 6,\n height: 6.66\n },\n {\n type: 'rectangle',\n fill: hexToRGBA(MUT_COLOR_PROMOTER),\n x: 0,\n y: 6.66,\n width: 6,\n height: 6.66\n },\n {\n type: 'rectangle',\n fill: hexToRGBA(MUT_COLOR_TRUNC),\n x: 0,\n y: 6.66,\n width: 6,\n height: 6.66\n },\n {\n type: 'rectangle',\n fill: hexToRGBA(MUT_COLOR_TRUNC_PASSENGER),\n x: 0,\n y: 6.66,\n width: 6,\n height: 6.66\n },\n {\n type: 'rectangle',\n fill: hexToRGBA(MUT_COLOR_INFRAME),\n x: 0,\n y: 6.66,\n width: 6,\n height: 6.66\n },\n {\n type: 'rectangle',\n fill: hexToRGBA(MUT_COLOR_INFRAME_PASSENGER),\n x: 0,\n y: 6.66,\n width: 6,\n height: 6.66\n },\n];\n\nexport default class CBioHelpModal extends React.Component{\n\n\n constructor(props: ICBioHelpModalProps){\n super(props);\n }\n\n generateOncoprintLegend() {\n const svgNameSpace = 'http://www.w3.org/2000/svg'\n const svgElement = document.createElementNS(svgNameSpace, 'svg')\n\n const legendEleWidth = 280\n \n const cellWidth = 6\n const cellHeight = 23\n const cellVerticalPadding = 15\n const cellMarginRight = cellWidth + 3\n\n shapeBank.forEach((shape, index) => {\n const offsetX = (index % 3) * (legendEleWidth)\n const textOffsetX = offsetX + cellMarginRight\n const offsetY = Math.floor(index / 3) * (cellHeight + cellVerticalPadding)\n const textOffsetY = offsetY + 15\n const g = document.createElementNS(svgNameSpace, 'g')\n if (!shape[\"stroke\"]) {\n shape[\"stroke\"] = [0,0,0,0];\n shape[\"stroke-width\"] = 0;\n }\n g.appendChild(shapeToSvg(defaultShape, offsetX, offsetY))\n g.appendChild(shapeToSvg(shape, offsetX, offsetY))\n \n const text = document.createElementNS(svgNameSpace, 'text');\n text.setAttributeNS(null, 'x', textOffsetX.toString());\n text.setAttributeNS(null, 'y', textOffsetY.toString());\n text.setAttributeNS(null, 'font-size', '12');\n text.setAttributeNS(null, 'font-family', 'Arial');\n var textNode = document.createTextNode(labels[index]);\n text.appendChild(textNode)\n\n g.appendChild(text);\n svgElement.appendChild(g)\n });\n\n svgElement.setAttribute(\n 'width', '840')\n svgElement.setAttribute(\n 'height','175')\n svgElement.style.paddingTop = '20px'\n // This is important you need to include this to succesfully render in cytoscape.js!\n svgElement.setAttribute('xmlns', svgNameSpace)\n \n return svgElement\n }\n\n render(){\n\n const legendPadding = '45px';\n\n return( \n {this.props.handleClose(EModalType.CHELP)}}>\n \n PathwayMapper cBioPortal Edition 2.2\n \n {(!this.props.patientView &&\n \n

\n PathwayMapper shows you your genes of interest with the alteration frequencies of selected genetic profiles of the chosen study overlaid on a TCGA pathway using a white to red color scale (the more frequently altered a gene is, the more red it's shown). All available TCGA pathways are ranked with the aim to choose the pathway that matches your interest the most. By default we display the pathway with highest ranking with the default ranking options but you may look at your genes of interest in the context of other pathways as well by choosing from the pathway table. \n
\n
\n Refer to the documentation here for the notation used.\n
\n
\n To search for a particular pathway of your interest, use the search field on top of the pathway table. To switch to another pathway, click on the button in the associated row of the pathway table. Ranking criteria might be changed by changing the options at the bottom of the table. \n
\n
\n The buttons on top of the pathway are:\n

    \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n
    Save as PNG
    Save as SVG
    Perform layout: Layout is recalculated taking current node positions into account
    Add selected genes to query: You may select additional genes from the pathway by left clicking (Shift + left click to add more genes)
    Add all valid genes to query: All valid gene symbols will be added to the query; others will be ignored
    Edit pathway: Edit both the topology and the geometry of the current pathway with the full blown PathwayMapper editor
    \n
\n

\n
)\n },\n {(this.props.patientView &&\n \n

\n PathwayMapper shows you your genes of interest with the mutation types, copy number alterations and fusions of selected genetic profiles of the chosen study overlaid on a TCGA pathway using the OncoPrint color scheme. All available TCGA pathways are ranked with the aim to choose the pathway that matches your interest the most. By default we display the pathway with the highest number of genes of interest matching the ones in a pathway but you may look at your genes of interest in the context of other pathways as well by choosing from the pathway table. \n
\n
\n Refer to the documentation here for the notation used.\n
\n
\n Genetic alteration legend:\n
\n

\n
\n

Putative driver and unknown significance annotations are based on data from OncoKB and CancerHotspots.org.

\n
\n To search for a particular pathway of your interest, use the search field on top of the pathway table. To switch to another pathway, click on the button in the associated row of the pathway table.\n
\n
\n The buttons on top of the pathway are:\n
    \n \n \n \n \n \n \n \n \n \n \n
    Save as PNG
    Save as SVG
    Perform layout: Layout is recalculated taking current node positions into account
    \n
\n

\n
\n )}\n
\n\n );\n }\n\n}\n","import { makeObservable, observable } from 'mobx';\nimport { observer } from 'mobx-react';\nimport React from 'react';\nimport { Button, Checkbox, Col, ControlLabel, Form, FormControl, Row, Modal } from 'react-bootstrap';\nimport GridOptionsManager from '../managers/GridOptionsManager';\nimport { EModalType } from '../ui/react-pathway-mapper';\nimport PathwayActions from '../utils/PathwayActions';\ninterface IGridSettingsProps{\n show: boolean;\n handleClose: Function;\n pathwayActions: PathwayActions;\n}\n\nexport enum EGridType{\n GRID,\n GUIDE,\n NONE\n}\n\n@observer\nexport default class GridSettings extends React.Component{\n\n\n\n @observable\n private gridSize: number;\n \n @observable\n private guideColor: string;\n\n private defaultSettings = GridOptionsManager.defaultGridGuideOptions;\n\n @observable\n private enabledType: EGridType;\n constructor(props: IGridSettingsProps){\n super(props);\n makeObservable(this);\n \n this.gridSize = this.defaultSettings.gridSpacing;\n this.guideColor = this.defaultSettings.guidelinesStyle.strokeStyle;\n }\n\n setEnabledType(newType: EGridType){\n if(newType === this.enabledType){\n this.enabledType = EGridType.NONE;\n return;\n }\n\n this.enabledType = newType;\n }\n\n render(){\n\n return(\n {this.enabledType = this.props.pathwayActions.enabledType;}}\n onHide={() => {\n this.props.handleClose(EModalType.GRID);\n }}>\n \n \n Grid Settings\n \n \n \n
\n \n \n Enable Grids:\n \n\n \n {this.setEnabledType(EGridType.GRID);}}>\n \n \n \n \n Enable Guidelines:\n \n\n \n {this.setEnabledType(EGridType.GUIDE);}}>\n \n \n \n \n Grid Size:\n \n\n \n {this.gridSize = e.target.value;}}/>\n \n \n \n \n Guideline Color:\n \n\n \n {this.guideColor = e.target.value;}}/>\n \n \n
\n
\n\n \n \n \n
\n );\n\n\n } \n}","import React from 'react';\nimport {Modal, Button} from 'react-bootstrap';\nimport { EModalType } from '../ui/react-pathway-mapper';\n\ninterface IConfirmationModalProps{\n show: boolean;\n handleClose: (modalId: EModalType) => void;\n}\n\nexport default class ConfirmationModal extends React.Component{\n\n static pendingFunction: Function;\n\n constructor(props: IConfirmationModalProps){\n super(props);\n\n }\n\n render(){\n\n\n return(\n {this.props.handleClose(EModalType.CONFIRMATION);}}\n >\n \n Confirmation\n \n \n
\n All unsaved changes will be lost. Do you want to continue?\n
\n
\n \n \n \n\n \n \n );\n }\n}","import _ from \"lodash\";\nimport { IColorValueMap } from \"../ui/react-pathway-mapper\";\nimport GraphUtilities from \"../utils/GraphUtilities\";\nimport EditorActionsManager from \"./EditorActionsManager\";\n\nlet sharedb;\nlet socket;\nlet connection;\n\nexport default class ShareDBManager {\n\n readonly NODEMAP_NAME = 'nodes';\n readonly EDGEMAP_NAME = 'edges';\n readonly LAYOUT_PROPS_NAME = 'layoutProperties';\n readonly GLOBAL_OPTS_NAME = 'globalOptions';\n //For storing genomic data information per gene\n readonly GENOMIC_DATA_MAP_NAME = 'genomicDataMap';\n //For storing visibility information of genomic data according to the cancer type\n readonly VISIBLE_GENOMIC_DATA_MAP_NAME = 'visibleGenomicDataMapByType';\n readonly GENOMIC_DATA_GROUP_NAME = 'genomicDataGroupList';\n readonly GENOMIC_DATA_GROUP_COUNT = 'genomicDataGroupCount';\n readonly GENOMIC_DATA_COLOR_SCHEME_NAME = 'genomicDataColorScheme';\n \n doc: any;\n postFileLoad: any;\n editor: EditorActionsManager;\n constructor(postFileLoadCallback) {\n //Doc data maps names and keys\n this.postFileLoad = postFileLoadCallback;\n };\n\n\n\n getDoc(){\n return this.doc;\n }\n\n setEditor(editor: EditorActionsManager){\n this.editor = editor;\n }\n\n //Applies any given sharDB opeation to shared document and notifies other clients\n applyShareDBOperation(op) {\n this.doc.submitOp(op, this.shareDBError);\n };\n\n //Clears genomic data in shared document and notifies other clients\n clearShareDBGenomicData() {\n var ops = [];\n var genomicMap = this.doc.data[this.GENOMIC_DATA_MAP_NAME];\n var visMap = this.doc.data[this.VISIBLE_GENOMIC_DATA_MAP_NAME];\n var genomicDataGroupMap = this.doc.data[this.GENOMIC_DATA_GROUP_NAME];\n var genomicDataGroupCount = this.doc.data[this.GENOMIC_DATA_GROUP_COUNT];\n //Reset all genomic maps\n for (const key of Object.keys(genomicMap)) {\n ops.push({p: [this.GENOMIC_DATA_GROUP_NAME, key], od: genomicMap[key]});\n }\n for (const key of Object.keys(visMap)) {\n ops.push({p: [this.VISIBLE_GENOMIC_DATA_MAP_NAME, key], od: visMap[key]});\n }\n for (const key of Object.keys(genomicDataGroupMap)) {\n ops.push({p: [this.GENOMIC_DATA_GROUP_NAME, key], od: genomicDataGroupMap[key]});\n }\n //Reset genomic data group count to 0\n ops.push({p: [this.GENOMIC_DATA_GROUP_COUNT], na: -genomicDataGroupCount});\n this.doc.submitOp(ops, this.shareDBError);\n };\n\n /*\n * Updates shared document object\n * @param mapName: map name of the object\n * @param objectKey: key of the object\n * @param object: new object\n *\n */\n updateShareDBObject(mapName, objectKey, object) {\n this.doc.submitOp([{\n p: [mapName, objectKey],\n od: this.doc.data[mapName][objectKey],\n oi: object\n }], this.shareDBError);\n };\n\n /*\n * Inserts a new shared document object\n * @param mapName: map name of the object\n * @param objectKey: key of the object\n * @param object: new object\n *\n */\n insertShareDBObject(mapName, objectKey, object) {\n this.doc.submitOp([{p: [mapName, objectKey], oi: object}], this.shareDBError);\n };\n\n /*\n * Deletes a shared document object\n * @param mapName: map name of the object\n * @param objectKey: key of the object\n *\n */\n deleteShareDBObject(mapName, objectKey) {\n this.doc.submitOp([{p: [mapName, objectKey], od: this.doc.data[mapName][objectKey]}], this.shareDBError);\n };\n\n //Initializes layout properties of the shared document\n initializeShareDBLayoutProperties() {\n this.doc.submitOp([{\n p: [this.LAYOUT_PROPS_NAME, 0],\n li: [this.editor.layoutProperties]\n }], this.shareDBError);\n };\n\n //Initializes global options of the shared document\n initializeShareDBGlobalOptions() {\n this.doc.submitOp([{\n p: [this.GLOBAL_OPTS_NAME, 0],\n li: [this.editor.getGlobalOptions()]\n }], this.shareDBError);\n };\n\n /*\n * Updates layout properties of the shared document and notifies other clients\n * @param object: new layout properties object\n *\n */\n updateShareDBLayoutProperties(object) {\n this.doc.submitOp([{\n p: [this.LAYOUT_PROPS_NAME, 0],\n ld: this.doc.data[this.LAYOUT_PROPS_NAME][0],\n li: object\n }], this.shareDBError);\n };\n\n /*\n * Updates global options of the shared document and notifies other clients\n * @param object: new global options object\n *\n */\n updateShareDBGlobalOptions(object) {\n this.doc.submitOp([{\n p: [this.GLOBAL_OPTS_NAME, 0],\n ld: this.doc.data[this.GLOBAL_OPTS_NAME][0],\n li: object\n }], this.shareDBError);\n };\n\n updateShareDBGenomicDataOverlayColorScheme(object : IColorValueMap) {\n this.doc.submitOp([{\n p: [this.GENOMIC_DATA_COLOR_SCHEME_NAME, 0],\n ld: this.doc.data[this.GENOMIC_DATA_COLOR_SCHEME_NAME][0],\n li: object\n }], this.shareDBError);\n };\n\n //Increments shared data group count\n //Use this function to increment and keep the group count synchronized\n incrementShareDBGroupCount() {\n this.doc.submitOp([{p: [this.GENOMIC_DATA_GROUP_COUNT], na: 1}], this.shareDBError);\n };\n\n //Checks whether given operation is a replace or add/delete operation\n isShareDBReplaceEvent(op) {\n return (op.hasOwnProperty(\"oi\") && op.hasOwnProperty(\"od\"))\n || (op.hasOwnProperty(\"li\") && op.hasOwnProperty(\"ld\"));\n };\n\n /*\n * Gets the initial value of the shared document\n * without this function shared document values cannot be reached\n */\n initializeSharedDBDoc() {\n this.doc.subscribe();\n };\n\n shareDBError(err) {\n if (err) {\n console.error(err);\n }\n };\n\n initShareDB() {\n sharedb = require('sharedb/lib/client');\n socket = new WebSocket('ws://' + window.location.host);\n connection = new sharedb.Connection(socket);\n\n var self = this;\n\n var id = this.getParam('id');\n\n var loadFileCallback = function () {\n self.onFileLoaded();\n };\n\n //Creates new shared db document and initializes values\n var createNewDocument = () => {\n var new_id = self.getCustomObjId();\n var data = {\n nodes: {},\n edges: {},\n layoutProperties: [this.editor.layoutProperties],\n globalOptions: [this.editor.getGlobalOptions()],\n genomicDataMap: {},\n visibleGenomicDataMapByType: {},\n genomicDataGroupList: {},\n genomicDataGroupCount: 0,\n genomicDataColorScheme: [{\n '-100' : \"#0000ff\",\n '0' : \"#ffffff\",\n '100' : \"#ff0000\"\n }]\n };\n window.history.pushState(null, null, '?id=' + new_id);\n self.doc = connection.get('cy', new_id);\n self.doc.create(data, loadFileCallback);\n };\n\n //Check if id exists in parameters\n //If exists open the shared document\n if (id) {\n // Check any document exists with given id\n this.doc = connection.get('cy', id);\n this.doc.fetch(function (err) {\n if (err)\n throw err;\n\n if (self.doc.type === null) {\n createNewDocument();\n return;\n }\n self.doc.subscribe(loadFileCallback);\n });\n }\n else {\n //Create new shared document\n createNewDocument();\n }\n };\n\n /*\n * After a file has been initialized and loaded, we can access the\n * document. We will wire up the data in shared document to the UI.\n *\n */\n onFileLoaded() {\n this.initializeSharedDBDoc();\n this.syncInitialSharedDocData();\n this.initSharedDocEventHandlers();\n\n this.postFileLoad();\n };\n\n /*\n * Synchronizes initial data in the shared document to\n * client's application.\n */\n syncInitialSharedDocData() {\n var self = this;\n var nodeMap = self.doc.data[this.NODEMAP_NAME];\n var edgeMap = self.doc.data[this.EDGEMAP_NAME];\n var shareDBLayoutProperties = self.doc.data[this.LAYOUT_PROPS_NAME][0];\n var globalOptions = self.doc.data[this.GLOBAL_OPTS_NAME][0];\n var genomicDataMap = self.doc.data[this.GENOMIC_DATA_MAP_NAME];\n var visDataMap = self.doc.data[this.VISIBLE_GENOMIC_DATA_MAP_NAME];\n var groupedGenomicDataMap = self.doc.data[this.GENOMIC_DATA_GROUP_NAME];\n var groupedGenomicDataCount = self.doc.data[this.GENOMIC_DATA_GROUP_COUNT];\n let genomicDataColorScheme = self.doc.data[this.GENOMIC_DATA_COLOR_SCHEME_NAME][0];\n\n var invalidGenes = [];\n var highlightedGenes = [];\n var invalidHighlightedGenes = [];\n var hiddenGenes = [];\n for (const key of Object.keys(nodeMap)) {\n var tmpNode = nodeMap[key];\n var tmpNodeId = tmpNode.id;\n\n if (tmpNode.isInvalidGene && tmpNode.isHighlighted) {\n invalidHighlightedGenes.push(tmpNodeId);\n }\n else if (tmpNode.isInvalidGene) {\n invalidGenes.push(tmpNodeId);\n }\n else if (tmpNode.isHighlighted) {\n highlightedGenes.push(tmpNodeId);\n }\n if (tmpNode.isHidden) {\n hiddenGenes.push(tmpNodeId);\n }\n }\n var highlightedEdges = [];\n for (const key of Object.keys(edgeMap)) {\n var tmpEdge = edgeMap[key];\n var tmpEdgeId = tmpEdge.id;\n if (tmpEdge.isHighlighted) {\n highlightedEdges.push(tmpEdgeId);\n }\n }\n\n //TODO Workaround for legacy pathways\n\n // Workaround for backward compatibility of legacy pathways\n // Addition of pubmed id field on server if legacy collaborative\n // pathways does not have !\n for (const key of Object.keys(edgeMap)) {\n const tmpEdge = edgeMap[key];\n\n if (tmpEdge.pubmedIDs == undefined \n || tmpEdge.name == undefined \n || tmpEdge.bendPoint == undefined \n || tmpEdge.anchorPoints == undefined\n || tmpEdge.edgeCurveStyle == undefined) {\n const pubmedIDs = (tmpEdge.pubmedIDs == undefined) ? [] : tmpEdge.pubmedID;\n const edgeLabel = (tmpEdge.name == undefined) ? \"\" : tmpEdge.name;\n let anchorPoints = [];\n if (tmpEdge.bendPoint) {\n anchorPoints = tmpEdge.bendPoint;\n }\n else if (tmpEdge.anchorPoints) {\n anchorPoints = tmpEdge.anchorPoints;\n }\n const edgeCurveStyle = tmpEdge.edgeCurveStyle ? tmpEdge.edgeCurveStyle : \"bezier\";\n\n const param = {\n type: tmpEdge.type,\n source: tmpEdge.source,\n id: self.getCustomObjId(),\n target: tmpEdge.target,\n pubmedID: pubmedIDs,\n name: edgeLabel,\n anchorPoints: anchorPoints,\n edgeCurveStyle: edgeCurveStyle\n };\n\n const newEdge: any = self.edgeInitializer(param);\n\n\n const tmpEdgeID = tmpEdge.id;\n const newEdgeID = newEdge.id;\n\n const ops = [\n {p: [self.EDGEMAP_NAME, tmpEdgeID], od: tmpEdge},\n {p: [self.EDGEMAP_NAME, newEdgeID], oi: newEdge}\n ]\n self.applyShareDBOperation(ops);\n }\n\n }\n\n //Add real time nodes to local graph\n this.editor.addNewElementsLocally(nodeMap, edgeMap);\n //Adds different type of highlight to nodes and hides if their property is hidden\n this.editor.highlightElementsInitially(invalidHighlightedGenes, invalidGenes, highlightedGenes, highlightedEdges, hiddenGenes);\n\n //Update layout properties & global options!!\n if (shareDBLayoutProperties.name == \"cose-bilkent\") {\n shareDBLayoutProperties.name = \"fcose\";\n this.updateLayoutProperties(shareDBLayoutProperties);\n }\n this.editor.updateLayoutPropertiesCallback({li: shareDBLayoutProperties});\n this.editor.changeGlobalOptions({li: globalOptions});\n\n //Sync already available genomic data !\n\n if (!groupedGenomicDataMap) {\n\n self.insertShareDBObject(self.GENOMIC_DATA_MAP_NAME, '0', []);\n for (const key of Object.keys(visDataMap)) {\n var currentMap = _.clone(groupedGenomicDataMap['0']);\n // currentMap.push(visibilityMapKeys[key]);\n self.updateShareDBObject(self.GENOMIC_DATA_MAP_NAME, '0', currentMap);\n }\n }\n\n if (!groupedGenomicDataCount) {\n var count = self.doc.data[self.GENOMIC_DATA_GROUP_COUNT];\n var op = [{\n p: [self.GENOMIC_DATA_GROUP_COUNT],\n na: -count\n }];\n self.applyShareDBOperation(op);\n groupedGenomicDataCount = self.doc.data[self.GENOMIC_DATA_GROUP_COUNT];\n }\n\n if (!genomicDataColorScheme) {\n self.insertShareDBObject(self.GENOMIC_DATA_COLOR_SCHEME_NAME, '0', this.editor.getGenomicDataOverlayColorScheme());\n genomicDataColorScheme = self.doc.data[self.GENOMIC_DATA_COLOR_SCHEME_NAME]['0'];\n }\n\n this.editor.updateGenomicDataColorSchemeHandler({li: genomicDataColorScheme});\n\n for (const key_g of Object.keys(genomicDataMap)) {\n this.editor.genomicDataOverlayManager.genomicDataMap[key_g] =\n genomicDataMap[key_g];\n\n }\n\n for (const key_g of Object.keys(groupedGenomicDataMap)) {\n this.editor.genomicDataOverlayManager.groupedGenomicDataMap[key_g] =\n groupedGenomicDataMap[key_g];\n const data = groupedGenomicDataMap[key_g];\n if(data.length !== 1){\n console.log(\"Grouped genomic data expected to be of length 1 (from sync)\");\n }\n data.forEach((profileId: any) => {this.editor.addToProfiles(profileId)});\n }\n\n for (const key_g of Object.keys(visDataMap)) {\n this.editor.genomicDataOverlayManager.visibleGenomicDataMapByType[key_g] =\n visDataMap[key_g];\n this.editor.adjustVisibilityShareDB(key_g, visDataMap[key_g]);\n \n }\n\n //Does not seem necessary for not but just for sake of completeness\n this.editor.genomicDataOverlayManager.groupedGenomicDataCount = groupedGenomicDataCount;\n\n this.editor.genomicDataOverlayManager.showGenomicData();\n this.editor.genomicDataOverlayManager.notifyObservers();\n this.editor.cy.fit(50);\n };\n\n /*\n * Initialize event listeners for any operation coming from shareDB\n *\n */\n initSharedDocEventHandlers () {\n\n var self = this;\n\n //Setup event handlers for maps\n var nodeAddRemoveHandler = function (op) {\n self.editor.shareDBNodeAddRemoveEventCallBack(op);\n };\n\n var edgeAddRemoveHandler = function (op) {\n self.editor.shareDBEdgeAddRemoveEventCallBack(op);\n };\n\n var genomicDataAddRemoveHandler = function (op) {\n self.editor.shareDBGenomicDataHandler(op);\n };\n\n var genomicDataVisibilityChangeHandler = function (op) {\n self.editor.shareDBGenomicDataVisibilityHandler(op);\n self.checkShareDBGenomicData();\n };\n\n var genomicDataGroupChangeHandler = function (op) {\n self.editor.shareDBGenomicDataGroupChangeHandler(op);\n };\n\n var updateElementHandler = function (op) {\n self.editor.updateElementCallback(op);\n };\n\n var updateLayoutPropsHandler = function (op) {\n self.editor.updateLayoutPropertiesCallback(op);\n };\n\n var updateGlobalOptionsHandler = function (op) {\n self.editor.changeGlobalOptions(op);\n };\n\n var updateGenomicDataColorSchemeHandler = function (op) {\n self.editor.updateGenomicDataColorSchemeHandler(op);\n }\n\n\n //Event listeners for maps\n this.doc.on('op', function (op, source) {\n for (var i = 0; i < op.length; i++) {\n var handleOp = op[i];\n var path = handleOp.p[0];\n var isReplaceEvent = self.isShareDBReplaceEvent(handleOp);\n\n if (!isReplaceEvent) {\n if (path === self.NODEMAP_NAME) {\n nodeAddRemoveHandler(handleOp);\n }\n else if (path === self.EDGEMAP_NAME) {\n edgeAddRemoveHandler(handleOp);\n }\n else if (path === self.GENOMIC_DATA_MAP_NAME) {\n genomicDataAddRemoveHandler(handleOp);\n }\n else if (path === self.VISIBLE_GENOMIC_DATA_MAP_NAME) {\n genomicDataVisibilityChangeHandler(handleOp);\n }\n else if (path === self.GENOMIC_DATA_GROUP_NAME) {\n genomicDataGroupChangeHandler(handleOp);\n }\n }\n else { //Then it is update event\n if (path === self.NODEMAP_NAME) {\n updateElementHandler(handleOp);\n }\n else if (path === self.EDGEMAP_NAME) {\n updateElementHandler(handleOp);\n }\n else if (path === self.LAYOUT_PROPS_NAME) {\n updateLayoutPropsHandler(handleOp);\n }\n else if (path === self.GLOBAL_OPTS_NAME) {\n updateGlobalOptionsHandler(handleOp);\n }\n else if (path === self.GENOMIC_DATA_COLOR_SCHEME_NAME) {\n updateGenomicDataColorSchemeHandler(handleOp);\n }\n }\n }\n });\n };\n\n /*\n * Make sure that genomic cloud data is syncronized\n */\n checkShareDBGenomicData () {\n\n var self = this;\n var genomicDataMap = self.doc.data[this.GENOMIC_DATA_MAP_NAME];\n var visDataMap = self.doc.data[this.VISIBLE_GENOMIC_DATA_MAP_NAME];\n var groupedGenomicDataMap = self.doc.data[this.GENOMIC_DATA_GROUP_NAME];\n var groupedGenomicDataCount = self.doc.data[this.GENOMIC_DATA_GROUP_COUNT];\n\n for (var key in genomicDataMap) {\n this.editor.genomicDataOverlayManager.genomicDataMap[key] =\n genomicDataMap[key];\n }\n\n for (var key in visDataMap) {\n this.editor.genomicDataOverlayManager.visibleGenomicDataMapByType[key] =\n visDataMap[key];\n }\n\n for (var key in groupedGenomicDataMap) {\n this.editor.genomicDataOverlayManager.groupedGenomicDataMap[key] =\n groupedGenomicDataMap[key];\n }\n this.editor.genomicDataOverlayManager.groupedGenomicDataCount = groupedGenomicDataCount;\n this.editor.genomicDataOverlayManager.showGenomicData();\n this.editor.genomicDataOverlayManager.notifyObservers();\n };\n \n /*\n * Gets the first empty index from the shared document\n * genomic data group count and increments counter by 1\n *\n */\n\n getEmptyGroupID() {\n var returnCount = this.doc.data[this.GENOMIC_DATA_GROUP_COUNT];\n this.incrementShareDBGroupCount();\n return returnCount;\n };\n\n /*\n * Gets the first empty index from the shared document\n * Initializes & inserts a new genomic data\n * by group id or group name\n *\n */\n groupGenomicData(cancerNames, inGroupId) {\n var genomicGroupMap = this.doc.data[this.GENOMIC_DATA_GROUP_NAME];\n var genomicVisMap = this.doc.data[this.VISIBLE_GENOMIC_DATA_MAP_NAME];\n\n var groupID = \"\" + inGroupId;\n var currentGroup = [];\n\n if (genomicGroupMap.hasOwnProperty(groupID))\n currentGroup = _.clone(genomicGroupMap[groupID]);\n\n for (var i in cancerNames) {\n if (!genomicVisMap.hasOwnProperty(cancerNames[i]))\n currentGroup.push(cancerNames[i]);\n }\n\n // If group id already exists change existing object\n if (genomicGroupMap.hasOwnProperty(groupID)) {\n this.updateShareDBObject(this.GENOMIC_DATA_GROUP_NAME, groupID, currentGroup);\n }\n else {\n //Insert new group\n this.insertShareDBObject(this.GENOMIC_DATA_GROUP_NAME, groupID, currentGroup);\n }\n\n };\n\n //Clears genomic data on shared document\n clearGenomicData() {\n this.clearShareDBGenomicData();\n };\n\n addGenomicData(geneData) {\n var genomicMap = this.doc.data[this.GENOMIC_DATA_MAP_NAME];\n\n //Iterate over all genmoic data which is mapped by geneSymbol to list of alteration values\n //that are also mapped by cancer name and associated value\n var ops = [];\n for (var geneSymbol in geneData) {\n var genomicMapEntry = {};\n if (genomicMap.hasOwnProperty(geneSymbol))\n genomicMapEntry = _.clone(genomicMap[geneSymbol]);\n\n for (var cancerType in geneData[geneSymbol]) {\n if (!(cancerType in genomicMapEntry))\n genomicMapEntry[cancerType] = parseInt(geneData[geneSymbol][cancerType]).toFixed(2);\n }\n ops.push({\n p: [this.GENOMIC_DATA_MAP_NAME, geneSymbol],\n oi: genomicMapEntry\n });\n }\n this.applyShareDBOperation(ops);\n };\n\n addGenomicVisibilityData(visMap) {\n var ops = [];\n for (var cancerStudy in visMap) {\n ops.push({\n p: [this.VISIBLE_GENOMIC_DATA_MAP_NAME, cancerStudy],\n oi: visMap[cancerStudy]\n });\n }\n this.applyShareDBOperation(ops);\n };\n\n changeVisibility(nodesToHide, isHidden) {\n var self = this;\n var nodeMap = self.doc.data[this.NODEMAP_NAME];\n\n nodesToHide.forEach(function (ele) {\n var nodeID = ele.id();\n if (nodeMap.hasOwnProperty(nodeID)) {\n var realTimeNode = nodeMap[nodeID];\n realTimeNode.isHidden = isHidden;\n self.updateShareDBObject(self.NODEMAP_NAME, nodeID, realTimeNode);\n }\n });\n };\n\n changeHighlight(elementsToHighlight, isHighlighted) {\n var self = this;\n var nodeMap = self.doc.data[this.NODEMAP_NAME];\n var edgeMap = self.doc.data[this.EDGEMAP_NAME];\n\n elementsToHighlight.forEach(function (ele) {\n var elementID = ele.id();\n if (nodeMap.hasOwnProperty(elementID)) {\n var realTimeNode = nodeMap[elementID];\n realTimeNode.isHighlighted = isHighlighted;\n self.updateShareDBObject(self.NODEMAP_NAME, elementID, realTimeNode);\n }\n if (edgeMap.hasOwnProperty(elementID)) {\n var realTimeEdge = edgeMap[elementID];\n realTimeEdge.isHighlighted = isHighlighted;\n self.updateShareDBObject(self.EDGEMAP_NAME, elementID, realTimeEdge);\n }\n });\n };\n\n addNewNode(nodeData, posData) {\n var realTimeGeneratedID = this.getCustomObjId();\n var params = {\n name: nodeData.name,\n type: nodeData.type,\n id: realTimeGeneratedID,\n parent: nodeData.parent,\n w: nodeData.w,\n h: nodeData.h,\n minWidth: nodeData.minWidth,\n minWidthBiasLeft: nodeData.minWidthBiasLeft,\n minWidthBiasRight: nodeData.minWidthBiasRight,\n minHeight: nodeData.minHeight,\n minHeightBiasTop: nodeData.minHeightBiasTop,\n minHeightBiasBottom: nodeData.minHeightBiasBottom\n };\n\n //Ensures new node is compatible with the other nodes\n var newNode = this.nodeInitializer(params);\n if (posData) {\n newNode.x = posData.x;\n newNode.y = posData.y;\n }\n this.insertShareDBObject(this.NODEMAP_NAME, realTimeGeneratedID, newNode);\n };\n\n addNewEdge(edgeData) {\n var realTimeGeneratedID = this.getCustomObjId();\n var params = {\n type: edgeData.type,\n id: realTimeGeneratedID,\n source: edgeData.source,\n target: edgeData.target,\n pubmedIDs: edgeData.pubmedIDs,\n name: edgeData.name,\n anchorPoints: edgeData.anchorPoints\n };\n\n //Ensures new edge is compatible with the other edge\n var newEdge = this.edgeInitializer(params);\n this.insertShareDBObject(this.EDGEMAP_NAME, realTimeGeneratedID, newEdge);\n };\n\n reconnectEdge = function(sourceID, targetID, edgeData) {\n var edgeMap = this.doc.data[this.EDGEMAP_NAME];\n var edge = edgeMap[edgeData.id];\n var edgeID = edge.id;\n\n edge.source = sourceID;\n edge.target = targetID;\n\n if(edgeMap.hasOwnProperty(edgeID)) {\n this.updateShareDBObject(this.EDGEMAP_NAME, edgeID, edge);\n }\n else {\n throw new Error('Element does not exist in Real Time');\n }\n };\n\n\n removeElement (elementID) {\n var edgeMap = this.doc.data[this.EDGEMAP_NAME];\n var nodeMap = this.doc.data[this.NODEMAP_NAME];\n\n if (nodeMap.hasOwnProperty(elementID)) {\n this.deleteShareDBObject(this.NODEMAP_NAME, elementID);\n }\n else if (edgeMap.hasOwnProperty(elementID)) {\n this.deleteShareDBObject(this.EDGEMAP_NAME, elementID);\n }\n else {\n throw new Error('Element does not exist in Real Time');\n }\n };\n\n moveElement (ele) {\n var nodeMap = this.doc.data[this.NODEMAP_NAME];\n\n var elementID = ele.id();\n var newPos = ele.position();\n\n if (nodeMap.hasOwnProperty(elementID)) {\n var tmpNode = nodeMap[elementID];\n tmpNode.x = newPos.x;\n tmpNode.y = newPos.y;\n this.updateShareDBObject(this.NODEMAP_NAME, elementID, tmpNode);\n }\n else {\n throw new Error('Element does not exist in nodes !!! ');\n }\n };\n\n //This function is used for movements of all selected elements wrt alignment selected\n changeElementsPositionByAlignment (coll) {\n var self = this;\n var nodeMap = self.doc.data[this.NODEMAP_NAME];\n\n coll.forEach(function (ele) {\n var elementID = ele.node.id();\n if (nodeMap.hasOwnProperty(elementID)) {\n var tmpNode = nodeMap[elementID];\n tmpNode.x = ele.nextPosition.x;\n tmpNode.y = ele.nextPosition.y;\n self.updateShareDBObject(self.NODEMAP_NAME, elementID, tmpNode);\n }\n else {\n throw new Error('Element does not exist in nodes !!! ');\n }\n });\n };\n\n resizeElement (ele, previousWidth, previousHeight) {\n var nodeMap = this.doc.data[this.NODEMAP_NAME];\n\n var elementID = ele.id();\n var newWidth = ele.width();\n var newHeight = ele.height();\n var currentX = ele.position('x');\n var currentY = ele.position('y');\n\n if (nodeMap.hasOwnProperty(elementID)) {\n var tmpNode = nodeMap[elementID];\n tmpNode.x = currentX + newWidth - previousWidth;\n tmpNode.y = currentY + newHeight - previousHeight;\n tmpNode.w = newWidth;\n tmpNode.h = newHeight;\n this.updateShareDBObject(this.NODEMAP_NAME, elementID, tmpNode);\n }\n else {\n throw new Error('Element does not exist in nodes !!! ');\n }\n };\n\n setSizeOfElement (ele, newWidth, newHeight) {\n var nodeMap = this.doc.data[this.NODEMAP_NAME];\n\n var elementID = ele.id();\n\n if (nodeMap.hasOwnProperty(elementID)) {\n var tmpNode = nodeMap[elementID];\n tmpNode.w = newWidth;\n tmpNode.h = newHeight;\n this.updateShareDBObject(this.NODEMAP_NAME, elementID, tmpNode);\n }\n else {\n throw new Error('Element does not exist in nodes !!! ');\n }\n };\n\n resizeCompound (ele, minWidth, minWidthBiasLeft, minWidthBiasRight, minHeight, minHeightBiasTop, minHeightBiasBottom) {\n var nodeMap = this.doc.data[this.NODEMAP_NAME];\n\n var elementID = ele.id();\n var currentX = ele.position('x');\n var currentY = ele.position('y');\n\n if (nodeMap.hasOwnProperty(elementID)) {\n var tmpNode = nodeMap[elementID];\n tmpNode.x = currentX;\n tmpNode.y = currentY;\n tmpNode.minWidth = minWidth;\n tmpNode.minWidthBiasLeft = minWidthBiasLeft;\n tmpNode.minWidthBiasRight = minWidthBiasRight;\n tmpNode.minHeight = minHeight;\n tmpNode.minHeightBiasTop = minHeightBiasTop;\n tmpNode.minHeightBiasBottom = minHeightBiasBottom;\n this.updateShareDBObject(this.NODEMAP_NAME, elementID, tmpNode);\n }\n else {\n throw new Error('Element does not exist in nodes !!! ');\n }\n };\n\n changeNodePositionsShareDB (nodes) {\n var self = this;\n var nodeMap = self.doc.data[self.NODEMAP_NAME];\n\n nodes.forEach(function (ele) {\n var nodeID = ele.id();\n if (nodeMap.hasOwnProperty(nodeID)) {\n var realTimeNode = nodeMap[nodeID];\n realTimeNode.x = ele.position('x');\n realTimeNode.y = ele.position('y');\n self.updateShareDBObject(self\n .NODEMAP_NAME, nodeID, realTimeNode);\n }\n else {\n throw new Error('Element does not exist in nodes !!! ');\n }\n });\n };\n\n changeHighlightInvalidGenes (nodeIDs, isInvalid) {\n var nodeMap = this.doc.data[this.NODEMAP_NAME];\n\n //TODO check compound operation inside or outside of for ?\n for (var i in nodeIDs) {\n var nodeID = nodeIDs[i];\n if (nodeMap.hasOwnProperty(nodeID)) {\n var collaborativeNode = nodeMap[nodeID];\n collaborativeNode.isInvalidGene = isInvalid;\n this.updateShareDBObject(this.NODEMAP_NAME, nodeID, collaborativeNode);\n }\n }\n\n };\n\n addPubmedIDs (edgeID, pubmedIDs) {\n var edgeMap = this.doc.data[this.EDGEMAP_NAME];\n\n\n if (edgeMap.hasOwnProperty(edgeID)) {\n var tmpEdge = edgeMap[edgeID];\n var nonDuplicateArray = [];\n for (var i = 0; i < pubmedIDs.length; i++) {\n if (tmpEdge.pubmedIDs.indexOf(pubmedIDs[i]) < 0) {\n nonDuplicateArray.push(pubmedIDs[i]);\n }\n }\n tmpEdge.pubmedIDs = tmpEdge.pubmedIDs.concat(nonDuplicateArray);\n this.updateShareDBObject(this.EDGEMAP_NAME, edgeID, tmpEdge);\n }\n else {\n throw new Error('Edge does not exist in real time !!! ');\n }\n };\n\n removePubmedID(edgeID, pubmedIDs) {\n var edgeMap = this.doc.data[this.EDGEMAP_NAME];\n\n if (edgeMap.hasOwnProperty(edgeID)) {\n var tmpEdge = edgeMap[edgeID];\n var removedIndices = [];\n for (var i = 0; i < pubmedIDs.length; i++) {\n var tmpID = pubmedIDs[i];\n var index = tmpEdge.pubmedIDs.indexOf(tmpID);\n if (index >= 0) {\n removedIndices.push(index);\n }\n }\n for (var i = 0; i < removedIndices.length; i++) {\n tmpEdge.pubmedIDs.remove(removedIndices[i]);\n }\n this.updateShareDBObject(this.EDGEMAP_NAME, edgeID, tmpEdge);\n\n }\n else {\n throw new Error('Edge does not exist in real time !!! ');\n }\n };\n\n updateEdgeAnchorPoints(edgeID, anchorPointsArray, edgeCurveStyle) {\n\n var edgeMap = this.doc.data[this.EDGEMAP_NAME];\n \n if (edgeMap.hasOwnProperty(edgeID)) {\n var tmpEdge = edgeMap[edgeID];\n tmpEdge.anchorPoints = anchorPointsArray;\n tmpEdge.edgeCurveStyle = edgeCurveStyle;\n this.updateShareDBObject(this.EDGEMAP_NAME, edgeID, tmpEdge);\n }\n else {\n throw new Error('Edge does not exist in real time !!! ');\n }\n };\n\n changeName(ele, newName) {\n var nodeMap = this.doc.data[this.NODEMAP_NAME];\n var edgeMap = this.doc.data[this.EDGEMAP_NAME];\n\n var elementID = ele.id();\n\n if (ele.isNode()) {\n if (nodeMap.hasOwnProperty(elementID)) {\n var tmpNode = nodeMap[elementID];\n tmpNode.name = newName;\n this.updateShareDBObject(this.NODEMAP_NAME, elementID, tmpNode);\n }\n else {\n throw new Error('Element does not exist in nodes !!! ');\n }\n }\n else {\n if (edgeMap.hasOwnProperty(elementID)) {\n var tmpEdge = edgeMap[elementID];\n tmpEdge.name = newName;\n this.updateShareDBObject(this.EDGEMAP_NAME, elementID, tmpEdge);\n }\n else {\n throw new Error('Element does not exist in edges !!! ');\n }\n }\n };\n\n changeParent(rootNode, newParentId, connectedEdges) {\n var self = this;\n var nodeLookupTable = {};\n\n function traverseFromRoot(rootNode, parId) {\n /*\n remove outermost node,\n create new real time node with given parentId,\n pass id of this real time node to children,\n repeat in a recursive manner\n after that restore the edges that dissapear by removed nodes\n during change parent\n */\n\n var refNode = rootNode.nodeRef;\n var children = rootNode.children;\n var newParentId = parId;\n\n if (refNode) {\n var refNodeId = refNode.id();\n var nodeData = refNode.data();\n var posData = refNode.position();\n var currentWidth = refNode.data('w');\n var currentHeight = refNode.data('h');\n\n var newNodeData =\n {\n name: nodeData.name,\n type: nodeData.type,\n x: posData.x,\n y: posData.y,\n w: currentWidth,\n h: currentHeight,\n parent: -1\n };\n\n if (parId) {\n newNodeData.parent = parId;\n }\n\n self.removeElement(refNodeId);\n var newNode = self.nodeInitializer(newNodeData);\n var newNodeId = newNode.id;\n self.insertShareDBObject(self.NODEMAP_NAME, newNodeId, newNode);\n newParentId = newNodeId;\n nodeLookupTable[refNodeId] = newNodeId;\n }\n\n for (const childNode of children) {\n traverseFromRoot(childNode, newParentId);\n }\n }\n\n //Begin traversing from given root node\n traverseFromRoot(rootNode, newParentId);\n\n //Restore edges that dissapear by the change parent operation\n //TODO compound operations ?\n connectedEdges.forEach(function (edge, index) {\n var edgeData = edge.data();\n self.removeElement(edge.id());\n\n var newSource = nodeLookupTable[edgeData.source];\n var newTarget = nodeLookupTable[edgeData.target];\n\n if (newSource) {\n edgeData.source = newSource;\n }\n\n if (newTarget) {\n edgeData.target = newTarget;\n }\n\n self.addNewEdge(edgeData);\n });\n };\n\n removeAllElements() {\n var nodeMap = this.doc.data[this.NODEMAP_NAME];\n var edgeMap = this.doc.data[this.EDGEMAP_NAME];\n var ops = [];\n\n //Remove all real time nodes\n for (const key of Object.keys(nodeMap)) {\n ops.push({\n p: [this.NODEMAP_NAME, key],\n od: nodeMap[key]\n });\n }\n\n //Remove all real time edges\n for (const key of Object.keys(edgeMap)) {\n ops.push({\n p: [this.EDGEMAP_NAME, key],\n od: edgeMap[key]\n });\n }\n\n this.applyShareDBOperation(ops);\n };\n\n loadGraph(nodes, edges) {\n var self = this;\n this.removeAllElements();\n\n //Function that traverses graph tree recursively.\n var oldIdNewIdMap = {};\n\n function traverseTree(node, newParentId) {\n node.data.x = node.position.x;\n node.data.y = node.position.y;\n\n //Update parent !\n if (newParentId) {\n var parent = node.data.parent;\n if (parent) {\n node.data.parent = newParentId;\n }\n }\n\n //Create new real time node\n var newNodeId = self.getCustomObjId();\n var params = node.data;\n oldIdNewIdMap[params.id] = newNodeId;\n var newNode = self.nodeInitializer(params);\n newNode.id = newNodeId;\n\n self.insertShareDBObject(self.NODEMAP_NAME, newNodeId, newNode);\n\n //If node has children recursively traverse sub graphs and update parent field of child nodes\n if (node.children.length > 0) {\n for (const tmpNode of node.children) {\n traverseTree(tmpNode, newNodeId);\n }\n }\n }\n\n //Create graph hierarchy from given list of flat nodes\n var tree = GraphUtilities.createGraphHierarchyRealTime(nodes);\n //Traverse from root nodes of tree\n for (const rootLevelNode of tree) {\n traverseTree(rootLevelNode, undefined);\n }\n\n /*\n Create real time edges, update the source and target fields, since new ids will be generated for the nodes in\n real time\n */\n for (const edge of edges) {\n edge.data.source = oldIdNewIdMap[edge.data.source];\n edge.data.target = oldIdNewIdMap[edge.data.target];\n\n var edgeCurveStyle = \"bezier\";\n if (edge.data.bendPointPositions && edge.data.bendPointPositions.length > 0) {\n edge.data['anchorPoints'] = edge.data['bendPointPositions'];\n delete edge.data['bendPointPositions'];\n edgeCurveStyle = \"segments\";\n }\n else if (edge.data.controlPointPositions && edge.data.controlPointPositions.length > 0) {\n edge.data['anchorPoints'] = edge.data['controlPointPositions'];\n delete edge.data['controlPointPositions'];\n edgeCurveStyle = \"unbundled-bezier\";\n }\n\n var params = edge.data;\n params.edgeCurveStyle = edgeCurveStyle;\n var newEdgeID = self.getCustomObjId();\n params.id = newEdgeID;\n \n var newEdge = self.edgeInitializer(params);\n self.insertShareDBObject(self.EDGEMAP_NAME, newEdgeID, newEdge);\n }\n };\n\n mergeGraph (nodes, edges) {\n var self = this;\n var nodeMap = self.doc.data[this.NODEMAP_NAME];\n\n var realTimeNodeMap = nodeMap;\n var realTimeNodeLookupTable = {};\n var realTimeNodeNameLookupTable = {};\n var oldIdNewIdMap = {};\n\n //Create lookup table for real time nodes\n //items are stored in an array in the resulting array of nodeMap.items()\n // [0] - id, [1] - object\n for (var i in realTimeNodeMap) {\n var nodeMapItem = realTimeNodeMap[i];\n realTimeNodeLookupTable[nodeMapItem.id] = nodeMapItem;\n realTimeNodeNameLookupTable[nodeMapItem.name] = nodeMapItem;\n }\n\n //Recursive traverse definition\n function traverseTree(node, newParentId) {\n //Search by name !\n //We have not found a node that exist in the graph, add normally\n if (!(node.data.name in realTimeNodeNameLookupTable)) {\n node.data.x = node.position.x;\n node.data.y = node.position.y;\n\n //Update parent !\n if (newParentId) {\n var parent = node.data.parent;\n if (parent) {\n node.data.parent = newParentId;\n }\n }\n\n //Create new real time node\n var newNodeId = self.getCustomObjId();\n oldIdNewIdMap[node.data.id] = newNodeId;\n var newNode = self.nodeInitializer(node.data);\n newNode.id = newNodeId;\n self.insertShareDBObject(self.NODEMAP_NAME, newNodeId, newNode);\n\n //If node has children recursively traverse sub graphs and update parent field of child nodes\n if (node.children.length > 0) {\n for (const tmpNode of node.children) {\n traverseTree(tmpNode, newNodeId);\n }\n }\n }\n // At this point there exists another node in the graph with the same name as 'node'\n // we need to update parent field of children of this node if any\n else {\n var sameNameNode = realTimeNodeNameLookupTable[node.data.name];\n var sameNodeId = sameNameNode.id;\n oldIdNewIdMap[node.data.id] = sameNodeId;\n\n //If node has children recursively traverse sub graphs and update parent field of child nodes\n if (node.children.length > 0) {\n for (const tmpNode of node.children) {\n traverseTree(tmpNode, sameNodeId);\n }\n }\n }\n }\n\n //Traverse from root nodes of tree\n var tree = GraphUtilities.createGraphHierarchyRealTime(nodes);\n for (const rootLevelNode of tree) {\n traverseTree(rootLevelNode, rootLevelNode.data.id);\n }\n\n /*\n Create real time edges, update the source and target fields, since new ids will be generated for the nodes in\n real time\n */\n var ops = [];\n for (const edge of edges) {\n edge.data.source = oldIdNewIdMap[edge.data.source];\n edge.data.target = oldIdNewIdMap[edge.data.target];\n var newEdge = self.edgeInitializer(edge.data);\n var newEdgeID = this.getCustomObjId();\n newEdge.id = newEdgeID;\n ops.push({\n p: [self.EDGEMAP_NAME, newEdgeID],\n oi: newEdge\n });\n }\n self.applyShareDBOperation(ops);\n };\n\n updateLayoutProperties (newLayoutProperties) {\n this.updateShareDBLayoutProperties(newLayoutProperties);\n };\n\n updateGlobalOptions (newOptions) {\n this.updateShareDBGlobalOptions(newOptions);\n };\n\n updateGenomicDataOverlayColorScheme(newColorScheme: IColorValueMap) {\n this.updateShareDBGenomicDataOverlayColorScheme(newColorScheme);\n }\n\n /*\n * Creates graph hierarchy from given flat list of nodes list, nodes list is assumed to have parent-child\n * relationship by a field 'parent' which represents to the id of the parent node This function is specific\n * for the needs of TCGA Pathway Curation Tool 04/07/2016\n *\n * @param nodes {array}: flat list of nodes of a graph\n * @return {array}: Tree representation in array, entries are root level nodes. node.children gives children nodes\n * of each node in the returned array.\n * a node in corresponding level.\n *\n * */\n createGraphHierarchy (nodes) {\n //Some arrays and maps for creating graph hierarchy\n var tree = [];\n var mappedArr = {};\n\n // First map the nodes of the array to an object -> create a hash table.\n for (var i = 0, len = nodes.length; i < len; i++) {\n var arrElem = nodes[i];\n mappedArr[arrElem.data.id] = arrElem;\n mappedArr[arrElem.data.id].children = [];\n }\n\n for (const id of Object.keys(mappedArr)) {\n var mappedElem = mappedArr[id];\n\n // If the element is not at the root level, add it to its parent array of children.\n if (mappedElem.data.parent) {\n mappedArr[mappedElem.data.parent].children.push(mappedElem);\n }\n // If the element is at the root level, add it to first level elements array.\n else {\n tree.push(mappedElem);\n }\n }\n return tree;\n };\n\n //Makes sure that edge is compatible with edges in shared document\n edgeInitializer (params) {\n var edge: any = {};\n edge.id = params.id || this.getCustomObjId();\n edge.type = params.type || \"undefined\";\n edge.source = params.source || \"undefined\";\n edge.target = params.target || \"undefined\";\n edge.name = params.name || \"\";\n edge.isHighlighted = params.isHighlighted || false;\n edge.anchorPoints = params.anchorPoints || [];\n edge.edgeCurveStyle = params.edgeCurveStyle || \"bezier\"\n\n if (params.pubmedIDs) {\n if (edge.pubmedIDs == undefined) {\n edge.pubmedIDs = [];\n }\n if(params.pubmedIDs.length > 0)\n edge.pubmedIDs.push(params.pubmedIDs);\n }\n else {\n edge.pubmedIDs = [];\n }\n\n if (params.anchorPoints) {\n if (edge.anchorPoints == undefined) {\n edge.anchorPoints = [];\n }\n // legacy workaround\n if (Array.isArray(params.anchorPoints[0])) {\n edge.anchorPoints = params.anchorPoints[0];\n }\n else {\n edge.anchorPoints = params.anchorPoints;\n }\n }\n else {\n edge.anchorPoints = [];\n }\n return edge;\n };\n\n //Makes sure that node is compatible with nodes in shared document\n nodeInitializer(params) {\n var node: any = {};\n node.id = params.id || this.getCustomObjId();\n node.name = params.name || \"undefined\";\n node.type = params.type || \"undefined\";\n node.parent = params.parent || \"undefined\";\n node.x = params.x || \"undefined\";\n node.y = params.y || \"undefined\";\n node.w = params.w || \"undefined\";\n node.h = params.h || \"undefined\";\n node.minWidth = params.minWidth || 0;\n node.minWidthBiasLeft = params.minWidth || 0;\n node.minWidthBiasRight = params.minWidth || 0;\n node.minHeight = params.minWidth || 0;\n node.minHeightBiasTop = params.minWidth || 0;\n node.minHeightBiasBottom = params.minWidth || 0;\n node.isHidden = params.isHidden || false;\n node.isInvalidGene = params.isInvalidGene || false;\n node.isHighlighted = params.isHighlighted || false;\n return node;\n };\n\n //Makes sure that layout properties is compatible with layout properties in shared document\n layoutPropertiesInitializer (params) {\n var layoutProperties: any = {};\n layoutProperties.name = params.name || 'undefined';\n layoutProperties.nodeRepulsion = params.nodeRepulsion || 'undefined';\n // this.nodeOverlap = params.nodeOverlap || 'undefined';\n layoutProperties.idealEdgeLength = params.idealEdgeLength || 'undefined';\n layoutProperties.edgeElasticity = params.edgeElasticity || 'undefined';\n layoutProperties.nestingFactor = params.nestingFactor || 'undefined';\n layoutProperties.gravity = params.gravity || 'undefined';\n layoutProperties.numIter = params.numIter || 'undefined';\n layoutProperties.tile = params.tile || 'undefined';\n layoutProperties.animate = params.animate || 'undefined';\n layoutProperties.randomize = params.randomize || false;\n layoutProperties.gravityRangeCompound = params.gravityRangeCompound || 'undefined';\n layoutProperties.gravityCompound = params.gravityCompound || 'undefined';\n layoutProperties.gravityRange = params.gravityRange || 'undefined';\n layoutProperties.tilingPaddingVertical = params.tilingPaddingVertical || 'undefined';\n layoutProperties.tilingPaddingHorizontal = params.tilingPaddingHorizontal || 'undefined';\n layoutProperties.initialEnergyOnIncremental = params.initialEnergyOnIncremental || 'undefined';\n return layoutProperties;\n };\n\n //Makes sure that global options is compatible with global options in shared document\n globalOptionsInitializer (params) {\n var globalOptions: any = {};\n globalOptions.zoomLevel = params.zoomLevel || 'undefined';\n globalOptions.panLevel = params.panLevel || 'undefined';\n return globalOptions;\n };\n\n //Create unique ID for elements\n getCustomObjId () {\n // see http://stackoverflow.com/a/8809472\n // we need to take care of our own IDs because the ones automatically generated by cytoscape (also UUID)\n // don't comply with xsd:SID type that must not begin with a number\n // Public Domain/MIT\n var d = Date.now();\n if (typeof performance !== 'undefined' && typeof performance.now === 'function') {\n d += performance.now(); //use high-precision timer if available\n }\n return 'xxxxxxxx-xxxx-4xxx-yxxx-xxxxxxxxxxxx'.replace(/[xy]/g, function (c) {\n var r = (d + Math.random() * 16) % 16 | 0;\n d = Math.floor(d / 16);\n return (c === 'x' ? r : (r & 0x3 | 0x8)).toString(16);\n });\n };\n\n getParam (urlParam) {\n const regExp = new RegExp(urlParam + '=(.*?)($|&)', 'g');\n let match: any = window.location.search.match(regExp);\n if (match && match.length) {\n match = match[0];\n match = match.replace(urlParam + '=', '').replace('&', '');\n } else {\n match = null;\n }\n return match;\n };\n\n}\n","/**\n * Created by istemi on 27.09.2016.\n */\n\nexport default class GraphUtilities {\n \n \n static createGraphHierarchy(nodes)\n {\n //Some arrays and maps for creating graph hierarchy\n var tree = [];\n var mappedArr = {};\n\n // First map the nodes of the array to an object -> create a hash table.\n for (var i = 0, len = nodes.length; i < len; i++)\n {\n var arrElem = nodes[i];\n mappedArr[arrElem.id()] = arrElem;\n mappedArr[arrElem.id()].childNodes = [];\n }\n\n for (var id in mappedArr)\n {\n var mappedElem = mappedArr[id];\n\n // If the element is not at the root level, add it to its parent array of children.\n if (mappedElem.parent().length > 0)\n {\n mappedArr[mappedElem.parent().id()].childNodes.push(mappedElem);\n }\n // If the element is at the root level, add it to first level elements array.\n else\n {\n tree.push(mappedElem);\n }\n }\n return tree;\n };\n\n /*\n * Creates graph hierarchy from given flat list of nodes list, nodes list is assumed to have parent-child\n * relationship by a field 'parent' which represents to the id of the parent node This function is specific\n * for the needs of TCGA Pathway Curation Tool 04/07/2016\n *\n * @param nodes {array}: flat list of nodes of a graph\n * @return {array}: Tree representation in array, entries are root level nodes. node.children gives children nodes\n * of each node in the returned array.\n * a node in corresponding level.\n *\n * */\n static createGraphHierarchyRealTime(nodes)\n {\n //Some arrays and maps for creating graph hierarchy\n var tree = [];\n var mappedArr = {};\n\n // First map the nodes of the array to an object -> create a hash table.\n for (var i = 0, len = nodes.length; i < len; i++)\n {\n var arrElem = nodes[i];\n mappedArr[arrElem.data.id] = arrElem;\n mappedArr[arrElem.data.id].children = [];\n }\n for (var id in mappedArr)\n {\n var mappedElem = mappedArr[id];\n\n // If the element is not at the root level, add it to its parent array of children.\n if (mappedElem.data.parent != -1)\n {\n mappedArr[mappedElem.data.parent].children.push(mappedElem);\n }\n // If the element is at the root level, add it to first level elements array.\n else\n {\n tree.push(mappedElem);\n }\n }\n return tree;\n };\n}","import EditorActionsManager from \"../managers/EditorActionsManager\";\nimport GraphUtilities from \"../utils/GraphUtilities\";\n\nexport default class SVGExporter {\n SVGNameSpace = \"http://www.w3.org/2000/svg\";\n svg = document.createElementNS(this.SVGNameSpace, \"svg\");\n NODE_FILL_COLOR = \"rgb(255,255,255)\";\n FAMILY_FILL_COLOR = \"rgb(255,255,255)\";\n FAMILY_STROKE_COLOR = \"rgb(204,204,204)\";\n NODE_STROKE_COLOR = \"rgb(0,0,0)\";\n COMPARTMENT_STROKE_WIDTH = 2;\n NODE_STROKE_WIDTH = 1;\n NODE_OPACITY = 0.5;\n ROUNDING_FACTOR = 6;\n GENOMICDATA_LABEL_Y_OFFSET = -15;\n EDGE_ARROW_SCALE = 1.7;\n EDGE_WIDTH = 1;\n T_ARROW_HEAD_WIDTH = 2 * this.EDGE_ARROW_SCALE;\n T_ARROW_HEAD_HEIGHT = 8 * this.EDGE_ARROW_SCALE;\n TRIANGLE_ARROW_HEAD_HEIGHT = 8 * this.EDGE_ARROW_SCALE;\n TRIANGLE_ARROW_HEAD_WIDTH = 8 * this.EDGE_ARROW_SCALE;\n DASH_PARAMETERS = \"5, 3\";\n COMPOUND_MARGIN = 8;\n NODE_FONT_SIZE = 14;\n\n edgeEditing: any;\n editor: EditorActionsManager;\n constructor(edgeEditing: any, editor: EditorActionsManager) {\n this.edgeEditing = edgeEditing;\n this.editor = editor;\n }\n\n resetSVG() {\n this.svg = document.createElementNS(this.SVGNameSpace, \"svg\");\n }\n\n exportGraph(nodes, edges) {\n //Reset SVG\n this.resetSVG();\n this.svg.setAttribute(\"version\", \"1.1\");\n this.svg.setAttribute(\"xmlns\", \"http://www.w3.org/2000/svg\");\n //Set viewport of output SVG\n var cyBounds = this.editor.cy.extent();\n this.svg.setAttribute(\n \"viewBox\",\n cyBounds.x1 + \" \" + cyBounds.y1 + \" \" + cyBounds.w + \" \" + cyBounds.h\n );\n\n var self = this;\n var nodeMap = {};\n\n var nodeTree = GraphUtilities.createGraphHierarchy(nodes);\n var traverseFunction = function(node) {\n //Create SVG for current node\n nodeMap[node.id()] = node;\n var genomicDataSVG = self.editor.getGenomicDataSVG(node).children;\n var oncoprintDataSVG = self.editor.getOncoprintDataSVG(node);\n self.svg.appendChild(self.createRect(node));\n var labelOffset =\n (genomicDataSVG && genomicDataSVG.length > 0) ||\n oncoprintDataSVG.outerHTML !== \"\"\n ? self.GENOMICDATA_LABEL_Y_OFFSET\n : 0;\n self.svg.appendChild(self.createNodeLabel(node, labelOffset));\n\n //Append Genomic Data SVG\n if (genomicDataSVG) {\n while (genomicDataSVG.length > 0) {\n var elemSVG = genomicDataSVG[0];\n var nodePosition = node.position();\n var svgX = elemSVG.getAttribute(\"x\");\n var svgY = elemSVG.getAttribute(\"y\");\n elemSVG.setAttribute(\n \"x\",\n nodePosition.x - node.width() / 2 + parseFloat(svgX)\n );\n elemSVG.setAttribute(\n \"y\",\n nodePosition.y - node.height() / 2 + parseFloat(svgY)\n );\n self.svg.appendChild(elemSVG);\n }\n }\n //Append Oncoprint Data SVG\n else if (oncoprintDataSVG.outerHTML !== \"\") {\n var nodePosition = node.position();\n\n const width = parseInt(oncoprintDataSVG.getAttribute(\"width\"));\n const height = parseInt(oncoprintDataSVG.getAttribute(\"height\"));\n const verticalPadding = 8;\n\n const y =\n nodePosition.y + node.height() / 2 - (height + verticalPadding);\n oncoprintDataSVG.setAttribute(\"x\", nodePosition.x - width / 2);\n oncoprintDataSVG.setAttribute(\"y\", y);\n self.svg.appendChild(oncoprintDataSVG);\n }\n\n //Traverse children\n if (node.childNodes) {\n for (var i in node.childNodes) {\n traverseFunction(node.childNodes[i]);\n }\n }\n };\n\n //Traverse node hierarchy\n for (var i in nodeTree) {\n var rootLevelNode = nodeTree[i];\n traverseFunction(rootLevelNode);\n }\n\n edges.forEach(function(edge) {\n self.drawEdge(edge);\n });\n\n return this.svg.outerHTML;\n }\n\n drawEdge(edge) {\n const sourceEndpoint = edge.sourceEndpoint();\n const targetEndpoint = edge.targetEndpoint();\n const targetArrowShape = edge.style(\"target-arrow-shape\");\n const lineStyle = edge.style(\"line-style\");\n const curveStyle = edge.style(\"curve-style\");\n const anchorPoints = curveStyle === \"segments\" ? \n edge.segmentPoints() : \n edge.controlPoints();\n\n const labelElement = this.createEdgeLabel(edge);\n if (labelElement) {\n this.svg.appendChild(labelElement);\n }\n\n let lastAnchor = {\n x: sourceEndpoint.x,\n y: sourceEndpoint.y\n }\n let edgeEndpoint = {\n x: targetEndpoint.x,\n y: targetEndpoint.y\n };\n\n if (anchorPoints && anchorPoints.length > 0) {\n lastAnchor = {\n x: anchorPoints[anchorPoints.length - 1].x,\n y: anchorPoints[anchorPoints.length - 1].y\n }\n }\n\n var unitV = this.unitVector({\n x: targetEndpoint.x - lastAnchor.x,\n y: targetEndpoint.y - lastAnchor.y,\n });\n var inverseUnitV = this.scale(unitV, -1);\n\n var targetX = targetEndpoint.x;\n var targetY = targetEndpoint.y;\n\n //Draw Triangle arrow head\n if (targetArrowShape === \"triangle\") {\n targetX =\n targetEndpoint.x +\n this.TRIANGLE_ARROW_HEAD_HEIGHT * inverseUnitV.x;\n targetY =\n targetEndpoint.y +\n this.TRIANGLE_ARROW_HEAD_HEIGHT * inverseUnitV.y;\n\n var point1Vector = this.rotateVector(unitV, Math.PI / 2);\n var point2Vector = this.rotateVector(unitV, -Math.PI / 2);\n\n point1Vector = this.scale(\n point1Vector,\n this.TRIANGLE_ARROW_HEAD_WIDTH / 2\n );\n point2Vector = this.scale(\n point2Vector,\n this.TRIANGLE_ARROW_HEAD_WIDTH / 2\n );\n\n var point1X = targetX + point1Vector.x;\n var point1Y = targetY + point1Vector.y;\n\n var point2X = targetX + point2Vector.x;\n var point2Y = targetY + point2Vector.y;\n\n edgeEndpoint = {\n x: (point1X + point2X) / 2,\n y: (point1Y + point2Y) / 2\n }\n\n var polySVG = document.createElementNS(this.SVGNameSpace, \"polygon\");\n polySVG.setAttribute(\n \"points\",\n point1X +\n \",\" +\n point1Y +\n \",\" +\n point2X +\n \",\" +\n point2Y +\n \",\" +\n targetEndpoint.x +\n \",\" +\n targetEndpoint.y\n );\n\n this.svg.appendChild(polySVG);\n }\n //Draw T type arrow head\n else if (targetArrowShape === \"tee\") {\n targetX =\n targetEndpoint.x \n targetY =\n targetEndpoint.y \n\n //Calculate T shape points\n var point1Vector = this.rotateVector(unitV, Math.PI / 2);\n var point2Vector = this.rotateVector(unitV, -Math.PI / 2);\n point1Vector = this.scale(point1Vector, this.T_ARROW_HEAD_HEIGHT / 2);\n point2Vector = this.scale(point2Vector, this.T_ARROW_HEAD_HEIGHT / 2);\n\n var point1X = targetX + point1Vector.x;\n var point1Y = targetY + point1Vector.y;\n var point2X = targetX + point2Vector.x;\n var point2Y = targetY + point2Vector.y;\n\n edgeEndpoint = {\n x: (point1X + point2X) / 2,\n y: (point1Y + point2Y) / 2\n }\n\n //Draw edge arrow line here !\n var lineSVG = document.createElementNS(this.SVGNameSpace, \"line\");\n lineSVG.setAttribute(\"x1\", point1X);\n lineSVG.setAttribute(\"y1\", point1Y);\n lineSVG.setAttribute(\"x2\", point2X);\n lineSVG.setAttribute(\"y2\", point2Y);\n lineSVG.setAttribute(\"stroke-width\", this.T_ARROW_HEAD_WIDTH.toString());\n lineSVG.setAttribute(\"stroke\", \"black\");\n this.svg.appendChild(lineSVG);\n }\n \n // no anchors means a single line connecting source and target end points\n if (!anchorPoints || anchorPoints.length < 1) {\n const lineSVG = document.createElementNS(this.SVGNameSpace, \"line\");\n lineSVG.setAttribute(\"x1\", sourceEndpoint.x);\n lineSVG.setAttribute(\"y1\", sourceEndpoint.y);\n lineSVG.setAttribute(\"x2\", edgeEndpoint.x);\n lineSVG.setAttribute(\"y2\", edgeEndpoint.y);\n lineSVG.setAttribute(\"stroke-width\", this.EDGE_WIDTH.toString());\n lineSVG.setAttribute(\"stroke\", \"black\");\n if (lineStyle === \"dashed\") {\n lineSVG.setAttribute(\"stroke-dasharray\", this.DASH_PARAMETERS);\n }\n this.svg.appendChild(lineSVG);\n }\n else if (curveStyle === \"unbundled-bezier\" || curveStyle === \"bezier\") {\n const pathSVG = document.createElementNS(this.SVGNameSpace, \"path\");\n let pathPoints: string[] = [];\n\n for (let i = 0; i < anchorPoints.length; i++) {\n if (i === 0) {\n pathPoints.push(\"M\" + sourceEndpoint.x + \",\" + sourceEndpoint.y);\n pathPoints.push(\"Q\" + anchorPoints[i].x + \",\" + anchorPoints[i].y);\n if (anchorPoints.length === 1) {\n pathPoints.push(edgeEndpoint.x + \",\" + edgeEndpoint.y);\n }\n else {\n const furtherEndPoint = {\n x: (anchorPoints[i].x + anchorPoints[i+1].x) / 2,\n y: (anchorPoints[i].y + anchorPoints[i+1].y) / 2 \n }\n pathPoints.push(furtherEndPoint.x + \",\" + furtherEndPoint.y);\n }\n }\n else {\n if (i < anchorPoints.length - 1) {\n const furtherEndPoint = {\n x: (anchorPoints[i].x + anchorPoints[i+1].x) / 2,\n y: (anchorPoints[i].y + anchorPoints[i+1].y) / 2 \n }\n pathPoints.push(\"T\" + furtherEndPoint.x + \",\" + furtherEndPoint.y);\n }\n else {\n pathPoints.push(\"T\" + edgeEndpoint.x + \",\" + edgeEndpoint.y);\n }\n }\n }\n pathSVG.setAttribute(\n 'd',\n pathPoints.join(\" \")\n );\n pathSVG.setAttribute('stroke-width', this.EDGE_WIDTH.toString());\n pathSVG.setAttribute('stroke', 'black');\n if (lineStyle === \"dashed\") {\n pathSVG.setAttribute(\"stroke-dasharray\", this.DASH_PARAMETERS);\n }\n pathSVG.setAttribute('fill', 'none');\n this.svg.appendChild(pathSVG);\n }\n // anchors means polyline\n else {\n const polylineSVG = document.createElementNS(this.SVGNameSpace, \"polyline\");\n let polylinePoints: string[] = [];\n\n for (let i = 0; i < anchorPoints.length; i++) {\n if (i === 0) {\n polylinePoints.push(sourceEndpoint.x + \",\" + sourceEndpoint.y);\n polylinePoints.push(anchorPoints[i].x + \",\" + anchorPoints[i].y);\n if (anchorPoints.length === 1) {\n polylinePoints.push(edgeEndpoint.x + \",\" + edgeEndpoint.y);\n }\n }\n else if (i === anchorPoints.length - 1) {\n polylinePoints.push(anchorPoints[i].x + \",\" + anchorPoints[i].y);\n polylinePoints.push(edgeEndpoint.x + \",\" + edgeEndpoint.y);\n }\n else {\n polylinePoints.push(anchorPoints[i].x + \",\" + anchorPoints[i].y);\n }\n }\n polylineSVG.setAttribute(\n 'points',\n polylinePoints.join(\" \")\n );\n polylineSVG.setAttribute('stroke-width', this.EDGE_WIDTH.toString());\n polylineSVG.setAttribute('stroke', 'black');\n if (lineStyle === \"dashed\") {\n lineSVG.setAttribute(\"stroke-dasharray\", this.DASH_PARAMETERS);\n }\n polylineSVG.setAttribute('fill', 'none');\n this.svg.appendChild(polylineSVG);\n }\n \n }\n\n createRect(node) {\n var nodeRectangle = document.createElementNS(this.SVGNameSpace, \"rect\");\n var nodePosition = node.position();\n if (node.isParent()) {\n nodeRectangle.setAttribute(\n \"x\",\n nodePosition.x - node.width() / 2 - this.COMPOUND_MARGIN / 2 + \"\"\n );\n nodeRectangle.setAttribute(\n \"y\",\n nodePosition.y - node.height() / 2 - this.COMPOUND_MARGIN / 2 + \"\"\n );\n nodeRectangle.setAttribute(\"width\", node.width() + this.COMPOUND_MARGIN);\n nodeRectangle.setAttribute(\n \"height\",\n node.height() + this.COMPOUND_MARGIN\n );\n } else {\n nodeRectangle.setAttribute(\"x\", nodePosition.x - node.width() / 2 + \"\");\n nodeRectangle.setAttribute(\"y\", nodePosition.y - node.height() / 2 + \"\");\n nodeRectangle.setAttribute(\"width\", node.width());\n nodeRectangle.setAttribute(\"height\", node.height());\n }\n\n nodeRectangle = this.createStyleForNodes(node, nodeRectangle);\n\n return nodeRectangle;\n }\n\n createNodeLabel(node, genomicDataOffset) {\n var verticalTextOffset = 5;\n var nodePosition = node.position();\n var svgText = document.createElementNS(this.SVGNameSpace, \"text\");\n\n if (node.isParent()) {\n verticalTextOffset = 20;\n svgText.setAttribute(\"x\", nodePosition.x);\n svgText.setAttribute(\n \"y\",\n nodePosition.y + node.height() / 2 + verticalTextOffset\n );\n } else {\n svgText.setAttribute(\"x\", nodePosition.x);\n svgText.setAttribute(\n \"y\",\n nodePosition.y + verticalTextOffset + genomicDataOffset\n );\n }\n\n svgText.setAttribute(\"font-family\", \"Arial\");\n svgText.setAttribute(\"text-anchor\", \"middle\");\n svgText.setAttribute(\"font-size\", this.NODE_FONT_SIZE.toString());\n svgText.innerHTML = node.data(\"name\");\n return svgText;\n }\n\n createStyleForNodes(node, nodeRectangle) {\n var nodeType = node.data().type;\n var strokeWidth = node.css(\"border-width\") || this.NODE_STROKE_WIDTH;\n var strokeColor = this.NODE_STROKE_COLOR;\n var fillColor = this.NODE_FILL_COLOR;\n var opacity = this.NODE_OPACITY;\n var strokeOpacity = 1;\n\n if (nodeType == \"GENE\" || nodeType == \"COMPARTMENT\") {\n nodeRectangle.setAttribute(\"rx\", this.ROUNDING_FACTOR);\n nodeRectangle.setAttribute(\"ry\", this.ROUNDING_FACTOR);\n\n if (nodeType == \"COMPARTMENT\")\n strokeWidth = this.COMPARTMENT_STROKE_WIDTH;\n }\n\n if (nodeType == \"PROCESS\") {\n opacity = 0;\n strokeOpacity = 0;\n }\n\n if (nodeType == \"FAMILY\") {\n fillColor = this.FAMILY_FILL_COLOR;\n strokeColor = this.FAMILY_STROKE_COLOR;\n }\n\n var styleString =\n \"stroke-width:\" +\n strokeWidth +\n \";\" +\n \"stroke:\" +\n strokeColor +\n \";\" +\n \"fill-opacity:\" +\n opacity +\n \";\" +\n \"fill:\" +\n fillColor +\n \";\" +\n \"stroke-opacity:\" +\n strokeOpacity +\n \";\";\n\n nodeRectangle.setAttribute(\"style\", styleString);\n\n return nodeRectangle;\n }\n\n createEdgeLabel(edge) {\n const labelText = edge.data(\"name\");\n \n if (labelText === \"\") {\n return undefined;\n }\n const svgTextElement = document.createElementNS(this.SVGNameSpace, \"text\");\n\n const fontSize = edge.style(\"font-size\");\n const fontFamily = edge.style(\"font-family\");\n\n // get rotation angle in degrees for transform: rotate()\n const labelRotationAngle = this.getEdgeLabelRotationAngle(edge);\n const lineHeight = edge._private.rscratch.labelLineHeight;\n\n // adjust margins to compensate for the label hack (see stylesheet)\n const dx = (lineHeight / 4) * Math.sin(edge._private.rscratch.labelAngle);\n const dy = (lineHeight / 4) * Math.cos(edge._private.rscratch.labelAngle);\n\n const labelPos = {\n x: edge._private.rscratch.labelX + dx,\n y: edge._private.rscratch.labelY - dy\n }\n\n svgTextElement.setAttribute('x', labelPos.x.toString());\n svgTextElement.setAttribute('y', labelPos.y.toString());\n svgTextElement.setAttribute(\"font-family\", fontFamily);\n svgTextElement.setAttribute(\"text-anchor\", \"middle\");\n svgTextElement.setAttribute(\"font-size\", fontSize);\n\n svgTextElement.innerHTML = labelText;\n\n // adjusting for autorotate option\n // https://developer.mozilla.org/en-US/docs/Web/SVG/Attribute/transform#rotate \n svgTextElement.setAttribute(\n \"transform\", \n \"rotate(\" + \n labelRotationAngle +\n \" \" +\n labelPos.x.toString() +\n \" \" +\n labelPos.y.toString()+\n \")\");\n\n return svgTextElement;\n }\n\n getEdgeLabelRotationAngle(edge) {\n const labelAngle = edge._private.rscratch.labelAngle;\n\n if (!labelAngle) {\n return 0;\n }\n\n return this.toDegrees(labelAngle);\n }\n\n toDegrees(radians) {\n const pi = Math.PI;\n return radians * (180/pi);\n }\n\n unitVector(v) {\n var inverseLength = 1 / Math.sqrt(v.x * v.x + v.y * v.y);\n\n return {\n x: v.x * inverseLength,\n y: v.y * inverseLength,\n };\n }\n\n rotateVector(v, radians) {\n var newX = v.x * Math.cos(radians) - v.y * Math.sin(radians);\n var newY = v.x * Math.sin(radians) + v.y * Math.cos(radians);\n\n return { x: newX, y: newY };\n }\n\n scale(v, scalar) {\n var newX = v.x * scalar;\n var newY = v.y * scalar;\n\n return { x: newX, y: newY };\n }\n}\n","import $ from \"jquery\";\nimport { GeneticAlterationRuleSet, shapeToSvg } from \"oncoprintjs\";\nimport tippy from \"tippy.js\";\nimport \"tippy.js/dist/tippy.css\"; // optional for styling\nimport { IColorValueMap } from \"../ui/react-pathway-mapper\";\n\ninterface Color {\n r: number;\n g: number;\n b: number;\n}\n\ninterface ValueColorPair {\n value: number;\n color: Color;\n}\nexport default class GenomicDataOverlayManager {\n public genomicDataMap: {};\n public visibleGenomicDataMapByType: {};\n public groupedGenomicDataCount: number;\n public groupedGenomicDataMap: {};\n public patientData: any;\n private DEFAULT_VISIBLE_GENOMIC_DATA_COUNT: number;\n private observers: any[];\n private cy: any;\n private colorScheme: IColorValueMap;\n\n constructor(cy: any) {\n this.cy = cy;\n this.genomicDataMap = {};\n this.patientData = {};\n this.visibleGenomicDataMapByType = {};\n this.groupedGenomicDataMap = {};\n this.groupedGenomicDataCount = 0;\n this.DEFAULT_VISIBLE_GENOMIC_DATA_COUNT = 6;\n this.colorScheme = {\n \"-100\": \"#0000ff\",\n \"0\": \"#ffffff\",\n \"100\": \"#ff0000\",\n };\n // Observer-observable pattern related stuff\n this.observers = [];\n }\n\n getEmptyGroupID() {\n const oldCount = this.groupedGenomicDataCount;\n this.groupedGenomicDataCount++;\n return oldCount;\n }\n\n addGenomicDataLocally(genomicData, groupID) {\n this.parseGenomicData(genomicData, groupID);\n this.showGenomicData();\n this.notifyObservers();\n }\n\n preparePortalGenomicDataShareDB(genomicData) {\n const geneMap = {};\n const visMap = {};\n\n for (const cancerKey in genomicData) {\n for (const geneSymbol in genomicData[cancerKey]) {\n geneMap[geneSymbol] = {};\n geneMap[geneSymbol][cancerKey] = genomicData[cancerKey][geneSymbol];\n }\n\n visMap[cancerKey] = true;\n }\n\n return {\n genomicDataMap: geneMap,\n visibilityMap: visMap,\n };\n }\n\n addGenomicData(data) {\n this.genomicDataMap = data;\n }\n\n removeGenomicVisData() {\n this.visibleGenomicDataMapByType = {};\n }\n\n addGenomicDataWithGeneSymbol(geneSymbol, data) {\n this.genomicDataMap[geneSymbol] = data;\n }\n\n addGenomicGroupData(groupID, data) {\n this.groupedGenomicDataMap[groupID] = data;\n }\n\n addPortalGenomicData(data, groupID) {\n for (const cancerStudy of Object.keys(data)) {\n this.visibleGenomicDataMapByType[cancerStudy] = true;\n // Group current cancer study according to the groupID\n if (this.groupedGenomicDataMap[groupID] === undefined) {\n this.groupedGenomicDataMap[groupID] = [];\n }\n\n this.groupedGenomicDataMap[groupID].push(cancerStudy);\n\n var cancerData = data[cancerStudy];\n\n for (const geneSymbol of Object.keys(cancerData)) {\n if (this.genomicDataMap[geneSymbol] === undefined)\n this.genomicDataMap[geneSymbol] = {};\n\n this.genomicDataMap[geneSymbol][cancerStudy] = data[cancerStudy][\n geneSymbol\n ].toFixed\n ? data[cancerStudy][geneSymbol].toFixed(2)\n : data[cancerStudy][geneSymbol];\n }\n }\n //This parameter is used as flag for PatientView PathwayMapper Functions\n if (data[\"PatientView\"] == 1) {\n this.patientData = data;\n this.showPatientData();\n } else {\n this.showGenomicData();\n }\n this.notifyObservers();\n }\n\n clearAllGenomicData = function() {\n this.genomicDataMap = {};\n this.visibleGenomicDataMapByType = {};\n this.groupedGenomicDataMap = {};\n this.groupedGenomicDataCount = 0;\n };\n\n removeGenomicData() {\n this.genomicDataMap = {};\n }\n\n removeGenomicDataWithGeneSymbol(geneSymbol) {\n this.genomicDataMap[geneSymbol] = {};\n }\n\n addGenomicVisData(key, data) {\n this.visibleGenomicDataMapByType[key] = data;\n }\n\n prepareGenomicDataShareDB = function(genomicData) {\n const genomicDataMap = {};\n const cancerTypes = [];\n const visibleGenomicDataMapByType = {};\n\n // By lines\n const lines = genomicData.split(\"\\n\");\n // First line is meta data !\n const metaLineColumns = lines[0].split(\"\\t\");\n\n // Parse cancer types\n for (let i = 1; i < metaLineColumns.length; i++) {\n cancerTypes.push(metaLineColumns[i]);\n // Update initially visible genomic data boxes !\n if (i - 1 < this.DEFAULT_VISIBLE_GENOMIC_DATA_COUNT) {\n visibleGenomicDataMapByType[cancerTypes[i - 1]] = true;\n } else {\n visibleGenomicDataMapByType[cancerTypes[i - 1]] = false;\n }\n }\n\n // parse genomic data\n for (let i = 1; i < lines.length; i++) {\n // EOF check\n if (lines[i].length === 0) {\n break;\n }\n\n // Split each line by tab and parse genomic data content\n const lineContent = lines[i].split(\"\\t\");\n const geneSymbol = lineContent[0];\n\n // If current gene entry is not in genomic data map create new hashmap entry\n if (!(geneSymbol in genomicDataMap)) {\n genomicDataMap[geneSymbol] = {};\n }\n\n // Add each entry of genomic data\n for (let j = 1; j < lineContent.length; j++) {\n genomicDataMap[geneSymbol][cancerTypes[j - 1]] = lineContent[j];\n }\n }\n\n const returnObj = {\n genomicDataMap: genomicDataMap,\n visibilityMap: visibleGenomicDataMapByType,\n };\n\n return returnObj;\n };\n\n updateGenomicDataVisibility = function(_key, isVisible) {\n if (_key in this.visibleGenomicDataMapByType) {\n this.visibleGenomicDataMapByType[_key] = isVisible;\n }\n };\n\n hideGenomicData = function() {\n this.cy\n .style()\n .selector('node[type=\"GENE\"]')\n .style(\"text-margin-y\", 0)\n .style(\"background-image\", function(ele) {\n const dataURI = \"data:image/svg+xml;utf8,\";\n return dataURI;\n })\n .update();\n };\n\n countVisibleGenomicDataByType() {\n // Count the genomic data that will be displayed on nodes' body\n let genomicDataBoxCount = 0;\n for (let cancerType in this.visibleGenomicDataMapByType) {\n if (this.visibleGenomicDataMapByType[cancerType]) {\n genomicDataBoxCount++;\n }\n }\n\n return genomicDataBoxCount;\n }\n\n generateSVGForNode(ele) {\n const genomicDataBoxCount = this.countVisibleGenomicDataByType();\n\n // Experimental data overlay part !\n const dataURI = \"data:image/svg+xml;utf8,\";\n const svgNameSpace = \"http://www.w3.org/2000/svg\";\n\n const nodeLabel = ele.data(\"name\");\n // If there is no genomic data for this node return !\n if (!(nodeLabel in this.genomicDataMap)) {\n return dataURI;\n }\n\n const eleBBox = ele.boundingBox();\n const reqWidth = this.getRequiredWidthForGenomicData(genomicDataBoxCount);\n const overlayRecBoxW = reqWidth - 10;\n const overlayRecBoxH = 25;\n const svg: any = document.createElementNS(svgNameSpace, \"svg\");\n // It seems this should be set according to the node size !\n svg.setAttribute(\"width\", reqWidth);\n svg.setAttribute(\"height\", eleBBox.h);\n // This is important you need to include this to succesfully render in cytoscape.js!\n svg.setAttribute(\"xmlns\", svgNameSpace);\n\n // Overlay Data Rect\n const overLayRectBBox = {\n w: overlayRecBoxW,\n h: overlayRecBoxH,\n x: reqWidth / 2 - overlayRecBoxW / 2,\n y: eleBBox.h / 2 + overlayRecBoxH / 2 - 18,\n };\n\n const genomicFrequencyData = this.genomicDataMap[nodeLabel];\n\n let maxGenomicDataBoxCount = /*(genomicDataBoxCount > 3) ? 3:*/ genomicDataBoxCount;\n let genomicBoxCounter = 0;\n\n for (let i in this.groupedGenomicDataMap) {\n for (let j in this.groupedGenomicDataMap[i]) {\n const cancerType = this.groupedGenomicDataMap[i][j];\n if (!this.visibleGenomicDataMapByType[cancerType]) {\n continue;\n }\n\n if (genomicFrequencyData[cancerType] !== undefined) {\n genomicDataRectangleGenerator(\n overLayRectBBox.x +\n (genomicBoxCounter * overLayRectBBox.w) / maxGenomicDataBoxCount,\n overLayRectBBox.y,\n overLayRectBBox.w / maxGenomicDataBoxCount,\n overLayRectBBox.h,\n genomicFrequencyData[cancerType],\n svg,\n this.colorScheme\n );\n } else {\n genomicDataRectangleGenerator(\n overLayRectBBox.x +\n (genomicBoxCounter * overLayRectBBox.w) / maxGenomicDataBoxCount,\n overLayRectBBox.y,\n overLayRectBBox.w / maxGenomicDataBoxCount,\n overLayRectBBox.h,\n null,\n svg,\n this.colorScheme\n );\n }\n\n genomicBoxCounter++;\n }\n }\n\n function hexToRGB(hex: string) {\n var result = /^#?([a-f\\d]{2})([a-f\\d]{2})([a-f\\d]{2})$/i.exec(hex);\n\n return result\n ? {\n r: parseInt(result[1], 16),\n g: parseInt(result[2], 16),\n b: parseInt(result[3], 16),\n }\n : null;\n }\n\n function swap(a, b) {\n let temp = a;\n a = b;\n b = temp;\n }\n\n function findValueColorInterval(\n colorScheme: IColorValueMap,\n value: number\n ): { lower: ValueColorPair; upper: ValueColorPair } {\n const pairs = Object.entries(colorScheme)\n .map(([value, color]) => {\n return {\n value: Number(value),\n color: hexToRGB(color),\n };\n })\n .sort((o1, o2) => {\n return o1.value - o2.value;\n });\n\n if (value < pairs[0].value) {\n return {\n lower: {\n value: -Infinity,\n color: pairs[0].color,\n },\n upper: {\n value: pairs[0].value,\n color: pairs[0].color,\n },\n };\n } else if (value > pairs[pairs.length - 1].value) {\n return {\n lower: {\n value: pairs[pairs.length - 1].value,\n color: pairs[pairs.length - 1].color,\n },\n upper: {\n value: Infinity,\n color: pairs[pairs.length - 1].color,\n },\n };\n } else {\n for (let i = 0; i < pairs.length - 1; i++) {\n if (value >= pairs[i].value && value < pairs[i + 1].value) {\n return {\n lower: {\n value: pairs[i].value,\n color: pairs[i].color,\n },\n upper: {\n value: pairs[i + 1].value,\n color: pairs[i + 1].color,\n },\n };\n }\n }\n\n return {\n lower: {\n value: -Infinity,\n color: pairs[0].color,\n },\n upper: {\n value: Infinity,\n color: pairs[pairs.length - 1].color,\n },\n };\n }\n }\n\n /**\n * Map the percentage value to r,g,b values using a log scale, i.e instead of taking the ratio linearly by taking differences\n * between the lower and upper color r,g,b values, take the differences between their Math.log values. This makes the color\n * scale up to the upper value much quicker, i.e in a 0-100 mapping a value of 20 doesn't map to 1/5 way between two colors\n * but closer to half way. This is done because high numbers in alteration values are extremely rare and even small numbers\n * are usually significant.\n */\n function getMappedColor(\n lowerColor: Color,\n upperColor: Color,\n lowerValue: number,\n upperValue: number,\n percent: number\n ): Color {\n const up = Math.log(1 + upperValue);\n const low = Math.log(1 + lowerValue);\n const p = Math.log(1 + (percent >= 0 ? percent : percent * -1));\n\n // arbitrary value used to slow down the scaling of log instead of getting too much into math\n const scalingFactor = percent >= 0 ? 0.8 : 1.2;\n\n const ratio = ((p - low) / (up - low)) * scalingFactor;\n\n return {\n r: lowerColor.r + ratio * (upperColor.r - lowerColor.r),\n g: lowerColor.g + ratio * (upperColor.g - lowerColor.g),\n b: lowerColor.b + ratio * (upperColor.b - lowerColor.b),\n };\n }\n\n function genomicDataRectangleGenerator(\n x,\n y,\n w,\n h,\n percent,\n parentSVG,\n colorScheme\n ) {\n const limits = findValueColorInterval(colorScheme, Number(percent));\n let color: Color = { r: 255, g: 255, b: 255 };\n if (limits.lower.value === -Infinity) {\n color = limits.upper.color;\n } else if (limits.upper.value === Infinity) {\n color = limits.lower.color;\n } else {\n let upperValue = limits.upper.value;\n let lowerValue = limits.lower.value;\n let upperColor = limits.upper.color;\n let lowerColor = limits.lower.color;\n\n if (lowerValue < 0 && upperValue <= 0) {\n lowerValue *= -1;\n upperValue *= -1;\n swap(lowerValue, upperValue);\n } else if (lowerValue < 0 && upperValue > 0) {\n upperValue += lowerValue * -1;\n lowerValue = 0;\n }\n\n color = getMappedColor(\n lowerColor,\n upperColor,\n lowerValue,\n upperValue,\n Number(percent)\n );\n }\n\n let colorString = \"\";\n if (percent) {\n colorString = `rgb(${Math.round(color.r)}, ${Math.round(\n color.g\n )}, ${Math.round(color.b)})`;\n // Rectangle Part\n const overlayRect = document.createElementNS(svgNameSpace, \"rect\");\n overlayRect.setAttribute(\"x\", x);\n overlayRect.setAttribute(\"y\", y);\n overlayRect.setAttribute(\"width\", w);\n overlayRect.setAttribute(\"height\", h);\n overlayRect.setAttribute(\n \"style\",\n \"stroke-width:1;stroke:rgb(0,0,0);opacity:1;fill:\" + colorString + \";\"\n );\n\n // Text Part\n if (percent[0] === \"-\") {\n percent = percent.substr(1);\n }\n const textPercent =\n percent < 0.5 && percent > 0 ? \"<0.5\" : Number(percent).toFixed(1);\n const text = percent == -101 ? \"N/P\" : textPercent + \"%\";\n const fontSize = 14;\n const textLength = text.length;\n const xOffset = w / 2 - textLength * 4;\n const yOffset = fontSize / 3;\n\n const svgText = document.createElementNS(svgNameSpace, \"text\");\n svgText.setAttribute(\"x\", x + xOffset);\n svgText.setAttribute(\"y\", y + h / 2 + yOffset);\n svgText.setAttribute(\"font-family\", \"Arial\");\n svgText.setAttribute(\"font-size\", fontSize + \"\");\n svgText.innerHTML = text;\n\n parentSVG.appendChild(overlayRect);\n parentSVG.appendChild(svgText);\n } else {\n colorString = \"rgb(210,210,210)\";\n\n // Rectangle Part\n const overlayRect = document.createElementNS(svgNameSpace, \"rect\");\n overlayRect.setAttribute(\"x\", x);\n overlayRect.setAttribute(\"y\", y);\n overlayRect.setAttribute(\"width\", w);\n overlayRect.setAttribute(\"height\", h);\n overlayRect.setAttribute(\n \"style\",\n \"stroke-width:1;stroke:rgb(0,0,0);opacity:1;fill:\" + colorString + \";\"\n );\n\n parentSVG.appendChild(overlayRect);\n }\n }\n\n return svg;\n }\n\n // Just an utility function to calculate required width for genes for genomic data !\n getRequiredWidthForGenomicData(genomicDataBoxCount) {\n const term = genomicDataBoxCount > 3 ? genomicDataBoxCount - 3 : 0;\n return 150 + term * 35;\n }\n\n updateColorScheme(colorValueMap: IColorValueMap) {\n this.colorScheme = colorValueMap;\n }\n\n showGenomicData() {\n const self = this;\n\n const genomicDataBoxCount = this.countVisibleGenomicDataByType();\n\n if (genomicDataBoxCount < 1) {\n // Hide all genomic data and return\n this.hideGenomicData();\n return;\n }\n\n this.cy.nodes('[type=\"GENE\"]').forEach(node => {\n node.data('w', this.getRequiredWidthForGenomicData(genomicDataBoxCount));\n })\n\n this.cy\n .style()\n .selector('node[type=\"GENE\"]')\n .style(\"text-margin-y\", function(ele) {\n const nodeLabel = ele.data(\"name\");\n // If there is no genomic data for this node return !\n if (!(nodeLabel in self.genomicDataMap)) {\n return 0;\n }\n\n // Else shift label in Y axis\n return -15;\n })\n .style(\"background-image\", function(ele) {\n const x = encodeURIComponent(self.generateSVGForNode(ele).outerHTML);\n if (x === \"undefined\") {\n return \"none\";\n }\n const dataURI = \"data:image/svg+xml;utf8,\" + x;\n return dataURI;\n })\n .update();\n }\n\n parseGenomicData(genomicData, groupID) {\n this.genomicDataMap = this.genomicDataMap || {};\n this.visibleGenomicDataMapByType = this.visibleGenomicDataMapByType || {};\n this.groupedGenomicDataMap = this.groupedGenomicDataMap || {};\n const cancerTypes = [];\n\n // By lines\n const lines = genomicData.split(\"\\n\");\n // First line is meta data !\n const metaLineColumns = lines[0].split(\"\\t\");\n\n // Parse cancer types\n for (let i = 1; i < metaLineColumns.length; i++) {\n cancerTypes.push(metaLineColumns[i]);\n // Update initially visible genomic data boxes !\n if (i - 1 < this.DEFAULT_VISIBLE_GENOMIC_DATA_COUNT) {\n this.visibleGenomicDataMapByType[cancerTypes[i - 1]] = true;\n } else {\n this.visibleGenomicDataMapByType[cancerTypes[i - 1]] = false;\n }\n\n if (this.groupedGenomicDataMap[groupID] === undefined) {\n this.groupedGenomicDataMap[groupID] = [];\n }\n this.groupedGenomicDataMap[groupID].push(cancerTypes[i - 1]);\n }\n\n // parse genomic data\n for (let i = 1; i < lines.length; i++) {\n // EOF check\n if (lines[i].length === 0) {\n break;\n }\n\n // Split each line by tab and parse genomic data content\n const lineContent = lines[i].split(\"\\t\");\n const geneSymbol = lineContent[0];\n\n // If current gene entry is not in genomic data map create new map\n if (!(geneSymbol in this.genomicDataMap)) {\n this.genomicDataMap[geneSymbol] = {};\n }\n\n // Add each entry of genomic data\n for (let j = 1; j < lineContent.length; j++) {\n this.genomicDataMap[geneSymbol][cancerTypes[j - 1]] = lineContent[j];\n }\n }\n }\n\n // Simple observer-observable pattern for views!!!!!\n registerObserver(observer) {\n this.observers.push(observer);\n }\n\n notifyObservers() {\n for (const observer of this.observers) {\n observer.notify();\n }\n }\n\n //This method is needed to calculate the alteration Types for each gene\n getAlterationCountForPatient(geneData) {\n let count = 0;\n for (let altType in geneData) {\n count++;\n }\n return count;\n }\n\n //These methods are created to be used in CbioPortal PatientView they are not used\n //in ResultView Page or PathwayMapper Editor\n\n showPatientData() {\n const self = this;\n\n const data = this.patientData;\n\n // const genomicDataBoxCount = 3 //this.countVisibleGenomicDataByType(); //CHANGE\n const genomicDataBoxCount = data.geneticTrackData\n ? data.geneticTrackData.length\n : 3;\n if (genomicDataBoxCount < 1) {\n // Hide all genomic data and return\n this.hideGenomicData();\n return;\n }\n\n this.cy\n .style()\n .selector('node[type=\"GENE\"]')\n // It used to change the width of nodes only locally\n .style(\"width\", (ele) => {\n return this.getRequiredWidthForGenomicData(genomicDataBoxCount);\n })\n .style(\"text-margin-y\", function(ele) {\n const nodeLabel = ele.data(\"name\");\n\n // If there is no genomic data for this node return !\n if (!(nodeLabel in data)) {\n return 0;\n }\n\n // Else shift label in Y axis\n return -15;\n })\n .style(\"background-image\", function(ele) {\n const x = encodeURIComponent(\n // self.generateSVGForPatientNode(ele, data).outerHTML\n self.generateOncoprintForPatientNode(ele).outerHTML\n );\n if (x === \"undefined\") {\n return \"none\";\n }\n const dataURI = \"data:image/svg+xml;utf8,\" + x;\n return dataURI;\n })\n .update();\n\n this.cy.on(\"mouseover\", 'node[type=\"GENE\"]', function(event) {\n const node = event.target || event.cyTarget;\n const nodeLabel = node.data(\"name\");\n if (!data[nodeLabel]) {\n return;\n }\n\n let ref = node.popperRef();\n let dummyDomEle = document.createElement(\"div\");\n document.body.appendChild(dummyDomEle);\n\n let tip = tippy(dummyDomEle, {\n // tippy props:\n getReferenceClientRect: ref.getBoundingClientRect, // https://atomiks.github.io/tippyjs/v6/all-props/#getreferenceclientrect\n trigger: \"manual\", // mandatory, we cause the tippy to show programmatically.\n placement: \"bottom\",\n interactive: true,\n theme: \"cbioportal\",\n // your own custom props\n // content prop can be used when the target is a single element https://atomiks.github.io/tippyjs/v6/constructor/#prop\n content: () => {\n let content = self\n .generateHTMLContentForNodeTooltip(node, data)\n .get(0);\n\n return content;\n },\n onHidden(instance) {\n instance.destroy();\n dummyDomEle.remove();\n },\n });\n\n node.one(\"showqtipevent\", function() {\n tip.show();\n });\n\n node.on(\"mouseout\", function() {\n if (dummyDomEle && dummyDomEle[\"_tippy\"]) {\n tip.hide();\n }\n });\n\n node.trigger(\"showqtipevent\");\n });\n }\n\n //Every mutation type has a unique color coded. This method is used to retrieve the colors\n getOncoprintColors(selectedGene) {\n const oncoprintColors = {\n Missense_Mutation: \"rgb(0,128,0)\",\n inframe: \"#993404\",\n truncating: \"#000000\",\n Fusion: \"rgb(139,0,201)\",\n AMP: \"rgb(255,0,0)\",\n gain: \"#ffb6c1\",\n heatloss: \"#8fd8d8\",\n homdel: \"rgb(0,0,255)\",\n DeepDel: \"rgb(0,0,255)\",\n \"5'Flank\": \"rgb(207,88,188)\",\n in_frame_del: \"rgb(166,128,40)\",\n };\n\n if (oncoprintColors[selectedGene] !== undefined) {\n return oncoprintColors[selectedGene];\n } else {\n //Types are not on the list corresponds to black\n return \"rgb(0,0,0)\";\n }\n }\n generateSVGForPatientNode(ele, patientData) {\n //Here we should use the parameter patientData when calculating the expressions\n const genomicDataBoxCount = this.countVisibleGenomicDataByType();\n // Experimental data overlay part !\n const dataURI = \"data:image/svg+xml;utf8,\";\n const svgNameSpace = \"http://www.w3.org/2000/svg\";\n //nodeLabel refers to the nodeLabels in the overlay data\n const nodeLabel = ele.data(\"name\");\n // If there is no genomic data for this node return !\n if (!(nodeLabel in patientData)) {\n return dataURI;\n }\n //this parameter refers to the count of alteration types for each gene\n const alterationBoxCount = this.getAlterationCountForPatient(\n patientData[nodeLabel]\n );\n\n const eleBBox = ele.boundingBox();\n const svg: any = document.createElementNS(svgNameSpace, \"svg\");\n //this parameter is set to 12 since there are 12 different possiblities for types\n const term = alterationBoxCount > 12 ? alterationBoxCount - 12 : 0;\n const reqWidth = 150 + term * 35;\n\n const overlayRecBoxW = reqWidth - 10;\n const overlayRecBoxH = 25;\n\n // It seems this should be set according to the node size !\n svg.setAttribute(\"width\", reqWidth);\n svg.setAttribute(\"height\", eleBBox.h);\n // This is important you need to include this to succesfully render in cytoscape.js!\n svg.setAttribute(\"xmlns\", svgNameSpace);\n\n // Overlay Data Rect\n const overLayRectBBox = {\n w: overlayRecBoxW,\n h: overlayRecBoxH,\n x: reqWidth / 2 - overlayRecBoxW / 2,\n y: eleBBox.h / 2 + overlayRecBoxH / 2 - 18,\n };\n let genomicBoxCounter = 0;\n //required width is calculated for each gene since box count is different for each gene\n for (let j in patientData[nodeLabel]) {\n const genomicAlterationData = patientData[nodeLabel];\n const alterationType = j;\n\n if (!this.visibleGenomicDataMapByType[nodeLabel]) {\n continue;\n }\n //get the color string corresponding to the alterationType\n let colorString = this.getOncoprintColors(alterationType);\n\n if (genomicAlterationData[alterationType] !== undefined) {\n genomicDataRectangleGeneratorPatient(\n overLayRectBBox.x +\n (genomicBoxCounter * overLayRectBBox.w) / alterationBoxCount,\n overLayRectBBox.y,\n overLayRectBBox.w / alterationBoxCount,\n overLayRectBBox.h,\n 100,\n svg,\n alterationType,\n colorString\n );\n } else {\n genomicDataRectangleGeneratorPatient(\n overLayRectBBox.x +\n (genomicBoxCounter * overLayRectBBox.w) / alterationBoxCount,\n overLayRectBBox.y,\n overLayRectBBox.w / alterationBoxCount,\n overLayRectBBox.h,\n null,\n svg,\n \"\",\n null\n );\n }\n\n genomicBoxCounter++;\n }\n //This function differs from genomicRectangleGenerator. genomicDataRectangleGeneratorPatient\n //has an extra parameter text. In patient view alterationTypes of genes are displayed instead of\n //alteration percentage. Hence a text is sent to this method which is alterationType\n function genomicDataRectangleGeneratorPatient(\n x,\n y,\n w,\n h,\n percent,\n parentSVG,\n text,\n colorString\n ) {\n if (percent) {\n const isNegativePercent = percent < 0;\n // Rectangle Part\n const overlayRect = document.createElementNS(svgNameSpace, \"rect\");\n overlayRect.setAttribute(\"x\", x);\n overlayRect.setAttribute(\"y\", y);\n overlayRect.setAttribute(\"width\", w);\n overlayRect.setAttribute(\"height\", h);\n overlayRect.setAttribute(\n \"style\",\n \"stroke-width:1;stroke:rgb(0,0,0);opacity:1;fill:\" + colorString + \";\"\n );\n\n // Text Part\n const fontSize = 14;\n const textLength = 4;\n const xOffset = w / 2 - textLength * 4;\n const yOffset = fontSize / 3;\n\n const svgText = document.createElementNS(svgNameSpace, \"text\");\n if (colorString === \"rgb(0,0,0)\") {\n svgText.setAttribute(\"fill\", \"white\");\n }\n svgText.setAttribute(\"x\", x + xOffset);\n svgText.setAttribute(\"y\", y + h / 2 + yOffset);\n\n svgText.setAttribute(\"font-family\", \"Arial\");\n svgText.setAttribute(\"font-size\", fontSize + \"\");\n\n //first 4 letters of the alterationTypes are used\n svgText.innerHTML = text.substring(0, 4);\n parentSVG.appendChild(overlayRect);\n parentSVG.appendChild(svgText);\n } else {\n //Normally\n colorString = \"rgb(210,210,210)\";\n }\n }\n\n return svg;\n }\n\n generateOncoprintForPatientNode(ele) {\n // const dataURI = 'data:image/svg+xml;utf8,'\n // nodeLabel refers to the nodeLabels in the overlay data\n const patientData = this.patientData;\n const nodeLabel = ele.data(\"name\");\n const genomicData = patientData[nodeLabel];\n\n const svgNameSpace = \"http://www.w3.org/2000/svg\";\n const svgElement: any = document.createElementNS(svgNameSpace, \"svg\");\n\n if (!genomicData) {\n return { outerHTML: \"\" };\n }\n\n const ruleset = new GeneticAlterationRuleSet(\n genomicData.geneticTrackRuleSetParams\n );\n const cellWidth = 6;\n const cellPadding = 3;\n const cellHeight = 23;\n const cellVerticalPadding = 8;\n\n const universalShapes = ruleset.getUniversalShapes(cellWidth, cellHeight);\n\n const specificShapesPerDatum = ruleset.getSpecificShapesForDatum(\n genomicData.geneticTrackData,\n cellWidth,\n cellHeight\n );\n\n const shapesPerDatum = specificShapesPerDatum.map((specificShapes) =>\n universalShapes.concat(specificShapes)\n );\n\n shapesPerDatum.forEach((shapes, index) => {\n const offsetX = index * (cellWidth + cellPadding); // width + padding\n const offsetY = cellVerticalPadding;\n const g = document.createElementNS(svgNameSpace, \"g\");\n shapes.forEach((shape) =>\n g.appendChild(shapeToSvg(shape, offsetX, offsetY))\n );\n svgElement.appendChild(g);\n });\n\n // It seems this should be set according to the node size !\n svgElement.setAttribute(\n \"width\",\n ((cellWidth + cellPadding) * shapesPerDatum.length).toString()\n );\n svgElement.setAttribute(\n \"height\",\n (cellHeight + cellVerticalPadding).toString()\n );\n // This is important you need to include this to succesfully render in cytoscape.js!\n svgElement.setAttribute(\"xmlns\", svgNameSpace);\n\n return svgElement;\n }\n\n // Mapping of alteration type keys to strings\n // See: https://github.com/cBioPortal/cbioportal-frontend/blob/442e108208846255feb1ed5b309218cd44927fb9/src/shared/components/oncoprint/TooltipUtils.ts#L599\n getCNADisplayString(alterationTypeKey: number) {\n const disp_cna: { [integerCN: string]: string } = {\n \"-2\": \"HOMODELETED\",\n \"-1\": \"HETLOSS\",\n \"1\": \"GAIN\",\n \"2\": \"AMPLIFIED\",\n };\n return disp_cna[alterationTypeKey];\n }\n\n generateSvgIconForSample(iconColor: string, iconText: string) {\n var html =\n '' +\n '' +\n '' +\n \"\" +\n '' +\n '' +\n iconText +\n \"\" +\n \"\" +\n \"\";\n\n return html;\n }\n\n generateHTMLContentForNodeTooltip(ele, patientData) {\n const tooltipMaxHeight = \"200px\";\n const tooltipMaxWidth = \"200px\";\n const marginBetweenSamples = \"10px\";\n const sampleIconColorMap = patientData.sampleColors;\n const sampleIndexMap = patientData.sampleIndex;\n\n const nodeLabel = ele.data(\"name\");\n const data = patientData[nodeLabel];\n\n // Outer wrapper for the entire tooltip\n var wrapper = $(\"
\");\n wrapper.css({\n \"max-width\": tooltipMaxWidth,\n \"max-height\": tooltipMaxHeight,\n \"word-wrap\": \"break-word\",\n \"overflow-y\": \"auto\",\n });\n\n data.geneticTrackData.forEach((sample, sampleIndex) => {\n const sampleId = sample.sample;\n const iconColor = sampleIconColorMap[sampleId];\n const iconText = (sampleIndexMap[sampleId] + 1).toString();\n const sampleIconSvgHTML = this.generateSvgIconForSample(\n iconColor,\n iconText\n );\n\n const margin = sampleIndex > 0 ? marginBetweenSamples : \"0px\";\n\n // Inner wrapper for a single sample\n var sampleWrapper = $(\"
\");\n sampleWrapper.css({\n \"margin-top\": margin,\n });\n\n const sampleData = sample.data;\n var mutationInfo = [];\n var cnaInfo = [];\n var fusionInfo = [];\n sampleData.forEach((data) => {\n const geneSymbol = data.gene.hugoGeneSymbol;\n\n if (\n sample.disp_mut &&\n data.proteinChange &&\n data.mutationType !== \"Fusion\"\n ) {\n const proteinChange = data.proteinChange;\n mutationInfo.push({\n gene: geneSymbol,\n proteinChange: proteinChange,\n });\n }\n\n if (sample.disp_cna && data.alteration) {\n const cnaLabelKey = data.alteration;\n const cnaLabel = this.getCNADisplayString(cnaLabelKey);\n cnaInfo.push({\n gene: geneSymbol,\n cnaLabel: cnaLabel,\n });\n }\n\n if (\n sample.disp_fusion &&\n data.proteinChange &&\n data.mutationType === \"Fusion\"\n ) {\n const proteinChange = data.proteinChange;\n fusionInfo.push({\n gene: geneSymbol,\n proteinChange: proteinChange,\n });\n }\n });\n // Prepare HTML for tooltip\n var mutationInfoHTML = mutationInfo.length > 0 ? \"Mutation: \" : \"\";\n var cnaInfoHTML = cnaInfo.length > 0 ? \"CNA: \" : \"\";\n var fusionInfoHTML = fusionInfo.length > 0 ? \"Fusion: \" : \"\";\n\n mutationInfo.forEach((mutation, index) => {\n mutationInfoHTML +=\n \"\" + mutation.gene + \" \" + mutation.proteinChange + \"\";\n if (index !== mutationInfo.length - 1) {\n mutationInfoHTML += \", \";\n } else {\n mutationInfoHTML += \"
\";\n }\n });\n\n cnaInfo.forEach((cna, index) => {\n cnaInfoHTML += \"\" + cna.gene + \" \" + cna.cnaLabel + \"\";\n if (index !== cnaInfo.length - 1) {\n cnaInfoHTML += \", \";\n } else {\n cnaInfoHTML += \"
\";\n }\n });\n\n fusionInfo.forEach((fusion, index) => {\n fusionInfoHTML +=\n \"\" + fusion.gene + \" \" + fusion.proteinChange + \"\";\n if (index !== fusionInfo.length - 1) {\n fusionInfoHTML += \", \";\n } else {\n fusionInfoHTML += \"
\";\n }\n });\n const sampleIdHTML = \" \" + sampleId + \"\" + \"
\";\n sampleWrapper.append(\n $(\n \"
\" +\n sampleIconSvgHTML +\n sampleIdHTML +\n mutationInfoHTML +\n cnaInfoHTML +\n fusionInfoHTML +\n +\"
\"\n )\n );\n wrapper.append(sampleWrapper);\n });\n\n return wrapper;\n }\n}\n","import autobind from \"autobind-decorator\";\nimport { action, makeObservable, observable } from \"mobx\";\nimport LayoutProperties, { ILayoutProperties } from \"../modals/LayoutProperties\";\nimport { IColorValueMap, IProfileMetaData } from \"../ui/react-pathway-mapper\";\nimport CBioPortalAccessor from \"../utils/CBioPortalAccessor\";\nimport SVGExporter from \"../utils/SVGExporter\";\nimport GenomicDataOverlayManager from \"./GenomicDataOverlayManager\";\nimport ShareDBManager from \"./ShareDBManager\";\n\nconst _ = require('lodash');\n\nexport default class EditorActionsManager{\n\n public static defaultLayoutProperties: ILayoutProperties =\n {\n name: 'fcose',\n nodeRepulsion: 4500,\n idealEdgeLength: 50,\n edgeElasticity: 0.45,\n nestingFactor: 0.1,\n gravity: 0.25,\n numIter: 2500,\n tile: true,\n animate: true,\n randomize: false,\n gravityRangeCompound: 1.5,\n // Gravity force (constant) for compounds\n gravityCompound: 1.0,\n // Gravity range (constant)\n gravityRange: 3.8,\n // Amount of vertical space to put between degree zero nodes during tiling (can also be a function)\n tilingPaddingVertical: 10,\n // Amount of horizontal space to put between degree zero nodes during tiling (can also be a function)\n tilingPaddingHorizontal: 10,\n // Initial cooling factor for incremental layout\n initialEnergyOnIncremental: 0.5,\n animationDuration: 2000,\n animationEasing: 'cubic-bezier(0.17,0.72,0.41,0.98)',\n };\n \n public cy: any;\n public genomicDataOverlayManager: GenomicDataOverlayManager;\n public edgeEditing: any;\n public selectedNodeStack: any;\n public layoutProperties: ILayoutProperties;\n \n private FIT_CONSTANT: number;\n private observers: any[];\n private svgExporter: SVGExporter;\n private undoRedoManager: any;\n private isCbioPortal: boolean;\n private isCollaborative: boolean;\n private shareDBManager: ShareDBManager;\n private portalAccessor: CBioPortalAccessor;\n private viewUtilities: any;\n\n @observable\n private profiles: IProfileMetaData[];\n\n @observable\n private genomicDataOverlayColorScheme: IColorValueMap;\n\n private colorSchemeChangeCallback: (IColorValueMap) => void;\n\n constructor(isCollaborative: boolean, shareDBManager: any, cyInst: any, isCBioPortal: boolean,\n undoRedoManager: any, portalAccessor: CBioPortalAccessor, profiles: IProfileMetaData[],\n genomicDataOverlayColorScheme: IColorValueMap, colorSchemeChangeCallback: (IColorValueMap) => void)\n {\n // Set cy instance and set real time manager reference if collaborative mode\n makeObservable(this);\n this.cy = cyInst;\n this.isCollaborative = isCollaborative;\n this.isCbioPortal = isCBioPortal;\n this.profiles = profiles;\n this.genomicDataOverlayColorScheme = genomicDataOverlayColorScheme;\n this.colorSchemeChangeCallback = colorSchemeChangeCallback;\n \n const edgeEditingOptions = {\n bendPositionsFunction: function(ele) {\n return ele.data('bendPointPositions');\n },\n // A function parameter to get control point positions, should return positions of control points\n controlPositionsFunction: function(ele) {\n return ele.data('controlPointPositions');\n },\n // whether the anchor editing operations are undoable (requires cytoscape-undo-redo.js)\n undoable: true,\n // the size of bend shape is obtained by multipling width of edge with this parameter\n anchorShapeSizeFactor: 6,\n // whether to start the plugin in the enabled state\n enabled: !this.isCbioPortal,\n \n handleReconnectEdge: this.isCollaborative ? \n this.reconnectEdge.bind(this) :\n undefined,\n\n enableMultipleAnchorRemovalOption: true\n };\n \n this.edgeEditing = this.cy.edgeEditing(edgeEditingOptions);\n this.portalAccessor = portalAccessor;\n if(this.isCollaborative) {\n this.shareDBManager = shareDBManager;\n }\n\n this.FIT_CONSTANT = 50;\n\n this.layoutProperties = _.clone(EditorActionsManager.defaultLayoutProperties);\n this.observers = [];\n this.genomicDataOverlayManager = new GenomicDataOverlayManager(this.cy);\n this.svgExporter = new SVGExporter(this.edgeEditing, this);\n\n this.selectedNodeStack = {};\n this.undoRedoManager = undoRedoManager;\n this.undoRedoManager.action(\"changePositions\", this.doChangePosition, this.undoChangePosition);\n this.undoRedoManager.action(\"changeNodeSize\", this.doChangeNodeSize, this.undoChangeNodeSize);\n this.undoRedoManager.action(\"changeCompoundSize\", this.doChangeCompoundSize, this.undoChangeCompoundSize);\n this.undoRedoManager.action(\"changeName\", this.doChangename, this.undoChangeName);\n this.undoRedoManager.action(\"hideNode\", this.doHide, this.undoHide);\n this.undoRedoManager.action(\"showAllNodes\", this.doShow, this.undoShow);\n // HighlightOthers is the type of highlight from the menu and by searching, while highlightInvalidGenes is for only invalid genes\n this.undoRedoManager.action(\"highlightInvalidGenes\", this.doHighlightInvalidGenes, this.undoHighlightInvalidGenes);\n this.undoRedoManager.action(\"removeHighlightInvalidGenes\", this.undoHighlightInvalidGenes, this.doHighlightInvalidGenes);\n this.undoRedoManager.action(\"highlightOthers\", this.doHighlight, this.undoHighlight);\n this.undoRedoManager.action(\"removeOtherHighlight\", this.undoHighlight, this.doHighlight);\n\n };\n\n @action.bound\n setProfile(index: number, profile: IProfileMetaData) {\n this.profiles[index] = profile;\n }\n\n @action.bound\n addProfile(profile: IProfileMetaData) {\n this.profiles.push(profile);\n }\n\n @action.bound\n removeProfiles() {\n this.profiles.length = 0;\n }\n\n @action.bound\n setGenomicDataOverlayColorScheme(scheme: IColorValueMap) {\n this.genomicDataOverlayColorScheme = scheme;\n }\n\n @autobind\n setViewUtilities(viewUtilitiesRef: any) {\n this.viewUtilities = viewUtilitiesRef;\n }\n\n getGenomicDataOverlayColorScheme() : IColorValueMap {\n return this.genomicDataOverlayColorScheme;\n }\n\n handleChangePositionByAlignment(movedNodeArr: any)\n {\n if (this.isCollaborative)\n this.shareDBManager.changeElementsPositionByAlignment(movedNodeArr);\n else\n this.undoRedoManager.do(\"changePositions\", movedNodeArr)\n };\n\n /*\n * Undo redo for changing positions of nodes via programatically (node.position)\n * **/\n doChangePosition(movedNodes: any)\n {\n const newMovedNodes = [];\n\n for(let i = 0; i < movedNodes.length; i++)\n {\n const currentNodePosition =\n {\n x: movedNodes[i].node.position().x,\n y: movedNodes[i].node.position().y\n };\n newMovedNodes.push({node: movedNodes[i].node, oldPosition: currentNodePosition, nextPosition: movedNodes[i].nextPosition});\n movedNodes[i].node.position(movedNodes[i].nextPosition);\n }\n\n return newMovedNodes;\n };\n\n undoChangePosition(movedNodes: any)\n {\n var newMovedNodes = [];\n\n for(var i = 0; i < movedNodes.length; i++)\n {\n var currentNodePosition =\n {\n x: movedNodes[i].node.position().x,\n y: movedNodes[i].node.position().y\n };\n newMovedNodes.push({node: movedNodes[i].node, oldPosition: movedNodes[i].oldPosition, nextPosition: currentNodePosition});\n movedNodes[i].node.position(movedNodes[i].oldPosition);\n }\n\n return newMovedNodes;\n };\n\n changeNodePositionsByArrows(selectedNodes: any)\n {\n if (this.isCollaborative)\n this.shareDBManager.changeNodePositionsShareDB(selectedNodes);\n //node-editing extension already deals for the movement in local mode\n };\n\n /*\n * Undo redo for changing size of nodes\n * **/\n doChangeNodeSize (args: any)\n {\n args.ele.data('w', args.newWidth);\n args.ele.data('h', args.newHeight);\n args.ele.style('width', args.newWidth);\n args.ele.style('height', args.newHeight);\n\n return args;\n };\n\n undoChangeNodeSize(args: any)\n {\n args.ele.data('w', args.oldWidth);\n args.ele.data('h', args.oldHeight);\n args.ele.style('width', args.oldWidth);\n args.ele.style('height', args.oldHeight);\n\n return args;\n };\n\n /*\n * Undo redo for changing size of compounds\n * **/\n doChangeCompoundSize(args: any)\n {\n args.ele.style('min-width', args.newMinWidth);\n args.ele.style('min-width-bias-left', args.newMinWidthBiasLeft);\n args.ele.style('min-width-bias-right', args.newMinWidthBiasRight);\n args.ele.style('min-height', args.newMinHeight);\n args.ele.style('min-height-bias-top', args.newMinHeightBiasTop);\n args.ele.style('min-height-bias-bottom', args.newMinHeightBiasBottom);\n\n return args;\n };\n\n undoChangeCompoundSize(args: any)\n {\n if (args.oldMinWidth == undefined)\n {\n args.ele.style('min-width', 0);\n args.ele.style('min-width-bias-left', 0);\n args.ele.style('min-width-bias-right', 0);\n\n }\n else {\n args.ele.style('min-width', args.oldMinWidth);\n args.ele.style('min-width-bias-left', args.oldMinWidthBiasLeft);\n args.ele.style('min-width-bias-right', args.oldMinWidthBiasRight);\n }\n if (args.oldMinHeight == undefined)\n {\n args.ele.style('min-height', 0);\n args.ele.style('min-height-bias-top', 0);\n args.ele.style('min-height-bias-bottom', 0);\n }\n else {\n args.ele.style('min-height', args.oldMinHeight);\n args.ele.style('min-height-bias-top', args.oldMinHeightBiasTop);\n args.ele.style('min-height-bias-bottom', args.oldMinHeightBiasBottom);\n }\n\n return args;\n };\n\n changeName(ele: any, newName: any)\n {\n if (this.isCollaborative)\n {\n this.shareDBManager.changeName(ele, newName);\n }\n else\n {\n this.changeNameCy(ele, newName);\n }\n };\n\n changeNameCy(ele: any, newName: any)\n {\n var currentName = ele.data('name');\n var args = {ele: ele, oldName: currentName, newName: newName};\n this.undoRedoManager.do('changeName', args);\n };\n\n /*\n * Undo redo for changing name of nodes\n * **/\n doChangename(args: any)\n {\n\n var currentName = args.ele.data('name');\n var newArgs = {ele: args.ele, newName: args.newName, oldName: currentName};\n args.ele.data('name', args.newName);\n\n return newArgs;\n };\n\n undoChangeName(args: any)\n {\n\n var currentName = args.ele.data('name');\n var newArgs = {ele: args.ele, newName: args.newName, oldName: currentName};\n args.ele.data('name', args.oldName);\n\n return newArgs;\n };\n\n hideSelectedNodes()\n {\n //Hides the selected elements\n var sel = this.cy.nodes(\":selected\");\n var nodesToHide = sel;\n var b = true;\n //Hides the parents if they have no children\n sel.parent().each((parent: any) =>\n {\n b=true;\n parent.children().each(function(ch: any)\n {\n if (!ch.selected())\n {\n if (ch.visible()) b=false;\n }\n }\n );\n if (b) nodesToHide = nodesToHide.add(parent);\n });\n this.cy.elements(\":selected\").unselect();\n if (this.isCollaborative)\n this.shareDBManager.changeVisibility(nodesToHide, true);\n else\n this.undoRedoManager.do('hideNode', nodesToHide);\n };\n\n /*\n * Undo redo for hiding nodes\n * **/\n @autobind\n doHide(args: any)\n {\n this.viewUtilities.hide(args);\n return args;\n };\n\n @autobind\n undoHide(args: any)\n {\n this.viewUtilities.show(args);\n return args;\n };\n\n showAllNodes()\n {\n var hid = this.cy.nodes(\":hidden\");\n if (this.isCollaborative)\n this.shareDBManager.changeVisibility(hid, false);\n else\n this.undoRedoManager.do('showAllNodes', hid);\n };\n\n /*\n * Undo redo for showing all nodes\n * **/\n @autobind\n doShow(args: any)\n {\n this.viewUtilities.show(args);\n return args;\n };\n\n @autobind\n undoShow(args: any)\n {\n this.viewUtilities.hide(args);\n return args;\n };\n\n highlightElementsInitially(invalidHighlightedGenesIDs: string[], invalidGenesIDs: string[],\n highlightedGenesIDs: string[], highlightedEdgesIDs: string[], hiddenGenesIDs: string[])\n {\n for (var i in invalidHighlightedGenesIDs)\n {\n this.cy.$('#'+invalidHighlightedGenesIDs[i]).addClass('invalidGeneHighlight');\n }\n for (var i in invalidGenesIDs)\n {\n this.cy.$('#'+invalidGenesIDs[i]).addClass('invalidGene');\n }\n for (var i in highlightedGenesIDs)\n {\n this.cy.$('#'+highlightedGenesIDs[i]).addClass('highlightedNode');\n }\n for (var i in highlightedEdgesIDs)\n {\n this.cy.$('#'+highlightedEdgesIDs[i]).addClass('highlightedEdge');\n }\n for (var i in hiddenGenesIDs)\n {\n this.viewUtilities.hide(this.cy.$('#'+hiddenGenesIDs[i]))\n }\n };\n\n validateGenes()\n {\n var geneSymbols = this.getGeneSymbols();\n this.portalAccessor.validateGenes(geneSymbols, this);\n }\n\n //Get all gene symbols\n getGeneSymbols()\n {\n var geneSymbols: any[] = [];\n this.cy.nodes().forEach( function (gene: any)\n {\n if(gene.data().type === \"GENE\")\n geneSymbols.push(gene.data().name);\n });\n return geneSymbols;\n }\n\n\n highlightInvalidGenes(validGeneSymbols: any)\n {\n if (this.isCollaborative)\n {\n var invalidGenes: any[] = [];\n this.cy.nodes().forEach( function (gene: any)\n {\n if(gene.data().type === \"GENE\")\n {\n var geneName = gene.data().name;\n if(validGeneSymbols.indexOf(geneName) < 0)\n invalidGenes.push(gene.id());\n }\n });\n this.shareDBManager.changeHighlightInvalidGenes(invalidGenes, true);\n // TODO: Amendment by Ziya\n /*\n if (invalidGenes.length > 0)\n this.notificationManager.createNotification(\"Invalid genes are highlighted\",\"fail\");\n else\n this.notificationManager.createNotification(\"All gene symbols are valid\",\"success\");*/\n }\n else\n {\n var highlightedGenes = this.cy.collection();\n this.cy.nodes().forEach( function (gene: any)\n {\n if(gene.data().type === \"GENE\")\n {\n var geneName = gene.data().name;\n if(validGeneSymbols.indexOf(geneName) < 0)\n highlightedGenes = highlightedGenes.add(gene);\n }\n });\n // TODO: Amendment by Ziya\n /*\n if (highlightedGenes.size() > 0)\n this.notificationManager.createNotification(\"Invalid genes are highlighted\",\"fail\");\n else\n this.notificationManager.createNotification(\"All gene symbols are valid\",\"success\");*/\n\n var nodesToAddInvalidHighlight = this.cy.collection();\n highlightedGenes.forEach(function(ele: any){\n if (!ele.hasClass('invalidGeneHighlight') && !ele.hasClass('invalidGene'))\n nodesToAddInvalidHighlight = nodesToAddInvalidHighlight.union(ele);\n });\n this.undoRedoManager.do('highlightInvalidGenes', nodesToAddInvalidHighlight);\n }\n }\n\n removeInvalidGeneHighlights(actions: any[])\n {\n if (this.isCollaborative)\n {\n var geneIDs: any[] = [];\n this.cy.nodes().forEach( function (gene: any)\n {\n if(gene.data().type === \"GENE\")\n {\n if(gene.hasClass('invalidGeneHighlight') || gene.hasClass('invalidGene'))\n geneIDs.push(gene.id());\n }\n });\n this.shareDBManager.changeHighlightInvalidGenes(geneIDs, false);\n }\n else\n {\n var nodesToRemoveInvalidHighlight = this.cy.collection();\n this.cy.nodes().forEach(function(ele: any){\n if (ele.hasClass('invalidGeneHighlight') || ele.hasClass('invalidGene'))\n nodesToRemoveInvalidHighlight = nodesToRemoveInvalidHighlight.union(ele);\n });\n actions.push({name: \"removeHighlightInvalidGenes\", param: nodesToRemoveInvalidHighlight});\n // this.undoRedoManager.do('removeHighlightInvalidGenes', nodesToRemoveInvalidHighlight);\n }\n }\n\n doHighlightInvalidGenes(args: any)\n {\n args.each(function(n: any)\n {\n if(n.hasClass('highlightedNode'))\n {\n n.removeClass('highlightedNode');\n n.addClass(\"invalidGeneHighlight\");\n }\n else\n n.addClass(\"invalidGene\");\n });\n return args;\n };\n\n undoHighlightInvalidGenes(args: any)\n {\n args.each(function(n: any)\n {\n if(n.hasClass('invalidGeneHighlight'))\n {\n n.removeClass('invalidGeneHighlight');\n n.addClass(\"highlightedNode\");\n }\n else\n n.removeClass(\"invalidGene\");\n });\n return args;\n }\n\n highlightSelected()\n {\n var sel = this.cy.elements(\":selected\");\n sel.unselect();\n var elementsToHighlight = this.cy.collection();\n sel.forEach(function(ele: any){\n if (!ele.hasClass('invalidGeneHighlight') && !ele.hasClass('highlightedNode') && !ele.hasClass('highlightedEdge'))\n elementsToHighlight = elementsToHighlight.union(ele);\n });\n if (this.isCollaborative)\n this.shareDBManager.changeHighlight(elementsToHighlight, true);\n else\n this.undoRedoManager.do('highlightOthers', elementsToHighlight);\n };\n\n highlightNeighbors()\n {\n var sel = this.cy.elements(\":selected\");\n var neighbors = sel.neighborhood();\n neighbors = neighbors.union(sel);\n neighbors.unselect();\n var elementsToHighlight = this.cy.collection();\n neighbors.forEach(function(ele: any){\n if (!ele.hasClass('invalidGeneHighlight') && !ele.hasClass('highlightedNode') && !ele.hasClass('highlightedEdge'))\n elementsToHighlight = elementsToHighlight.union(ele);\n });\n if (this.isCollaborative)\n this.shareDBManager.changeHighlight(elementsToHighlight, true);\n else\n this.undoRedoManager.do('highlightOthers', elementsToHighlight);\n };\n\n highlightBySearch(args: any[])\n {\n if (this.isCollaborative)\n this.shareDBManager.changeHighlight(args, true);\n else\n this.undoRedoManager.do('highlightOthers', args);\n };\n\n removeOtherHighlight(actions: any[])\n {\n var nodesToRemoveHighlight = this.cy.collection();\n //TODO cytoscape selectors may provide more handy functionality instead of iterating over !\n this.cy.elements().forEach(function(ele: any){\n if (ele.hasClass('highlightedNode') || ele.hasClass('highlightedEdge') || ele.hasClass('invalidGeneHighlight'))\n nodesToRemoveHighlight = nodesToRemoveHighlight.add(ele);\n });\n\n if (this.isCollaborative)\n this.shareDBManager.changeHighlight(nodesToRemoveHighlight, false);\n else\n actions.push({name: \"removeOtherHighlight\", param: nodesToRemoveHighlight});\n // this.undoRedoManager.do('removeOtherHighlight', nodesToRemoveHighlight);\n };\n\n /*\n * Undo redo for highlighting of nodes\n * **/\n doHighlight(args: any)\n {\n args.each(function(n: any)\n {\n if (n.isEdge())\n n.addClass(\"highlightedEdge\");\n else\n {\n if(n.hasClass('invalidGene'))\n {\n n.removeClass(\"invalidGene\");\n n.addClass(\"invalidGeneHighlight\");\n }\n else\n n.addClass(\"highlightedNode\");\n }\n });\n return args;\n };\n\n undoHighlight(args: any)\n {\n args.each(function(n: any)\n {\n if (n.isEdge())\n n.removeClass(\"highlightedEdge\");\n else\n {\n if(n.hasClass('invalidGeneHighlight'))\n {\n n.removeClass(\"invalidGeneHighlight\");\n n.addClass(\"invalidGene\");\n }\n else\n n.removeClass(\"highlightedNode\");\n }\n });\n return args;\n };\n\n removeAllHighlight()\n {\n let actions: any[] = [];\n this.removeInvalidGeneHighlights(actions);\n this.removeOtherHighlight(actions);\n this.cy.undoRedo().do(\"batch\", actions);\n };\n\n postLayout()\n {\n if (this.isCollaborative)\n {\n //Previously this.cy.nodes() was sent as an argument in moveElements function but it caused a problem when\n // the compound node was moved before the child nodes\n var movedNodes = this.cy.collection();\n var parentNodes = this.cy.collection();\n this.cy.nodes().forEach(function(node: any)\n {\n if (!node.isParent())\n movedNodes = movedNodes.add(node);\n else\n parentNodes = parentNodes.add(node);\n });\n this.moveElements(movedNodes);\n this.moveElements(parentNodes);\n\n var newState = {\n zoomLevel: this.cy.zoom(),\n panLevel: this.cy.pan()\n };\n this.updateGlobalOptions(newState);\n }\n };\n\n /*\n * Gets the first empty index from the list in cloud model\n * **/\n getEmptyGroupID()\n {\n if(this.isCollaborative)\n return this.shareDBManager.getEmptyGroupID();\n else\n return this.genomicDataOverlayManager.getEmptyGroupID();\n };\n\n /*\n * Gets the first empty index from the list in cloud model\n * **/\n groupGenomicData(cancerNames: any[], groupID: string)\n {\n return this.shareDBManager.groupGenomicData(cancerNames, groupID);\n };\n\n addPubmedIDs(edge: any, pubmedIDs: number[])\n {\n if (this.isCollaborative)\n {\n this.shareDBManager.addPubmedIDs(edge.id(), pubmedIDs);\n }\n else\n {\n var pubmedArray = edge.data('pubmedIDs');\n var validPubmedIDs = _.filter(pubmedIDs, function(id: number){\n return !isNaN(id);\n });\n pubmedArray.push.apply(pubmedArray,validPubmedIDs);\n edge.data('pubmedIDs', _.uniq(pubmedArray));\n }\n }\n\n removePubmedID(edge: any, pubmedIDs: number[])\n {\n if (this.isCollaborative)\n {\n this.shareDBManager.removePubmedID(edge.id(), pubmedIDs);\n }\n else\n {\n var pubmedArray = edge.data('pubmedIDs');\n edge.data('pubmedIDs', _.difference(pubmedArray, pubmedIDs));\n }\n }\n\n updateEdgeAnchorPoints(edge: any)\n {\n if (this.isCollaborative)\n {\n var edgeCurveStyle = edge.css('curve-style')\n var numberOfAnchorPoints = 0;\n var anchors = this.edgeEditing.getAnchorsAsArray(edge);\n if (anchors !== undefined)\n numberOfAnchorPoints = anchors.length / 2;\n var anchorPointsArray = [];\n for (var j = 0; j < numberOfAnchorPoints; j++)\n {\n anchorPointsArray.push(\n {\n x: anchors[2*j],\n y: anchors[2*j+1]\n }\n );\n } \n this.shareDBManager.updateEdgeAnchorPoints(edge.id(), anchorPointsArray, edgeCurveStyle);\n }\n }\n\n //Related to order the nodes according to the selection of user\n pushSelectedNodeStack(ele: any)\n {\n this.selectedNodeStack[ele.id()] = ele;\n }\n\n removeElementFromSelectedNodeStack(ele: any)\n {\n var nodeID = ele.id();\n if (nodeID in this.selectedNodeStack)\n delete this.selectedNodeStack[ele.id()];\n }\n\n clearSelectedNodeStack()\n {\n this.selectedNodeStack = {};\n }\n\n exportSVG()\n {\n return this.svgExporter.exportGraph(this.cy.nodes(), this.cy.edges());\n }\n\n //Simple observer-observable pattern for views!!!!!\n registerObserver(observer: any)\n {\n this.observers.push(observer);\n };\n\n notifyObservers()\n {\n for (var i in this.observers)\n {\n var observer = this.observers[i];\n observer.notify();\n }\n };\n\n registerGenomicDataObserver(observer: any)\n {\n this.genomicDataOverlayManager.registerObserver(observer);\n }\n\n updateGenomicDataVisibility(dataMap: any)\n {\n if(this.isCollaborative)\n {\n //TODO compound OP\n // this.shareDBManager.clearGenomicVisData();\n this.shareDBManager.addGenomicVisibilityData(dataMap);\n }\n else\n {\n for (var _key in dataMap)\n {\n this.genomicDataOverlayManager.updateGenomicDataVisibility(_key, dataMap[_key]);\n }\n this.genomicDataOverlayManager.showGenomicData();\n }\n }\n\n updateGenomicDataColorScheme(colorValueMap: IColorValueMap)\n {\n this.setGenomicDataOverlayColorScheme(colorValueMap);\n \n if(this.isCollaborative)\n {\n this.shareDBManager.updateGenomicDataOverlayColorScheme(colorValueMap);\n }\n else\n {\n this.genomicDataOverlayManager.updateColorScheme(colorValueMap);\n this.genomicDataOverlayManager.showGenomicData();\n }\n }\n\n //Global options related functions, zoom etc..\n getGlobalOptions()\n {\n return {\n zoomLevel: this.cy.zoom(),\n panLevel: this.cy.pan()\n };\n }\n\n changeGlobalOptions(op: any)\n {\n var globalOptions = op.li;\n this.cy.zoom(globalOptions.zoomLevel);\n this.cy.pan(globalOptions.panLevel);\n }\n\n updateGlobalOptions(newOptions: any)\n {\n if(this.isCollaborative)\n this.shareDBManager.updateGlobalOptions(newOptions);\n }\n\n //Layout properties related functions\n saveLayoutProperties(newLayoutProps: any)\n {\n if(this.isCollaborative)\n {\n // Call a real time function that updated real time object and\n // its callback (updateLayoutPropertiesCallback) will handle sync of this object\n // across collaborators\n this.shareDBManager.updateLayoutProperties(newLayoutProps);\n }\n else\n {\n this.layoutProperties = _.clone(newLayoutProps);\n }\n };\n\n updateLayoutPropertiesCallback(op: any)\n {\n var newLayoutProps = op.li;\n this.layoutProperties = _.clone(newLayoutProps);\n LayoutProperties.layoutProperties = _.clone(this.layoutProperties);\n //Notify observers to reflect changes on colalborative object to the views\n this.notifyObservers();\n };\n\n performLayout()\n {\n this.undoRedoManager.do(\"layout\", {options: this.layoutProperties, eles: null, zoom: this.cy.zoom(), pan: this.cy.pan()});\n };\n\n //Node Related Functions\n addNode(nodeData: any, posData: any)\n {\n if (this.isCollaborative)\n {\n this.addNewNodeToShareDB(nodeData, posData);\n }\n else\n {\n this.addNodetoCy(nodeData,posData);\n }\n };\n\n addNodes(nodes: any[])\n {\n for (var i in nodes)\n {\n this.addNode(nodes[i].data, nodes[i].position);\n }\n };\n\n addNodesCy(nodes: any[])\n {\n var nodeArr: any[] = [];\n for (var i in nodes)\n {\n var nodeData = nodes[i].data;\n var posData = nodes[i].position;\n\n var newNode =\n {\n group: \"nodes\",\n data: nodeData,\n position: {}\n };\n\n if (nodeData.parent === undefined )\n {\n delete newNode.data.parent;\n }\n\n if (posData)\n {\n newNode.position =\n {\n x: posData.x,\n y: posData.y\n }\n }\n nodeArr[i] = newNode;\n }\n\n this.cy.add(nodeArr);\n this.cy.nodes().updateCompoundBounds();\n\n };\n\n addNodetoCy(nodeData: any, posData: any)\n {\n var newNode =\n {\n group: \"nodes\",\n data: nodeData,\n position: {}\n };\n\n if (nodeData.parent === undefined )\n {\n delete newNode.data.parent;\n }\n\n if (posData)\n {\n newNode.position =\n {\n x: posData.x,\n y: posData.y\n }\n }\n\n //his.cy.add(newNode);\n this.cy.nodes().updateCompoundBounds();\n this.undoRedoManager.do(\"add\", newNode);\n //Width was not properly updated only by changing data property\n var thatEle = this.cy.getElementById(nodeData.id);\n thatEle.style('width', thatEle.data('w'));\n };\n\n shareDBNodeAddRemoveEventCallBack(op: any)\n {\n //Get real time node object and sync it to node addition or removal\n var isRemove = Object.keys(op)[1] === 'od';\n var node = op.oi || op.od;\n //Removal Operation\n if (isRemove)\n {\n var nodeID = op.p[1];\n //Remove element from existing graph\n var cyEle = this.cy.$(\"#\" + nodeID);\n this.removeElementCy(cyEle);\n this.cy.nodes().updateCompoundBounds();\n }\n //Addition Operation\n else\n {\n this.addNewNodeLocally(node);\n }\n };\n\n addNewNodeLocally(realtimeNode: any)\n {\n var nodeData =\n {\n id: realtimeNode.id,\n type: realtimeNode.type,\n name: realtimeNode.name,\n parent: realtimeNode.parent,\n w: realtimeNode.w,\n h: realtimeNode.h\n };\n\n if (realtimeNode.x != \"undefined\" && realtimeNode.y != \"undefined\")\n {\n this.addNodetoCy(nodeData, {x: realtimeNode.x, y: realtimeNode.y});\n }\n else\n {\n // TODO: Amendment by Ziya\n this.addNodetoCy(nodeData, null);\n }\n\n this.cy.nodes().updateCompoundBounds();\n };\n\n addNewNodeToShareDB(nodeData: any, posData: any)\n {\n this.shareDBManager.addNewNode(nodeData,posData);\n };\n\n //Edge related functions\n addEdge(edgeData: any)\n {\n if (this.isCollaborative)\n {\n this.addNewEdgeShareDB(edgeData);\n }\n else\n {\n this.addNewEdgetoCy(edgeData);\n }\n };\n\n addEdges(edges: any[])\n {\n for (var i in edges)\n {\n this.addEdge(edges[i].data);\n }\n };\n\n addEdgesCy(edges: any[])\n {\n const newEdges = [];\n\n\n for (var i in edges)\n {\n const newEdge =\n {\n group: \"edges\",\n data: edges[i].data\n };\n newEdges.push(newEdge);\n }\n this.cy.add(newEdges);\n };\n\n addNewEdgeShareDB(edgeData: any)\n {\n this.shareDBManager.addNewEdge(edgeData);\n };\n\n addNewEdgetoCy(edgeData: any)\n {\n var newEdge =\n {\n group: \"edges\",\n data: edgeData\n };\n this.undoRedoManager.do(\"add\", newEdge);\n };\n\n shareDBEdgeAddRemoveEventCallBack(op: any)\n {\n\n //Get real time node object and sync it to node addition or removal\n var isRemove = Object.keys(op)[1] === 'od';\n var edge = op.oi || op.od;\n\n //Removal Operation\n if (isRemove)\n {\n var edgeID = op.p[1];\n //Remove element from existing graph\n var cyEle = this.cy.$(\"#\" + edgeID);\n this.removeElementCy(cyEle);\n }\n //Addition Operation\n else\n {\n this.addNewEdgeLocally(edge);\n }\n };\n\n addNewElementsLocally(realTimeNodeArray: any[], realTimeEdgeArray: any[])\n {\n const nodeList: any[] = [];\n const nodeMap: any = {};\n\n for (var i in realTimeNodeArray)\n {\n var realTimeNode = realTimeNodeArray[i];\n\n var nodeID = realTimeNode.id;\n\n //Added for backward compatibility when width was not defined\n var nodeWidth = (realTimeNode.w == undefined) ? 150 : realTimeNode.w ;\n var nodeHeight = (realTimeNode.h == undefined) ? 52 : realTimeNode.h ;\n var compoundMinWidth = (realTimeNode.minWidth == undefined) ? 0 : realTimeNode.minWidth ;\n var compoundMinWidthBiasLeft = (realTimeNode.minWidthBiasLeft == undefined) ? 0 : realTimeNode.minWidthBiasLeft ;\n var compoundMinWidthBiasRight = (realTimeNode.minWidthBiasRight == undefined) ? 0 : realTimeNode.minWidthBiasRight ;\n var compoundMinHeight = (realTimeNode.minHeight == undefined) ? 0 : realTimeNode.minHeight ;\n var compoundMinHeightBiasTop = (realTimeNode.minHeightBiasTop == undefined) ? 0 : realTimeNode.minHeightBiasTop ;\n var compoundMinHeightBiasBottom = (realTimeNode.minHeightBiasBottom == undefined) ? 0 : realTimeNode.minHeightBiasBottom;\n\n const nodeData =\n {\n group: 'nodes',\n // TODO: Amendment by Ziya\n position: {},\n data:\n {\n id: nodeID,\n type: realTimeNode.type,\n name: realTimeNode.name,\n parent: realTimeNode.parent,\n w: nodeWidth,\n h: nodeHeight\n },\n style:\n {\n 'min-width': compoundMinWidth,\n 'min-width-bias-left': compoundMinWidthBiasLeft,\n 'min-width-bias-right': compoundMinWidthBiasRight,\n 'min-height': compoundMinHeight,\n 'min-height-bias-top': compoundMinHeightBiasTop,\n 'min-height-bias-bottom': compoundMinHeightBiasBottom\n }\n };\n\n if (nodeData.data.parent === undefined )\n {\n delete nodeData.data.parent;\n }\n\n if (realTimeNode.x && realTimeNode.y)\n {\n nodeData.position =\n {\n x: realTimeNode.x,\n y: realTimeNode.y\n }\n }\n\n nodeMap[nodeID] = nodeData;\n nodeList.push(nodeData);\n }\n\n var edgeList = [];\n for (var i in realTimeEdgeArray)\n {\n var edge = realTimeEdgeArray[i];\n var edgeID = edge.id;\n\n //If source and and target is somehow lost in remote model do not create this edge\n if(!(edge.source in nodeMap && edge.target in nodeMap))\n continue\n\n var tmpData = {\n id: edgeID,\n type: edge.type,\n source: edge.source,\n target: edge.target,\n pubmedIDs: edge.pubmedIDs,\n name: edge.name,\n }\n\n if (edge.edgeCurveStyle == \"unbundled-bezier\") {\n tmpData['controlPointPositions'] = edge.anchorPoints;\n }\n else {\n tmpData['bendPointPositions'] = edge.anchorPoints;\n }\n\n var edgeData =\n {\n group: 'edges',\n data: tmpData\n };\n\n edgeList.push(edgeData);\n }\n\n this.cy.add(nodeList);\n this.cy.add(edgeList);\n\n this.edgeEditing.initAnchorPoints(this.cy.edges());\n\n this.cy.nodes().updateCompoundBounds();\n }\n\n addNewEdgeLocally(edge: any)\n {\n var edgeData ={\n id: edge.id,\n type: edge.type,\n source: edge.source,\n target: edge.target,\n pubmedIDs: edge.pubmedIDs,\n name: edge.name\n };\n if (edge.edgeCurveStyle == \"unbundled-bezier\") {\n edgeData['controlPointPositions'] = edge.anchorPoints;\n }\n else {\n edgeData['bendPointPositions'] = edge.anchorPoints;\n }\n this.addNewEdgetoCy(edgeData);\n this.edgeEditing.initAnchorPoints(this.cy.getElementById( edge.id ));\n };\n\n reconnectEdge(sourceID: string, targetID: string, edgeData: any) {\n\n if(this.isCollaborative){\n var edge = this.cy.getElementById(edgeData.id);\n this.reconnectEdgeInShareDB(sourceID, targetID, edgeData);\n }\n else{\n var location = {\n source: sourceID,\n target: targetID\n };\n\n var edge = this.cy.getElementById(edgeData.id);\n edge.move(location);\n }\n\n return this.cy.getElementById(edgeData.id);\n };\n\n reconnectEdgeInShareDB(sourceID: string, targetID: string, edgeData: any) {\n this.shareDBManager.reconnectEdge(sourceID, targetID, edgeData);\n };\n\n //Removal functions\n removeElement(ele: any)\n {\n if (this.isCollaborative)\n {\n this.removeElementsFromShareDB(ele);\n }\n else\n {\n this.removeElementsCy(ele);\n }\n };\n\n removeElementCy(ele: any)\n {\n this.undoRedoManager.do(\"remove\", ele);\n };\n\n removeElementsCy(ele: any)\n {\n this.undoRedoManager.do(\"remove\", ele);\n };\n\n removeElementsFromShareDB(eles: any[])\n {\n var self = this;\n eles.forEach(function (ele)\n {\n self.shareDBManager.removeElement(ele.id());\n });\n };\n\n removeElementFromShareDB(ele: any)\n {\n this.shareDBManager.removeElement(ele.id());\n };\n\n changeParents(eles: any[], newParentId: string)\n {\n if(this.isCollaborative)\n {\n this.changeParentShareDB(eles, newParentId);\n }\n else\n {\n var parentData = newParentId ? newParentId : null;\n\n // Old manual way to change parents in local mode\n //this.changeParentCy(eles, newParentId);\n\n //Save element's previous width & height in dim array\n const dim : any[]= [];\n const id : any[]= [];\n eles.forEach(function (ele: any)\n {\n var parameters =\n {\n id: ele.id(),\n width: ele.data(\"w\"),\n height: ele.data(\"h\")\n };\n dim.push(parameters);\n id.push(ele.id());\n });\n\n const parentElem = this.cy.getElementById(parentData);\n var param = {\n firstTime: true,\n parentData: parentData, // It keeps the newParentId (Just an id for each nodes for the first time)\n nodes: eles,\n posDiffX: (!parentData) ? 0 : parentElem.position('x') - eles[0].position('x'),\n posDiffY: (!parentData) ? 0 : parentElem.position('y') - eles[0].position('y')\n };\n this.undoRedoManager.do('changeParent', param);\n\n //The elements after change parent operation are different so we find them by using the saved ids\n // and add them to the collection\n var collection = this.cy.collection();\n for (var i in id)\n {\n var elementById = this.cy.getElementById(id[i]);\n collection = collection.add(elementById);\n }\n //Set their previous size to the new elements in the collection\n collection.forEach(function (ele: any, i: number)\n {\n if (ele.id() == dim[i].id)\n ele.data(\"w\", dim[i].width);\n ele.data(\"h\", dim[i].height);\n });\n }\n };\n\n changeParentShareDB (eles: any, newParentId: string)\n {\n\n var classRef = this;\n function getTopLevelParents(eles: any[])\n {\n var tpMostNodes = classRef.cy.collection();\n const parentMap : any = {};\n\n //Get all parents\n eles.forEach(function (node)\n {\n if(node.isParent())\n parentMap[node.id()] = node;\n });\n\n //Get all parents\n eles.forEach(function (node)\n {\n var nodeParent = node.parent();\n\n if(parentMap[nodeParent.id()] === undefined)\n tpMostNodes = tpMostNodes.union(node);\n });\n\n return tpMostNodes;\n }\n\n\n class NodeObj{\n public nodeRef: any;\n public children: any;\n constructor(nodeObj: any){\n this.nodeRef = nodeObj;\n this.children = [];\n }\n }\n var connectedEdges = eles.connectedEdges();\n // Traverses given elements and constructs subgraph relations\n // creates a nested structure into rootnodeObj\n function traverseNodes(eles: any[], rootNodeObj: any)\n {\n eles.forEach(function (ele)\n {\n connectedEdges = connectedEdges.union(ele.connectedEdges());\n\n if(ele.isParent())\n {\n rootNodeObj.children.push(new NodeObj(ele));\n var lengthOfChildrenArray = rootNodeObj.children.length;\n traverseNodes(ele.children(), rootNodeObj.children[lengthOfChildrenArray-1]);\n }\n else\n {\n rootNodeObj.children.push(new NodeObj(ele));\n }\n });\n }\n\n //Create new collection\n var topMostNodes = getTopLevelParents(eles);\n\n var rootNodeR = new NodeObj(null);\n\n traverseNodes(topMostNodes, rootNodeR);\n this.shareDBManager.changeParent(rootNodeR, newParentId, connectedEdges);\n };\n\n changeParentCy(eles: any[], newParentId: string)\n {\n let lockedNodes: any = {};\n const self = this;\n\n function removeNodes(nodes: any)\n {\n //Get removed edges first\n let removedEles = nodes.connectedEdges().remove();\n const children = nodes.children();\n\n if (children != null && children.length > 0)\n {\n children.forEach(function(childNode: any)\n {\n lockedNodes[childNode.id()] = true;\n });\n\n removedEles = removedEles.union(removeNodes(children));\n }\n\n removedEles = removedEles.union(nodes.remove());\n self.cy.nodes().updateCompoundBounds();\n return removedEles;\n }\n\n\n var removedEles = removeNodes(eles);\n this.undoRedoManager.do(\"remove\", removedEles);\n\n for (var i = 0; i < removedEles.length; i++)\n {\n var removedNode = removedEles[i];\n\n //Just alter the parent id of corresponding nodes !\n if (removedNode.isEdge() || lockedNodes[removedNode.id()])\n {\n continue;\n }\n\n removedNode._private.data.parent = newParentId;\n if(removedNode._private.parent){\n delete removedNode._private.parent;\n }\n }\n\n self.cy.add(removedEles);\n this.undoRedoManager.do(\"add\", removedEles);\n self.cy.nodes().updateCompoundBounds();\n };\n\n moveElements(eles: any[])\n {\n var classRef = this;\n //Sync movement to real time api\n if(this.isCollaborative)\n {\n eles.forEach(function (ele: any)\n {\n classRef.shareDBManager.moveElement(ele);\n });\n }\n };\n\n resizeElements(ele: any)\n {\n if(this.isCollaborative) {\n if (!ele.isParent()) {\n var previousWidth = ele.width();\n var previousHeight = ele.height();\n //Sync movement to real time api\n this.shareDBManager.resizeElement(ele, previousWidth, previousHeight);\n }\n else {\n var minWidth = ele.style('min-width');\n var minWidthBiasLeft = ele.style('min-width-bias-left');\n var minWidthBiasRight = ele.style('min-width-bias-right');\n var minHeight = ele.style('min-height');\n var minHeightBiasTop = ele.style('min-height-bias-top');\n var minHeightBiasBottom = ele.style('min-height-bias-bottom');\n\n //Sync movement to real time api\n this.shareDBManager.resizeCompound(ele, minWidth, minWidthBiasLeft, minWidthBiasRight, minHeight, minHeightBiasTop, minHeightBiasBottom);\n }\n }\n };\n\n mergeGraph(nodes: any[], edges: any[])\n {\n if (this.isCollaborative)\n {\n //Collaborative usage\n this.shareDBManager.mergeGraph(nodes,edges);\n }\n else\n {\n //Local usage file load\n this.mergeGraphCy(nodes,edges);\n }\n this.fitGraph();\n };\n\n mergeGraphCy(nodes: any[], edges: any[])\n {\n //Define arrays and maps\n const nodesToBeAdded = [];\n const edgesToBeAdded = [];\n const nodeMap : any= {};\n\n //Iterate over nodes and find nodes that does not exist in current graph by looking their name\n for (var index in nodes)\n {\n var ele = nodes[index];\n nodeMap[ele.data.id] = ele;\n\n if (this.cy.filter('node[name = \"'+ele.data.name+'\"]').length <= 0)\n {\n nodesToBeAdded.push(ele);\n }\n }\n\n this.cy.add(nodesToBeAdded);\n\n //Iterate over all edges\n for (var index in edges)\n {\n //Get corresponding source and target node in merge file\n var ele = edges[index];\n var sourceNode = nodeMap[ele.data.source];\n var targetNode = nodeMap[ele.data.target];\n\n //Check if there are nodes with same name in current graph\n var cySourceNode = this.cy.nodes('[name=\"'+sourceNode.data.name+'\"]');\n var targetNode = this.cy.nodes('[name=\"'+targetNode.data.name+'\"]');\n\n if (cySourceNode.length > 0)\n {\n ele.data.source = cySourceNode.id();\n }\n\n if (targetNode.length > 0)\n {\n ele.data.target = targetNode.id();\n }\n\n if (targetNode.length < 0 && cySourceNode.length < 0 ) {\n continue;\n }\n\n var edgesBtw = this.cy.filter('edge[source = \"'+cySourceNode.id()+'\"][target = \"'+targetNode.id()+'\"]');\n\n //We assume there could be one edge between source and target node with same type\n var isFound = false;\n edgesBtw.forEach(function(edge: any)\n {\n if (edge.data().type == ele.data.type)\n {\n isFound = true;\n return false;\n }\n //TODO: AMENDMENT by Ziya\n return true;\n });\n\n if (!isFound)\n {\n delete ele.data.id;\n edgesToBeAdded.push(ele);\n }\n }\n\n this.cy.add(edgesToBeAdded);\n };\n\n fitGraph()\n {\n if(this.isCollaborative)\n {\n this.cy.fit(this.FIT_CONSTANT);\n var newState =\n {\n zoomLevel: this.cy.zoom(),\n panLevel: this.cy.pan()\n };\n this.updateGlobalOptions(newState);\n }\n else\n {\n this.cy.fit(this.FIT_CONSTANT);\n }\n }\n\n loadFile(nodes: any[], edges: any[])\n {\n if (this.isCollaborative)\n {\n //Real time load graph\n this.loadfileShareDB(nodes, edges);\n }\n else\n {\n //Local usage file load\n this.loadFileCy(nodes,edges);\n }\n \n this.edgeEditing.initAnchorPoints(this.cy.edges());\n \n this.fitGraph();\n };\n\n loadFileCy(nodes: any[], edges: any[])\n {\n //Remove all elements\n this.removeElementCy(this.cy.elements());\n\n this.addNodesCy(nodes);\n this.addEdgesCy(edges);\n };\n\n loadfileShareDB(nodes: any[], edges: any[])\n {\n this.shareDBManager.loadGraph(nodes,edges);\n };\n\n removeAllElements()\n {\n if (this.isCollaborative)\n {\n this.shareDBManager.removeAllElements();\n }\n else\n {\n this.cy.remove(this.cy.elements());\n }\n };\n\n updateHighlight(ele: any, isHighlighted: boolean)\n {\n if (isHighlighted)\n this.undoRedoManager.do('highlightOthers', ele);\n else\n this.undoRedoManager.do('removeOtherHighlight', ele);\n };\n\n\n @autobind\n updateVisibility(ele: any, isHidden: boolean)\n {\n if (isHidden)\n this.viewUtilities.hide(ele);\n else\n this.viewUtilities.show(ele);\n };\n\n updateElementCallback(op: any)\n {\n var ele = op.oi;\n var eleID = ele.id;\n var cyEle = this.cy.$(\"#\" + eleID);\n this.changeNameCy(cyEle, ele.name);\n\n if (cyEle.isNode())\n {\n //Width and height of simple nodes and compounds is changed differently\n if (cyEle.isParent())\n {\n cyEle.style(\"min-width\", ele.minWidth);\n cyEle.style(\"min-width-bias-left\", ele.minWidthBiasLeft);\n cyEle.style(\"min-width-bias-right\", ele.minWidthBiasRight);\n cyEle.style(\"min-height\", ele.minHeight);\n cyEle.style(\"min-height-bias-top\", ele.minHeightBiasTop);\n cyEle.style(\"min-height-bias-bottom\", ele.minHeightBiasBottom);\n }\n else\n {\n cyEle.data('w', ele.w);\n cyEle.data('h', ele.h);\n //Position is changed only for simple nodes because the\n //position of compounds is defined by simple nodes' position\n cyEle.position({x: ele.x, y: ele.y});\n }\n\n this.updateVisibility(cyEle, ele.isHidden);\n this.updateHighlight(cyEle, ele.isHighlighted);\n\n if(ele.isInvalidGene)\n {\n this.doHighlightInvalidGenes(cyEle);\n }\n else\n {\n this.undoHighlightInvalidGenes(cyEle);\n }\n }\n else if(cyEle.isEdge())\n {\n var pubmedArray = ele.pubmedIDs;\n cyEle.data('pubmedIDs', pubmedArray);\n this.updateHighlight(cyEle, ele.isHighlighted);\n\n var anchorPoints = ele.anchorPoints;\n\n //If edge is reconnected\n if ( ele.source !== cyEle.source().id() || ele.target !== cyEle.target().id()){\n var location = {\n source: ele.source,\n target: ele.target\n };\n cyEle.move(location);\n //make sure that bend points are same\n this.edgeEditing.initAnchorPoints(cyEle);\n }\n else {\n if (ele.edgeCurveStyle === \"bezier\") {\n const anchors = this.edgeEditing.getAnchorsAsArray(cyEle);\n if (anchors && anchors.length > 0) {\n for (let i = 0; i < anchors.length / 2; i++) {\n this.edgeEditing.deleteSelectedAnchor(cyEle, 0);\n }\n }\n }\n else if (ele.edgeCurveStyle === \"unbundled-bezier\") {\n cyEle.data('controlPointPositions', anchorPoints);\n }\n else {\n cyEle.data('bendPointPositions', anchorPoints);\n }\n \n this.edgeEditing.initAnchorPoints(cyEle);\n }\n }\n };\n\n getGenomicDataSVG(node: any)\n {\n // @ts-ignore\n return this.genomicDataOverlayManager.generateSVGForNode(node);\n }\n\n getOncoprintDataSVG(node: any) \n {\n return this.genomicDataOverlayManager.generateOncoprintForPatientNode(node);\n }\n\n removeGenomicData()\n {\n if(this.isCollaborative)\n {\n this.shareDBManager.clearGenomicData();\n }\n else\n {\n // TODO wrap this in afunction in genomic data overlay manager\n this.genomicDataOverlayManager.clearAllGenomicData();\n this.genomicDataOverlayManager.hideGenomicData();\n this.genomicDataOverlayManager.notifyObservers();\n }\n\n }\n\n addGenomicData(genomicData: any)\n {\n const groupID = this.getEmptyGroupID();\n\n if(this.isCollaborative)\n {\n var parsedGenomicData = this.genomicDataOverlayManager.prepareGenomicDataShareDB(genomicData);\n this.shareDBManager.addGenomicData(parsedGenomicData.genomicDataMap);\n this.shareDBManager.groupGenomicData(Object.keys(parsedGenomicData.visibilityMap),\n groupID);\n this.shareDBManager.addGenomicVisibilityData(parsedGenomicData.visibilityMap);\n }\n else\n {\n this.genomicDataOverlayManager.addGenomicDataLocally(genomicData, groupID);\n }\n }\n\n adjustVisibilityShareDB(profileId: string, isEnabled: boolean){\n const targetProfileIndex = this.profiles.map(profile => profile.profileId).indexOf(profileId);\n this.setProfile(targetProfileIndex, {\n ...this.profiles[targetProfileIndex],\n enabled: isEnabled\n }); \n }\n\n addToProfiles(profileId: string){\n // Check if this profile already exists\n if(this.profiles.map(profile => profile.profileId).includes(profileId)){\n return;\n }\n\n this.addProfile({\n profileId: profileId, \n enabled: true\n });\n }\n\n addPortalGenomicData(genomicData: any, groupID: any)\n {\n \n if(this.isCollaborative)\n {\n var parsedGenomicData = this.genomicDataOverlayManager.preparePortalGenomicDataShareDB(genomicData);\n this.shareDBManager.addGenomicData(parsedGenomicData.genomicDataMap);\n this.shareDBManager.groupGenomicData(Object.keys(parsedGenomicData.visibilityMap),\n groupID);\n this.shareDBManager.addGenomicVisibilityData(parsedGenomicData.visibilityMap);\n }\n else\n {\n this.genomicDataOverlayManager.addPortalGenomicData(genomicData, groupID);\n }\n }\n\n shareDBGenomicDataHandler(op: any)\n {\n var isRemove = Object.keys(op)[1] === 'od';\n var newData = op.oi;\n var geneSymbol = op.p[1];\n\n\n if(!isRemove)\n {\n this.genomicDataOverlayManager.addGenomicDataWithGeneSymbol(geneSymbol, newData);\n\n }\n // Removal\n else\n {\n this.genomicDataOverlayManager.removeGenomicDataWithGeneSymbol(geneSymbol);\n }\n }\n\n\n shareDBGenomicDataGroupChangeHandler(op: any)\n {\n\n var isRemove = Object.keys(op)[1] === 'od';\n var data = op.oi;\n var key = op.p[1];\n\n // Addition\n if(!isRemove)\n {\n this.genomicDataOverlayManager.addGenomicGroupData(key, data);\n if(data.length !== 1){\n console.log(\"Grouped genomic data expected to be of length 1\");\n }\n data.forEach((profileId: any) => {this.addToProfiles(profileId)});\n }\n // //Removal\n // else\n // {\n //\n // }\n this.genomicDataOverlayManager.showGenomicData();\n this.genomicDataOverlayManager.notifyObservers();\n }\n\n shareDBGenomicDataVisibilityHandler(op: any)\n {\n var data = op.oi;\n var key = op.p[1];\n var isRemove = Object.keys(op)[1] === 'od';\n // Addition\n if(!isRemove)\n {\n this.genomicDataOverlayManager.addGenomicVisData(key, data);\n\n this.adjustVisibilityShareDB(key, data);\n }\n // Removal\n else\n {\n this.genomicDataOverlayManager.removeGenomicVisData();\n this.removeProfiles();\n }\n\n this.genomicDataOverlayManager.showGenomicData();\n this.genomicDataOverlayManager.notifyObservers();\n }\n\n updateGenomicDataColorSchemeHandler(op: any)\n {\n let colorScheme = op.li;\n \n this.setGenomicDataOverlayColorScheme(colorScheme);\n\n this.colorSchemeChangeCallback(colorScheme);\n \n this.genomicDataOverlayManager.updateColorScheme(colorScheme);\n this.genomicDataOverlayManager.showGenomicData();\n this.genomicDataOverlayManager.notifyObservers();\n }\n\n resizeNodesToContent(nodes: any[])\n {\n if(this.isCollaborative)\n {\n const visibleNumberOfData = this.genomicDataOverlayManager.countVisibleGenomicDataByType();\n const labelWithData = 148 + (visibleNumberOfData-3) * 36;\n const rt = this.shareDBManager;\n nodes.forEach(function( ele ){\n if (!ele.isParent())\n {\n var newWidth = 150;\n var newHeight = 52;\n if (ele.data('name') != \"\")\n {\n var labelLength = ele.style('label').length*10 + 6;\n newWidth = labelLength;\n newHeight = 24;\n }\n if (ele.data('type') !== \"PROCESS\" && visibleNumberOfData > 0)\n {\n newHeight = 52;\n if (visibleNumberOfData < 4)\n {\n if (150 > newWidth)\n newWidth = 150;\n }\n else\n {\n if (labelWithData > newWidth)\n newWidth = labelWithData;\n }\n }\n rt.setSizeOfElement(ele, newWidth, newHeight);\n }\n else\n {\n //Set the minWidth, minHeight and other properties of compound to 0\n rt.resizeCompound(ele, 0, 0, 0, 0, 0, 0);\n }\n });\n }\n else\n {\n const ur = this.cy.undoRedo();\n const actions: any[] = [];\n\n const visibleNumberOfData = this.genomicDataOverlayManager.countVisibleGenomicDataByType();\n const labelWithData = 150 + (visibleNumberOfData-3) * 36;\n nodes.forEach(function( ele: any){\n if (!ele.isParent())\n {\n let newWidth = 150;\n let newHeight = 52;\n if (ele.data('name') != \"\") {\n var labelLength = ele.style('label').length * 6 + 24;\n newWidth = labelLength;\n newHeight = 24;\n }\n if (ele.data('type') !== \"PROCESS\" && \n visibleNumberOfData > 0) {\n \n newHeight = 52;\n if (visibleNumberOfData < 4) {\n if (150 > newWidth)\n newWidth = 150;\n }\n else {\n if (labelWithData > newWidth)\n newWidth = labelWithData;\n }\n }\n const args = {\n ele: ele,\n oldWidth: ele.width(),\n newWidth: newWidth,\n oldHeight: ele.height(),\n newHeight: newHeight\n };\n actions.push({name: \"changeNodeSize\", param: args});\n }\n else\n {\n const args = {\n ele: ele,\n oldMinWidth: ele.style(\"min-width\"),\n newMinWidth: 0,\n oldMinWidthBiasLeft: ele.style(\"min-width-bias-left\"),\n newMinWidthBiasLeft: 0,\n oldMinWidthBiasRight: ele.style(\"min-width-bias-right\"),\n newMinWidthBiasRight: 0,\n oldMinHeight: ele.style(\"min-height\"),\n newMinHeight: 0,\n oldMinHeightBiasTop: ele.style(\"min-height-bias-top\"),\n newMinHeightBiasTop: 0,\n oldMinHeightBiasBottom: ele.style(\"min-height-bias-bottom\"),\n newMinHeightBiasBottom: 0\n };\n actions.push({name: \"changeCompoundSize\", param: args});\n }\n });\n\n ur.do(\"batch\", actions);\n }\n this.cy.nodeEditing('get').refreshGrapples();\n };\n\n\n\n}\n","import _ from \"lodash\";\nimport { action, makeObservable, observable } from \"mobx\";\nimport { observer } from \"mobx-react\";\nimport React from \"react\";\nimport {\n Button,\n Checkbox,\n Col,\n ControlLabel,\n Form,\n FormControl,\n InputGroup,\n Modal\n} from \"react-bootstrap\";\nimport EditorActionsManager from \"../managers/EditorActionsManager\";\nimport { EModalType } from \"../ui/react-pathway-mapper\";\nimport PathwayActions from \"../utils/PathwayActions\";\n\ninterface ILayoutPropertiesProps {\n show: boolean;\n handleClose: (modelId: EModalType) => void;\n pathwayActions: PathwayActions;\n}\n\nexport interface ILayoutProperties {\n name: string;\n animationDuration: number;\n animationEasing: string;\n nodeRepulsion: number;\n idealEdgeLength: number;\n edgeElasticity: number;\n nestingFactor: number;\n gravity: number;\n numIter: number;\n gravityRangeCompound: number;\n gravityCompound: number;\n gravityRange: number;\n tilingPaddingVertical: number;\n tilingPaddingHorizontal: number;\n initialEnergyOnIncremental: number;\n tile: boolean;\n animate: boolean;\n randomize: boolean;\n}\n\n@observer\nexport default class LayoutProperties extends React.Component<\n ILayoutPropertiesProps\n> {\n static layoutProperties: ILayoutProperties;\n\n @observable\n internalLayoutProperties: ILayoutProperties;\n\n constructor(props: ILayoutPropertiesProps) {\n super(props);\n makeObservable(this);\n this.internalLayoutProperties = _.clone(\n EditorActionsManager.defaultLayoutProperties\n );\n LayoutProperties.layoutProperties = _.clone(EditorActionsManager.defaultLayoutProperties);\n }\n\n @action.bound\n updateInternalLayoutProperty(property: string, val: boolean | number) {\n this.internalLayoutProperties[property] = val;\n }\n\n render() {\n\n return (\n {\n this.internalLayoutProperties = _.clone(LayoutProperties.layoutProperties);\n }}\n onHide={() => {\n this.internalLayoutProperties = _.clone(LayoutProperties.layoutProperties);\n this.props.handleClose(EModalType.LAYOUT);\n }}\n >\n \n \n Layout Properties\n \n \n \n
\n \n \n Node Repulsion:\n \n\n \n {\n this.updateInternalLayoutProperty(\"nodeRepulsion\", Number(e.target.value));\n }}\n />\n \n \n \n \n Ideal Edge Length:\n \n\n \n {\n this.updateInternalLayoutProperty(\"idealEdgeLength\", Number(e.target.value));\n }}\n />\n \n \n \n \n Edge Elasticity:\n \n\n \n {\n this.updateInternalLayoutProperty(\"edgeElasticity\", Number(e.target.value));\n }}\n />\n \n \n \n \n Nesting Factor:\n \n\n \n {\n this.updateInternalLayoutProperty(\"nestingFactor\", Number(e.target.value));\n }}\n />\n \n \n \n \n Gravity:\n \n\n \n {\n this.updateInternalLayoutProperty(\"gravity\", Number(e.target.value));\n }}\n />\n \n \n \n \n Gravity Range:\n \n\n \n {\n this.updateInternalLayoutProperty(\"gravityRange\", Number(e.target.value));\n }}\n />\n \n \n \n \n Compound Gravity:\n \n\n \n {\n this.updateInternalLayoutProperty(\"gravityCompound\", Number(e.target.value));\n }}\n />\n \n \n \n \n Compound Gravity Range:\n \n\n \n {\n this.updateInternalLayoutProperty(\"gravityRangeCompound\", Number(e.target.value));\n }}\n />\n \n \n \n \n Number of Iterations:\n \n\n \n {\n this.updateInternalLayoutProperty(\"numIter\", Number(e.target.value));\n }}\n />\n \n \n \n \n Tiling Vertical Padding:\n \n\n \n {\n this.updateInternalLayoutProperty(\"tilingPaddingVertical\", Number(e.target.value));\n }}\n />\n \n \n \n \n Tiling Horizontal Padding:\n \n\n \n {\n this.updateInternalLayoutProperty(\"tilingPaddingHorizontal\", Number(e.target.value));\n }}\n />\n \n \n \n \n Tile Disconnected:\n \n\n \n {\n this.updateInternalLayoutProperty(\"tile\", !this.internalLayoutProperties.tile);\n }}\n >\n \n \n \n \n Animate:\n \n\n \n {\n this.updateInternalLayoutProperty(\"animate\",!this.internalLayoutProperties.animate);\n }}\n >\n \n \n \n \n Incremental:\n \n\n \n {\n this.updateInternalLayoutProperty(\"randomize\", !this.internalLayoutProperties.randomize);\n }}\n >\n \n \n \n \n Incremental Cooling Factor:\n \n\n \n {\n this.updateInternalLayoutProperty(\"initialEnergyOnIncremental\", Number(e.target.value));\n }}\n />\n \n \n
\n
\n\n \n {\n LayoutProperties.layoutProperties = _.clone(this.internalLayoutProperties);\n this.props.pathwayActions.setLayoutProperties(\n LayoutProperties.layoutProperties\n );\n this.props.handleClose(EModalType.LAYOUT);\n }}\n >\n Save\n \n\n {\n this.internalLayoutProperties = _.clone(\n EditorActionsManager.defaultLayoutProperties\n );\n LayoutProperties.layoutProperties = _.clone(this.internalLayoutProperties);\n this.props.pathwayActions.setLayoutProperties(\n this.internalLayoutProperties\n );\n }}\n >\n Default\n \n \n \n );\n }\n}\n","import { observer } from 'mobx-react';\nimport React from 'react';\nimport { Button, Col, ControlLabel, Form, FormControl, InputGroup, Modal } from 'react-bootstrap';\nimport { IPathwayInfo } from '../managers/FileOperationsManager';\nimport { EModalType } from '../ui/react-pathway-mapper';\nimport PathwayActions from '../utils/PathwayActions';\n\ninterface IPathwayDetailsModalProps{\n show: boolean;\n handleClose: Function;\n pathwayActions: PathwayActions;\n}\n\n@observer\nexport default class PathwayDetailsModal extends React.Component{\n\n pathwayInfo: IPathwayInfo;\n\n constructor(props: IPathwayDetailsModalProps){\n super(props);\n }\n\n render(){\n\n this.pathwayInfo = this.props.pathwayActions.getPathwayInfo;\n\n return(\n\n {this.props.handleClose(4)}}>\n \n Pathway Properties\n \n \n
\n\n \n \n Pathway Title:\n \n \n {this.pathwayInfo.pathwayTitle = e.target.value;}}value={this.pathwayInfo.pathwayTitle}/>\n \n \n\n \n \n Pathway Description:\n \n \n \n \n \n\n
\n
\n\n \n \n \n
\n\n )\n\n }\n}","import autobind from \"autobind-decorator\";\nimport { action, makeObservable, observable } from \"mobx\";\nimport { observer } from \"mobx-react\";\nimport React from \"react\";\nimport { Button, Col, Modal, Row } from \"react-bootstrap\";\nimport { EModalType, IColorValueMap } from \"../ui/react-pathway-mapper\";\n\nconst addButtonImg = require(\"../images/add.svg\");\nconst deleteButtonImg = require(\"../images/delete-simple.svg\");\n\ninterface IValueColorObj {\n value: string;\n color: string;\n}\n\ninterface IProfilesColorSchemeModalProps {\n show: boolean;\n handleClose: (modalId: EModalType) => void;\n colorValueMapping: IColorValueMap;\n handleColorMappingChange: (colorMapping: IColorValueMap) => void;\n}\n\n@observer\nexport default class ProfilesColorSchemeModal extends React.Component<\n IProfilesColorSchemeModalProps,\n {}\n> {\n @observable\n colorMappings: IValueColorObj[];\n\n @observable\n showUniqueValuesWarningModal: boolean;\n\n constructor(props: IProfilesColorSchemeModalProps) {\n super(props);\n makeObservable(this);\n this.initColorMappings();\n }\n\n componentDidUpdate(prevProps) {\n if (prevProps.show === false && this.props.show === true) {\n this.initColorMappings();\n }\n }\n\n initColorMappings() {\n this.colorMappings = Object.entries(this.props.colorValueMapping)\n .map(([value, color]) => {\n return {\n value: value,\n color: color,\n };\n })\n .sort((o1, o2) => {\n return Number(o1.value) - Number(o2.value);\n });\n }\n\n @action.bound\n handleColorChange(index: number, color: string) {\n this.colorMappings[index].color = color;\n }\n\n @action.bound\n handleValueChange(index: number, value: string) {\n this.colorMappings[index].value = value;\n }\n\n @action.bound\n addDefaultColorMapping() {\n this.colorMappings.push({ value: \"0\", color: \"#ffffff\" });\n }\n\n @action.bound\n removeColorMapping(index: number) {\n this.colorMappings.splice(index, 1);\n }\n\n @action.bound\n setDefaultColorMapping() {\n this.colorMappings = [\n { value: \"-100\", color: \"#0000ff\" },\n { value: \"0\", color: \"#ffffff\" },\n { value: \"100\", color: \"#ff0000\" },\n ];\n }\n\n @action.bound\n setShowUniqueValuesWarningModal(val: boolean) {\n this.showUniqueValuesWarningModal = val;\n }\n\n @autobind\n handleSaveColorScheme(): boolean {\n const mapping = {};\n this.colorMappings.forEach((pair) => {\n mapping[pair.value] = pair.color;\n });\n\n if (Object.keys(mapping).length < 2) {\n this.setShowUniqueValuesWarningModal(true);\n return false;\n } else {\n this.props.handleColorMappingChange(mapping);\n return true;\n }\n }\n\n @autobind\n close() {\n this.props.handleClose(EModalType.PROFILES_COLOR_SCHEME);\n }\n\n render() {\n const mappingElements = this.colorMappings.map((mapping, index) => (\n \n \n \n {\n const value = event.target.value;\n this.handleValueChange(index, value);\n }}\n >\n \n \n {\n const color = event.target.value;\n this.handleColorChange(index, color);\n }}\n />\n \n \n 2 ? \"icon-enabled\" : \"icon-disabled\")\n }\n title={\"Remove\"}\n onClick={() => {\n this.removeColorMapping(index);\n }}\n >\n \n \n \n ));\n\n return (\n {\n this.close();\n }}\n bsSize=\"small\"\n >\n \n Study Data Overlay Color Scheme\n \n\n \n \n \n \n \n \n \n \n \n \n \n
\n {mappingElements}\n \n\n this.setShowUniqueValuesWarningModal(false)}\n bsSize=\"small\"\n >\n \n \n Warning \n \n \n \n

Please set at least two unique value-color mappings.

\n
\n \n {\n this.setShowUniqueValuesWarningModal(false);\n }}\n >\n OK\n \n \n \n
\n\n \n {\n this.close();\n }}\n >\n Cancel\n \n {\n this.setDefaultColorMapping();\n }}\n >\n Default\n \n {\n const close = this.handleSaveColorScheme();\n if (close) {\n this.close();\n }\n }}\n >\n Save\n \n \n \n );\n }\n}\n","import { action, computed, makeObservable, observable } from \"mobx\";\nimport { observer } from \"mobx-react\";\nimport React from \"react\";\nimport { Button, Modal } from \"react-bootstrap\";\nimport EditorActionsManager from \"../managers/EditorActionsManager\";\nimport { EModalType, IProfileMetaData } from \"../ui/react-pathway-mapper\";\ninterface IProfilesModalProps {\n profiles: IProfileMetaData[];\n editor: EditorActionsManager;\n show: boolean;\n handleClose: Function;\n handleProfileLabelClicked: (index: number) => void;\n enabledProfileCountLimit: number;\n}\n\n@observer\nexport default class ProfilesModal extends React.Component<\n IProfilesModalProps,\n {}\n> {\n\n\n @observable\n showEnabledProfileWarningModal: boolean = false;\n\n constructor(props: IProfilesModalProps) {\n super(props);\n\n makeObservable(this);\n }\n\n @action\n setShowEnabledProfileWarningModal(val: boolean) {\n this.showEnabledProfileWarningModal = val;\n }\n\n @computed get profileEnabledMap() {\n\n const enabledProfiles: IProfileMetaData[] = [];\n this.props.profiles.forEach(profile => {\n if (profile.enabled && enabledProfiles.length < this.props.enabledProfileCountLimit) {\n enabledProfiles.push(profile);\n }\n });\n\n const profileEnabledMap = {};\n this.props.profiles.forEach((profile: IProfileMetaData) => {\n const enabled = enabledProfiles.indexOf(profile) > -1;\n profileEnabledMap[profile.profileId] = enabled;\n });\n return profileEnabledMap;\n }\n\n handleProfileLabelClicked(index: number) {\n this.props.handleProfileLabelClicked(index);\n }\n\n render() {\n const profileLabels = this.props.profiles.map(\n (profile: IProfileMetaData, i: number) => (\n \n {\n const enabledProfileCount = this.props.profiles.filter(profile => profile.enabled).length;\n if (this.props.profiles[i].enabled || enabledProfileCount < this.props.enabledProfileCountLimit) {\n this.handleProfileLabelClicked(i);\n this.props.editor.updateGenomicDataVisibility(\n this.profileEnabledMap\n );\n }\n else {\n this.setShowEnabledProfileWarningModal(true);\n }\n }}\n style={{\n cursor: \"pointer\",\n margin: \"10px\"\n }}\n bsStyle={this.props.profiles[i].enabled ? \"primary\" : \"default\"}\n >\n {profile.profileId}\n \n \n )\n );\n\n return (\n {\n this.props.handleClose(EModalType.PROFILES);\n }}\n >\n \n Genomic Data Set(s) to Show\n \n \n {profileLabels.length > 0 ? (\n profileLabels\n ) : (\n

There is currently no data to show

\n )}\n this.setShowEnabledProfileWarningModal(false)}>\n \n \n Warning\n \n \n \n

At most 6 data sets can be displayed at the same time, please disable some other data set before enabling this.

\n
\n \n {\n this.setShowEnabledProfileWarningModal(false);\n }}>\n OK\n \n \n \n
\n \n );\n }\n}\n","import React from 'react';\nimport { EModalType } from '../ui/react-pathway-mapper';\nimport {Modal} from 'react-bootstrap';\ninterface IQuickHelpModalProps{\n show: boolean;\n handleClose: (modalId: EModalType) => void;\n}\n\nexport default class QuickHelpModal extends React.Component{\n\n constructor(props: IQuickHelpModalProps){\n super(props);\n }\n\n render(){\n\n\n return(\n {this.props.handleClose(EModalType.HELP)}}>\n \n Quick Help\n \n \n
    \n
  • To add a node: Drag and drop from node palette
  • \n
  • To add an interaction: Click on interaction type; then click on small circle on source node and release on target node
  • \n
  • To add a node into a container (family, complex, compartment or process): Drag the node into its container node or select nodes to be contained and right click on container node and choose \"Add Selected Into This\"
  • \n
  • To delete nodes/interactions: Select and perform Edit > Delete Selected
  • \n
  • To overlay experiment data: Select Alteration % > Load From cBioPortal...
  • \n
\n
\n\n
\n\n );\n }\n\n\n}","import _ from \"lodash\";\nimport { toast } from 'react-toastify';\nimport EditorActionsManager from \"../managers/EditorActionsManager\";\n\n\nexport default class CBioPortalAccessor{\n static readonly CNA_GAIN = 2;\n\n static readonly GET_ALL_CANCER_STUDIES_URL = \"https://www.cbioportal.org/webservice.do?cmd=getCancerStudies\";\n static readonly GET_GENETIC_PROFILES_URL = \"https://www.cbioportal.org/webservice.do?cmd=getGeneticProfiles&cancer_study_id=\";\n static readonly GET_PROFILE_DATA_URL = \"https://www.cbioportal.org/webservice.do?cmd=getProfileData\";\n static readonly MRNA_EXP_STUDY_NAME = \"_mrna_median_Zscores\";\n static readonly CNA_EXP_STUDY_NAME = \"_gistic\";\n static readonly VALIDATE_GENES_URL = 'https://www.cbioportal.org/api/genes/fetch?geneIdType=HUGO_GENE_SYMBOL&projection=ID'\n static readonly MUTATION_EXP_STUDY_NAME = \"_mutations\";\n\n static readonly CNA_DELETION = -2;\n static readonly Z_SCORE_UPPER_THRESHOLD = 2;\n static readonly Z_SCORE_LOWER_THRESHOLD = -2;\n \n static readonly MUTATION = \"Mutation\";\n static readonly GENE_EXPRESSION = \"Gene Expression\";\n static readonly CNA = \"Copy Number Alteration\";\n\n getDataTypes(){\n return [CBioPortalAccessor.MUTATION, CBioPortalAccessor.GENE_EXPRESSION, CBioPortalAccessor.CNA];\n }\n\n /*\n * Retrieves all cancer studies from cBioPortal\n * **/\n fetchCancerStudies(callbackFunction)\n {\n var cancerStudies = {};\n var request = new XMLHttpRequest();\n request.onreadystatechange = function ()\n {\n if(request.readyState === XMLHttpRequest.DONE && request.status === 200)\n {\n // By lines\n // Match all new line character representations\n var seperator = /\\r?\\n|\\r/;\n var lines = request.responseText.split(seperator);\n\n // start from first line skip node meta data\n for(var i = 1; i < lines.length; i++)\n {\n if (lines[i].length <= 0)\n continue;\n\n var lineData = lines[i].split('\\t');\n cancerStudies[lineData[0]] = lineData;\n }\n callbackFunction(cancerStudies);\n }\n else if (request.readyState === XMLHttpRequest.DONE && request.status !== 200)\n {\n toast.error(\"Could not retrieve studies!\");\n }\n };\n request.open(\"GET\", CBioPortalAccessor.GET_ALL_CANCER_STUDIES_URL);\n request.send();\n };\n\n /**\n * Retrieves all genetic profiles for given cancerStudy from cBioPortal\n */\n getSupportedGeneticProfiles(cancerStudy, callbackFunction)\n {\n var outData = {};\n var request = new XMLHttpRequest();\n var self = this;\n request.onreadystatechange = function ()\n {\n if(request.readyState === XMLHttpRequest.DONE && request.status === 200)\n {\n // By lines\n // Match all new line character representations\n var seperator = /\\r?\\n|\\r/;\n var lines = request.responseText.split(seperator);\n\n // start from first line skip node meta data\n for(var i = 1; i < lines.length; i++)\n {\n if (lines[i].length <= 0)\n continue;\n\n var lineData = lines[i].split('\\t');\n var cancerProfileName = lineData[0];\n if(self.isSupportedCancerProfile(cancerProfileName))\n {\n outData[cancerProfileName] = lineData;\n }\n }\n\n callbackFunction(outData);\n }\n else if (request.readyState === XMLHttpRequest.DONE && request.status !== 200)\n {\n console.error(\"Error retrieving studies\");\n }\n };\n request.open(\"GET\", CBioPortalAccessor.GET_GENETIC_PROFILES_URL + cancerStudy);\n request.send();\n };\n\n isSupportedCancerProfile(cancerProfileName: string)\n {\n return (cancerProfileName.endsWith(CBioPortalAccessor.MRNA_EXP_STUDY_NAME) ||\n cancerProfileName.endsWith(CBioPortalAccessor.CNA_EXP_STUDY_NAME) ||\n cancerProfileName.endsWith(CBioPortalAccessor.MUTATION_EXP_STUDY_NAME));\n };\n\n static getDataType(cancerProfileName: string)\n {\n if ( cancerProfileName.endsWith(this.MRNA_EXP_STUDY_NAME))\n {\n return this.GENE_EXPRESSION;\n }\n else if ( cancerProfileName.endsWith(this.CNA_EXP_STUDY_NAME))\n {\n return this.CNA;\n }\n else if ( cancerProfileName.endsWith(this.MUTATION_EXP_STUDY_NAME))\n {\n return this.MUTATION;\n }\n\n return \"\";\n }\n \n\n calcAlterationPercentages(paramLines, geneticProfileId, callbackFunction)\n {\n // By lines\n // Match all new line character representations\n const seperator = /\\r?\\n|\\r/;\n const lines = paramLines.split(seperator);\n let startIndex = 0;\n\n //Find starting index of actual data skip commented lines\n for (const i in lines)\n {\n if(!lines[i].startsWith('#'))\n {\n startIndex = parseInt(i);\n break;\n }\n }\n\n //Total number of tumor samples in the response\n const tumorSamples = lines[startIndex].split('\\t');\n const numOfTumorSamples = tumorSamples.length - 2;\n const outData: {} = {};\n outData[geneticProfileId] = {};\n\n const geneticProfileType = CBioPortalAccessor.getDataType(geneticProfileId);\n // skip meta line and iterate over tumor sample data\n for(let i = startIndex + 1; i < lines.length; i++)\n {\n if (lines[i].length <= 0)\n continue;\n\n //Iterate over samples for each gene to calculate profile data\n const lineData: string[] = lines[i].split('\\t');\n let profileDataAlteration = 0;\n for(let j = 2; j < lineData.length; j++)\n {\n if(lineData[j] !== 'NaN')\n {\n if( geneticProfileType === CBioPortalAccessor.MUTATION )\n profileDataAlteration++;\n else if ( (geneticProfileType === CBioPortalAccessor.CNA) \n && ( parseInt(lineData[j]) === CBioPortalAccessor.CNA_GAIN || parseInt(lineData[j]) === CBioPortalAccessor.CNA_DELETION ) ){\n profileDataAlteration++;\n }\n else if ( (geneticProfileType === CBioPortalAccessor.GENE_EXPRESSION) \n && (parseFloat(lineData[j]) >= CBioPortalAccessor.Z_SCORE_UPPER_THRESHOLD \n || parseFloat(lineData[j]) <= CBioPortalAccessor.Z_SCORE_LOWER_THRESHOLD)){\n profileDataAlteration++;\n }\n }\n }\n\n //\n outData[geneticProfileId][lineData[1]] = ( profileDataAlteration / numOfTumorSamples ) * 100;\n }\n\n callbackFunction(outData);\n }\n\n\n /*\n *\n * Retrieves profile data associated with the parameters below from cBioPortal\n * @params\n {\n caseSetId: \"gbm_tcga\",\n geneticProfileId: \"gbm_tcga_mutations\",\n genes: [\"BRCA1\", \"BRCA2\", \"TP53\"]\n }\n * */\n getProfileData(params, callbackFunction)\n {\n //params\n //caseSetId, geneticProfileId, genes\n\n const outData = {};\n const request = new XMLHttpRequest();\n const self = this;\n request.onreadystatechange = function ()\n {\n if(request.readyState === XMLHttpRequest.DONE && request.status === 200)\n {\n self.calcAlterationPercentages(request.responseText, params.geneticProfileId, callbackFunction);\n toast.success(params.geneticProfileId + \" has been succesfully loaded from cBioPortal.\");\n }\n };\n\n //Create query URL\n let queryURL = CBioPortalAccessor.GET_PROFILE_DATA_URL;\n //Fetch sequenced case list !!\n queryURL += \"&case_set_id=\" + params.caseSetId + \"_sequenced\";\n queryURL += \"&genetic_profile_id=\" + params.geneticProfileId;\n queryURL += \"&gene_list=\";\n let isFirst = true;\n for(const gene of params.genes)\n {\n if(!isFirst){\n queryURL += \"+\";\n } else {\n isFirst = false;\n }\n queryURL += gene;\n \n }\n request.open(\"GET\", queryURL);\n request.send();\n };\n\n validateGenes(nodeSymbols, editor: EditorActionsManager)\n {\n const request = new XMLHttpRequest();\n const self = this;\n\n request.onreadystatechange = function ()\n {\n if(request.readyState === XMLHttpRequest.DONE && request.status === 200)\n {\n const validGeneSymbols = JSON.parse(request.responseText);\n const validGeneArray = _.map(validGeneSymbols, function(object)\n {\n return object.hugoGeneSymbol;\n });\n editor.highlightInvalidGenes(validGeneArray);\n }\n };\n const queryURL = CBioPortalAccessor.VALIDATE_GENES_URL;\n request.open(\"POST\", queryURL);\n request.setRequestHeader(\"Content-type\", \"application/json\");\n request.send(JSON.stringify(nodeSymbols));\n }\n}\n","import autobind from \"autobind-decorator\";\nimport { action, computed, makeObservable, observable } from \"mobx\";\nimport { observer } from \"mobx-react\";\nimport React from \"react\";\nimport {\n Button,\n Checkbox,\n FormControl,\n ListGroup,\n ListGroupItem,\n Modal,\n} from \"react-bootstrap\";\nimport { EModalType, IDataTypeMetaData } from \"../ui/react-pathway-mapper\";\nimport CBioPortalAccessor from \"../utils/CBioPortalAccessor\";\n\ninterface IStudyModalProps {\n show: boolean;\n loadFromCBio: Function;\n handleClose: Function;\n}\n\n@observer\nexport default class StudyModal extends React.Component {\n @observable\n dataTypes: { [dataType: string]: IDataTypeMetaData } = {};\n\n @observable\n dataTypeFetchResultsReady: boolean = false;\n\n currentlySelectedItemIndex = -1;\n\n @observable\n selectedStudies: {\n data: any[];\n dataTypes: { [dataType: string]: IDataTypeMetaData };\n }[] = [];\n\n checkboxModalPosition: {\n bottom: number;\n } = {\n bottom: 0,\n };\n\n @observable\n selectedDataTypesPerStudy: string[] = [];\n\n @observable\n itemArray: any[] = [];\n\n @observable\n searchQuery: string = \"\";\n\n @observable\n showDataTypeSelectionModal = false;\n\n @observable\n studyListItemCheckboxChecked: boolean[] = [];\n\n @observable\n selectedStudyData: any[];\n\n @observable\n portalAccessor: CBioPortalAccessor;\n\n constructor(props: IStudyModalProps) {\n super(props);\n makeObservable(this);\n this.selectedStudyData = [];\n this.portalAccessor = new CBioPortalAccessor();\n this.fetchStudy();\n }\n\n @action.bound\n setDataTypeFetchResultsReady(ready: boolean) {\n this.dataTypeFetchResultsReady = ready;\n }\n\n @action.bound\n setItemArray(itemArray: any[]) {\n this.itemArray = itemArray;\n }\n\n @action.bound\n setSearchQuery(query: string) {\n this.searchQuery = query;\n }\n\n @action.bound\n setSelectedStudyData(data: any[]) {\n this.selectedStudyData = data;\n }\n\n @action.bound\n setDataTypeProperties(dataType: string, properties: IDataTypeMetaData) {\n this.dataTypes[dataType] = properties;\n }\n\n @action.bound\n initStudyListItemCheckboxChecked(studyCount: number) {\n this.studyListItemCheckboxChecked = Array(studyCount).fill(false);\n }\n\n @action.bound\n initSelectedDataTypesPerStudy(studyCount: number) {\n this.selectedDataTypesPerStudy = Array(studyCount).fill(\"\");\n }\n\n @action.bound\n toggleStudyListItemCheckboxChecked(studyIndex: number) {\n this.studyListItemCheckboxChecked[studyIndex] = !this\n .studyListItemCheckboxChecked[studyIndex];\n }\n\n @action.bound\n addSelectedStudy(selectedStudy: {\n data: any[];\n dataTypes: { [dataType: string]: IDataTypeMetaData };\n }) {\n this.selectedStudies.push(selectedStudy);\n }\n\n @action.bound\n removeSelectedStudy(selectedStudyData: any[]) {\n this.selectedStudies = this.selectedStudies.filter(\n (study) => study.data[0] != selectedStudyData[0]\n );\n }\n\n @action.bound\n clearSelectedStudies() {\n this.selectedStudies = [];\n }\n\n @action.bound\n setShowDataTypeSelectionModal(show: boolean) {\n this.showDataTypeSelectionModal = show;\n }\n\n @action.bound\n clearStudyCheckboxesChecked() {\n const length = this.studyListItemCheckboxChecked.length;\n this.studyListItemCheckboxChecked = Array(length).fill(false);\n }\n\n @action.bound\n clearSelectedDataTypesPerStudy() {\n const length = this.studyListItemCheckboxChecked.length;\n this.selectedDataTypesPerStudy = Array(length).fill(\"\");\n }\n\n @action.bound\n unselectDataTypesForStudy(index: number) {\n this.selectedDataTypesPerStudy[index] = \"\";\n }\n\n preparePortalAccess(studyId: string) {\n this.setDataTypeFetchResultsReady(false);\n this.portalAccessor.getSupportedGeneticProfiles(studyId, (data) => {\n this.disableAllDataTypes();\n // Iterate through profiles\n for (const profile of Object.keys(data)) {\n const type = CBioPortalAccessor.getDataType(profile);\n if (type !== \"\") {\n this.setDataTypeProperties(type, {\n ...this.dataTypes[type],\n enabled: true,\n profile: profile,\n });\n setTimeout(() => this.setDataTypeFetchResultsReady(true), 500);\n }\n }\n });\n }\n\n disableAllDataTypes() {\n for (const dataType of Object.keys(this.dataTypes)) {\n this.setDataTypeProperties(dataType, {\n enabled: false,\n checked: false,\n profile: undefined,\n });\n }\n }\n\n fetchStudy() {\n this.portalAccessor.getDataTypes().forEach((dataType) => {\n this.setDataTypeProperties(dataType, {\n enabled: false,\n checked: false,\n profile: undefined,\n });\n });\n\n this.portalAccessor.fetchCancerStudies((cancerStudies: any) => {\n let temp = [];\n for (const studyTitle in cancerStudies) {\n if (!cancerStudies.hasOwnProperty(studyTitle)) {\n continue;\n }\n const studyData = cancerStudies[studyTitle];\n temp.push(studyData);\n }\n const numOfStudies = temp.length;\n this.initStudyListItemCheckboxChecked(numOfStudies);\n this.initSelectedDataTypesPerStudy(numOfStudies);\n\n this.setItemArray(temp);\n });\n }\n\n @autobind\n resetModal() {\n this.disableAllDataTypes();\n this.setSelectedStudyData([]);\n this.clearSelectedStudies();\n this.clearStudyCheckboxesChecked();\n this.clearSelectedDataTypesPerStudy();\n this.currentlySelectedItemIndex = -1;\n this.searchQuery = \"\";\n }\n\n @autobind\n handleCheckboxClick(dataType) {\n this.setDataTypeProperties(dataType, {\n ...this.dataTypes[dataType],\n checked: !this.dataTypes[dataType].checked,\n });\n }\n\n @computed\n get selectedStudyDataTitle() {\n if (this.selectedStudyData.length > 1) {\n return this.selectedStudyData[1] || \"Choose study\";\n } else {\n return \"Choose study\";\n }\n }\n\n render() {\n\n return (\n {\n this.props.handleClose(EModalType.STUDY);\n this.resetModal();\n }}\n >\n \n Profile Data from cBioPortal\n \n \n \n

Select Cancer Study

\n
\n this.setSearchQuery(event.target.value)}\n />\n \n \n {this.itemArray.length < 1 ? (\n Fetching studies from cBioPortal...\n ) : (\n this.itemArray\n .map((item, index) => {\n return { item: item, index: index };\n })\n .filter((obj) =>\n obj.item[1]\n .toLowerCase()\n .includes(this.searchQuery.toLowerCase())\n )\n .map((obj) => {\n const item = obj.item;\n const index = obj.index;\n\n const studyTitle = item[1];\n const studyId = item[0];\n return (\n \n {\n const boundingRect = document\n .getElementById(\"listgroupitem\" + index)\n .getBoundingClientRect();\n const modalMargin = 30;\n this.checkboxModalPosition = {\n bottom: boundingRect.bottom - modalMargin,\n };\n this.setSelectedStudyData(item);\n this.preparePortalAccess(studyId);\n this.toggleStudyListItemCheckboxChecked(index);\n this.currentlySelectedItemIndex = index;\n\n if (this.studyListItemCheckboxChecked[index]) {\n this.setShowDataTypeSelectionModal(true);\n } else {\n this.removeSelectedStudy(item);\n this.unselectDataTypesForStudy(index);\n }\n }}\n >\n {studyTitle}\n \n {this.selectedDataTypesPerStudy[index] != \"\" && (\n \n {this.selectedDataTypesPerStudy[index]}\n \n )}\n \n );\n })\n )}\n \n \n
\n

\n Warning: At most six different data sets will be overlayed on the genes. You can toggle which ones are to be displayed via \"Alteration %\" {\">\"} \"View Settings\" menu.\n

\n
\n {\n this.setShowDataTypeSelectionModal(false);\n }}\n >\n \n {this.dataTypeFetchResultsReady === false ? (\n Fetching data types from cBioPortal...\n ) : (\n Object.keys(this.dataTypes).map((dataType: string) => {\n return (\n {\n this.handleCheckboxClick(dataType);\n }}\n checked={this.dataTypes[dataType].checked}\n >\n {dataType}\n \n );\n })\n )}\n \n \n {\n const currentDataTypes = { ...this.dataTypes };\n const selectedCount = Object.keys(currentDataTypes).filter(\n (dataType) => {\n return currentDataTypes[dataType].checked;\n }\n ).length;\n if (selectedCount == 0) {\n this.studyListItemCheckboxChecked[\n this.currentlySelectedItemIndex\n ] = false;\n }\n this.setShowDataTypeSelectionModal(false);\n }}\n >\n Cancel\n \n {\n const currentDataTypes = { ...this.dataTypes };\n this.addSelectedStudy({\n data: this.selectedStudyData,\n dataTypes: currentDataTypes,\n });\n this.selectedDataTypesPerStudy[\n this.currentlySelectedItemIndex\n ] = Object.keys(currentDataTypes)\n .filter((dataType) => {\n return currentDataTypes[dataType].checked;\n })\n .join(\", \");\n this.setShowDataTypeSelectionModal(false);\n }}\n >\n Add\n \n \n \n
\n\n \n {\n this.selectedStudies.forEach((study) => {\n this.props.loadFromCBio(study.dataTypes, study.data);\n });\n this.props.handleClose(EModalType.STUDY);\n this.resetModal();\n }}\n >\n Load Data\n \n \n \n );\n }\n}\n","import autobind from \"autobind-decorator\";\nimport { action, makeObservable, observable } from \"mobx\";\nimport { observer } from \"mobx-react\";\nimport React from 'react';\nimport { Checkbox, DropdownButton, MenuItem } from \"react-bootstrap\";\nimport PathwayActions from '../utils/PathwayActions.js';\nimport { IPathwayMapperTable } from \"./react-pathway-mapper\";\n\ninterface IRankingProps{\n pathwayActions: PathwayActions;\n bestPathwaysAlgos: any[][];\n tableComponent: (data: IPathwayMapperTable[], selectedPathway: string, onPathwaySelect: (pathway: string) => void) => JSX.Element;\n patientView ?: boolean;\n}\n\nconst TCGA_PANCAN_PATHWAY_NAMES = [\n \"Cell Cycle\", \n \"HIPPO\", \n \"MYC\",\n \"NOTCH\",\n \"NRF2\",\n \"PI3K\",\n \"RTK-RAS\",\n \"TGF-Beta\",\n \"TP53\",\n \"WNT\"\n];\n\n\n@observer\nexport default class Ranking extends React.Component{\n @observable\n bestPathways: any[];\n\n @observable\n shownPathways: any[];\n\n @observable\n dropDownTitle: string;\n\n @observable\n selectedPathway: string;\n isPercentageMatch: number;\n isAlterationEnabled: number;\n\n @observable\n considerOnlyTCGAPanPathways: boolean;\n\n @observable\n isExpanded: boolean;\n\n readonly COUNT_PERC_EXPLANATION = \"Whether we should favor the number of genes of interest matching the ones in a pathway or the percentage of such genes in that pathway. For instance, suppose genes of interest are A, B, and C, and the pathway contains genes B, C, D, and E. When we consider count, the score is 2 (for the two genes that match). However, when we consider percentage the score will be 50% as 2 of the 4 genes in the pathway are among genes of interest.\";\n readonly ALTERATION_EXPLANATION = \"When this is checked, each matching gene will not directly contribute to the score as 1 unit but with the alteration frequency percentage of that gene. For instance, suppose genes of interest are A, B, and C with alteration frequencies of 0.5, 0.2, and 0.3, respectively, and the pathway contains genes B, C, D, and E. When this is option isn't checked, the score will be 2 for match count and 50% for the match percentage. However, when this option is checked, the scores will be 0.2+0.3=0.5 and (0.2+0.3)/4=12.5% for match count and percentage, respectively.\";\n readonly TCGA_PANCAN_EXPLANATION = \"The pathways listed above were retrieved from PathwayMapper. When this option is checked, only the pathways under TCGA > PanCanAtlas will be shown. Uncheck to show all.\";\n\n constructor(props: IRankingProps){\n super(props);\n makeObservable(this);\n \n this.isPercentageMatch = 0;\n this.isAlterationEnabled = 0;\n this.considerOnlyTCGAPanPathways = true;\n this.dropDownTitle = \"Match count\";\n this.isExpanded = false;\n this.setBestPathwayMethod(0);\n this.selectedPathway = this.shownPathways[0].pathwayName;\n }\n\n @autobind\n setBestPathwayMethod(i: number){\n this.bestPathways = this.props.bestPathwaysAlgos[i];\n this.filterBestPathwaysByTCGAPanPathways();\n }\n\n @autobind\n onPathwayClick(pathway: string){\n this.selectedPathway = pathway;\n this.props.pathwayActions.changePathway(this.selectedPathway);\n }\n\n @autobind\n onApplyClick(){\n // Mapping from dropdown + checkbox selection to pathway method.\n this.setBestPathwayMethod(2 * this.isAlterationEnabled + this.isPercentageMatch);\n }\n\n @action.bound \n filterBestPathwaysByTCGAPanPathways() {\n this.shownPathways = this.bestPathways.filter((data: any) => {\n if (this.considerOnlyTCGAPanPathways) {\n return TCGA_PANCAN_PATHWAY_NAMES.indexOf(data.pathwayName) > -1;\n }\n return true;\n });\n // change selected pathway if we are filtered and doesn't exist\n if (this.considerOnlyTCGAPanPathways \n && TCGA_PANCAN_PATHWAY_NAMES.indexOf(this.selectedPathway) < 0) {\n this.selectedPathway = this.shownPathways[0].pathwayName;\n this.props.pathwayActions.changePathway(this.selectedPathway);\n }\n }\n\n @action.bound\n toggleConsiderOnlyTCGAPanPathways() {\n this.considerOnlyTCGAPanPathways = !this.considerOnlyTCGAPanPathways;\n this.filterBestPathwaysByTCGAPanPathways();\n }\n\n\n componentDidMount(): void {\n this.props.pathwayActions.changePathway(this.selectedPathway);\n }\n\n render(){\n const lengthThreshold = 13;\n \n return (\n
\n\n {/*\n
\n  Pathways\n
*/}\n\n { this.props.tableComponent &&\n this.props.tableComponent(\n this.shownPathways.map((data: any) => ({\n name: data.pathwayName, score: data.score, genes: data.genesMatched\n })),\n this.selectedPathway,\n this.onPathwayClick)\n }\n {\n
\n \n Show TCGA PanCancer Atlas pathways only  \n \n \n \n
\n }\n {(!this.props.patientView &&\n
\n {\n
\n \n  Ranking options\n \n
\n }\n
\n \n {this.isPercentageMatch = 0; this.dropDownTitle = \"Match count\"; this.onApplyClick();} }>Match count\n {this.isPercentageMatch = 1; this.dropDownTitle = \"Match percentage\"; this.onApplyClick();}}>Match percentage\n \n   \n
\n\n {this.isAlterationEnabled = (this.isAlterationEnabled === 1) ? 0 : 1; this.onApplyClick();}}\n style={{fontSize: \"13px\", marginTop: \"18px\", bottom: \"4px\"}}>\n Consider alteration frequency  \n \n \n
\n
\n )}\n
\n \n );\n \n }\n\n \n}\n","import { makeObservable, observable } from \"mobx\";\nimport { observer } from \"mobx-react\";\nimport React from 'react';\n// @ts-ignore\nimport openImage from \"../images/toolbar/edit.svg\";\n// @ts-ignore\nimport layoutImage from \"../images/toolbar/layout-cose.svg\";\n// @ts-ignore\nimport savePNGImage from \"../images/toolbar/save_png.svg\";\n// @ts-ignore\nimport saveSVGImage from \"../images/toolbar/save_svg.svg\";\nimport EditorActionsManager from \"../managers/EditorActionsManager\";\nimport { EModalType, IAlterationData } from '../ui/react-pathway-mapper';\nimport PathwayActions from '../utils/PathwayActions';\n// @ts-ignore\nconst addSelImage = require(\"../images/toolbar/add-selected.svg\");\n// @ts-ignore\nconst addAllImage = require(\"../images/toolbar/add-all.svg\");\n// @ts-ignore\nconst aboutImage = require(\"../images/toolbar/about.svg\");\n\n\ninterface IToolbarProps {\n pathwayActions: PathwayActions;\n selectedPathway: string;\n alterationData: IAlterationData;\n handleOpen: (modalId: number) => void;\n genes: any[];\n validGenes: any;\n showMessage: (message: string) => void;\n pathwayGenes: string[];\n onAddGenes: (selectedGenes: string[]) => void;\n patientView ?: boolean;\n}\n\n@observer\nexport default class Toolbar extends React.Component{\n\n\n @observable\n selectedGenes: string[];\n\n @observable\n private editor: EditorActionsManager;\n constructor(props: IToolbarProps){\n super(props);\n makeObservable(this);\n\n this.selectedGenes = [];\n }\n\n \n render(){\n\n\n const studyQuery = \"q=\" + JSON.stringify(this.props.alterationData) + \"&g=\" + this.props.genes.map(gene => gene.hugoGeneSymbol).join(\"+\");\n return (\n
\n {this.props.pathwayActions.saveAs(\"PNG\");}}/>\n\n {this.props.pathwayActions.saveAs(\"SVG\");}}/>\n\n \n {(!this.props.patientView && [\n {\n this.selectedGenes = this.props.pathwayActions.getSelectedNodes()\n .filter((node: any) => node.data().type === \"GENE\")\n .map((node: any) => node.data().name as string);\n\t const noneGeneList = this.props.pathwayActions.getSelectedNodes()\n .filter((node: any) => node.data().type !== \"GENE\")\n .map((node: any) => node.data().name as string);\n const invalidGenes: string[] = [];\n\t let message = \"\";\n if(noneGeneList.length > 0){\n message += \"Selection contains nodes that are not genes: \" + noneGeneList.join(', ') + \". \";\n }\n\n this.selectedGenes.forEach((gene: string) => {\n if(!this.props.validGenes.hasOwnProperty(gene)){\n invalidGenes.push(gene);\n }\n });\n\n if(invalidGenes.length === 0){\n\n if(this.selectedGenes.length > 0 && noneGeneList.length === 0){\n this.props.onAddGenes(this.selectedGenes);\n }\n } else {\n\t message += \"Following gene symbols are invalid or already in gene list: \" + invalidGenes.join(\", \") + \".\";\n }\n\n\t if(message.length > 0) {\n\t this.props.showMessage(message);\n\t }\n }}/>\n ,\n \n {\n\n this.selectedGenes = this.props.pathwayGenes.filter((gene: string) => {\n return this.props.validGenes.hasOwnProperty(gene);\n });\n \n if(this.selectedGenes.length > 0){\n this.props.onAddGenes(this.selectedGenes);\n }\n }}/>,\n \n\n {{window.open(\"http://pathwaymapper.org/?pathwayName=\" + this.props.selectedPathway +\"&\"+ studyQuery )}}}/>\n ])}\n {this.props.handleOpen(EModalType.CHELP); }}/>\n \n
);\n }\n}\n","import autobind from \"autobind-decorator\";\nimport { action, computed, makeObservable, observable } from \"mobx\";\nimport EditorActionsManager from \"../managers/EditorActionsManager\";\nimport FileOperationsManager, {\n IPathwayInfo\n} from \"../managers/FileOperationsManager\";\nimport GridOptionsManager from \"../managers/GridOptionsManager\";\nimport ViewOperationsManager from \"../managers/ViewOperationsManager\";\nimport ConfirmationModal from \"../modals/ConfirmationModal\";\nimport { EGridType } from \"../modals/GridSettings\";\nimport { ILayoutProperties } from \"../modals/LayoutProperties\";\nimport {\n EModalType, IPathwayData, IProfileMetaData\n} from \"../ui/react-pathway-mapper\";\nimport SaveLoadUtility from \"./SaveLoadUtility\";\n\nexport default class PathwayActions {\n @observable\n selectedPathway: string;\n fileManager: FileOperationsManager;\n editor: EditorActionsManager;\n undoRedoManager: any;\n pathwayHandler: (pathwayName: string) => void;\n handleOpen: (modalId: EModalType) => void;\n eh: any;\n profiles: IProfileMetaData[];\n gridOptionsManager: GridOptionsManager;\n\n uploader: any;\n merger: any;\n isCBioPortal: boolean;\n isCollaborative: boolean;\n viewOperationsManager: ViewOperationsManager;\n overlayUploader: any;\n\n @observable\n enabledType: EGridType;\n\n constructor(\n pathwayHandler: (pathwayName: string) => void,\n profiles: IProfileMetaData[],\n fileManager: FileOperationsManager,\n handleOpen: (modalId: EModalType) => void,\n isCBioPortal: boolean,\n isCollaborative: boolean\n ) {\n makeObservable(this);\n this.pathwayHandler = pathwayHandler;\n this.profiles = profiles;\n this.fileManager = fileManager;\n this.handleOpen = handleOpen;\n this.isCBioPortal = isCBioPortal;\n this.isCollaborative = isCollaborative;\n this.enabledType = EGridType.NONE;\n }\n\n @action.bound\n addProfile(profile: IProfileMetaData) {\n this.profiles.push(profile);\n }\n\n @action.bound\n clearProfiles() {\n this.profiles.length = 0;\n }\n\n emphasizeQueryGenes(queryGenes: string[]) {\n if (this.editor)\n this.editor.cy.nodes().forEach((node: any) => {\n const nodeName = node.data().name;\n const nodeType = node.data().type;\n if (queryGenes.includes(nodeName) && nodeType === \"GENE\") {\n node.style({ \"border-width\": \"4px\", \"font-weight\": \"bold\" });\n }\n });\n }\n\n getSelectedNodes() {\n return this.editor.cy.nodes(\":selected\");\n }\n\n setLayoutProperties(layoutProperties: ILayoutProperties) {\n this.editor.saveLayoutProperties(layoutProperties);\n }\n\n doesCyHaveElements() {\n return this.editor.cy.elements().length > 0;\n }\n\n @autobind\n toggleGrid(isEnabled: boolean) {\n this.gridOptionsManager.setSnapToGuidelines(false);\n this.gridOptionsManager.setShowGrid(isEnabled);\n }\n\n @autobind\n toggleGuide(isEnabled: boolean) {\n this.gridOptionsManager.setSnapToGuidelines(isEnabled);\n this.gridOptionsManager.setShowGrid(false);\n }\n\n adjustGridSettings(gridSize: number, color: string) {\n this.gridOptionsManager.currentProperties.gridSpacing = gridSize;\n this.gridOptionsManager.currentProperties.guidelinesStyle.strokeStyle = color;\n this.gridOptionsManager.currentProperties.guidelinesStyle.horizontalDistColor = color;\n this.gridOptionsManager.currentProperties.guidelinesStyle.verticalDistColor = color;\n }\n\n @autobind\n resizeToContent() {\n this.editor.resizeNodesToContent(this.editor.cy.nodes());\n }\n\n @autobind\n align(param: string) {\n this.viewOperationsManager.handleNodeAlignment(param);\n }\n\n @autobind\n onChangeFile(e: any, isMerge: boolean) {\n const file = e.target.files[0] as File;\n this.processFile(file, isMerge);\n //Can't load the same file twice in a row without this\n e.target.value = \"\";\n }\n\n uploadOverlay() {\n this.overlayUploader.click();\n }\n\n overlayFromText(file: File) {\n // Create a new FormData object.\n const formData = new FormData();\n formData.append(\"graphFile\", file);\n const request = new XMLHttpRequest();\n request.onreadystatechange = () => {\n if (\n request.readyState === XMLHttpRequest.DONE &&\n request.status === 200\n ) {\n const linesOfData = request.responseText.split(\"\\n\");\n if (linesOfData.length > 0) {\n const profileIdsFromFile = linesOfData[0].split(\"\\t\").slice(1);\n profileIdsFromFile.forEach(id =>\n this.addProfile({ profileId: id, enabled: true })\n );\n } else {\n console.log(\"Error: No valid data\");\n }\n this.editor.addGenomicData(request.responseText);\n }\n };\n request.open(\"POST\", \"/loadGraph\");\n request.send(formData);\n }\n\n @autobind\n upload() {\n if (this.editor.cy.elements().length > 0) {\n this.handleOpen(EModalType.CONFIRMATION);\n ConfirmationModal.pendingFunction = () => {\n this.uploader.click();\n };\n } else {\n this.uploader.click();\n }\n }\n\n @autobind\n merge() {\n this.merger.click();\n }\n\n setOverlayUploader(inputRef: any) {\n this.overlayUploader = inputRef;\n }\n\n @autobind\n setUploaders(inputRef: any, isMerge: boolean) {\n if (isMerge) this.merger = inputRef;\n else this.uploader = inputRef;\n }\n\n @computed\n get getPathwayInfo() {\n return this.fileManager.getPathwayInfo;\n }\n\n @autobind\n setPathwayInfo(other: IPathwayInfo) {\n this.fileManager.setPathwayInfo(other);\n }\n\n @autobind\n undo() {\n this.undoRedoManager.undo();\n }\n\n @autobind\n redo() {\n this.undoRedoManager.redo();\n }\n\n @autobind\n export(isSIFNX: boolean) {\n //this.editor.cy.remove('.eh-handle');\n this.eh.hide();\n this.fileManager.saveGraph(isSIFNX, this.editor);\n }\n\n @autobind\n resetUndoStack() {\n this.undoRedoManager.reset();\n }\n\n @autobind\n newPathway() {\n const commitNewPathway = () => {\n this.editor.removeAllElements();\n this.fileManager.setPathwayInfo({\n pathwayTitle: \"New Pathway\",\n pathwayDetails: \"\"\n });\n //this.removeAllData()\n this.resetUndoStack();\n this.pathwayHandler(\"Dummy\");\n };\n\n if (this.editor.cy.elements().length > 0) {\n this.handleOpen(EModalType.CONFIRMATION);\n ConfirmationModal.pendingFunction = commitNewPathway;\n } else {\n commitNewPathway();\n }\n }\n\n @autobind\n changePathway(pathwayName: string) {\n this.pathwayHandler(pathwayName);\n\n if (!this.isCBioPortal) {\n this.fileManager.setPathwayInfo({\n pathwayTitle: pathwayName,\n pathwayDetails: \"\",\n });\n // At the beginning changePathway is called editor is not ready hence removeData shall not be called\n if (this.editor) {\n //this.removeAllData()\n this.resetUndoStack();\n }\n }\n }\n\n @autobind\n highlightNeighbours() {\n this.editor.highlightNeighbors();\n }\n\n @autobind\n highlightSelected() {\n this.editor.highlightSelected();\n }\n\n @autobind\n validateGenes() {\n this.editor.validateGenes();\n }\n\n @autobind\n showAll() {\n this.editor.showAllNodes();\n }\n\n @autobind\n hideSelected() {\n this.editor.hideSelectedNodes();\n }\n\n @autobind\n deleteSelected() {\n const selectedEles = this.editor.cy.elements(\":selected\");\n this.editor.removeElement(selectedEles);\n }\n\n @autobind\n addEdge(edgeTypeIndex: number) {\n // @ts-ignore\n window.edgeAddingMode = edgeTypeIndex + 1;\n if (edgeTypeIndex === -1) {\n this.eh.disable();\n this.eh.hide();\n return;\n } else {\n // @ts-ignore\n this.eh.enable();\n }\n }\n\n @autobind\n changeNodeName(oldName: string, newName: string) {\n const cyNode = this.editor.cy.$('[name=\"' + oldName + '\"]')[0];\n this.editor.changeName(cyNode, newName);\n }\n\n @autobind\n addNode(nodeType) {\n const nodeData = {\n type: nodeType.toUpperCase(),\n name: \"New \" + nodeType,\n w: \"150\",\n h: \"52\"\n };\n const extent = this.editor.cy.extent();\n const posData = {\n x: (extent.x1 + extent.x2) / 2,\n y: (extent.y1 + extent.y2) / 2\n };\n\n this.editor.addNode(nodeData, posData);\n this.pathwayHandler(\"Additional Pathway\");\n }\n\n @autobind\n searchGene(geneName: string) {\n const selector = \"node[name @*= '\" + geneName + \"']\";\n const nodesContainingSearchedGene = this.editor.cy.filter(selector);\n let nodesToSelect = this.editor.cy.collection();\n nodesContainingSearchedGene.forEach(function(ele, index) {\n if (\n !ele.hasClass(\"highlightedNode\") &&\n !ele.hasClass(\"invalidGeneHighlight\")\n )\n nodesToSelect = nodesToSelect.union(ele);\n });\n this.editor.highlightBySearch(nodesToSelect);\n }\n\n @autobind\n removeAllData() {\n this.editor.removeGenomicData();\n this.clearProfiles();\n }\n\n @autobind\n removeAllHighlight() {\n this.editor.removeAllHighlight();\n }\n\n @autobind\n processFile(file: File, isMerge: boolean) {\n // Create a new FormData object.\n const formData = new FormData();\n formData.append(\"graphFile\", file);\n const request = new XMLHttpRequest();\n request.onreadystatechange = () => {\n if (request.readyState === XMLHttpRequest.DONE) {\n if (request.status === 200) {\n const pathwayData: IPathwayData = SaveLoadUtility.parseGraph(\n request.responseText,\n false\n );\n\n if (isMerge) {\n this.editor.mergeGraph(pathwayData.nodes, pathwayData.edges);\n const graphJSON = this.editor.cy.json();\n\n //TODO change file name maybe, probabyly not necessary ?\n // Pathway nodes and edges are now combination of both previous and new pathway.\n pathwayData.nodes = graphJSON.elements.nodes; //this.editor.cy.nodes().map((node) => ({data: node.data()}));\n pathwayData.edges = graphJSON.elements.edges; //this.editor.cy.edges().map((edge) => ({data: edge.data()}));\n pathwayData.title = \"Additional Pathway\";\n } else {\n this.editor.loadFile(pathwayData.nodes, pathwayData.edges);\n this.fileManager.setPathwayInfo({\n pathwayTitle: pathwayData.title,\n pathwayDetails: pathwayData.description\n });\n }\n\n this.pathwayHandler(pathwayData.title + \"_imported\");\n this.resetUndoStack();\n } else {\n console.error(\n \"Error processing file: \" +\n request.readyState +\n request.responseText\n );\n }\n }\n };\n request.open(\"POST\", \"/loadGraph\");\n request.send(formData);\n }\n\n @autobind\n saveAs(type: string) {\n if (type === \"SVG\") {\n this.fileManager.saveAsSVG(this.editor);\n } else if (type === \"PNG\") {\n this.fileManager.saveAsPNG(this.editor.cy);\n } else if (type === \"JPEG\") {\n this.fileManager.saveAsJPEG(this.editor.cy);\n }\n }\n\n @autobind\n editorHandler(\n editor,\n eh,\n undoRedoManager,\n viewOperationsManager: ViewOperationsManager,\n gridOptionsManager: GridOptionsManager\n ) {\n this.editor = editor;\n this.eh = eh;\n this.undoRedoManager = undoRedoManager;\n this.viewOperationsManager = viewOperationsManager;\n this.gridOptionsManager = gridOptionsManager;\n }\n\n @autobind\n loadSampleData() {\n const data =\n \"gene\\tlung\\tovarian\\tbreast\\ty\\n\" +\n \"PTEN\\t-7\\t-20\\t10\\t20\\n\" +\n \"NF1\\t-12\\t-4\\t30\\t20\\n\" +\n \"PIK3CA\\t18\\t40\\t-50\\t20\\n\" +\n \"KRAS\\t11\\t-5\\t0\\t20\\n\" +\n \"ZIYA\\t0\\t-2\\t0\\t20\\n\" +\n \"AKT1\\t3\\t30\\t-10\\t20\\n\" +\n \"AKT2\\t6\\t-3\\t20\\t20\\n\" +\n \"AKT3\\t6\\t-3\\t20\\t20\\n\" +\n \"\\n\";\n this.editor.addGenomicData(data);\n\n this.addProfile({ profileId: \"lung\", enabled: true });\n this.addProfile({ profileId: \"ovarian\", enabled: true });\n this.addProfile({ profileId: \"breast\", enabled: true });\n }\n\n @autobind\n performLayout() {\n this.editor.performLayout();\n }\n}\n","import { makeObservable, observable } from \"mobx\";\nimport { observer } from \"mobx-react\";\nimport React from \"react\";\nimport { Button, ButtonGroup, ButtonToolbar, FormControl, FormGroup, Glyphicon, InputGroup, Navbar } from \"react-bootstrap\";\n// @ts-ignore\nimport aboutSvg from '../images/toolbar/about.svg';\n// @ts-ignore\nimport ahbSvg from '../images/toolbar/align/align-horizontal-bottom.svg';\n// @ts-ignore\nimport ahmSvg from '../images/toolbar/align/align-horizontal-middle.svg';\n// @ts-ignore\nimport ahtSvg from '../images/toolbar/align/align-horizontal-top.svg';\n// @ts-ignore\nimport avcSvg from '../images/toolbar/align/align-vertical-center.svg';\n// @ts-ignore\nimport avlSvg from '../images/toolbar/align/align-vertical-left.svg';\n// @ts-ignore\nimport avrSvg from '../images/toolbar/align/align-vertical-right.svg';\n// @ts-ignore\nimport deleteSvg from '../images/toolbar/delete-simple.svg';\n// @ts-ignore\nimport gridSvg from '../images/toolbar/grid.svg';\n// @ts-ignore\nimport guideSvg from '../images/toolbar/guidelines.svg';\n// @ts-ignore\nimport hideSvg from '../images/toolbar/hide-selected.svg';\n// @ts-ignore\nimport layoutSvg from '../images/toolbar/layout-cose.svg';\n// @ts-ignore\nimport layoutPropSvg from '../images/toolbar/layout-properties.svg';\n// @ts-ignore\nimport loadSvg from '../images/toolbar/load.svg';\n// @ts-ignore\nimport newSvg from '../images/toolbar/new.svg';\n// @ts-ignore\nimport portalSvg from '../images/toolbar/portal.svg';\n// @ts-ignore\nimport helpSvg from '../images/toolbar/quick-help.svg';\n// @ts-ignore\nimport redoSvg from '../images/toolbar/redo.svg';\n// @ts-ignore\nimport saveSvg from '../images/toolbar/save.svg';\n// @ts-ignore\nimport setingsSvg from '../images/toolbar/settings.svg';\n// @ts-ignore\nimport showSvg from '../images/toolbar/show-all.svg';\n// @ts-ignore\nimport undoSvg from '../images/toolbar/undo.svg';\nimport { EGridType } from \"../modals/GridSettings\";\nimport PathwayActions from \"../utils/PathwayActions\";\nimport { EModalType } from \"./react-pathway-mapper\";\n\n\ninterface IButtonbarProps {\n pathwayActions: PathwayActions;\n handleOpen: (modelId: EModalType) => void;\n}\n\ninterface ISVGFunction{\n svg: any;\n function: () => void;\n tooltip: string; \n isFocused?: boolean;\n}\n\n\n@observer\nexport default class Buttonbar extends React.Component{\n\n\n @observable\n private searchedGene: string;\n\n\n constructor(props: IButtonbarProps) {\n super(props);\n makeObservable(this);\n \n this.searchedGene = \"\";\n this.props.pathwayActions.enabledType = EGridType.NONE;\n }\n\n setEnabledType(newType: EGridType){\n if(newType === this.props.pathwayActions.enabledType){\n this.props.pathwayActions.enabledType = EGridType.NONE;\n } else {\n this.props.pathwayActions.enabledType = newType;\n }\n\n // Enabled type calculated\n\n if(this.props.pathwayActions.enabledType === EGridType.GRID){\n this.props.pathwayActions.toggleGrid(true);\n }\n else if(this.props.pathwayActions.enabledType === EGridType.GUIDE){\n this.props.pathwayActions.toggleGuide(true);\n } else {\n this.props.pathwayActions.toggleGrid(false); // This will disable both.\n }\n }\n render() {\n \n const fileFunctions: ISVGFunction[] = [\n {svg: newSvg, function: this.props.pathwayActions.newPathway, tooltip: \"New Pathway\"},\n {svg: loadSvg, function: this.props.pathwayActions.upload, tooltip: \"Import Pathway\" },\n {svg: saveSvg, function: () => {this.props.pathwayActions.export(false)}, tooltip: \"Export Pathway\"}];\n \n const modFunctions: ISVGFunction[] = [\n {svg: deleteSvg, function: this.props.pathwayActions.deleteSelected, tooltip: \"Delete Selected\"}];\n\n if(!this.props.pathwayActions.isCollaborative){\n modFunctions.push({svg: undoSvg, function: () => {this.props.pathwayActions.undo();}, tooltip: \"Undo\"},\n {svg: redoSvg, function: () => {this.props.pathwayActions.redo();}, tooltip: \"Redo\"});\n }\n const alignFunctions: ISVGFunction[] = [\n {svg: ahtSvg, function: () => {this.props.pathwayActions.align(\"hTop\");}, tooltip: \"Align Horizontal Top\"},\n {svg: ahmSvg, function: () => {this.props.pathwayActions.align(\"hMid\");}, tooltip: \"Align Horizontal Middle\"},\n {svg: ahbSvg, function: () => {this.props.pathwayActions.align(\"hBot\");}, tooltip: \"Align Horizontal Bottom\"},\n {svg: avlSvg, function: () => {this.props.pathwayActions.align(\"vLeft\");}, tooltip: \"Align Vertical Left\"},\n {svg: avcSvg, function: () => {this.props.pathwayActions.align(\"vCen\");}, tooltip: \"Align Vertical Center\"},\n {svg: avrSvg, function: () => {this.props.pathwayActions.align(\"vRight\");}, tooltip: \"Align Vertical Right\"}];\n \n const utilFunctions: ISVGFunction[] = [\n {isFocused: this.props.pathwayActions.enabledType === EGridType.GRID, svg: gridSvg, function: () => {this.setEnabledType(EGridType.GRID);}, tooltip: \"Enable Grid: Show and snap to grid\"},\n {isFocused: this.props.pathwayActions.enabledType === EGridType.GUIDE, svg: guideSvg, function: () => {this.setEnabledType(EGridType.GUIDE);}, tooltip: \"Enable Guidelines: Enable and snap to alignment guidelines\"}];\n\n const visibilityFunctions: ISVGFunction[] = [\n {svg: hideSvg, function: () => {this.props.pathwayActions.hideSelected();}, tooltip: \"Hide Selected\"},\n {svg: showSvg, function: () => {this.props.pathwayActions.showAll();}, tooltip: \"Show All\"}];\n\n const layoutFunctions: ISVGFunction[] = [\n {svg: layoutSvg, function: () => {this.props.pathwayActions.performLayout();}, tooltip: \"Perform Layout\"},\n {svg: layoutPropSvg, function: () => {this.props.handleOpen(EModalType.LAYOUT);}, tooltip: \"Layout Properties\"}];\n\n const portalFunctions: ISVGFunction[] = [\n {svg: portalSvg, function: () => {this.props.handleOpen(EModalType.STUDY);}, tooltip: \"Fetch Genomic Data From cBioPortal\"},\n {svg: setingsSvg, function: () => {this.props.handleOpen(EModalType.PROFILES);}, tooltip: \"Genomic Data Visibility Settings\"}];\n\n const infoFunctions: ISVGFunction[] = [\n {svg: helpSvg, function: () => {this.props.handleOpen(EModalType.HELP);}, tooltip: \"Quick Help\"},\n {svg: aboutSvg, function: () => {this.props.handleOpen(EModalType.ABOUT);}, tooltip: \"About\"}];\n \n const allFunctions = [fileFunctions, modFunctions, alignFunctions, utilFunctions, visibilityFunctions, portalFunctions, layoutFunctions, infoFunctions];\n\n \n return (\n \n \n { allFunctions.map((functions, index) =>\n \n { functions.map((svg: ISVGFunction, index) => \n (\n )\n )\n }\n )\n }\n \n \n \n { this.searchedGene = e.target.value;}}\n placeholder=\"Search Genes...\"\n onKeyPress={(e: any) => { if (e.key !== \"Enter\") return; this.props.pathwayActions.searchGene(this.searchedGene) }} />\n {this.props.pathwayActions.searchGene(this.searchedGene)}}\n style={{cursor: 'pointer'}}\n >\n \n \n \n \n \n \n \n )\n }\n\n}\n","import { EModalType } from \"../ui/react-pathway-mapper\";\nimport EditorActionsManager from \"./EditorActionsManager\";\n\nexport default class ContextMenuManager {\n private cy: any;\n private editor: EditorActionsManager;\n private handleOpen: (modalId: EModalType) => void;\n private undoRedoManager: any;\n private isCollaborative: any;\n constructor(cy: any, editor: EditorActionsManager,\n handleOpen: (modalId: EModalType) => void, undoRedoManager: any,\n isCollaborative: boolean){\n this.cy = cy;\n this.editor = editor;\n this.handleOpen = handleOpen;\n this.undoRedoManager = undoRedoManager;\n this.isCollaborative = isCollaborative;\n this.init();\n }\n\n init() {\n const classRef = this;\n\n const ctxMenus = this.cy.scratch('cycontextmenus') ? \n this.cy.contextMenus('get') :\n this.cy.contextMenus();\n\n let menuItems = [\n {\n id: 'deleteSelected',\n content: 'Delete Selected',\n coreAsWell: true,\n onClickFunction: () => {\n const selectedEles = this.cy.elements(':selected');\n classRef.editor.removeElement(selectedEles);\n },\n disabled: false, \n hasTrailingDivider: false,\n },\n {\n id: 'hideSelected',\n content: 'Hide Selected',\n coreAsWell: true,\n onClickFunction: function () {\n classRef.editor.hideSelectedNodes();\n },\n disabled: false,\n hasTrailingDivider: false, \n },\n {\n id: 'loadFromCBioPortal',\n content: 'Load From cBioPortal...', \n coreAsWell: true,\n onClickFunction: () => {\n this.handleOpen(EModalType.STUDY);\n },\n disabled: false,\n hasTrailingDivider: false,\n },\n //Context menu items when clicking on nodes/compounds\n {\n id: 'remove', \n content: 'Delete', \n selector: 'node, edge',\n onClickFunction: function (event) {\n var ele = event.target;\n // The function to be executed on click\n var selectedElements = classRef.cy.nodes(':selected').union(ele);\n classRef.editor.removeElement(selectedElements);\n },\n disabled: false,\n hasTrailingDivider: false, \n coreAsWell: false \n },\n {\n id: 'addSelected',\n content: 'Add Selected Into This', \n selector: 'node',\n onClickFunction: function (event)\n {\n var ele = event.target;\n var selectedNodes = classRef.cy.nodes(':selected');\n var containerType = ele.data('type');\n var validNodes = classRef.cy.collection();\n\n //Do nothing if node is GENE\n if (ele._private.data['type'] === 'GENE' || selectedNodes.size() < 1) {\n return;\n }\n //Prevent actions like adding root node to children & addition to itself\n else\n {\n var notValid = false;\n selectedNodes.forEach(function (tmpNode, i)\n {\n if (ele.id() == tmpNode.id()) {\n notValid = true;\n return false;\n }\n\n if (tmpNode.isParent()) {\n notValid = classRef.isChildren(tmpNode, ele);\n if (notValid) {\n return false;\n }\n }\n\n return true;\n });\n\n if (notValid) {\n return;\n }\n }\n\n\n selectedNodes.forEach(function (tmpNode, i)\n {\n\n if(containerType == \"FAMILY\" || containerType == \"COMPLEX\")\n {\n if(tmpNode.data('type') != \"COMPARTMENT\" && tmpNode.data('type') != \"PROCESS\")\n {\n validNodes = validNodes.add(tmpNode);\n }\n }\n else\n {\n validNodes = validNodes.add(tmpNode);\n }\n\n });\n\n var compId = ele.id();\n classRef.editor.changeParents(validNodes, compId);\n //Unselecting nodes to remove them from selectedNodeStack\n selectedNodes.unselect();\n\n },\n disabled: false,\n hasTrailingDivider: false, \n coreAsWell: false \n },\n {\n id: 'removeSelected',\n content: 'Remove Selected From Parent', \n selector: 'node',\n onClickFunction: function (event) {\n const ele = event.target;\n const selectedNodes = classRef.cy.nodes(':selected');\n\n let notValid = false;\n selectedNodes.forEach(function (tmpNode, i) {\n\n if (tmpNode.isParent()) {\n notValid = classRef.isChildren(tmpNode, ele);\n if (notValid) {\n return false;\n }\n }\n\n return true;\n });\n\n if (notValid) {\n return;\n }\n\n classRef.editor.changeParents(selectedNodes, null);\n //Unselecting nodes to remove them from selectedNodeStack\n selectedNodes.unselect();\n },\n disabled: false, \n hasTrailingDivider: false,\n coreAsWell: false \n },\n {\n id: 'performLayout', \n content: 'Perform Layout', \n coreAsWell: true,\n onClickFunction: () => {\n this.editor.performLayout();\n },\n disabled: false, \n hasTrailingDivider: false, \n }\n\n ];\n let nonCollabItems = [ \n //Context menu items when clicking on blank space\n {\n id: 'undoAction', \n content: 'Undo', \n coreAsWell: true,\n onClickFunction: () => {\n this.undoRedoManager.undo();\n },\n disabled: false, \n hasTrailingDivider: false, \n },\n {\n id: 'redoAction',\n content: 'Redo',\n coreAsWell: true,\n onClickFunction: () => {\n this.undoRedoManager.redo();\n },\n disabled: false,\n hasTrailingDivider: false,\n }\n ];\n\n if(!this.isCollaborative){\n menuItems = menuItems.concat(nonCollabItems);\n }\n ctxMenus.appendMenuItems(menuItems);\n }\n\n //TODO better move this to another class\n //Utility function to check whether query node is children of given node\n isChildren(node, queryNode)\n {\n var parent = queryNode.parent()[0];\n while(parent)\n {\n if (parent.id() == node.id()) {\n return true;\n }\n parent = parent.parent()[0];\n }\n return false;\n }\n}\n","import tippy from 'tippy.js';\nimport 'tippy.js/dist/tippy.css'; // optional for styling\nimport EditorActionsManager from \"./EditorActionsManager\";\nexport default class QtipManager{\n private cy: any;\n private editor: any;\n constructor(cy: any, editor: EditorActionsManager)\n {\n this.cy = cy;\n this.editor = editor;\n }\n\n generateEdgeQtip(edge) {\n const self = this;\n const pubmedURL = 'https://www.ncbi.nlm.nih.gov/pubmed/';\n const pubmedData = edge.data('pubmedIDs');\n\n const wrapper = document.createElement('div');\n\n // header\n const header = document.createElement('div');\n header.classList.add('row', 'node-tooltip-header');\n header.innerHTML = \"INTERACTION DETAILS\";\n\n wrapper.append(header);\n\n // edge label input\n const textInputWrapper = document.createElement('div');\n textInputWrapper.classList.add('col-xs-6', 'inputCol');\n\n const inputElement = document.createElement('input');\n inputElement.type = 'text';\n inputElement.value = edge.data('name');\n inputElement.classList.add('form-control');\n\n inputElement.addEventListener(\"change\", function(event) {\n // @ts-ignore\n const value = event.target.value;\n self.editor.changeName(edge, value);\n });\n\n textInputWrapper.appendChild(inputElement);\n\n const edgeLabelRowElement = document.createElement('div');\n edgeLabelRowElement.classList.add('row', 'geneDetails');\n const colElement = document.createElement('div');\n colElement.classList.add('col-xs-6', 'qtipLabel');\n colElement.innerHTML = \"Label:\";\n\n edgeLabelRowElement.appendChild(colElement);\n edgeLabelRowElement.appendChild(textInputWrapper);\n\n wrapper.appendChild(edgeLabelRowElement);\n \n wrapper.appendChild(document.createElement('hr'));\n\n // pubmed id input\n const pubmedTextInputWrapper = document.createElement('div');\n pubmedTextInputWrapper.classList.add('col-xs-6', 'inputCol');\n\n const pubmedIdInputElement = document.createElement('input');\n pubmedIdInputElement.type = 'text';\n pubmedIdInputElement.classList.add('form-control');\n\n pubmedIdInputElement.addEventListener(\"change\", function(event) {\n // @ts-ignore\n const value = event.target.value;\n const pubmedIdsToAdd = value.split(';');\n \n // @ts-ignore\n event.target.value = \"\";\n\n self.editor.addPubmedIDs(edge, pubmedIdsToAdd);\n\n const pubmedIds = edge.data(\"pubmedIDs\")\n generatePubmedLinks(pubmedIds);\n });\n\n pubmedTextInputWrapper.appendChild(pubmedIdInputElement);\n\n const pubmedIdRowElement = document.createElement('div');\n pubmedIdRowElement.classList.add('row', 'geneDetails');\n const pubmedIdColElement = document.createElement('div');\n pubmedIdColElement.classList.add('col-xs-6', 'qtipLabel');\n pubmedIdColElement.innerHTML = \"Add Pubmed ID(s):\";\n\n pubmedIdRowElement.appendChild(pubmedIdColElement);\n pubmedIdRowElement.appendChild(pubmedTextInputWrapper);\n\n wrapper.appendChild(pubmedIdRowElement);\n\n if (pubmedData.length > 0) {\n generatePubmedLinks(pubmedData);\n }\n\n function generatePubmedLinks(argData) {\n if (document.getElementsByClassName(\"pubmedIDList\").length > 0) {\n document.getElementsByClassName(\"pubmedIDList\").item(0).remove();\n }\n const pubmedIdListWrapper = document.createElement('div');\n pubmedIdListWrapper.classList.add(\"pubmedIDList\");\n\n pubmedIdListWrapper.appendChild(document.createElement('hr'));\n\n const pubmedIdLabel = document.createElement('label');\n pubmedIdLabel.classList.add(\"col-xs-12\", \"pubmedIDLabel\");\n pubmedIdLabel.innerHTML = \"Pubmed IDs\";\n\n pubmedIdListWrapper.appendChild(pubmedIdLabel);\n\n for (var key in argData)\n {\n if(!argData.hasOwnProperty(key)){\n continue;\n }\n const pubmedId = argData[key];\n\n if (isNaN(pubmedId))\n continue;\n\n const pubmedIdListElement = document.createElement('div');\n\n const pubmedIdRemoveButton = document.createElement('i');\n pubmedIdRemoveButton.classList.add('fa', 'fa-times', 'qtipRemovePmedID');\n pubmedIdRemoveButton.setAttribute('aria-hidden', 'true');\n pubmedIdRemoveButton.setAttribute('pubmedId', pubmedId);\n\n pubmedIdRemoveButton.addEventListener(\"click\", function(event) {\n (event.target as HTMLElement).parentElement.remove();\n const pubmedId = (event.target as HTMLElement).getAttribute('pubmedId');\n self.editor.removePubmedID(edge, [pubmedId]);\n const pubmedIds = edge.data('pubmedIDs');\n if (pubmedIds.length === 0) {\n document.getElementsByClassName(\"pubmedIDList\").item(0).remove();\n }\n });\n \n const pubmedContent = document.createElement('div');\n const pubmedIdLabel = document.createElement('label');\n const pubmedIdLink = document.createElement('a');\n pubmedIdLink.setAttribute('target', '_blank');\n const pubmedLink = pubmedURL + pubmedId;\n pubmedIdLink.setAttribute('href', pubmedLink);\n pubmedIdLink.innerHTML = pubmedId.toString();\n\n pubmedIdLabel.appendChild(pubmedIdLink);\n pubmedContent.appendChild(pubmedIdLabel);\n pubmedContent.appendChild(pubmedIdRemoveButton);\n pubmedIdListElement.appendChild(pubmedContent);\n\n pubmedIdListWrapper.appendChild(pubmedIdListElement);\n }\n if (edge.data('pubmedIDs').length > 0) {\n wrapper.appendChild(pubmedIdListWrapper);\n }\n }\n\n wrapper.classList.add(\"tooltip-text-style\");\n return wrapper;\n }\n\n generateNodeQtip(node) {\n const self = this;\n\n const header = document.createElement('div');\n header.classList.add('row', 'node-tooltip-header');\n header.innerHTML = node.data('type').toUpperCase() + \" DETAILS\";\n\n const textInputWrapper = document.createElement('div');\n textInputWrapper.classList.add('col-xs-8', 'inputCol');\n\n const inputElement = document.createElement('input');\n inputElement.type = 'text';\n inputElement.value = node.data('name');\n inputElement.classList.add('form-control');\n\n inputElement.addEventListener(\"change\", function(event) {\n // @ts-ignore\n const value = event.target.value;\n self.editor.changeName(node, value);\n });\n\n textInputWrapper.appendChild(inputElement);\n\n const wrapper = document.createElement('div');\n const rowElement = document.createElement('div');\n rowElement.classList.add('row', 'geneDetails');\n const colElement = document.createElement('div');\n colElement.classList.add('col-xs-4', 'qtipLabel');\n colElement.innerHTML = \"Name:\";\n\n rowElement.appendChild(colElement);\n rowElement.appendChild(textInputWrapper);\n\n wrapper.append(header);\n wrapper.append(rowElement);\n\n if (node.data('type') === \"GENE\") {\n const buttonWrapper = document.createElement('div');\n buttonWrapper.classList.add('row', 'centerText', 'geneDetails');\n \n const button = document.createElement('button');\n button.type = 'button';\n button.classList.add('btn', 'btn-default');\n button.innerHTML = \"My Cancer Genome\";\n button.addEventListener(\"click\", function (event) {\n event.preventDefault();\n const name = node.data('name');\n window.open(\"https://www.mycancergenome.org/content/gene/\" + name);\n })\n\n buttonWrapper.append(button);\n wrapper.append(buttonWrapper)\n }\n\n wrapper.classList.add(\"tooltip-text-style\");\n return wrapper;\n }\n\n addQtipToElements(eles)\n {\n const self = this;\n eles.forEach(function(ele)\n {\n let ref = ele.popperRef();\n let dummyDomEle = document.createElement('div');\n document.body.appendChild(dummyDomEle);\n let tip = tippy(dummyDomEle, { // tippy props:\n getReferenceClientRect: ref.getBoundingClientRect, // https://atomiks.github.io/tippyjs/v6/all-props/#getreferenceclientrect\n trigger: 'manual', // mandatory, we cause the tippy to show programmatically.\n placement: 'bottom',\n interactive: true,\n theme: 'pathwaymapper',\n // your own custom props\n // content prop can be used when the target is a single element https://atomiks.github.io/tippyjs/v6/constructor/#prop\n content: () => {\n let content = ele.isNode() ? \n self.generateNodeQtip(ele) :\n self.generateEdgeQtip(ele);\n \n return content;\n },\n onHidden(instance) {\n instance.destroy();\n dummyDomEle.remove();\n }\n });\n \n self.cy.one(\"pan zoom\", function() {\n if (dummyDomEle && dummyDomEle[\"_tippy\"]) {\n tip.hide();\n }\n });\n\n ele.one(\"showqtipevent\", function() {\n tip.show();\n });\n });\n }\n\n\n //Utility Functions\n capitalizeFirstLetter(string)\n {\n return string.charAt(0).toUpperCase() + string.slice(1);\n }\n\n\n}\n","import cytoscape from 'cytoscape';\nimport $ from \"jquery\";\nimport 'jquery-ui-dist/jquery-ui';\nimport EditorActionsManager from \"../managers/EditorActionsManager\";\n\n\nexport default class DragDropNodeAddPlugin {\n\n\n\n pathwayHandler: (pathwayName: string) => void;\n\n private cy: any;\n private editor: EditorActionsManager;\n\n constructor(editor: EditorActionsManager, cy: any, pathwayHandler: (pathwayName: string) => void)\n {\n this.editor = editor;\n this.cy = cy;\n this.pathwayHandler = pathwayHandler;\n this.initNodeAdd();\n }\n\n //TODO JQUERY IS IGNORED\n initNodeAdd()\n {\n var nodeAddClass = this;\n var defaults = {\n height: 30, //height of the icon container\n width: 30, //width of the icon container\n padding: 5, //padding of the icon container(from right & top)\n backgroundColorDiv: '#fbfbfb', //background color of the icon container\n borderColorDiv: '#fff', //border color of the icon container\n borderWidthDiv: '0px', //border width of the icon container\n borderRadiusDiv: '5px', //border radius of the icon container\n\n icon: '', //icon class name\n\n nodeParams: function(){\n // return element object to be passed to cy.add() for adding node\n return {};\n }\n };\n\n const self = this;\n\n // @ts-ignore\n $.fn.cytoscapeNodeadd = function(params: any) {\n var options = $.extend(true, {}, defaults, params);\n var fn = params;\n\n var functions = {\n destroy: function() {\n var $this = $(this);\n\n $this.find(\".ui-cytoscape-nodeadd\").remove();\n },\n init: function()\n {\n return $(this).each(function()\n {\n var components = options.components;\n for (const component of components)\n {\n var dragContainer = component.container;\n //var explanationText = component.explanationText;\n\n var $nodeadd = $('
');\n dragContainer.append($nodeadd);\n var $nodeDragHandle = $('
\\\n \\\n \\\n \\\n
');\n $nodeadd.append($nodeDragHandle);\n\n $nodeDragHandle.bind(\"mousedown\", function(e: any)\n {\n e.stopPropagation(); // don't trigger dragging of nodeadd\n e.preventDefault(); // don't cause text selection\n });\n\n //Setup UI\n dragContainer.find(\".ui-cytoscape-nodeadd-nodediv\").css({\n background: options.backgroundColorDiv,\n border: options.borderWidthDiv + ' solid ' + options.borderColorDiv,\n 'border-radius': options.borderRadiusDiv\n });\n\n //Init Draggable\n dragContainer.find(\"#ui-cytoscape-nodeadd-icon\").draggable({\n helper: \"clone\",\n cursor: \"pointer\"\n });\n }\n\n // @ts-ignore TODO: AMENDMENT ATTENTION\n var $container = $(this);\n //Init Droppable\n // @ts-ignore TODO: Droppable is ignored\n $container.droppable({\n activeClass: \"ui-state-highlight\",\n // accept: \"#ui-cytoscape-nodeadd-icon\",\n drop: function(event: any, ui: any) {\n $container.removeClass(\"ui-state-highlight\");\n\n var currentOffset = $container.offset();\n var relX = event.pageX - currentOffset.left;\n var relY = event.pageY - currentOffset.top;\n\n var nodeType = $(ui.helper).attr('nodeType').toUpperCase();\n\n var cy = nodeAddClass.cy;\n\n //Hold a map for parents and candidate parent nodes for this addition\n var nodeMap = {};\n var parentMap = {};\n //Loop through nodes for hit testing about drag position on canvas\n cy.nodes().forEach(function(node: any)\n {\n var nodeBbox = node.renderedBoundingBox();\n //Rectangle point test\n if ( (relX <= nodeBbox.x2 && relX >= nodeBbox.x1) && (relY <= nodeBbox.y2 && relY >= nodeBbox.y1) && node.data().type != 'GENE' )\n {\n //If node has a children put an entry to the parentMap\n if (node.children().length > 0)\n {\n parentMap[node.id()] = true;\n }\n\n //If parent of this node is already added to the node map remove it, since our candidate is in deeper level !\n if (parentMap[node._private.data.parent])\n {\n delete nodeMap[node._private.data.parent];\n }\n\n //Add an entry to node map\n nodeMap[node.id()] = node;\n }\n });\n\n //Check if any parent found, if so set parent field\n var parent = nodeMap[Object.keys(nodeMap)[0]];\n var nodeData = {w: \"0\", h: \"100\", parent: 0, type: nodeType, name:'New '+ $(ui.helper).attr('nodeType')};\n if (parent)\n {\n if(parent.data().type == \"FAMILY\" || parent.data().type == \"COMPLEX\")\n {\n if(nodeType != \"COMPARTMENT\" && nodeType != \"PROCESS\")\n {\n nodeData.parent = parent.id();\n }\n }\n else\n {\n nodeData.parent = parent.id();\n }\n }\n if (nodeType === \"PROCESS\") {\n nodeData.w = \"100\";\n nodeData.h = \"35\";\n }\n else {\n nodeData.w = \"150\";\n nodeData.h = \"52\";\n }\n\n //Adjust position according to the zoom level and pan !\n //To set rendered position !!!\n //TODO refactor this !\n relX = relX / cy.zoom() + cy.extent().x1;\n relY = relY / cy.zoom() + cy.extent().y1;\n nodeAddClass.editor.addNode(nodeData,{x: relX,y: relY});\n self.pathwayHandler(\"Additional Pathway\");\n\n }\n });\n\n });\n }\n };\n\n if (functions[fn]) {\n return functions[fn].apply(this, Array.prototype.slice.call(arguments, 1));\n } else if (typeof fn == 'object' || !fn) {\n return functions.init.apply(this, arguments);\n } else {\n $.error(\"No such function `\" + fn + \"` for jquery.cytoscapenodeadd\");\n }\n\n return $(this);\n };\n\n // @ts-ignore\n $.fn.cynodeadd = $.fn.cytoscapeNodeadd;\n try{\n /* Adding as an extension to the core functionality of cytoscape.js*/\n cytoscape('core', 'nodeadd', function(options: any) {\n\n // @ts-ignore\n $(this.container()).cytoscapeNodeadd(options);\n });\n } catch(err){\n console.log(err);\n }\n }\n\n\n\n\n}\n","import autobind from \"autobind-decorator\";\nimport cytoscape from 'cytoscape';\nimport $ from \"jquery\";\nimport { observer } from \"mobx-react\";\nimport React from 'react';\nimport pathways from \"../data/pathways.json\";\n// @ts-ignore\nimport compartmentImg from \"../images/nodes/compartment.svg\";\n// @ts-ignore\nimport complexImg from \"../images/nodes/complex.svg\";\n// @ts-ignore\nimport familyImg from \"../images/nodes/family.svg\";\n// @ts-ignore\nimport geneImg from \"../images/nodes/gene.svg\";\n// @ts-ignore\nimport processImg from \"../images/nodes/process.svg\";\n// @ts-ignore\nimport resizeCue from '../images/resizeCue.svg';\nimport ContextMenuManager from \"../managers/ContextMenuManager\";\nimport EditorActionsManager from \"../managers/EditorActionsManager\";\nimport QtipManager from \"../managers/QtipManager\";\nimport ShareDBManager from \"../managers/ShareDBManager\";\nimport ViewOperationsManager from \"../managers/ViewOperationsManager\";\nimport CBioPortalAccessor from \"../utils/CBioPortalAccessor\";\nimport DragDropNodeAddPlugin from \"../utils/DragDropNodeAddPlugin\";\nimport SaveLoadUtility from \"../utils/SaveLoadUtility\";\nimport { EModalType, IColorValueMap, IProfileMetaData } from './react-pathway-mapper';\n\n// @ts-ignore\nwindow.$ = $;\n\nconst edgeHandles = require('cytoscape-edgehandles');\nconst edgeEditing = require('cytoscape-edge-editing');\nconst fcose = require('cytoscape-fcose');\nconst nodeEditing = require('cytoscape-node-editing');\nconst undoRedo = require('cytoscape-undo-redo');\nconst panzoom = require('cytoscape-panzoom');\nconst styleSheet = require('../utils/GraphStyleSheet.tsx');\nconst panzoomOpts = require('../utils/PanzoomOptions.tsx');\nconst navigator = require('cytoscape-navigator');\nconst contextMenus = require('cytoscape-context-menus');\nconst konva = require('konva');\nconst viewUtilities = require('cytoscape-view-utilities');\nconst gridGuide = require('cytoscape-grid-guide');\nconst popper = require('cytoscape-popper');\nconst layoutUtilities = require('cytoscape-layout-utilities');\n\ntype PathwayMapperType = {\n isCollaborative: boolean;\n isCbioPortal: boolean;\n editorHandler: Function;\n selectedPathway: string;\n setActiveEdge: Function;\n profiles: IProfileMetaData[];\n pathwayHandler: (pathwayName: string) => void;\n handleOpen: (modalId: EModalType) => void;\n onPathwayChangeCompleted: () => void;\n genomicDataOverlayColorScheme: IColorValueMap;\n colorSchemeChangeCallback: (IColorValueMap) => void;\n};\n@observer\nexport default class CytoscapeArea extends React.Component{\n private cy:any;\n private cyDiv: HTMLDivElement | undefined;\n private editor: EditorActionsManager;\n private edgeAddingMode: any;\n private viewOperationsManager: ViewOperationsManager;\n private qtipManager: QtipManager;\n private genomicDataExplorerView: any;\n private pathwayDetailsView: any;\n private viewUtilities: any;\n private isCollaborative: boolean;\n private isCbioPortal: boolean;\n private shareDBManager: ShareDBManager;\n private cxtMenuManager: ContextMenuManager;\n private dragDropNodeAddManager: DragDropNodeAddPlugin;\n private undoRedoManager: any;\n private portalAccessor: CBioPortalAccessor;\n private isMountedFirst = true;\n private eh: any;\n private lastSelectedEdge: any;\n\n\n constructor (props: PathwayMapperType) {\n super(props);\n this.isCollaborative = props.isCollaborative;\n this.edgeAddingMode = 0;\n this.isCbioPortal = props.isCbioPortal;\n }\n\n componentWillUpdate(nextProps: PathwayMapperType) {\n\n if (this.props.selectedPathway !== nextProps.selectedPathway) {\n this.getPathway(nextProps.selectedPathway);\n }\n \n }\n\n componentDidUpdate(prevProps: PathwayMapperType) {\n if (this.isCbioPortal && \n prevProps.selectedPathway !== this.props.selectedPathway) {\n this.props.onPathwayChangeCompleted();\n }\n }\n\n // This method only opens pathways that are available in pathway.json. Namely, imported or merged pathways are not opened via this method.\n // Yet, they individually call parsing method.\n getPathway(selectedPathway: string){\n\n if(!selectedPathway || selectedPathway === '') return;\n\n const data = pathways[selectedPathway];\n\n // It might be non-existent due to pathway being created using collaborative mode, or pathway loaded elsewhere (import vs.)\n if(!data){ \n return;\n }\n // TODO Problematic const data = pathways[\"../samples/BLCA-2014-RTK-RAS-PI(3)K-pathway.txt\"];\n\n const parsedGraph = SaveLoadUtility.parseGraph(data, true);\n\n\n const allEles = parsedGraph;\n this.editor.loadFile(allEles.nodes, allEles.edges);\n }\n\n render(){\n return (
\n
\n
\n
);\n }\n\n componentDidMount(): void {\n if(this.isMountedFirst){\n this.init();\n this.isMountedFirst = false;\n }\n this.getPathway(this.props.selectedPathway);\n }\n\n @autobind\n cyDivHandler(div:HTMLDivElement){\n this.cyDiv = div;\n }\n\n init(){\n\n // Create portal accessor\n this.portalAccessor = new CBioPortalAccessor();\n\n // Initializes cytoscape\n this.initCyJS();\n // Initialize cytoscape based handlers here\n this.initCyHandlers();\n this.initKeyboardHandlers();\n this.initUndoRedoFunctionality();\n this.initCBioPortalFunctionalities();\n this.placePanzoomAndOverlay();\n\n //this.appManager = this;\n }\n\n placePanzoomAndOverlay(){\n //TODO place navigator !!!\n var offset = 5;\n // @ts-ignore\n var topCy = $(this.cyDiv).offset().top;\n //var bottomCy = $('.cyContainer').offset().bottom;\n // @ts-ignore\n var leftCy = $(this.cyDiv).offset().left;\n //var rightCy = $('.cyContainer').offset().right;\n // @ts-ignore\n var heightCy = $(this.cyDiv).outerHeight();\n // @ts-ignore\n var widthCy = $(this.cyDiv).outerWidth();\n var heightNavigator = $('.cytoscape-navigator-wrapper').outerHeight();\n var widthNavigator = $('.cytoscape-navigator-wrapper').outerWidth();\n\n if(!this.isCbioPortal) {\n \n $('.cytoscape-navigator-wrapper').css('top', heightCy + topCy - heightNavigator - offset + 16);\n $('.cytoscape-navigator-wrapper').css('left', widthCy + leftCy - widthNavigator - offset + 24 - 0.5 + 0.35);\n }\n else {\n $('.cytoscape-navigator-wrapper').css('bottom', 10.5);\n $('.cytoscape-navigator-wrapper').css('right', 0);\n }\n $('.cytoscape-navigator-wrapper').css('z-index', 1039);\n\n //Relative is used so that its position depends on the below properties\n $('.cy-panzoom').css('position', 'relative');\n $('.cy-panzoom').css('top', 2);\n $('.cy-panzoom').css('left', widthCy - 51);\n $('.cy-panzoom').css('z-index', 1039);\n //Makes the width of panzoom container to 0\n $('.cy-panzoom').css('width', 200);\n }\n\n getPathwayData() {\n return this.pathwayDetailsView.getPathwayData();\n }\n\n initCyJS() {\n \n try {\n panzoom(cytoscape, $); // register extension\n } catch(err){\n console.log(err);\n }\n try { \n navigator(cytoscape); // register extension\n } catch(err){\n console.log(err);\n }\n try { \n gridGuide(cytoscape, $); // register extension\n } catch(err){\n console.log(err);\n }\n try { \n undoRedo(cytoscape); // register extension\n } catch(err){\n console.log(err);\n }\n try { \n contextMenus(cytoscape, $); // register extension\n } catch(err){\n console.log(err);\n }\n try { \n nodeEditing(cytoscape, $, konva); // register extension\n } catch(err){\n console.log(err);\n }\n try { \n edgeEditing(cytoscape, $, konva); // register extension\n } catch(err){\n console.log(err);\n }\n try { \n viewUtilities(cytoscape, $); // register extension\n } catch(err){\n console.log(err);\n }\n try { \n edgeHandles(cytoscape, $);\n } catch(err){\n console.log(err);\n }\n try {\n popper(cytoscape);\n } catch (err) {\n console.log(err);\n }\n try {\n fcose(cytoscape);\n } catch (err) {\n console.log(err);\n }\n try {\n layoutUtilities(cytoscape);\n } catch (err) {\n console.log(err);\n }\n\n this.cy = cytoscape({\n container: this.cyDiv,\n boxSelectionEnabled: true,\n autounselectify: false,\n wheelSensitivity: 0.1,\n style: styleSheet,\n textureOnViewport: false,\n motionBlur: true,\n layout: {name: 'preset'}\n });\n\n this.edgeAddingMode = 0;\n // var allEles = SaveLoadUtilities.parseGraph(sampleGraph);\n\n this.undoRedoManager = this.cy.undoRedo();\n // Create Manager Classes\n this.shareDBManager = new ShareDBManager(() => {\n const dbDoc = this.shareDBManager.getDoc();\n });\n this.editor = new EditorActionsManager(this.isCollaborative,\n this.shareDBManager,\n this.cy,\n this.isCbioPortal,\n this.undoRedoManager,\n this.portalAccessor,\n this.props.profiles,\n this.props.genomicDataOverlayColorScheme,\n this.props.colorSchemeChangeCallback);\n this.shareDBManager.setEditor(this.editor);\n if(this.isCollaborative){\n this.shareDBManager.initShareDB();\n }\n\n this.qtipManager = new QtipManager(this.cy, this.editor);\n \n this.cxtMenuManager = new ContextMenuManager(this.cy, \n this.editor,\n this.props.handleOpen, \n this.undoRedoManager, \n this.props.isCollaborative);\n \n this.dragDropNodeAddManager = new DragDropNodeAddPlugin(this.editor, this.cy, this.props.pathwayHandler);\n\n // Initialize panzoom\n this.cy.panzoom(panzoomOpts);\n\n this.cy.layoutUtilities({\n desiredAspectRatio: this.cy.width() / this.cy.height()\n });\n\n // Node Add initialization\n this.cy.nodeadd(\n {\n // Once the explanationText is cast to uppercase they will be node types\n components:\n [\n {\n container: $('#simpleNodeDiv'),\n nodeType: 'Gene',\n icon: geneImg\n },\n {\n container: $('#familyNodeDiv'),\n nodeType: 'Family',\n icon: familyImg\n },\n {\n container: $('#complexNodeDiv'),\n nodeType: 'Complex',\n icon: complexImg\n },\n {\n container: $('#compartmentNodeDiv'),\n nodeType: 'Compartment',\n icon: compartmentImg\n },\n {\n container: $('#processNodeDiv'),\n nodeType: 'Process',\n icon: processImg\n }\n ]\n\n });\n const self = this;\n const edgeHandleDefaults ={\n preview: true, // whether to show added edges preview before releasing selection\n stackOrder: 4, // Controls stack order of edgehandles canvas element by setting it's z-index\n handleSize: 10, // the size of the edge handle put on nodes\n handleColor: '#1abc9c', // the colour of the handle and the line drawn from it\n handleLineType: 'ghost', // can be 'ghost' for real edge, 'straight' for a straight line, or 'draw' for a draw-as-you-go line\n handleLineWidth: 1, // width of handle line in pixels\n handleNodes: 'node', // selector/filter function for whether edges can be made from a given node\n hoverDelay: 1, // time spend over a target node before it is considered a target selection\n cxt: false, // whether cxt events trigger edgehandles (useful on touch)\n enabled: false, // whether to start the extension in the enabled state\n toggleOffOnLeave: true, // whether an edge is cancelled by leaving a node (true), or whether you need to go over again to cancel (false; allows multiple edges in one pass)\n edgeType: function( sourceNode, targetNode ) {\n // can return 'flat' for flat edges between nodes or 'node' for intermediate node between them\n // returning null/undefined means an edge can't be added between the two nodes\n return 'flat';\n },\n handlePosition: function( node ){\n return 'middle top'; // sets the position of the handle in the format of \"X-AXIS Y-AXIS\" such as \"left top\", \"middle top\"\n },\n loopAllowed: function( node ) {\n // for the specified node, return whether edges from itself to itself are allowed\n return false;\n },\n nodeLoopOffset: -50, // offset for edgeType: 'node' loops\n nodeParams: function( sourceNode, targetNode ) {\n // for edges between the specified source and target\n // return element object to be passed to cy.add() for intermediary node\n return {};\n },\n edgeParams: function( sourceNode, targetNode, i ) {\n // for edges between the specified source and target\n // return element object to be passed to cy.add() for edge\n // NB: i indicates edge index in case of edgeType: 'node'\n return {};\n },\n start: function( sourceNode )\n {\n // fired when edgehandles interaction starts (drag on handle)\n var type = self.getGlobalEdgeType();\n //self.cy.edgehandles('option', 'ghostEdgeType', type);\n },\n complete: function( sourceNode, targetNodes, addedEntities )\n {\n // // Remove recently added edge !\n // // FBI takes this case from now on :O\n // // We will take care of addition in our manager :)\n self.cy.remove(addedEntities);\n self.editor.addEdge({\n source: sourceNode.id(),\n target: targetNodes[0].id(),\n // @ts-ignore\n type: self.getGlobalEdgeType(window.edgeAddingMode),\n pubmedIDs: [],\n name: \"\"\n });\n },\n stop: function( sourceNode )\n {\n // fired when edgehandles interaction is stopped (either complete with added edges or incomplete)\n //TODO refactor this, so terrible for now\n //$('.edge-palette a').blur().removeClass('active');\n self.edgeAddingMode = -1;\n self.eh.disable();\n self.eh.hide();\n self.props.setActiveEdge(-1);\n },\n };\n //Edge Handles initialization\n this.eh = this.cy.edgehandles(edgeHandleDefaults);\n this.eh.disable();\n this.props.editorHandler(this.editor, this.eh, this.undoRedoManager);\n\n if(!this.isCbioPortal) {\n this.cy.nodeEditing({\n padding: 5, // spacing between node and grapples/rectangle\n undoable: true, // and if cy.undoRedo exists\n\n grappleSize: 8, // size of square dots\n grappleColor: \"#ffc90e\", // color of grapples\n inactiveGrappleStroke: \"inside 1px blue\",\n boundingRectangle: true, // enable/disable bounding rectangle\n boundingRectangleLineDash: [4, 8], // line dash of bounding rectangle\n boundingRectangleLineColor: \"ffc90e\",\n boundingRectangleLineWidth: 1.5,\n zIndex: 999,\n\n moveSelectedNodesOnKeyEvents: function () {\n return true;\n },\n\n minWidth: function (node) {\n var data = node.data(\"resizeMinWidth\");\n return data ? data : 15;\n }, // a function returns min width of node\n minHeight: function (node) {\n var data = node.data(\"resizeMinHeight\");\n return data ? data : 15;\n }, // a function returns min height of node\n\n // Getters for some style properties the defaults returns ele.css('property-name')\n // you are encouraged to override these getters\n getCompoundMinWidth: function (node) {\n return node.style('min-width');\n },\n getCompoundMinHeight: function (node) {\n return node.style('min-height');\n },\n getCompoundMinWidthBiasRight: function (node) {\n return node.style('min-width-bias-right');\n },\n getCompoundMinWidthBiasLeft: function (node) {\n return node.style('min-width-bias-left');\n },\n getCompoundMinHeightBiasTop: function (node) {\n return node.style('min-height-bias-top');\n },\n getCompoundMinHeightBiasBottom: function (node) {\n return node.style('min-height-bias-bottom');\n },\n\n\n isFixedAspectRatioResizeMode: function (node) {\n return node.is(\".fixedAspectRatioResizeMode\")\n },// with only 4 active grapples (at corners)\n isNoResizeMode: function (node) {\n return undefined;\n }, // no active grapples\n\n // These optional function will be executed to set the width/height of a node in this extension\n // Using node.css() is not a recommended way (http://js.cytoscape.org/#eles.style) to do this. Therefore, overriding these defaults\n // so that a data field or something like that will be used to set node dimentions instead of directly calling node.css()\n // is highly recommended (Of course this will require a proper setting in the stylesheet).\n setWidth: function (node, width) {\n node.style('width', width);\n },\n setHeight: function (node, height) {\n node.style('height', height);\n },\n setCompoundMinWidth: function (node, minWidth) {\n node.style('min-width', minWidth);\n },\n setCompoundMinHeight: function (node, minHeight) {\n node.style('min-height', minHeight);\n },\n setCompoundMinWidthBiasLeft: function (node, minWidthBiasLeft) {\n node.style('min-width-bias-left', minWidthBiasLeft);\n },\n setCompoundMinWidthBiasRight: function (node, minHeightBiasRight) {\n node.style('min-width-bias-right', minHeightBiasRight);\n },\n setCompoundMinHeightBiasTop: function (node, minHeightBiasTop) {\n node.style('min-height-bias-top', minHeightBiasTop);\n },\n setCompoundMinHeightBiasBottom: function (node, minHeightBiasBottom) {\n node.style('min-height-bias-bottom', minHeightBiasBottom);\n },\n\n cursors: { // See http://www.w3schools.com/cssref/tryit.asp?filename=trycss_cursor\n // May take any \"cursor\" css property\n default: \"default\", // to be set after resizing finished or mouseleave\n inactive: \"not-allowed\",\n nw: \"nw-resize\",\n n: \"n-resize\",\n ne: \"ne-resize\",\n e: \"e-resize\",\n se: \"se-resize\",\n s: \"s-resize\",\n sw: \"sw-resize\",\n w: \"w-resize\"\n },\n resizeToContentCueImage: resizeCue,\n resizeToContentFunction: this.editor.resizeNodesToContent.bind(this.editor),\n });\n }\n //Navigator for cytoscape js\n var navDefaults = {\n container: '.cytoscape-navigator-wrapper' // can be a HTML or jQuery element or jQuery selector\n , viewLiveFramerate: 0 // set false to update graph pan only on drag end; set 0 to do it instantly; set a number (frames per second) to update not more than N times per second\n , thumbnailEventFramerate: 10 // max thumbnail's updates per second triggered by graph updates\n , thumbnailLiveFramerate: false // max thumbnail's updates per second. Set false to disable\n , dblClickDelay: 200 // milliseconds\n , removeCustomContainer: true // destroy the container specified by user on plugin destroy\n , rerenderDelay: 100 // ms to throttle rerender updates to the panzoom for performance\n };\n\n //TODO: AMENDMENT declaration removed\n this.cy.navigator(navDefaults); // get navigator instance, nav\n\n const viewUtilitiesOpts = {\n node: {\n highlighted: {\n 'border-width': 2,\n 'border-color': '#bc1142'\n }, // styles for when nodes are highlighted.\n unhighlighted: {\n 'opacity': function (ele: any) {\n // We return the same opacity because to override the unhibhlighted ele opacity in view-utilities\n return ele.css('opacity');\n }\n }// styles for when nodes are unhighlighted.}\n },\n edge: {\n highlighted: {}, // styles for when edges are highlighted.\n unhighlighted: {\n 'opacity': function (ele: any) {\n // We return the same opacity because to override the unhibhlighted ele opacity in view-utilities\n return ele.css('opacity');\n }\n } // styles for when edges are unhighlighted.\n },\n setVisibilityOnHide: false, // whether to set visibility on hide/show\n setDisplayOnHide: true, // whether to set display on hide/show\n neighbor: () => { // return desired neighbors of tapheld node\n return false;\n },\n neighborSelectTime: 500 //ms, time to taphold to select desired neighbors\n };\n\n this.viewUtilities = this.cy.viewUtilities(viewUtilitiesOpts);\n\n this.editor.setViewUtilities(this.viewUtilities);\n\n this.placePanzoomAndOverlay();\n }\n\n getGlobalEdgeType()\n {\n var type = \"NONE\";\n // @ts-ignore\n if (window.edgeAddingMode === 1)\n {\n type = 'ACTIVATES';\n }\n // @ts-ignore\n else if (window.edgeAddingMode === 2)\n {\n type = 'INHIBITS';\n }\n // @ts-ignore\n else if (window.edgeAddingMode === 3)\n {\n type = 'INDUCES';\n }\n // @ts-ignore\n else if (window.edgeAddingMode === 4)\n {\n type = 'REPRESSES';\n }\n // @ts-ignore\n else if (window.edgeAddingMode === 5)\n {\n type = 'BINDS';\n }\n return type;\n }\n\n initCyHandlers(){\n var that = this;\n\n var tappedBefore: any;\n var tappedTimeout: number;\n this.cy.on('tap', function (event: any) {\n var tappedNow = event.target;\n if (tappedTimeout !== -1 && tappedBefore !== -1) {\n clearTimeout(tappedTimeout);\n }\n if (tappedBefore === tappedNow) {\n tappedNow.trigger('doubleTap');\n tappedBefore = -1;\n } else {\n // @ts-ignore TODO AMENDMENTsa\n tappedTimeout = setTimeout(function () {\n tappedBefore = -1;\n }, 300);\n tappedBefore = tappedNow;\n }\n });\n\n this.cy.on('doubleTap', 'node', function (e: any) {\n\n // if cBioPortal ignore\n if(that.props.isCbioPortal) return;\n\n const eventIsDirect = (e.target === this);\n \n if (eventIsDirect) { \n that.qtipManager.addQtipToElements(e.target); \n e.target.trigger(\"showqtipevent\");\n }\n });\n \n this.cy.on('doubleTap', 'edge', function (e: any) {\n \n // if cBioPortal ignore\n if(that.props.isCbioPortal) return;\n \n const eventIsDirect = (e.target === this);\n \n if (eventIsDirect) {\n that.qtipManager.addQtipToElements(e.target); \n e.target.trigger(\"showqtipevent\");\n }\n });\n\n this.cy.on('select', 'node', (e: any) => {\n this.editor.pushSelectedNodeStack(e.target);\n });\n\n // this.cy.on('select', 'edge', function( e )\n // {\n // var eventIsDirect = (e.target === this);\n // $(\".qtip\").remove();\n //\n // if( eventIsDirect ) {\n // that.qtipManager.addQtipToElements(e.target);\n // }\n // });\n\n this.cy.on('unselect', 'node', (e: any) => {\n this.editor.removeElementFromSelectedNodeStack(e.target);\n });\n\n this.cy.on('free', 'node', (e: any) => {\n //Collect all nodes with descendants in case of compounds\n var selectedNodes = this.cy.nodes(':selected');\n var nodes = e.target;\n nodes = nodes.union(nodes.descendants());\n nodes = nodes.union(selectedNodes);\n this.editor.moveElements(nodes);\n });\n\n this.cy.on('layoutstop', () => {\n this.editor.postLayout();\n });\n\n // //TODO fix this when cytoscape is updated !!!\n // //Due to cytoscape.js bug, only workaround that worked :(\n // this.cy.on('add', 'node', function(event)\n // {\n // // event.target.select();\n // this.cy.style().update();\n // this.cy.forceRender();\n // });\n\n this.cy.on(\"nodeediting.resizeend\", (_e: any, _type: any, node: any) => {\n \n //Updates 'data' properties from 'style'\n node.data('w', node.width());\n node.data('h', node.height());\n //Used for collaborative mode\n this.editor.resizeElements(node);\n });\n\n this.cy.on('select', 'edge', (e: any) => {\n this.lastSelectedEdge = e.target;\n });\n\n this.cy.on('bendPointMovement', () => {\n this.editor.updateEdgeAnchorPoints(this.lastSelectedEdge);\n });\n\n this.cy.on('nodeediting.moveend', () => {\n this.editor.changeNodePositionsByArrows(this.cy.nodes(\":selected\"));\n });\n\n }\n\n initKeyboardHandlers() {\n if (!this.isCollaborative && !this.isCbioPortal) {\n $(document).keydown((e: any) => {\n if (e.which === 89 && (e.ctrlKey || e.metaKey)) {\n this.undoRedoManager.redo();\n }\n else if (e.which === 90 && (e.ctrlKey || e.metaKey)) {\n this.undoRedoManager.undo();\n }\n });\n }\n else {\n $('a[role=\"redo\"]').hide();\n $('a[role=\"undo\"]').hide();\n }\n $(document).keydown((e: any) => {\n if (e.which === 65 && (e.ctrlKey || e.metaKey)) {\n // @ts-ignore\n var tn = document.activeElement.tagName;\n if (tn != \"TEXTAREA\" && tn != \"INPUT\") {\n e.preventDefault();\n this.cy.elements().select();\n }\n }\n else if (e.which === 8 || e.which === 46) {\n // @ts-ignore\n var tn = document.activeElement.tagName;\n if (tn != \"TEXTAREA\" && tn != \"INPUT\") {\n var selectedElements = this.cy.$(':selected');\n this.editor.removeElement(selectedElements);\n }\n }\n });\n }\n\n initUndoRedoFunctionality() {\n if (this.isCollaborative || this.isCbioPortal) {\n $('[role=\"undo\"]').hide();\n $('[role=\"redo\"]').hide();\n /* TODO: AMENDMENT\n document.getElementById(\"localOrCollaborativeToolbar\").style.display = \"none\";\n */\n }\n }\n\n\n initCBioPortalFunctionalities() {\n if (this.isCbioPortal) {\n const contextMenu = this.cy.contextMenus('get');\n\n contextMenu.destroy();\n }\n }\n\n\n}","import autobind from \"autobind-decorator\";\nimport { action, computed, makeObservable, observable } from \"mobx\";\nimport { observer } from \"mobx-react\";\nimport { IGeneticAlterationRuleSetParams } from 'oncoprintjs';\nimport React from 'react';\nimport { Col, Row } from \"react-bootstrap\";\nimport { toast, ToastContainer } from 'react-toastify';\nimport 'react-toastify/dist/ReactToastify.min.css';\nimport ReactTooltip from 'react-tooltip';\nimport \"../css/pmv1.css\";\nimport \"../css/pmv2.css\";\nimport '../css/qtip.css';\nimport \"../css/supp.css\";\nimport pathways from \"../data/pathways.json\";\nimport EditorActionsManager from \"../managers/EditorActionsManager\";\nimport FileOperationsManager from '../managers/FileOperationsManager';\nimport GridOptionsManager from '../managers/GridOptionsManager';\nimport ViewOperationsManager from '../managers/ViewOperationsManager';\nimport AboutModal from '../modals/AboutModal';\nimport CBioHelpModal from '../modals/CBioHelpModal';\nimport ConfirmationModal from '../modals/ConfirmationModal';\nimport GridSettings from '../modals/GridSettings';\nimport LayoutProperties from '../modals/LayoutProperties';\nimport PathwayDetailsModal from '../modals/PathwayDetailsModal';\nimport ProfilesColorSchemeModal from \"../modals/ProfilesColorSchemeModal\";\nimport ProfilesModal from '../modals/ProfilesModal';\nimport QuickHelpModal from '../modals/QuickHelpModal';\nimport StudyModal from '../modals/StudyModal';\nimport Ranking from \"../ui/Ranking\";\nimport Toolbar from \"../ui/Toolbar\";\nimport CBioPortalAccessor from '../utils/CBioPortalAccessor';\nimport PathwayActions from '../utils/PathwayActions';\nimport SaveLoadUtility from '../utils/SaveLoadUtility';\nimport Buttonbar from \"./Buttonbar\";\nimport CytoscapeArea from \"./CytoscapeArea\";\nimport Menubar from './Menubar';\nimport Sidebar from './Sidebar';\n\nconst maxHeapFn = require('@datastructures-js/max-heap');\nlet maxHeap = maxHeapFn();\n\ninterface IPathwayMapperProps{\n isCBioPortal: boolean;\n genes: any[];\n isCollaborative?: boolean;\n cBioAlterationData?: ICBioData[];\n sampleIconData?: ISampleIconData,\n pathwayName? : string;\n alterationData?: IAlterationData;\n onAddGenes?: (selectedGenes: string[]) => void;\n changePathwayHandler?: (pathwayGenes: string[]) => void;\n addGenomicDataHandler?: (addGenomicData: (alterationData: ICBioData[]) => void) => void;\n tableComponent?: (data: IPathwayMapperTable[], selectedPathway: string, onPathwaySelect: (pathway: string) => void) => JSX.Element;\n validGenes?: any;\n toast: any;\n showMessage: (message: string) => void;\n //PatientView variable\n patientView ?: boolean;\n messageBanner? : () => JSX.Element;\n}\n\nexport interface ICBioData{\n altered: number;\n gene: string;\n percentAltered: string​;\n sequenced: number;\n geneticTrackData?: any[]; // TODO GeneticTrackDatum[]: this is currently a private type within cbioportal repo\n geneticTrackRuleSetParams?: IGeneticAlterationRuleSetParams;\n}\n\nexport interface ISampleIconData {\n sampleIndex: { [s: string]: number },\n sampleColors: { [s: string]: string }\n}\n\n/**\n * Maps integer values to color code strings\n */\nexport interface IColorValueMap {\n [value: string]: string\n}\n\nexport enum EModalType{\n STUDY,\n CONFIRMATION,\n PROFILES,\n ABOUT,\n PW_DETAILS,\n GRID,\n HELP,\n LAYOUT,\n CHELP,\n PROFILES_COLOR_SCHEME\n}\n\nexport interface IPathwayData{\n title: string;\n description: string;\n nodes: any[];\n edges: any[];\n}\n\nexport interface IAlterationData{\n [key: string]: {[key: string]: number};\n}\n\nexport interface IProfileMetaData{\n profileId: string;\n studyId?: string;\n enabled: boolean;\n}\n\nexport interface IDataTypeMetaData{\n enabled: boolean;\n checked: boolean;\n profile: string;\n}\n\nexport interface IPathwayMapperTable{\n name: string;\n score: number;\n genes: string[];\n}\n\n@observer\nexport class PathwayMapper extends React.Component {\n static readonly CBIO_PROFILE_NAME = \"cBioPortal_data\";\n\n\n readonly MAX_ALLOWED_PROFILES_ENABLED = 6;\n \n @observable\n selectedPathway: string;\n\n fileManager: FileOperationsManager;\n\n @observable\n editor: EditorActionsManager;\n\n pathwayActions: PathwayActions;\n\n @observable\n isModalShown: boolean[];\n\n @observable\n colorValueMap: IColorValueMap;\n\n portalAccessor: CBioPortalAccessor;\n\n @observable\n alterationData: IAlterationData;\n\n @observable\n patientData: any [][] = [];\n\n @observable\n pathwayGeneMap: {[key: string]: {[key: string]: string}} = {};\n\n bestPathwaysAlgos: any[][] = [];\n\n @observable\n oldName = \"\";\n \n @observable\n profiles: IProfileMetaData[] = [];\n\n setActiveEdge: (edgeId: number) => void;\n viewOperationsManager: ViewOperationsManager;\n gridOptionsManager: GridOptionsManager;\n\n\n\n constructor(props: IPathwayMapperProps){\n super(props);\n makeObservable(this);\n \n this.fileManager = new FileOperationsManager();\n this.pathwayActions = new PathwayActions(this.pathwayHandler, this.profiles, this.fileManager, \n this.handleOpen, this.props.isCBioPortal, this.props.isCollaborative);\n this.selectedPathway = \"\";\n if(this.props.pathwayName){\n this.pathwayActions.changePathway(this.props.pathwayName);\n }\n this.isModalShown = [false, false, false, false, false, false, false, false, false, false];\n // TODO: Change below\n this.alterationData = {}; //{\"study1_gistic\" : {\"CDK4\": 11, \"MDM2\": 19, \"TP53\": 29}, \"study2_gistic\" : {\"MDM2\": 99, \"TP53\": 98}, \"study3_mutations\": {\"MDM2\": 1, \"TP53\": 2}};\n this.extractAllGenes();\n\n this.colorValueMap = {\n '-100' : \"#0000ff\",\n '0' : \"#ffffff\",\n '100' : \"#ff0000\"\n }\n\n if(this.props.isCBioPortal){\n //this.overlayPortalData();\n \n // If cBioPortal mode is 'on' it is very likely to have cBioALterationData\n // but to be on the safe side below assertion is made.\n if(this.props.cBioAlterationData ){\n if( this.props.patientView){\n //PatientView PathwayMapper has a different functionality\n //Alteration types are overlayed instead of alterationpercentage\n this.calculatePatientData(this.props.cBioAlterationData);\n this.addSampleIconData(this.props.sampleIconData);\n }\n else{\n this.calculateAlterationData(this.props.cBioAlterationData);\n\n }\n }\n\n if(this.props.addGenomicDataHandler){\n this.props.addGenomicDataHandler(this.addGenomicData);\n }\n\n this.profiles.push({profileId: PathwayMapper.CBIO_PROFILE_NAME, enabled: true});\n this.getBestPathway(0);\n this.getBestPathway(1);\n this.getBestPathway(2);\n this.getBestPathway(3);\n }\n /*\n const profile1 = {profileId: \"study1_gistic\", studyId: \"study1\", enabled: true};\n const profile2 = {profileId: \"study2_gistic\", studyId: \"study2\", enabled: true};\n const profile3 = {profileId: \"study3_mutations\", studyId: \"study3\", enabled: true};\n const profile4 = {profileId: \"study3_mutations\", studyId: \"study3\", enabled: true};\n const profile5 = {profileId: \"study3_mutations\", studyId: \"study3\", enabled: true};\n const profile6 = {profileId: \"study3_mutations\", studyId: \"study3\", enabled: true};\n this.profiles.push(profile1, profile2, profile3, profile4, profile5, profile6);\n */\n\n }\n\n @action.bound\n setColorMapping(colorValueMap: IColorValueMap) {\n this.colorValueMap = colorValueMap;\n this.editor.updateGenomicDataColorScheme(this.colorValueMap);\n }\n\n @action\n setSelectedPathway(pathway: string) {\n this.selectedPathway = pathway;\n }\n\n @action\n setEditor(editor: EditorActionsManager) {\n this.editor = editor;\n }\n\n @action\n addProfile(profile: IProfileMetaData) {\n this.profiles.push(profile);\n }\n\n @action\n toggleProfileEnabled(index: number) {\n this.profiles[index].enabled = !this.profiles[index].enabled;\n }\n\n calculateAlterationData(cBioAlterationData: ICBioData[]){\n // Transform cBioDataAlteration into AlterationData\n this.alterationData[PathwayMapper.CBIO_PROFILE_NAME] = {};\n cBioAlterationData.forEach((geneAltData: ICBioData) => {\n const perc = (geneAltData.altered / geneAltData.sequenced) * 100;\n \n // NaN value is replaced with -101 since NaN value leads to some runtime exceptions (such as with toFixed() function),\n // hence it is represented as -101. It will be recognized in the genomic data svg creation to show N/P instead of\n // a percentage. -101 is chosen because this percentage is impossible to get.\n this.alterationData[PathwayMapper.CBIO_PROFILE_NAME][geneAltData.gene] = ((Object.is(perc, NaN) ? -101 : perc));\n \n\n });\n }\n \n calculatePatientData(cBioAlterationData: ICBioData[]){\n // Transform cBioDataAlteration into Patient Data every alteration is accepted 100% altered\n\n this.alterationData[PathwayMapper.CBIO_PROFILE_NAME] = {};\n \n const allTypes = cBioAlterationData.map(x => x.gene); \n //const allTypes = cBioAlterationData.map(x => x.percentAltered);\n const uniqueTypes = allTypes.filter((x, i, a) => a.indexOf(x) == i)\n //This is a flag for GenomicDataOverlayManager showPatientData\n this.patientData[\"PatientView\"] = 1;\n\n uniqueTypes.forEach(x => {\n this.patientData[x]= {};\n });\n\n cBioAlterationData.forEach((geneAltData: ICBioData) => {\n const perc = (geneAltData.altered / geneAltData.sequenced) * 100;\n\n this.alterationData[PathwayMapper.CBIO_PROFILE_NAME][geneAltData.gene] = ((Object.is(perc, NaN) ? -101 : perc));\n\n this.patientData[geneAltData.gene][geneAltData.percentAltered] = ((Object.is(perc, NaN) ? -101 : perc));\n this.patientData[geneAltData.gene][\"geneticTrackData\"] = geneAltData.geneticTrackData;\n this.patientData[geneAltData.gene][\"geneticTrackRuleSetParams\"] = geneAltData.geneticTrackRuleSetParams;\n });\n\n }\n\n addSampleIconData(sampleIconData: any) {\n if (sampleIconData) {\n this.patientData[\"sampleColors\"] = sampleIconData.sampleColors;\n this.patientData[\"sampleIndex\"] = sampleIconData.sampleIndex;\n }\n }\n\n getGeneStudyMap(studyGeneMap: any){\n \n const genomicDataMap: any = {};\n for (const cancerStudy of Object.keys(studyGeneMap)) {\n\n const cancerData = studyGeneMap[cancerStudy];\n\n for (const geneSymbol of Object.keys(cancerData)) {\n if (genomicDataMap[geneSymbol] === undefined) genomicDataMap[geneSymbol] = {};\n\n genomicDataMap[geneSymbol][cancerStudy] = studyGeneMap[cancerStudy][geneSymbol].toFixed(2);\n }\n }\n return genomicDataMap;\n }\n\n getAlterationAveragePerGene(genomicDataMap: any){\n\n const geneAlterationMap: any = {};\n for(const gene of Object.keys(genomicDataMap)){\n let sum = 0, count = 0;\n\n for(const alteration of Object.values(genomicDataMap[gene])){\n sum += parseFloat(alteration as string);\n count++;\n }\n if(count === 0){\n geneAlterationMap[gene] = 0;\n } else {\n geneAlterationMap[gene] = sum / count;\n }\n }\n\n return geneAlterationMap;\n }\n\n\n /**\n * \n * @param rankingMode: number => 0 = Count, 1 = Percentage, 2 = Count with Alteration, 3 = Percentage with Alteration\n * \n */\n getBestPathway(rankingMode: number) {\n \n const genomicDataMap = this.getGeneStudyMap(this.alterationData);\n const alterationPerGene = this.getAlterationAveragePerGene(genomicDataMap);\n maxHeap = maxHeapFn();\n\n const matchedGenesMap: any = {};\n const bestPathways: any[] = [];\n for(const pathwayName in this.pathwayGeneMap){\n if(this.pathwayGeneMap.hasOwnProperty(pathwayName)){\n \n const genesMatching = [];\n // Calculate sum of all alterations\n let sumOfAlterations = 0;\n for(const gene of this.props.genes){\n \n if(this.pathwayGeneMap[pathwayName].hasOwnProperty(gene.hugoGeneSymbol) \n && this.pathwayGeneMap[pathwayName][gene.hugoGeneSymbol] === \"GENE\"){\n genesMatching.push(gene.hugoGeneSymbol);\n sumOfAlterations += alterationPerGene[gene.hugoGeneSymbol];\n }\n }\n matchedGenesMap[pathwayName] = genesMatching;\n let geneCount = 0;\n // Count number of genes *not processess* in a pathway\n for(const geneType of Object.values(this.pathwayGeneMap[pathwayName])){\n if(geneType === \"GENE\"){\n geneCount++;\n }\n }\n\n if(rankingMode === 0){\n maxHeap.insert(genesMatching.length, {pathwayName: pathwayName});\n } else if(rankingMode === 1){\n maxHeap.insert(genesMatching.length / geneCount * 100, {pathwayName: pathwayName}); \n } else if(rankingMode === 2){\n maxHeap.insert(sumOfAlterations, {pathwayName: pathwayName}); \n } else if(rankingMode === 3){\n maxHeap.insert(genesMatching.length * sumOfAlterations / geneCount, {pathwayName: pathwayName});\n }\n\n }\n }\n while(maxHeap.size() > 0){\n const top = maxHeap.extractMax();\n const pathwayName = top.getValue().pathwayName;\n bestPathways.push({score: top.getKey(), genesMatched: matchedGenesMap[pathwayName], pathwayName: pathwayName});\n }\n if(this.bestPathwaysAlgos.length === 0) // First pathway of the first method is shown as the default pathway.\n this.setSelectedPathway(bestPathways[0].pathwayName);\n this.bestPathwaysAlgos.push(bestPathways);\n }\n \n // This method extracts all genes of a pathway and adds it to the pathwayGeneMap\n // so that it can be used by percentage calculation and genomic data \n // Note: Pathway title\n @autobind\n includePathway(pathwayData?: IPathwayData, pathwayName?: string){\n const genes = pathwayData.nodes;\n const geneHash: any = {};\n\n for(const gene of genes){\n\n if(gene.data.type === \"GENE\")\n geneHash[gene.data.name] = gene.data.type;\n }\n\n this.pathwayGeneMap[pathwayData.title] = geneHash;\n\n }\n\n extractAllGenes(){\n for(const pathwayName in pathways){\n if(pathways.hasOwnProperty(pathwayName)){\n\n const pathwayData: IPathwayData = SaveLoadUtility.parseGraph(pathways[pathwayName], true);\n this.includePathway(pathwayData);\n }\n }\n \n }\n\n\n loadRedirectedPortalData(){\n\n if(!this.props.alterationData){ // If size 0 that means it is not redirected.\n return;\n }\n \n const redirectedProfiles = Object.keys(this.props.alterationData).map((data: string) : IProfileMetaData => ({profileId: data, enabled: true}));\n redirectedProfiles.forEach((redirectedProfile) => {\n this.addProfile(redirectedProfile);\n });\n this.editor.addPortalGenomicData(this.props.alterationData, this.editor.getEmptyGroupID());\n }\n\n exists(profileId: string){\n\n let exists = false;\n this.profiles.forEach((profile: IProfileMetaData) => {\n if(profile.profileId === profileId){\n exists = true;\n }\n });\n\n return exists;\n }\n\n @autobind\n loadFromCBio(dataTypes: {[dataType: string]: IDataTypeMetaData}, studyData: any[]){\n if(!this.pathwayActions.doesCyHaveElements()){\n toast.warn('Your pathway is empty!');\n return;\n }\n\n for (const metadata of Object.values(dataTypes))\n {\n if(!metadata.checked) {\n continue;\n } \n if(this.exists(metadata.profile)){\n toast.warn(metadata.profile + \" already exists.\");\n continue;\n }\n\n const studyId = studyData[0];\n const profileId = metadata.profile;\n\n const enableNewProfile = this.profiles.length < this.MAX_ALLOWED_PROFILES_ENABLED;\n\n const newProfile = {\n studyId: studyId,\n profileId: profileId,\n enabled: enableNewProfile\n }\n\n this.addProfile(newProfile);\n\n const genes = this.editor.cy.nodes()\n .filter(node => node.data(\"type\") === \"GENE\")\n .map(node => node.data(\"name\"));\n\n \n this.portalAccessor.getProfileData({\n caseSetId: studyId,\n geneticProfileId: profileId,\n genes: genes\n },\n (data: any) => {\n this.editor.addPortalGenomicData(data, this.editor.getEmptyGroupID());\n let visibilityObject = {};\n visibilityObject[newProfile.profileId] = newProfile.enabled;\n this.editor.updateGenomicDataVisibility(visibilityObject);\n });\n \n }\n }\n\n @autobind\n setActiveEdgeHandler(setActiveEdge: (edgeId: number) => void){\n this.setActiveEdge = setActiveEdge;\n }\n\n @autobind\n colorSchemeChangeCallback(colorScheme: IColorValueMap) {\n this.colorValueMap = colorScheme;\n }\n\n @autobind\n addGenomicData(cBioAlterationData: ICBioData[]){\n\n this.calculateAlterationData(cBioAlterationData);\n this.editor.removeGenomicData();\n this.editor.addPortalGenomicData(this.alterationData, this.editor.getEmptyGroupID());\n }\n\n @autobind\n emphasizeQueryGenes() {\n this.pathwayActions.emphasizeQueryGenes(this.props.genes.map((gene: any) => gene.hugoGeneSymbol));\n }\n\n render() {\n const isCBioPortal = this.props.isCBioPortal; \n\n const cytoComp = ;\n\n return (\n\n
\n
\n {!isCBioPortal && \n \n
\n \n
\n
\n \n
\n
\n }\n { isCBioPortal &&\n \n \n \n \n {this.props.messageBanner ?\n {this.props.messageBanner()}\n :\n \n }\n \n {this.selectedPathway}\n \n \n }\n \n
\n {\n (!isCBioPortal && \n
\n \n
)\n }\n\n { isCBioPortal ?\n (\n {cytoComp}\n
Powered by PathwayMapper
\n )\n : (cytoComp)\n }\n {\n (isCBioPortal &&\n \n \n )\n }\n
\n\n {/* isCBioPortal &&\n \n Powered by PathwayMapper\n */\n }\n\n { (
\n\n {\n (
\n \n \n \n \n \n \n \n \n \n \n
)\n }\n { !this.props.isCBioPortal &&\n \n \n \n \n }\n \n\n {this.pathwayActions.setUploaders(ref, false);}}\n style={{display: 'none'}}\n onChange={(e) => {this.pathwayActions.onChangeFile(e, false);}}\n />\n {this.pathwayActions.setUploaders(ref, true);}}\n style={{display: 'none'}}\n onChange={(e) => {this.pathwayActions.onChangeFile(e, true);}}\n />\n {this.pathwayActions.setOverlayUploader(ref);}}\n style={{display: 'none'}}\n onChange={(e) => {this.pathwayActions.overlayFromText(e.target.files[0]);}}\n />\n
)\n }\n
\n
\n );\n }\n\n componentDidMount(){\n if(!this.props.isCBioPortal){\n $(\".container\").css('width', \"auto\");\n $(\".container\").css('paddingLeft', 0);\n $(\".container\").css('marginLeft', 5);\n } else {\n this.pathwayActions.emphasizeQueryGenes(this.props.genes.map((gene: any) => gene.hugoGeneSymbol));\n }\n }\n\n componentDidUpdate(){\n if(this.props.isCBioPortal){\n this.pathwayActions.emphasizeQueryGenes(this.props.genes.map((gene: any) => gene.hugoGeneSymbol));\n }\n }\n\n @action.bound\n handleOpen(modalId: EModalType){\n this.isModalShown[modalId] = true;\n }\n\n\n @action.bound\n handleClose(modalId: EModalType){\n this.isModalShown[modalId] = false;\n }\n\n @autobind\n editorHandler(editor, eh, undoRedoManager){\n\n this.setEditor(editor);\n this.gridOptionsManager = new GridOptionsManager(this.editor.cy);\n this.viewOperationsManager = new ViewOperationsManager(this.editor, this.editor.cy);\n this.pathwayActions.editorHandler(editor, eh, undoRedoManager, this.viewOperationsManager, this.gridOptionsManager);\n \n if(this.props.isCBioPortal){\n if(this.props.patientView){\n this.editor.addPortalGenomicData(this.patientData, this.editor.getEmptyGroupID());\n }\n else{\n this.editor.addPortalGenomicData(this.alterationData, this.editor.getEmptyGroupID());\n }\n } else {\n this.portalAccessor = new CBioPortalAccessor();\n this.loadRedirectedPortalData();\n }\n\n }\n\n @autobind\n pathwayHandler(pathway: string){\n this.setSelectedPathway(pathway);\n if(this.pathwayGeneMap[pathway] && this.props.changePathwayHandler)\n this.props.changePathwayHandler(\n Object.keys(this.pathwayGeneMap[pathway])\n .filter(gene => (!this.alterationData[PathwayMapper.CBIO_PROFILE_NAME].hasOwnProperty(gene)))\n );\n }\n}\n\nexport default PathwayMapper;","import React from 'react';\nimport { MenuItem, Nav, Navbar, NavDropdown } from 'react-bootstrap';\nimport pathways from \"../data/pathways.json\";\nimport ConfirmationModal from '../modals/ConfirmationModal';\nimport PathwayActions from '../utils/PathwayActions';\nimport { EModalType } from './react-pathway-mapper';\n\ninterface IMenubarProps{\n pathwayActions: PathwayActions;\n handleOpen: (modalId: EModalType) => void;\n setActiveEdge: Function;\n}\n\n\nexport default class Menubar extends React.Component{\n\n\n constructor(props: IMenubarProps){\n super(props);\n }\n\n render(){\n const nodeTypes = [\"Gene\", \"Family\", \"Complex\", \"Compartment\", \"Process\"];\n const edgeTypes = [\"Activates\", \"Inhibits\", \"Induces\", \"Represses\", \"Binds\"];\n\n const pathwayDropdownData: {[pwHead: string]: string[]} = {};\n for(const pwName of Object.keys(pathways)){\n // If a pathway name ain't include 'pathway' word then it is under pancanatlas.\n const isPancanatlas = !pwName.includes('pathway');\n const dashPos = pwName.indexOf('-');\n const pwHead = (isPancanatlas) ? 'PanCanAtlas' : pwName.substring(0, dashPos);\n if(pwHead in pathwayDropdownData){\n pathwayDropdownData[pwHead].push(pwName);\n } else {\n pathwayDropdownData[pwHead] = [pwName];\n }\n }\n\n return(\n \n \n \n \n );\n }\n}","import { action, makeObservable, observable } from \"mobx\";\nimport { observer } from \"mobx-react\";\nimport React from \"react\";\nimport { Button, Panel } from \"react-bootstrap\";\nimport \"../css/supp.css\";\n// @ts-ignore\nimport acImg from \"../images/edges/activates.svg\";\n// @ts-ignore\nimport bindImg from \"../images/edges/binds.svg\";\n// @ts-ignore\nimport indImg from \"../images/edges/induces.svg\";\n// @ts-ignore\nimport inhImg from \"../images/edges/inhibits.svg\";\n// @ts-ignore\nimport repImg from \"../images/edges/represses.svg\";\nimport PathwayActions from \"../utils/PathwayActions\";\nimport { EModalType } from \"./react-pathway-mapper\";\n\n\n\ninterface ISideBarProps{\n pathwayActions: PathwayActions;\n setActiveEdgeHandler: Function;\n handleOpen: Function;\n}\n\n@observer\nexport default class Sidebar extends React.Component{\n\n @observable\n activeEdge: number = -1;\n\n constructor(props: ISideBarProps){\n super(props);\n makeObservable(this);\n props.setActiveEdgeHandler(this.setActiveEdge);\n }\n\n addEdge(edgeIndex: number){\n if(edgeIndex === this.activeEdge){\n this.setActiveEdge(-1);\n this.props.pathwayActions.addEdge(-1);\n return;\n }\n this.setActiveEdge(edgeIndex);\n this.props.pathwayActions.addEdge(edgeIndex);\n }\n\n @action.bound\n setActiveEdge(edgeIndex: number){\n this.activeEdge = edgeIndex;\n }\n\n render(){\n\n const edgeTypes = [\"Activates\", \"Inhibits\", \"Induces\", \"Represses\", \"Binds\"];\n\n const edgeImgs = [acImg, inhImg, indImg, repImg, bindImg];\n\n const nodeIds = [\"simpleNodeDiv\", \"familyNodeDiv\", \"complexNodeDiv\", \"compartmentNodeDiv\", \"processNodeDiv\"];\n\n return(\n
\n \n \n Network\n \n \n \n
\n \n
\n
\n \n
\n
\n \n
\n
\n
\n\n \n \n Node Palette\n \n \n \n {\n nodeIds.map((id) => {\n return (\n
\n
);\n })\n }\n
\n
\n\n \n \n Interaction Palette\n \n \n
\n {\n edgeTypes.map((edgeType: string, i: number) => {\n return ();\n })\n }\n
\n
\n
\n
\n );\n }\n}"],"sourceRoot":""} \ No newline at end of file +{"version":3,"sources":["webpack://pathway-mapper/webpack/bootstrap","webpack://pathway-mapper/external \"react\"","webpack://pathway-mapper/external \"react-bootstrap\"","webpack://pathway-mapper/external \"mobx\"","webpack://pathway-mapper/external \"autobind-decorator\"","webpack://pathway-mapper/external \"jquery\"","webpack://pathway-mapper/external \"mobx-react\"","webpack://pathway-mapper/external \"lodash\"","webpack://pathway-mapper/external \"cytoscape\"","webpack://pathway-mapper/./src/images/toolbar/layout-cose.svg","webpack://pathway-mapper/external \"react-toastify\"","webpack://pathway-mapper/external \"oncoprintjs\"","webpack://pathway-mapper/./src/images/toolbar/save_png.svg","webpack://pathway-mapper/./src/images/toolbar/save_svg.svg","webpack://pathway-mapper/external \"file-saver\"","webpack://pathway-mapper/./src/images/toolbar/edit.svg","webpack://pathway-mapper/external 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= require(\"react-toastify\");","module.exports = require(\"oncoprintjs\");","module.exports = \"data:image/svg+xml;base64,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\"","module.exports = \"data:image/svg+xml;base64,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\"","module.exports = require(\"file-saver\");","module.exports = \"data:image/svg+xml;base64,PHN2ZyB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciIHdpZHRoPSIyNCIgaGVpZ2h0PSIyNCIgdmlld0JveD0iMCAwIDI0IDI0IiBmaWxsPSJub25lIiBzdHJva2U9ImN1cnJlbnRDb2xvciIgc3Ryb2tlLXdpZHRoPSIyIiBzdHJva2UtbGluZWNhcD0icm91bmQiIHN0cm9rZS1saW5lam9pbj0icm91bmQiIGNsYXNzPSJmZWF0aGVyIGZlYXRoZXItZWRpdCI+PHBhdGggZD0iTTExIDRINGEyIDIgMCAwIDAtMiAydjE0YTIgMiAwIDAgMCAyIDJoMTRhMiAyIDAgMCAwIDItMnYtNyI+PC9wYXRoPjxwYXRoIGQ9Ik0xOC41IDIuNWEyLjEyMSAyLjEyMSAwIDAgMSAzIDNMMTIgMTVsLTQgMSAxLTQgOS41LTkuNXoiPjwvcGF0aD48L3N2Zz4=\"","module.exports = require(\"tippy.js\");","module.exports = \"data:image/svg+xml;base64,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\"","module.exports = \"data:image/svg+xml;base64,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\"","module.exports = \"data:image/svg+xml;base64,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\"","module.exports = require(\"tippy.js/dist/tippy.css\");","module.exports = require(\"react-tooltip\");","module.exports = \"data:image/svg+xml;base64,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\"","module.exports = \"data:image/svg+xml;base64,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\"","module.exports = \"data:image/svg+xml;base64,PD94bWwgdmVyc2lvbj0iMS4wIiBlbmNvZGluZz0iaXNvLTg4NTktMSI/Pgo8IS0tIEdlbmVyYXRvcjogQWRvYmUgSWxsdXN0cmF0b3IgMTYuMC4wLCBTVkcgRXhwb3J0IFBsdWctSW4gLiBTVkcgVmVyc2lvbjogNi4wMCBCdWlsZCAwKSAgLS0+CjwhRE9DVFlQRSBzdmcgUFVCTElDICItLy9XM0MvL0RURCBTVkcgMS4xLy9FTiIgImh0dHA6Ly93d3cudzMub3JnL0dyYXBoaWNzL1NWRy8xLjEvRFREL3N2ZzExLmR0ZCI+CjxzdmcgdmVyc2lvbj0iMS4xIiBpZD0iQ2FwYV8xIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciIHhtbG5zOnhsaW5rPSJodHRwOi8vd3d3LnczLm9yZy8xOTk5L3hsaW5rIiB4PSIwcHgiIHk9IjBweCIKCSB3aWR0aD0iNzUuNDA2cHgiIGhlaWdodD0iNzUuNDA2cHgiIHZpZXdCb3g9IjAgMCA3NS40MDYgNzUuNDA2IiBzdHlsZT0iZW5hYmxlLWJhY2tncm91bmQ6bmV3IDAgMCA3NS40MDYgNzUuNDA2OyIKCSB4bWw6c3BhY2U9InByZXNlcnZlIj4KPGc+Cgk8cGF0aCBkPSJNMzUuNDM2LDExLjQ1NEg3Ljc1NXY2My45NTJoMjcuNjgyTDM1LjQzNiwxMS40NTRMMzUuNDM2LDExLjQ1NHogTTMyLjU3Myw3Mi41NDNIMTAuNjE4VjE0LjMxN2gyMS45NTVWNzIuNTQzegoJCSBNNzAuMjc0LDExLjQ1NGgtMjcuNjh2MzcuNDY0aDI3LjY4MlYxMS40NTRINzAuMjc0eiBNNjcuNDEyLDQ2LjA1NUg0NS40NTdWMTQuMzE3aDIxLjk1NVY0Ni4wNTV6IE0wLjgzNSw1LjAxMVYwaDczLjczNnY1LjAxMQoJCUgwLjgzNXoiLz4KPC9nPgo8Zz4KPC9nPgo8Zz4KPC9nPgo8Zz4KPC9nPgo8Zz4KPC9nPgo8Zz4KPC9nPgo8Zz4KPC9nPgo8Zz4KPC9nPgo8Zz4KPC9nPgo8Zz4KPC9nPgo8Zz4KPC9nPgo8Zz4KPC9nPgo8Zz4KPC9nPgo8Zz4KPC9nPgo8Zz4KPC9nPgo8Zz4KPC9nPgo8L3N2Zz4K\"","module.exports = \"data:image/svg+xml;base64,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\"","module.exports = \"data:image/svg+xml;base64,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\"","module.exports = \"data:image/svg+xml;base64,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\"","module.exports = \"data:image/svg+xml;base64,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\"","module.exports = 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= \"data:image/svg+xml;base64,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\"","module.exports = \"data:image/svg+xml;base64,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\"","module.exports = \"data:image/svg+xml;base64,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\"","module.exports = \"data:image/svg+xml;base64,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\"","module.exports = \"data:image/svg+xml;base64,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\"","module.exports = \"data:image/svg+xml;base64,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\"","module.exports = \"data:image/svg+xml;base64,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\"","module.exports = 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IGlua3NjYXBlOmZsYXRzaWRlZD0idHJ1ZSIKICAgICAgIGlua3NjYXBlOnJvdW5kZWQ9IjAiCiAgICAgICBpbmtzY2FwZTpyYW5kb21pemVkPSIwIgogICAgICAgZD0ibSAyMTkuMTc2NTIsMjYyLjU1ODE4IC0xNy43MDc1NywtNy4yOTYzNyAxNS4xNzI2MiwtMTEuNjg3MDEgeiIKICAgICAgIGlua3NjYXBlOnRyYW5zZm9ybS1jZW50ZXIteD0iLTIuNjk0NjIxOSIKICAgICAgIGlua3NjYXBlOnRyYW5zZm9ybS1jZW50ZXIteT0iMC4wNzg0ODk2NTMiCiAgICAgICB0cmFuc2Zvcm09Im1hdHJpeCgwLjM5NDM0MDk4LDAuODk5Nzc1MDQsLTAuOTE4OTY0MTksMC4zODYxMDY2Myw0NzQuOTg1ODMsMS4zNjE3MzI5KSIgLz4KICA8L2c+Cjwvc3ZnPgo=\"","module.exports = \"data:image/svg+xml;base64,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\"","module.exports = \"data:image/svg+xml;base64,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\"","module.exports = require(\"react-toastify/dist/ReactToastify.min.css\");","module.exports = 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+3zTF66t6TUA+P2ho8eczQ2Mn4ts2VKMu8HyGP6R+H1L4625MbrmhWpo46ZeQOOmnC8X7KbgPbdu2CD9hWuDHabBo0ZZLKuMZyhu907pv2zJco/rjDEppl071XM0d31qQL/FTlvfwYMpKLj62qgByyz6mxbffwTrte/cWfS3DvXOB8F7aq4156iSwcI9+/ev14c5ap5pFtgSNY/B4uuPPrBobcGgd8m8q2iIGCCtBVXAerDq11+kcz2CZUyBs/k9TzytOTEyts+xrR+3a6fSUg3ExC333U+jJ07WFpWPAVK8x6tPPH42erI2sPJdetUCGnPeeZoi7RPEZPz7jz+I7/qz6uTWvnMX+s9jT0hHdmeAbaov3nuX/vjpR6XlHBAHNy+8z6JwNAWTwHuvvKQaqTv14kto3s23WLTSGOmTmPR/Fv0G/VGN8WLynCn6oczEYGYitAXcx1/Fc4AIW1MQMYwoY6OWKaPPKBYEf/60jD59Z7FqP4P4vPy6G2jQiFFykacVc88Vvt+dDz9Cg0eOVr3GeI5siZq3ZawyCp7Xf9f+Te++9KLqdi4WGLfd/6Bq5ovU5CR6ZdFjqu42Ndk5ps2aS9GxsZoj7nE+G1avlOdj6o88cPhIuv2BB8Vi3Ly4Avgen7z1phxrTZkxey5dfv2NujMx1IDx8a3nn6uTRQVoGXMR4Lpk8Zu05o/flJa69B8yVIyz86mzEMoIzLIExOPOzf/Sd598LBY/dUUxwPWff+ttcjwyZ9k9dugQvfzYQ9JfVQ28x6iJE+n8S2ZJYWzpnMrE+BS3a4c4nyV09MB+pbUuF112Oc295vo611778p9hGFW69upND73wMk2ecZGmyF6I1tlXL6AFt92pOhBmihUqIk0xGDsTOPsj8MacCMVEhNQ1Wr4jBmFYb+ffejvNWXCtHMxMQRRwvJh0nbUWtlRlCem3zA3E5sDP4/dMsVRNyVZKxaJI7TPByPET6Wox6bSOERO+A0Soq1IsJuMDe3erilCk57pXLOpgSdQjQpsbEJO/fPetqgiFNQ3WUGSBMAXPLp5hU8sgwDM/95pr5TiHrCBaRWhTJzM9gw4fUN9dGzF+At3x4CPS8mxNhIIaKzkW9OjrpiDgKm73LrM1962B+Wn+bbcLcf2AtCBbOyfs2vUfMozufuRxOQaqgfSGeSY++dwzGMYGINBmXT1f1hfWA1anw8eNE6v7EUrLOSAIjx7cL0WHM0GUpbkgojGTp1CfwYN1TyYQZag80qNv/UEJPqi2RKzrBedursoSRCUsUVrFP34OP68mXq1VU7IFWEThS2wK+lPvgYMoIKC+D2xTJzsrS94LU3BNLrhkttxGZMyDXZnVv60wG2Q0afqFcrGttrjBWHXq+HFVf/IuPXvKrW21hV9zBcI9JTGeMmulSqoBVvJps+YYykEq3WrEYkHNpebU0SMy+t8Iw8aMlfcQAlMPcJW4+PIrpFA2BTtlqSb+7SxEGcYGOnXvQR27dDNkgfIXogGJ3tX8ElOTkzWn37AX8A813Q4EmEh69Otn2MKH/JJ9Bw9RjuoCX1GIK2dhrsoSJmMkgi8t0yb+8XPy51VcK5DM2VHBI9j6Upv03cQfbx/7W2AbA9mZGZSjkt0hPCKCOnevnwOSOQeE0eG4fdJ9Rg305YnTppsVk1hEJqlsCYOefftRMNfGr0O1EE2SKZNMgasSdjOMgEVvlx69KCq6tdJyDixcjaRgwj2HO4u/ipi0BubDdh07U0zbdkrLOTCvYQFfe9HPTyjD2EBbsRJVW/VpAQ8rouDVtgwhNiA6nEmZEFdqjv0BgUHSncCohQ/bOQjSUHNDgBuAM4UogkTUAi7AscOHNA/Y+Dn8vCl4XwSa+fg6Jmk/3l9te6xK/Ckvc45l2ZXAxI6JTS0yGEErwRrcSJozCFRZ9tUXqv0evrCooY5n1xy47mrbvrDMoUiEp4bt5eYExFdxcZHcMjclOraNTe4jCGBVKyeMxUJ+fp5uVy+8H4K5jI77fgEB0jJqiuwzJoFRLEQZxgZ8hLAx6o+H3/P185dRr6YgubelMqGOoKSkhEpVVureQkDatL0mviesde4qfqIIBFMTEY4CQg4WbLXtr6Qzp6WvG8SNJfD/+Dn8vCkhYeEyyMxRVjgvby8ZnWoKtkgRMe7Ma+kSiHuBSU3te2NSNxrB3xzAAvCf1SvrBWPVMGLCBOo/dLhFIYL3UEumj/ybzq6g1hiAH3OhEIVq4HrZMm54eHqIsbr+OF1ZUWkxOt8cMBzYssuC81FLl4exCvNb7VGWhSjDMBIMWKqJtIXONiq2XRFzVZawhYVE8RgoLVHtw3tQ1VcTAQOWLEi2gommlTh/NTb+vbpOWcjmAvosSriaIos1uDedfmtvTh47Sn8s+8FspoHzZ15qsSADwKJMzdIGVxFpuW9C44a9wDirhiN8yhsLLEQZhmlWYHLt2a+/clQX5E+1Vi4R/28uzyre19rkbQsIGujYrZtqUALqzL/65CKZv9LZbh1M4wKpx3774XvVspKwyiFVD3JhMowzYCHKMEyzAtHUCGJR2zY6c+IEZVhJio7/x8+ZgvfD+5rL12cPYDXp3ruvTCqtBlwG/rvoUVp4zdUyT63RaFmm6QIL6PZN/9KWDeuUlrogsHDUhEkO7ccMUxsWogzDNCvgZoDqLK3btFVazpGVmUEnjxwx69iPdvw/fs4UvB/e19FuDBFRUTJBtSW/XeSFRKWhO+ZdRq8++Tjt27GdraSMJCUxgX5dql5MAzmCL7rsCtWcoQzjKFiIMgzT7AgOCaWuPXoqR+eA/+ehuL1UbCZ1Ftrx/2p+pHg/vK+jwdbpsHHjaOYV86wGN8D6tWntGnrqvoVsJWVkwvqVv/wsC2aocd5FF1PXnr2alE844/qwEGUYptkBX8suYsJVsyoeP3yYss3UTEY7/t8UvA/eT2/iZ6Mgtc5Fl19JNy68V7NPKltJmzcILDqwZzet+V29tCSS1qNErFqaNYZxJCxEGYZpdsDXEpHzannusHWJ1EymaZxk2ibRjv83Be+D93Nm5CtE74Tzp9HTi9+h0ZMmK63WMbWSonY86qozTRvkDP3l229US/giFzLqr0dG1a86xjCOhoUowzDNkvDICJlT1BQUEzi0b1+90qM4RrtaZSO8D97P2WALFdVL7njgYXr5wyXSdxTWUq3ASvrpO2/Rw7ffQv+u+dupxQUY52EtZ+ioiZOor4ESvgxjD7jXMQzTLEH1I1RBUvOzRA18pLipDY7Rbgp+35HVlLQAAYEcptfddTe98+33dOdDj1D33n2U/7VOemoKvfXCs/THTz8aSn7NuC6w5B8/fIhWfP+das7Q6DZt5AJGrVACwzgDFqIMwzRLICBRBQnVkExBYvi05GTlqBocqyWMd3Q1Jb0gjdToSefRolffoFc+/oxmXb1ARkNbAwL0u08+pp2bN+kuB8i4LgX5efSrEKGo720K8tFecOkcimnXXmlhGOfDQpRhmGYLqiDBkmhKTlY2HT144GzpSPyNY7Sb4uhqSkaBlTSmbVuae811tPjLb+jB51+k4WPHWxTMKJcJ0ZLFPqNNAlhAt27YQNv/3ai01KX/sGE0bOzY6ipIDNNAsBBlGKbZYq7KUlVVZXUaJ8UfVPqNimO0m+Loakr2AFH9/YcMo/88/gS9+cXXNGPOZWbzkJ44fJgO79/HVtEmQOKZ0/TL0m9U3S1CwsJo+qw5Tkk5xjCWYCHKMEyzxVKVpVPHjlJWRvV2Jv7GsSnOqKZkbyKjWtKVN95MNy28l3z96vu1ItckxGi5Yg1mGidYPP31808Uf/Kk0lKX8y68mLr06Mk5Q5kGh4UowzDNFktVltJTU+n08eNyWx5/49gUZ1VTsjfYih08cjSNHD9RaanLSSG6iwsLlSOmsQFrNiLk1/35h9JSF84ZyrgSLEQZhmnWmKuyhBKIR/bHUWFBgfxbrSSis6opOQJfX1/qN3So6hZ9RloqFeTnK0dMYwOBScu/+Ur2XVM4ZyjjarAQZRimWWOpytLRQwcp8fQp+bcpzq6mZG8QzBQUHKJ6/kUFhVRU1Lwtokh7pJbuyNVBztB1K/+UOW/VGDflfOo3ZKjL5wytCRRkmj4sRBmGkfj6+armwkSgQ2mJDbklxYReVlpGVeKPKfCtbOi0R5iQzVVZSjh1krZsWC//NqUhqinZG18/f3HP6yfAhwhQq6cPIMDV7llJcQlVVhgXbpXiM/HShZubzH+pFvVdUlwkRJn6d9ACChiUFBcrR42Dmpyhf/70o2pgXWz79rKevJpvsBE8vTylhdUU9B8Z6CfOxwj4LVz7ykrjYtTdzV3V9xtggWFaOc0ZwIXH38w5lYjrZcs54dkrL69fkMLdw108H67tw85ClGEYCfzF1KyCSOmTl5tteJCsFL+Xk5UlxagpiDb3dAGLorkqS9ie/uW7b1S3qRuqmpIzKC8rrVdZCsATFvfM3b2+8MN2vlrVKS2gb+H383Lrl5+0BCZ2uBh4eNY/n6zMDJvcCwrz8ygvp366LlcmLyeHfln6rdmcodNnz6VoFX9oo0DgqIlaCCL4VBu1auL3MtPSbLJIY7HkHxikHNUlIz1NNZOAo3EXCyY14Q7kOdlQ2axYLLxw/03BIs0/MEAu2lwVFqIMw0h8ff1kShdTIERPHDli1kJmDQS9HI7bJ8RG/UklPCJSTJANv1q3VGVJDfxcQ1dTshWIv8KCPFWrH76XmqUUk1lQSIhYtNRfPCBVUFpyknKkD4jeIwcOGBKyOB81y1dGSiqdOXncUBoqCKHD++MoMyNDaXF9cM6b16+l7RvVc4YOHjmKhowao7mPawGLSGRhUOPQvr2qPqpayM7MNFuOVCv4nvDfVstocfLoEbnwcTaQgqHhEaoL/jMnTpzN0qEXPMuJp09TSmKC0nIO7HoEBgXLRZurwkKUYRiJX0AAdezSVTmqy4ZVf1Fi/BnlSDsQAQf27KZdWzcrLefABNG2YyeX8LHEpGWuypIarlZNyQhYWBw9eFDVaujt60M+KpMlJrMWLVtTWGSk0nIOWL3X/PGbWLjoEx+YRA/t3UOrV/yitOgjTCxm1LIeIA3V2j9+p2xxXnqBKPh92Q+GF18NAdxHVvywVHV7Nlzcr+mz5whBom4hNIqnh4d0T1ETVnju9+3crnshUH3ffpN90xbgMtO2Q0fV75ySmEirRH/DItuZ4JxQZCIktH6AY4IQkpvXrTVkFYUldPVvv6oK/5atW4v730I5ck1YiDIMI8GkAnHl41PfEoZchO+8+Hy1ZVPjxIKtr41r/qYPXvuv6gCJqN1O3bq5jI+luSpLarTv3NklqylpBfdm/cq/aPnXXyotdYGVC1YUNSBquvXqrRzVZfWKFfT1/z6kLI2WRFhj1/75O73x7FPSCmYELKA6d+uuHNVlx6Z/6fP33qaUpESlxTIQAdv+2UCvPPGo2fybrgjE/x8/LZNWMVPc3NxpysWXUMeu4lmzs1UMz25su3ZiMVDfRQXW7U/eXizHAK3b4Cij+/m7b9PSTz9R3UHRC/y4zbki/LFsGX354XuUkZamtDgHLJxi29cfZ/B9f/jiM/pJPJP5edpdVNC3P3n7TSli1UDBDewauDJuYjXqfI9dhnEyZ06eoJcefUiuhGuDSfXeJ5+VgsgcGES//ugD6XtlCup4XzrvasN+jgf37aWXxXmZ+sYhqOD+p58Tq9lopcU8mMDfeObJeltZ8Am75b77afTEyZrFHraGFj/3DO3buUNpqU/7zl2o3+AhFKyyqgfw60pOiKddW7ZY3P5CCpm5112vKnwbAkQb//zdN/JeW+Py62+kC+dcZpN/q9E+iYUAfvfg3r1UWlo/pZQlMNyniolrx6ZNlJ6aorTWx9L3w3vs3raF3nj6SbM+mLCQ9R4wSCb7V9vix7VGrtK927dbnXS1PKPHDh2kVxY9ZvY7wfreo28/KaDVqmBhWzv+1Enas22rVUGM/nrnw4/IPKxqwg7XZ9vGDfTmM09L615tevUfQHc9/BiFhpu3vOvtF+gPW4V4fvvF51QtfPBJnDhtuvh941YxWP47CrHftWeversA+I7f/u8j1fGxhogWUdR/6FBqFROruouA8e/g3j1yoWvNL3Tg8JF0+wMPml0o1QbvBSv9R6+9qmopBub6BlyG0A6rqun4iT771vPPieeorhuEljEX92v9qpX0/isvmRXoOI/+Q4dTu06dzLouYXF/SFwvWJ7NWe6xoFy46EnRZ9QXauDYoUP08mMP1fMrbhkdTfc99Sy1URHNWkC/+OStN2nVr/V3Oq66+Vbpr1zTF1iIMs0CFqLqg6IpGCQ3iZX1uy+/YDjwRAtIAn/3o4ukZdFVwFCIrcRXn3jcYpALJkAM7rA02GJhMtIna0QgRI4eq4keYOm9+7EnLD4TBXl59L83X5cuG45GyzOKHK8/fvk5/fD5p0qL43A1Iapl8WgP4Id71yOPiUXo0Hrf++TRo/TaU4soyYD7jl70CFGA8RHj2c7Nm5QW7WD8/Y941juIxXdtbBGiAG4s7778Yr3ftzeXXjWfLrnyKlXXiRpcQYhqm50YhmkWYPAcOGKEHCQcBSw0l117PbXr2FFpcQ0wuZqrslSb6LZtqVV0jE0i1CiwfBw7eNBhIhTbuJMvvMjqvQkIChKLsPlCFJm3tDgTTLRTL75EBuQ0JyB64c+KlE2OBoszbP2r2a7QX/BMm4sIb0gg+q+84Sbpy6oXiNiM1FTV72wLCAqde821FN2mjdJif/As4JmwJEJdBRaiDMPUARaf6bPmyK1zCBN7golqwW130pBRozVbaZ2JuSpLtZHVlMy4JTgDoylxtDDlootlDXItFn6I9uv/338MTfCOAIJj/q23U/8hQ5WW5gEsTxXlzkn+bq7v4VnGM41n2xXFaJsOHemmhfca2oGxh6+qGu3Fc3PTwvuoVUyM0mI/8AzgWbBkeXclWIgymsG2bf6hfZTw5ft0/LUn5Cv+83cod+92qnLx6FIvL/UcmdW5M63UW3ZzU52YIdIQkWmLoMJ5qdV79vZG0vD6uRHVwPaGWooS5I9Dsm+cv15g8br8hpvotvsfkM719gDWsweefYHGTz3fJt9KR4II/h79+pv1W0V7tz59zfpt6QH9EalVTMF981TJiwlghVVNq2Qj8Em77q67ad7Nt6j6UKqBc8E9xfbd+PMvkM+DLcS2a6/62Zauhykto2PozocflS4ztlqCsDWpls4MSdytJYTH/+PnTMFzquYjWRu9/QK5PN3cHW+dx3lbuqZ4pvFs4xm31VKOMdGcaEQfwbXQA/pq5+495Lmdf8mlcgtdC7iuasng8flqfVVP8njMG/BBffC5l2jkhElKq23g/qDv4xnAs6AF9Cm164k+aMszhIICfir9WK0feSwSKP9mGoiyzDTK27uDcrZvpJwdmylj9a+UtXE1ZW1aS3n7dlDhqaNUdPwwVRQWkLsQKB4qN9fRlOVkUfIPn1HaH8uoJDmBKvJz5as0NYny9myjvAO7yScqmrxCxQrMgPBxNJgAEECDoIbaTDh/msytZ0kY1Qi9fTt21ElNE9u+nQzosEWoQQSfOXFS+oXVgM9DlGvfwUM0DbgQRWVlpdJHrLbFos+gQdK6pVVYmILPhrULIiM6tq30GUUwiJ5tKnz28HETaN6NN9Pca66Tk3tDbGlrBecG37P40ydlXkxTBgwfTlMvmkm+drD6eIvJNjcnWwYdiWVedaMAPnAjJ05UnQRwfuircbt2SD9NW8Bk3HvgIJp5xTwpQuG/aERgw3dw8IiRNHjUaCGSfSg9BYnttaXFwTng9+bfdjvNnn+NnJwP7N4t/ufc9Rg9+TzRh8bLRZsWcN3wXcZMOo+CQkMpLzubcrK1pXDCs9dHXJMrRX+9QizEIIjixHNVu8/3HzKMJl4w3awYxT1CTl5smdfuQ3jvSdMvlL7FSGxuDj39Ap+FnK+njh0V41v9HJL2BIFGF1wymyJamA96wvkgUn3seVOpa6/estpPalKSGJe0GSowlsIqf+N/7qWhY8bS4bi4OsFj+O7nz7xUCl18ll5grcX9Gz1pMgWLRQaeIUvBaQjQmjzjwnr+qJ5CbKJPILitdrolWF6xHa5nxyQwOJiGjR5DA0eMkvl5EcWv9fmpAdlOLrh0Ft149z00VLyX2thhDvnMpqbWmRuxqEQFrgHiWukV/TW4i/tTUVlBu7ZsrhOUBZ/TGWLerG2t5WClBqKqvEyIzk2UuWEllaTUdUq3iLi5fm07UuSECyigWx+brHFaKc/Po6Sln1C+EJuWcBcDYospMyls+DhyM9h5HQkeBjjToxQhMgtjsmgVG6s5j6X0F0pLlYMrVr4QVVod5i2BrbXk+PjqMprivDCxYzWrZwCAtTo1OUlMYDly7vIUA1prMXHYq5RfDRC6SJosg3ksjBywJISFR8gAC2f0UXtTp68oYMDGdrSaBdsoiB5PFtdTRjuL64mFCfqkOYtsDRBW6Skpsi/qRvSx4JAQGZTkqHsDH1YE25g7P/SPkNAwmcKr9jnU6V8Cvc+oOeo8Y2qIawJBgOAUCMYaEHWN9Dj5CCbU+Vxh4ZYkFr/lqChm5v3NobdfWP1+NmLLeIexCYEwqHRVVak+aECYY4vatDAB+gEEtiz96qB+q/asA1i0cU5yV0kFfC8IODyL+F72nBOsPT81aB0vrAExjf6D6kzAyBykhum9N3eNWIg2AOX5uZT8w+eUF7dLHBm7/BB6Lc6/hMJHn+fQiR5b7ml/LaeMdX9gVFZazQOLbdT02RQ6dKxDz4thGIZhmMYPKwUnU1lWKre3bRGhwDMknAK69HS42Cs6fVy6DGgRoaCytER8v58of7/4frzGYRiGYRjGAixEnUzBoTjK3bNN/MsGkebmRkG9+pNPC8dWdoFozt6ynsrzcpQWbVQU5ksramma+YTZDMMwDMMwLESdSGVJMeXu3kKVih+GUTyDQii4zyByMxBYoIfihNNUcMxYvd+S5ERKX/ubtJAyDMMwDMOowULUiSDavPDkUeXIKG4U1LMf+UY7LhEuqCorpdydm6g8V5819BxVMhNA/oE9vEXPMAzDMIwqLESdhRBjsDBWFJgvHagFj8BACu43hNw0pjIxSklqEuUfrJs+RC+wAGdtXiuDsxiGYRiGYUxhIeok4G9ZeOIwVWnMp2aOgM49yDe2vXLkGJByIS9uJ5XlZistxkGwE1tFGYZhGIZRg4Wok6jIz5NWRltAns7gPoNliiRHUpaVUR3VrzFS3hJVZWUy6l5vwBPDMAzDME0fh+QRLU1PpZydm6jg8D6qLCkhdx9fChk4gkIGjyR3B28puyoFh+NkacwKnRUTauPfsRvFzLuZPAODlBb7A2to1sa/KXXFUputtwDppfw796CWM+aST8topVUd+KXmH4qjnF2bzkbc+7aOpYhx55OP+JthGIZhmKaFXYUoosFRKShj/V+qkeGB3ftS69nzZdR3c0JWF1j3J6X9uUyIu3MlGPXg5uFJUdNmU9jICQ7NHYoqSglfvEeFxw8pLUZxo4CuPanlhZeRT5T1NFNFp45RihC/RSrBXChp2vLiKyik/zDxtm5KK8MwDMMwjR27KZrS9BQ688limT/SXHoiBL8gmTv8JZsTKOdZnHDKsAgFXuGRFNi1l+MT2J86SsWJ9Wts6yWo9wCKueIGqyIU1yRzwyo6/dFrqiIUwIqc+utSKjxxRGlhGIZhGKYpYBdVU5IUr1jRDist5qiivH07qPDoAeW4eWC7f6gbBXTqJsRohHLsGLBAgG+orXlOfVu3oajzLyEP/7p1g01B+dCMv1dQ6m9LZYS9JeBjCmu7refGMAzDMIzrYLMQRWBL0g+fUXHiGaXFMrBuQezAH7C5AGtxeU6WcqQfd19f6dbg5umltDiGkqQEKjSYwL4G+AOHj5tK3pEtlRZ1pC/q5nWUvuY3KUi1gO374uR45YhhGIZhmMaOTUIUVXPSV/1CRadPKC3aKE6Kp4pC40E7jQkILoh0WyoM+bSKId/YdsqRY8B55h/aa2PKJjcK7jtYbstb8+UsOnGYMiBCy8qUFutgEVOSKIQop4JiGIZhmCaBcSEqxED+/l2Uu3srDqrbNFKRn9tskpwj8rw46Yxx/1B3d+kb6hHguEh5gK1vmcBeCFKjeIWFU+iwcVYzI6AWffrfv1G5TtGLa1iakSJFM8MwDMMwjR/DQrS8IJ+yNq83ZOmrLC2liqIC5ahpU1lYKNNZGcVTCFAksXdokJJYVCBKvjQlUWkwgDi/4H5DZboli2ABc2APFZ40EnhUJaP6qyqNB30xDMMwDOM6GFY3JSkJ4mVQuLhh57Z5pOEpzUqj8uxM5Ug/2Jb3bmHZ39JWsJjI37/bpmwGPpEtKXTQSHLz9FRa1KksL6OCIwd0bcnXBv2GEzgxDMMwTNPAmBCtqpKR8pXFxvw83dw9HB544xKI6wRraEWJwUhvd3fy79CF3H39lQbHUJKcQIVmUidpQojDwB59ZYopa6DWPhYxRpE19jmXKMMwDMM0CQwJUfjowb/PqK+eR2AQeQaHKkdNF/g0lsA/tMxYhSIPvwAhRLs6dFse97Dg6AHpt2sUr7BICh4wzKo1FCD9ktHqUm4eHtXWYbGQYRiGYRim8eM4hWMBv9j2Di1T6SpgyxspkYTcq27QiY8QXd5RrZQjx4Agpbz9u20IAHKjwO59xLk69jwB8pL6teng8KT+DMMwDMM4B0MzOoQALJpGBAHKNQb27Fe9xdrEQWaAMqP+oW5u5Neuk7SKOpLi08epNC1ZOdKPR2AgBfcZqNnVwt3XT/YBI/i17SiT5TMMwzAM0zQwZloSIsk3ug256xYUbkKE9pdR4M0BBCkhVZER3L19pPDCdrSjQFGB/EP7rFY1soR/u86iL7RVjqzjERBIPq2sRNar4BkUIuvsQ8gyDMMwDNM0MLzH6RvTjgI6dlOOtOEb04YiJ06TIqvJowQqIVWVEWBxRsS8IynNTKfCE9bKspoH+UKD+gyU1ZS0gt8J7j/UavnP2sD3NHzMZPLX2d8YhmEYhnFtDAtRiI8IISqtlXKsAaIqes61mn++sSMDldKSDSeyRz5OhwZ0IXfosUPGXQcECBzyb99FWsj1ENCpO4UNH6vJtcPNw5Mixl9A4aMms28owzAMwzQxbJrZ4a/XetZ88o6IUlrUQDBLX2qz4HbysZbsvAmBnJzVvpf6A5WwHQ+LsyNTXFUUF8ltea113ushxGdAl56GxDIsnBCXYSMmWHQ9wDZ+q5lXUuTE6Zoi8hmGYRiGaVzYbGLy79iV2lxzJwV07SXFyVngRxrbnmLm3USx828jr/AWyn80D5AOqSwrQznSB1wX4IPrSAtgSXI8FSecUo704+EfIIRoL8M+rLCoR02bTVHT50rBWRsEM4WNGE8d7nyEQoeOcaifLMMwDMMwDYdblUD5t20gyX1asrQCYjvVN7YdeQYGK//Z/EBuzoQv3jcUrAQ3hjYL7tCUIN4ISNWUvnK5rPdutLY8/DVj5t1slzRcCJYqOn1C/u0ZEka+MW15G55hGIZhmgH2m+3d3MgnqjUF9Rog80o2ZxEKUQ5rqJE6/ADXEUn/HQVyh+YfijMsQiESsS0Pq6g9gHU0oEsPCuo9gPzatGcRyjAMwzDNBJ7xHQCMzIiYr6rQ73/pDP9QbMmXpqcoR/rxEIuMgE7dWDAyDMMwDGMTrCQcAPJzlmYIoWfA6wH+oQjqcpTIqyovowLkDi02njsU1Y0cnVqKYRiGYZimDwtRB4At+fKcbOVIH8iv6RUWoRzZnzJxXtW5Q425BiN6HQUJmkUuWIZhGCukJifROy89T1dPm0KXTRpH18+8kD59ZzFlZaQrP8E0JcrLymjDqr/onusXyPuN12P/7w7a/u9GqjRcKrt5w0LUAVQU5Es/TCN4hoY51L+2+MwJKssynjvUKyRMZkrQmzuUYRimqQFR8s/qVbTm99+otKQ6JiA/L5d+X/Yj7di0SQaGMk2LlKQk+v7zTyn+5EmlhejQvr207KsvxOLDWKac5g4LUQeAQKWKokLlSA9uMpG9o6yNclv+2EHDQVQAZUe9IppXKi6GYRg1EA+Qn1Pf6FBRXk7ZmWIeMFjQhHFdiouKqLiw/vyeJ/pBsaF5n2Eham8QMZ+dSVVipawXBCp5R7R0WN7M8twcKjp9XDnSj5uXl4yWd3dgIJWrgLRbOds3UuLXH9KJ15+kk28/T8k/fUWFQsizlYNhGGuwCG1eVFZW8Na8QeyXR5SRoKRn2h8/Usa6P6Uo1QMSuUdfcSMFduuttNiX3D3bKGnpJzJfpxGQVir2mjuFWG66FlH49mas/5Nytv1jxqrtJu5PL2p50eUNWq4Wj+2Zkydo/66dVG60OpYJAYFB1KVnT4pu05bcOSMCw1ilrLSUvv7oA/pl6bdKyzlmXb2ALp13NXmKBXxjRm2s8RVzVb8hQ6lFy+ZRsrs2xw4dopcfe4gy0+v6ALeMjqb7nnqW2rTvoLQwWmEhamdQ2hNiL3fXFqVFOxB4sfNvd0hEOkp5pvz6HWVt/BtH1Y06QZWjVhdf4dDUUg0FMh1kblxN6atXUGVxkdJqHhQbQHlb1M1vCH/ZtORkeu2pRXT04AGlxX6EhIXRtEtn0/jzp1FoeLjSyjCMKc1BiJoba4aPHU83LryHAoOaV85wFqL2h80edgaCpjzXYMR8YLDDEtmXF+RR0alj4l/GRGh10vmeTVKEliQn0JlP3qLUFT9oEqGgLDOdEr/5n/S5bQiyMzMpLSVZObIvOVlZ9JWYXO+/8ToZiIGADIZhmifmxpqkhHgqLChQjhjGOCxE7UxFYQGV5+UqR/rwDo8kDyH4HAHEVllmmnKkH+/wFuQX2145aiJUVVH+oX105uM3qODIfjRUt2sEC470v5YbTtVlCxXwR3KwD1pOdpZMS/Pbj9+fjQhmGKZ5YW6sqagol9v2DGMrLETtDFI3abWq1cHNjbzCIok8PJUG+wG/1cLjh6nCyHlJ3MivfWfyDA5VjpsAYgDN3budEr/5SAaXGaU44TQVHD+kHDU9sPX43ZKPadPaNRx8wTAMw9gdFqJ2BvlDjaRHQqQ8coi6OcDfEBHghSePSPFlBHff6lrwSGbfJIAI3beDkn/4TC4cbKGyolyWS23KkfQlJcX0wxefUcLpU0oLwzAMw9gHm4KVyvPzZIL04qR4Ks/NkpbA0ow0WRkIATchg0bKBOjNBnEpM/9ZRakrlkorpB7cff0o5vIbKLBHX6XFfsCPMeGL94XoylNa9OEb3UYGUdmr4hNEW0niaSpOTqAS0Xcqy8qoLCtd1uZHZH5gtz4U0K23w8qcwjqc+O3/ZL5XW8ECosWUmRQ+dopTa+8f3LeXXn70IcrLresGEhnVkq6+9TaKiIxSWqxTVVVJyQkJtO3ff2jL+vXyWI3Z86+hS668qtEHXzCMvWgOwUrmxprY9u3p/qefo5ato5WW5gEHK9kfXTMnhEzWv2vozJLFdPiJ/9CRpxaKf78p0xWhPWfnZpmnMnf3VtG2TL4QRd5cgMCC36AR65iHEKKO2PrGuRSdPEqVRQadyt3cyL9Td5vODedQKM4hZfnXdOK1J+ngw7fSiTefoaTvllDmhpWUvXktFRyOo8Jjh2Q/Sly6RJzzEeW37UtpWrI8D3uIUICSrH7tOjpVhFrC19+POnTpKtMwaX117dWbxk6ZSv95dBE98uLLZlOybF6/1mEBUgzDMEzzRNPsCcsnJu+jzz1Aycu+oPwDu+V2rzXKMlKpyoYqPo2OyorqiHkDRmZYRJFH1N7ASl144oghcQxktLwQooaS7IvrkH9wL51842k69c4L0lpcnHQGmX+VH1CnsriYyjLtXyoN+VPTV/1afQ52AnX3fWPaKUeNG4jpXv0H0OXX30Q+KkFzSOOSFH9G3FYOUGAYhmHsg1UhChGKvJgQEXqtmxBXbg4IvnFVKsvL5fUygod/gPTFtDewAJakJCpH+vGOiCKf6DbKkQ6EWIFlHJWJ9Ao/iF67XwtFFOft36U02I5nUAiFDh3tsJKsDUG1GO1Pnbp3V1rOgdJ2CadPc/UQhmEYC8CvHnlXV/6ynH757huLr79/W0FnTpxo1sGgFn1E4eeYvuoXyljzm26fR/HWFD56IkVdMLvpBLlYoSwni+I/WSwjqfUS3HcwtZ5zjV1FDaygmRv+orTffzRw/wRuuIeTxT2cpdsiinRR8Z+/K4WwXrxCwyl2/m12tTTCgp/w5QdKmiY7IARbxNip1OK8ixqkfzvSb8uS39vMK+bR7AXXkpcOvzf0w+TEBNq9bSvt372LjuyPq+dfpUabDh2oU7fu1GfgYPEaJBPtGwXDnDyHLZvpwN49dFC8kB/RCJOmz6Arrr+JgkJClBbtFBUW0qG4vbR761Y6duignKxQl9wSfv7+1K1Xb+oiXv0GD6EOnbvYxe8Q+WFPHD0i78uRuH3ivPbJ87MFNzd3mj5rtugj14jzDlBa61OQn08/fvEZrfhh6dnvH922Ld167/9Rl569qLS0hOJ27qBtG/+R9ytRLIBMGTVxEs2/9Q5NRReMXPfaeHp60aVXXU0z5lxGPrUWydZ8RC++4kp57vge6PuH4+KovNx8Xt7wyEj5/Xv26y/vdavomAZ3+3FFH1GjY4o1+g8ZStffvZCiWrVWWupjyUf0urvupgO7d9MfP/2o+1kKCg6m6aJ/TWiGhUQsClEkQIeYMJKg3d3Lm1rNuppCBgxXWoyBiGSIGQS0lCTHU4WSQLeypIhKUpOpSuWhRicty87QVe8d2+KewZhYlKh1IcLgF4mUSohkR6J5BGAh+AoCSU2YlaQmUfySxVSakaq0aEUIvlFCtE+fY2wL3AzYlk/45iPK379badGH0QAqJPVP+eVbytq0DkfVjTqAK0DMvJvII8B+yf3zD4jJTFwL9bKd+vFv35lirryZPEMaJqWVIycHTNDLv/1aTrCmTL34Epp38y2qW/emYGhBacCfvvqSNv69yiZLqq+fH02fPVd+vl5BmnjmtExB9e/aNeKcbLfm4rvf+fAjNHjkaDk2aAGTElJgff/ZEkpLSVFajdG9dx+aIxYDPfsPMFSKFfc3btdOWvrZJ3RI9CN7gwn13qeeleepBvrFdiHM3nzuaWllr83ICZOo94CBtOzLzyk1OUlpVQfi8Jb77qfREyebFWv2vO4Qifc++axYHHVTWiwL0QHDhksr1x4hloyAewvf7Ysvv5Jax7bR3NfsjSsJUXuOKWrgmkNMTpp+odlny5wQtRchoWHyHIaMHkMedtQDrozZUQzb8Fmb1xkSocBTCDa9CdAhKnO2baTTH75Kh59cSAf+70Y69tIjMjgq4Yv3pH9f1qY18oXAqOKEU3Lb2fQF4apHhAIIlJKUpHPvk5wgA2gQSIPPS1/5MyUIUX7yrefoyNP3VJeCNPF/hQAzEpzl5g6hGyzFrz0pzUyTUelGQS11I9vyCFjL27dT/MuAL6F4+P06dCF3P/PWFL1gYVJ05rgNeVTrggVKiykXN5gIdTSY1D3NWHktWXNqgwl464b19Mz999CGVX/ZPGFAsHwvhNMLDz9AJ44clhOSNXDfIQKevu8e2rhmtV1EKMB3kwJKwzkATFgfvf4qvfvyCzaLIQBh8Ly4Dsu//pJKiouVVm3g538Wi4wXhbBwhAgFpSWllJeTbf4eifYiMd6Wl9W3SEJcvP/KS1ZFKKisrL4P5u6Cva87RGeZjvF95+ZNhkUowDOz5vff6Nn/u5d2b91id9HV2LD3mKIG3jMrI8PhxUIsgUIii59/hn7/8XvZ55oD7srf9ZCJum3YxvSNbSfFqFbK83Mp4esPKfG7JfJzjaYacgaonpS+cjllrvuzzpY3clJCjOpGTPweAQH2XfFisD99wnCVJ4jigE7dyBMCWQf4/jm7thj3lfXzJ//2Xey6HYUFTmmamIg0CgdLwHUictJ0IZa7Ki2MKRCAm9etobdeeNbw9rc5sK2KutcQo5aACDp68CB9+NorlJGmd4fCfmBS++DVl2n9yj+VFvuACQplWLG9DX80LeDn8PP4vaY+wTnqujcEENFvPPMk7dj0r3y2miOOHFNcETyf3y75H239Z32zuOeqsz3EFbYykZzdCPCZ8xcTNbbntQDLIlI9GbaiNQC4RnlxO+tcI1jcjPhiurl7CAEWYFeLKCyzhccOqrouaAHppJC2Sa+rAPLI4nON3kcZHNXSvH+OIYQosZc1LLBnP5kft6H9tlwVCMDD++Po8/ferbftai+Q8/Szd9+m9FTzVi7UwP592feUkmQ8UM8cPr4+1T5cVp5XbAsv++pzKSAcBbaEN65ebTXQAf+Pn1PbQm6sePv4UFh4RI0z1Vkcdd3hExwYZD93IT3Ap/arj96X29LNDWeMKa4Ivuu3Sz6mM6dOKi1NF49FAuXfZynPyaKM1SsMC1EEm0SOmyqjiq0iOlnuri2UsfZ3IeK0O4+7ArCOBfUacNZqiC1ppLYinSsYvA98aSHC7AUEYeb6v6jCYP5QJLEPHzVJpm/SClZuuJd5+3bI+6obMbGH9B9KgT362V3oofBC0WnbH2jco6Be/Rs8AC89NVVuY5rWgA8ODaVREyfbNGFi4Ifz/57t25SWc3Ts2pX6Dx1mduseAnDpp0usbvvCz7NLj54UFR1NUa3rviJaRFFBXp4MpjEHvn9YRAR16tqN3E0WSzh/bF/DjwxBL+ZA8v+O3brX+3xLLySrnjH3cuo3ZIj0UTQHziFu9076bsn/LFof4YfWUXyHmHbtVD8PYis327x7FLYQYTHrO3iw9M00BwQ5xHtmeprSog4CLpCHVu1cTF9hEZHy3Ey3MdE3ho0dS9Ft2qrv8ohrc/rEcRnAo2V7FQFQ7Tt3plhx7Ws+G+993oUX0dAx48jL+5zBQ+t1V3tPS6/2nbvQJfOups7de9b5Tvju+3bukEJJCxCz6Pcto2PqvD/6IgS0pf6Ka41Aqe59+ph9/hyBI8caLWgdU8xdW7VXi5atpNAz/U4AgWI9+varN67UAGs7rgfulznQJ8eeN4UuuuxKmjFnLk2adiFNnDajzmvCBdOo94BBcgyAHzv6rin5ubnSZxTBiubOpymgGqyUhxrc3y2ReReNENRnIEXPuVaTiCnLTKP4T9+xa25HZyErDi24QwpvDK5GqypBsCNK3K9tR6XFRsS55OzYREk/fqbbV1YiBtqIsVOoxdRLdFlE4Web+PVHlH9wj9KiD2zLR19xIwV266202A9b+3QNvrHtqc382xvcP9SRAQQQB78u/ZY+f+8dpeUciBhfcPudqsFKUgTs2kmvPvE45au4hAQEBtKlVy2gMeedJwdXS+C9UhITacX339HKX39WjXCGOPjPY09Qq5gYpaUaCNifv/tGNdgKjJ96Ac2cd1V1RLIVq6ZRigoLaMniN2nNH78pLXVBdO6lV82nzmLitBaQgMkS/oZff/yhavQ4RNX8W2+TgVweKgIF1tA/f1pGn76zWFX4QXxeft0NNGjEqDoR4dbAFim2jHHPa2MtmAsL1g2rV9K7L71o0ed45PiJNG3WHLFY6KY5aMPadUcgFCqEoYiDPQJBIHbNBSvVAJF5iehvCD6x1u9h5V/16y8yrY+aSEKxiXueeFouFpxFQwYrWRtTkFECCwQ803qCGC3dN2sVsawFK/UeOIiuu/NusVjSFmCG5wHf0ZwvM+71wkVPWozkb+zUMzthK7fg6AExYZtfmVkClqKAzj01pSHCDciL2yWjzRsjCOZB/k+ABwYiR0XXWwXXzK5pm8Q9LDxx2JgIFUg/TSPb8uI+FifqT11Vg3eLVuTbOlY5si/+nbrZReiXZ2dSaZZlq1JzBWLxyIH9ZkXobfc/KFP7WJuMAQZwCMz5t95O8268WVVgJSfEU/zJE/WeuVIxyZw6dlQ5qgvEDUqgto6JdZgIBZnpGXT4gLqVbMT4CXTHg49Qt959NIkhWEWHjR1H9z35jExnZQrcTuJ275IBQGoUFxbSgb27VUUoUmTdK4QNotX1iFBHgnt9xfU30i33I5WTdaFeG0vXffjY8XTXw49Ja5c9RKgWIHgfeuFlmjzjIk39HqJ1thBCC267s46lt4bMjAw6efRos/AbBJbGFP+AALr9gYfoormX25TazZ5ANN5w90KKaWtmN0AF7P5ZKySClxFt0VioJ0SRHqko/pT4l7EvjYhi/3adMJMoLeZB2UkkGG9sW/IAifr92nUWIlJZNSlCFH/rBe9hz63estwcKjp9TDnSj3dUa2nt1YX43ghwQ8CWIUR/8e/Qxa4pm2oDf2XviBbiX7aJD5ldITHe0H1u6iAi21wQ0ZjJU6jP4MG6XS5glRg5YSL16FM/hRi21jBJlZtYS2ERhU+dKRA4sFYEBAQqLY4BE0aK6COZafUXLPAthZXPSA5SiOfzL5mlKlBOHT1CGanqQVnZWVmqvoW4HhdcMltuT7sSw0aPpckXXqQpRVhtLF13CJVpWAQ5UbBg8TXr6vnSMqYH3Jfh48bRwOEjlJZzQJgdPbhfLraaA5bGlNGTJlPfQUNcxl8fW+zYbjdiucR3wBjXrnNnpeUchWJOjT91Uvbvpkq9OwhrD6w+RvGNaUte4ZHKkWXKxOeUZTomF5ejgagJ7NqrzkMgBbWBvuIuJtuzgtYOIK1VWXaWcqQTCML2QhD665usYYWFNdToosJocJQmxAOMqkqo9GToBtUC3w/WZiNpuhoLsLaYirsaLPlFwpcL2+mmwKLXo18/8tYYvGhKUHCIFJBqwH/N1Je0TByrBTW4iT/ePsbOQQ/VgihJTKL1d5XgTgBBaQSMNbCItmjVSmk5B4R3Xo66T392ZgblqEQah0dEUOfu3eUE6iogXywS1QcE6l+QWrru7Tp1lrk4nUmn7j2oY5duhizv/mKxhCIOavcmNTlZCrTmgMUxpW9/8lZZlDUUGKdQbMKotT0wJJjadeykHJ0DOxnwFW3IlFKOpk4vxwSEgBujAS56tuUhDkqSE6nchdM0mUUMDoE9+9cT3FVy8jZiEfW0mwDDOaC2vFHXCrgaoH663vNBmqhiaUk3hiO35UvFYgd5X+2VzL448YwM6GuqlAuxnWXG/wlWHg939b6BHItqwRYQFdhyNGq5wMAOK4OaJRBbdqZCFJO32mRQJf6o5a60NxhHi5FBQyVTQ7QQQ7ZsgSMwJDwSlv26YOGQn59Xb8sW4gyiRS2qPrJlKwrWsF3sTMJbtKDW5oKcrGDpuse2bSdFrjNp276D9GE0Ar4/FhxqfQWLLCy2mgOWxpSo1q1dxhoK0L98Dd5vgHEVAWBqFIu5q9lYRKVV68xJ3cE2NaDqECrOwKpmDQwaJSkJinhrXGALGZWQ6myni8HP6HVz8/KWW/32AMIeFbHECVU36MRHCEKf1nWDP7SAClioZmUIWGE7dnPItjzymmau+8OuwXBlOZlywYbFVFMElrVjhw8pR+fAliEiTs2t+EvE4qdUxRoFqwUsGIYR/QOWTHe3+pMOgg5MRZaXt5dqeUlsayJq3FqqI1uBBaPQTB5dTFa2WCA9PD3E9ax/LSsrKtWjxEUfRXSv2neGyHFm9LUWILKNRmE78robwUd8plE/ZPyeL6r9qdwfbNVqLSzR2HHYmOIIxK02er+tgee7KVPnyawQD7EtgUO+bTpo3pavqqyQtdkb1WQuOhnKXba+5CrpC1sH8T2M5uxEHlG8tz1ARShkIjCEGKj9O/fQvy0PS0TimXqVprRi1AprFXFP8vbvlgn27dnPEARWcOQAVTbByQCCBfW4Tx45orScw09MjIiwNmeFwGCJajf1cOAArQaEWitxnmps/Hs1JZw2brnXirmJoyEsOLgnVZX1+7+7GHdQ1c2VwL2D2DaKK113xnZcZUxhHEudpxNWLaNbjm5eXhTQpafmJPaidxn2J6yDGGDgr+kT1VrWgkfC8dBh4yy+woaPp6hpsyn2qlso9upbzb6iL7+eIsZNpfDRk6n17AXU4c5HKHb+7XIb2Z5AgNnjoYJFFsnkjZayRFJ9/45ddQ/a0pKecMqwRdioFdYaZVnplLH2D1lz394UnjpKZekNV7HHEWCL+59VK+nLD95TtbggjU5M23bKkeviJcYinKuaPyuc/l99chFtWb+u2WxvMgzDuDLnFEdVFZWkpRi2anmFRmjelgcQO+7eln2l8DNe4S1kEnGPgEDpe4qI7shJM6jzwy9Rjxc+oB7PvUed7n+WOt7zJHX8zyJqs+AOan3pVRZfrS6ZJwVmUJ9BFNR7oNkXksxDsLa88DIKHTJaBmJZFGlmfOesIbfl7SBEKwrzhUA6Ztj659OiJfm01J8TDr6XpRkGRZm4ngFde+m2wloDW/Kpv/9oUzopS2DBln8kTlqDXQn4dq78ebnMQ6jn9cX779C9N1wrS+ippUqRkbxjxxuK9nY2eEa79+4rE5arkRR/hv676FFaeM3V8rubizZnGIZhHM9ZVQVrVmlqomGrFnI0wkdUM0K0eSIyskaAib9haYTgi557HXW672nquPAJ8gwKliIHaYEgkpGrEhWDCg7uNSy4HIL4Poh+b0jgViFrqhvBBkFYnpNtuKa9tMJ20G+FtQT6cNKPX1Denq2a+ggKEtRztbACPiN39zYqzzVf9aYhQPT08m++klV09LyWf/O1FGjmGDBsOA0eNUp0E/vdJ0cSERUlE7xb8iNLTU6S3/2OeZfRq08+Tvt2bGcrKcMwjJM5O6tUlhQZ9g/FdnxAlx4y6EYrEB6+Me1kScfouddS18dfo073PiW3wEMGIX+aGyV++7ESeFMXCNKszeuozMVEgFHcvb1tFmKwzBWdPCpzsxrBsCAUQq80LdlwpgXfVjF2rS2P65Cx8mfK2fGvpnUKhHfLGXMpuN+Qc4sijSDYruBwnCax25iJbdeeZl01n4IbuJqUHiCYh40bRzOvmGdVPCPIZdPaNfTUfQvZSsowDONkzo7Q5YjEyzEm7DxDw8mvjc6kyGLSx+QfffkNQniOlNV8aoBPX9pfy6sjk82ArVFb8p02NXDNkLbJ6FaxUUGIlBKlGSnGsh8IgYCKR+5CBNuLgoN7KH39X5rEIUR32PCxsrZ9QKfuuurqAwQt5WzfSOV56vkbmwIQobfc+3+yYohRP2ZUBXnnxefpmfvvMfz68sP3qURneVYkRL/o8ivpxoX3yiosWnC0lXTVrz/Tcw/9n+p31PJ6+bFHKG7nDuXdGIZhGj9nhWhZRprhnJ7wndS7tWkOCKmsLespb5/lwRY/h8h7V6I6BZOBydqgb2ltYJUsSamf+FcLEGSIljciCOGLiXywRqyCWHz4te1kszW4BrglJP/yrTwnLQR06y0D0ZCGyze2nQx20wuqkKGvGl0AuCrwCZ1y8UxZnhBlFm0JpoPF8dihg7Rn+zZDr71CDKrVWNcCApcmnD+Nnl78jqzEohVTKylq76O2uq3gPSBu1b6nlteBPbt1C3KGYRhXploBCBFRlptlKP0QJnFs6WqOlrdCweF9lLHmd6vn4hkQKMSvayVjlnlFjehQ+JbaIEYhghDFXWFwIYH8nQGduhkShHCTMGoRRBCavbblYRFO/eUbuaDSAtKMRU668GzuUvyNSlmw0uoB/TR76z+Gs024Iigt+OL7H9F1d/w/imhRP3l6YwMiGtH+dzzwML384RLpO6qnfCSspJ++8xY9fPst9O+av+sl0GcYhmGMI2ddbK+WZWYYClTyDAwmvzbtMdorLcYpSYqnlF++0ySo/Np1Iq9gF4rgFd9f+sja4TropUqIQbktbzDQDHXljaakQhCZMQHsRn5tO9glWh5uAaiclH9onzhQGi2AcqqRE6eTX+y5VEQQ4chliv6sF1iiXcUqigpG/3n8CXr6zXcsvh549gW53a4GEtr7+PrZzVLtKuD7tOnQga67625659vv6c6HHqHuvfso/2ud9NQUmVXgj59+VE8ezzAMw+imeqapKKfynEwoUnmoBwgYr7AI5cg4qDufvPxrucVsDbgBhAweqSs4yhk01MRdmpkmRbwRkMMUNd7dhfAwAkSokbylCNDya9OxbnUqA0D8ZW/bSJkbVskFlVWLtPj/0CGjZJCc6aIBW/O6fZ0FyIebs2OTS1hFff39pMDEdrqlV9/BQ2jS9BlyC96Uk8eOyi3gxuBuEBYRKUSz/gorKFU6etJ5tOjVN+iVjz+jWVcvoBAN5S4hQL/75GPauXmTS10fXIPQ8PB6fZphGMbVkcqpsqy0usqRXoTwgmXS3dd4fVUgg5P+WEaFxw8rLRYQnxkqRChEjKuBpP5GfOnkhGZgESARv1d0+oTx9EmBwbK8plERjX5jJPcsFhPwLbaVgiP7Ke3PH4UY1LZdCjeSFuddpLqIQZ5aVM7CfdSLK1lFtYAynf2GDKW2Heo/RxBba//4jbKz7BMMiKj1Tt26U++Bg+z26iNeE6fNoJlXzpOlEI2Cfh/Tti3NveY6WvzlN/Tg8y/KfKmWIu1RMvPX77+jLAM+oyFhYdR7wEDV72T0hdRa8266lbr26m1o/GEYhmlI5GhbUVhgSMh4+PiSvxCitlgCIYLT/vqJcnZtFkfWxZhvdFsKHTLG/uUgbQQTgJuHsTyiMrimypiAwfUrPHHYkH8v8IttTz5RxrblIbrKsoy5dMAdwFNP3lkVkNoredmX0j1AC/ADjbrwsrN+ofUQ9xCiHL6renElq6hWwiMiadTESeJr139+j+zfT4fi9tlFWLdo1Ypuvf8BevSlV+z2ekS8br7nPmrTvoPdxBdyjvYfMky6Nrz5xdc0Y85lZvOQnjh8mA7v1399Js+4iB587kXV72T0BTcLWLf1+L0yDMO4CooQLaRKA5GYXjLYxHhpRgiYzHV/Uda/a4Wisj6gI8o6cuI0zfXsnYqYDCHMhSpXGpwDhE9xvLHa2dgWh18kLIGGEPdMJnTXORkju4CtAW6wQCb/+IXmuvr4zKjpc8ivdRulRR0ktw/s3lfeT70gD2+1n6pB67aT8fTykoFJsAiagsjsdX/+Qfl5xgLgGjvwtb3yxpvppoX3kq9ffbcVXB+I0XKDftkMwzBMNVI1VRYXak55cw436U+H0ptGgCUhe/Nayljzm7QmWUUIg5DBoyiwW2+lwfUwujVvC0gfZNQKh+1x/w5dDIkugPRZsKbrxSMwiHzhi2nwcyE+k3/4jIqTzFcCqosbhQ4dTSEDhln9TFjaA7v3NhS0BKt07u6tMidvYyGqdTQNHzdeOarL/t276MiBuGrf22YI3BcGjxxNI8dPVFrqAl/aYrGIZxiGYYwjhSgmzkqdW7vu3t6ytryhYBMxseXt3U5pf/6k2b/Qv2NXihg7RUY8uyrSsuhElwEIn8Ljh+T2vBFkWdYI4+l5EK2udVu8Nj5Rrck7wphVuzw/j5KXf0OFJ4/KY6sSSfwA+mnUBbM0u5DA/QPXxgglQhwXnzmhHLk+yLM5ZNQYimpVP40WfCH/Wb2KCguMVc1qCvj6+lK/oUNVt+gz0lJlSVWGYRjGOO4QhdKqpXN71TMohHyiLW9zqgIRum8HJf/0JVUUabMmICo/6vxL7ZY031FAnDvTd7U8N0eInpPKkT5gvUXeTFu2xyGAK4p1WoTcqi3pRgLcEKGfvOxzyj+wW2mBrdMy3i1aUsyVN+iqmoQFRVCv/oaCltCn8+J2GthhaDhat4mloaPHKEd12bVli0xG31ytoli8BAWHSMFuSlFBIRVpHMOaIugTSPzPMI0N7ruuhTtuSEVhvu6Jxic6lrz0BpuIz4AITfrxc82WNIiCyEkzDKXVcTYQO24GEtPDGm0kKKQ4OZ5Ks9KVI30gIMevvfFteYD8pZUl+iLmPXz9xOd21h3gBhGKfpO310p5w1rd2Cu8BbW55g7yDAlXWjQCsSyujZGgJQBrraEsFA0EglyGjRtfnf7HhPy8XNq8bg2VFFv3Iff185X5R01BFH5pSePNu4mofB/f+guZiooKqlApbQv3HP9AdZelkqIi54p69GX/AOlmYEpJcRGVlxkozatQLr67ln7hLFzqujN2wVFjCvqCqy0i0TvVxhMAf348y00VQxZRWP38YjuopsAxiwERCrESPnoShQwY3ihuAtwGYBXVC2qW4/roAYFeRULwGAkyE2cqg4V0LyRMgFuF3tRNiJT30Zk8X7MIBW7V19E7siXFzr+1XqJ+uBPkH9xDiV9/RGl/LTdrucS1Qf15I/2uLDuj2nWgEU18SOM0eOQo5aguWzdsoBNHDsvB2xJeou+rbWFjiz8vN9vq7zc2ykXfgRgzxR3jo7+6xT8jPc2uteutAXEG9wIPz/pCNCszwybXgsL8PMrLyVaOGh5L1z0tNUUIF/1p5piGxdyYAnehHGRsMTimYAGVkaYt0NVZoGJbVkaGclQXLLAspZRr7LhTZYVuMQMrJdLvaLZqic6Su3e7LhEKAnsNoPAx8Au1Lem5s8B1MZJkH0JUr0UUVuzCU8cMiR0PMVjLfJk2XleIUL2pm+AfimAlrZTn51LS959pE6ESNxlAFzV9Nvm2ipUtOEdEsyd89QEdefoeOvPxm5SzcxPl7toiCymoITMKdOstMzXoBfcTiwSjKbUaAlj8RoyfSIFB9YO0crKzaNvGf6jUyqLD19dP5sk0BUL0xJEjZlf7rgwmukKxEFKz/MFSo2YpxdIlNDxCdQI9c+KEmGyM7WIYJSgkRCbwNyUjJZXOnDxuaDcG1uDD++Mo08zE2RBYuu4njx6RPr1M48LcmFJcVERHDhxQXQhaA890wulTdOpodZyBq4Bx4fiRQ8rROTw9veQ1cG/KFlEMQpWl+oQokqBrTaGE98/avFaIiU91iVBEc7ecPkeIpgClxfVxE6s3Pb6INchAMZ15RJEqqDQtRTnShwzGqVXe0iiVKHMoFjKaEQsXVC/SGnBWlplOiV99KH0utYLFQIspF8sUTBhwsAA6/uoiOvO/16XwrO2XXJaTSUWnj2NkUlrqIkufCuFsBFQIq2hEFhhYzlCRqf/QoUpLXTatXUPxJy37I/sFBFBHM2VDN6z6ixLjtWY5cB0gno8ePKhqOfT29SEfFdGDBTpSYoWE1vdpTzh9mjavW+tUqyiqT7Vuo56ia+0fv1N2ln43Egjq35f94FKLC0vXPSUxkTb+vVp+Z6bxYGlM2fj3KtEPxfitk9zsbFrxw1K5wHYVMB5Uj7H1UzEGBAVSTJt2ut3ZGhNya15uDevAO6KFpvQ22AZFeqaUn7+V1ZO0gu3UlhddbpfSoc7EXQgsQxY0IUQrdQzoEPdFp45TZZH+aGbk0wzs0Y/c/WwX+NjW1mNNQWCUT8toTQ9USXICxX/+LhUcPaC0WAcuI2GjJlHo4FHSyp/y05dCyH5gtmws+n3BkQNmM0agDj4KNhjZnq8Qn9+YApaAv78/jRg3gdTyZqLOOqyilgSUp7j+ELNqidUhYt958Xk6bKck+c4AfmjrV/5Fy7/+UmmpC3KNqlmQAcRfbPv6fu1VYsH5wxef0U/iPeF/6wwwmXfu1l05qsuOTf/S5++9TSlJiUqLZXD/t/2zgV554lGrC5OGwNx1B78s/ZZ+/vYbp113xnYsjSnJCQn0wav/1Tym4GcQePnGs0/RlvXrlNaGB/0R4wHGBYwPpsBtKqq1MYNIY8GtvLCgKuGL92SpRK2EDR9HLS+83OLWLrZt0/9aTpn/rNK1fYto/NZzrnHpfKHmgPBI+vELytm+UWnRBqyEbRbcodnKDJ/exK8/rE6erhOI/Dbzbydvg9WUaoOcmUnfLdGcPgpZD2Kvvo382loOPEPFpKSln0irr3bcKGTgcGp18RXSEpqy/Gu5/W7O2lmDd2QUxYrrAYGsBvyaE7/9WLf7CqypsbinoToDpTRycN9eevnRhygvt+6kGtu+Pd3/9HPUsrX697FGXk4OvfPS87T93/p9uHVsG1q46EnVsqA1YHtp8XPP0L6d5l0p2nfuQv0GD6FgFcuVVuAP2K1XH+rYpYvqwgaTzpmTJ+jg3r1WXQpMQf9JFcJsx6ZNUoCb4/Lrb6QL51xWHUhgAj5//aqV9P4rL0lBq4a/EIj9hw6ndp06kadhNxk3IYijZLlWc/6RABPwK4seM/t9PMTn9+jbT1zT3vK8TMFWfPypk7Rn21bKtlLaFKLhzocfkTlY1fIq49psWL2S3n3pRSo3WQQOHD6Sbn/gQbMC3xparjuuE65XB9EP1e6dGt7iO/UZNIhaRcfU+U74jK8/+kCKXFNmXb2ALp13tebPMMVRz7hezJ0H+gyslZb6nVbgC9q9T1/pHtSiZUultRptY0pn6j1gkAy4NO1zeJ7TU1Jo364dmhZP1u7bsUOH6OXHHqLM9LouNrgOE6dNp/BIbSkR4RN64ugR2r11i3RfUgPX5aaF99GYSZObtEVUtxCF1anFlJkUjpyeZi4Myj4mL/+K8vfvEUfafRixrd3qoisoZNAI8UGNzx8Cgjv11++E+F6No+pGDSA6O/aaO6T/pBaKzpyk+M/e1p/IXlzT8JETKWrabLv43eoVotYEN65f7s7NlLJiqQxQ0kNAl54UPfdaaZFO/f2H6ntgRYQCuAm0vPAyChs2VrXPQQzHL1lMpRn6/MsCu/ehmCtuJHeViE974KhJChP5P3+vpndffkF1IrckvgB+f9O6tfL34cflSGD9Wvj4E7LGem0w8ezetoXefOZph1m/kHf17seeoE7duikt9cnJyhLX4UUhaPUtTI1w6VXz5UstzRRAoM6PX35OP3z+qdLiOBpSiAJHXfeOXbuJe76ozrPVnIWoI5g840Kaf6uYC2v5XjtzTAFGhagj6CsW7Lfd/6AY6xrX7rBe9EtsMbC4+/mpDjCY+AuPHaTTH74qRChyPWoXY8jZCIEbPLBxRMirIs4b/rNu7vrOH5WlNLtHiGuMhOkV+fpLLyKIJ6j3ALuIUCPIPKtmHm64bkDEJ/0AX2J9382vXSdqdclV0pqeu28nZW/9R14nLcAtIn//LrM5bb2CQ2UuUl2IBRoS4rt51/cfdHWwuOzVv7+0jKnx75q/ZQSyOfD7A0eMoOmz5yotjgMiMy0lRU5UtYHf4rGDBx0mQlGbf/KFF1G7jpaLHiDAYO4111J0GwP5lnWCwKFCCxHwCOCZevElZjMjNCUcdd0zUlMpx4o1mLGNpPj4etZBZ44prkSrmBi6Qiz8m7oIBe4QlLoSd4sJvqq8/lY7JvTMDSsp/rN3qDRdXxANhFHkxBkUNmK8WStrYwDX0hMR4TpziVYKEao1YAzWx8ITh6V41QvEEQKV7IUUtB7avyssnqaiAUh/UNFv9LpxAGyBt569QPotI3dn1sZVurfRi+JPUnHCaeWoLrCY6t1e9wwIkjX8G2tfDgkLp5ETJsmtN1MQHLBr82a5VWsOWMSmz5pDM8TEAdHmKKoqkZRa/TwsnZ+tTLnoYjrvwos1Wbrad+ost9YwqTgSPFewBFsC25bzb72d+g9RD0hrSjjiuqOvVWpc4DL2xVljiquAfov+C/eR5oA7hAQijbVSVVEphEO8FJ41oOY3UuKk/PKd5mpJNWCrHymaIsaeJ//dqIEQDQrRb3HEAGfGn8kUpBsyJ5osgcVGcO+BhqL6zaE3gX95Xq5026gBojpz/V906r2XdAUl1QB/V/gTw6UBE3Hevp3i2uiPzK4oKKDcPVvVg4uEmETQEu6tViBCfVpXp45yFF5e3tJ/yBSk+nC3caBGvjpsCalFq6IaydGDB6zmZAwICqLLb7iJbrv/AbmF7gjcPTB81X/WsCBUS6tkK/CdvO6uu2nezbeo+lGqgcUIfC8ffO4lKe4dBfqCWtJ6U1pGx9CdDz8qtx/V0hzpoWV0tGpqHU8vT9WAt9rgvuH+mYLrquV7WMMR1x1+yR6m4x3GfJUFCcRSoHgGbFmMmnvGvcV87W6gcIpRzJ2HI7DUj+05poSEhqkuUrTcN09P0Q8cqFWGjx1PDzz7AvXqP8Cm/tOY8Fj0+KJFhSeO6KqPXZadRe7i4YPlM33lz5S64nvdPnQScZHDR0yQ6XZsKTXpSiBIKz9up64sAUiABx9HXw3ipeDwfsrdtVkIL72Ww7YUMf4CQ1H95qgUi47cPds0WyDxc8h/iocLv5fy4+fSz1Rv1gYAP9OYy647W3GrSrx3xvo/qVRXgNM5IJJlkn9T66dYcOFctYp/j4AgajF1pu6k/XrBRJ+alCQTzddm7HlTacDw4TYEv1SDCPqgkFDat2NbHdEJ8QI/LkRhW0uwjMG6XafONP78Cyg6tq3070KwjDXLnVbadOgot5tNg57kzoQYn+J27aCCPP0uLLWBsO89cBDNvGKeFKGYHIxc28DgYBo2egwNHDFKTLZeMpl2sZ0qu+CeTJs1m7r27GX1ngD8PL7HmEnnUZC4dnnZ2ZpT2eD9+4jrceWNN9MVQhRAOMTt3FHnnvYfMowmXjDdrBiVCwU/X+k+gSCSGiBCZ155FbUT9xU/Yw/sed37DBosn6/a3wvXAzsH+3bsoCIUhlGIbd9O+lLbIpi8fbzpzImTMuiuBnzeFNHnsVB0pBiqjbmxxt6gX86YM5e6WOjHto4p+N2ZV1Y/y7Cao4Rx7WDG2HbtxDlcRuGR5u+bj6+P+MxUGQBoL9BPxk2ZStfccZd8loPF2NuccKusqKjK+HsFpQlBqae6ks2IjhY2dAxFXTDLYQEdDQFyX575ZLHcbtYKLKhIVxU2VD1gpgZYoVN+/oayNiH1hI7JXFzryAkXUOTki+y6wsJC5AwCecykR3IUSOsVPeca8kflI4XyvByK//QtKjqtfUFVFzcKGzmBWk5HINc5C0fB4TgZNY/3t454j+FjqeWMuWSksIFeECiRFH+GSorFQCq6DaI2EdVrNDhCDQgUiIXKikrRd9ykJQFR2kb7EbbMUxITqvNy2qBHYZ2CRUMtUXsNtc9dN+J6BoeEyKAkR1kl4MOK/JaGzq8GO50n8msmx8ebL5soPgeiDgEytUUCLORI/ZSPQBZxPz2F2GsdE2vVIgog3JCCB2VG0bfCwiOkAHDU9a7ByHWHKGwVG6uaRgggkwAS5uM9YemFtdiWgKsa6twXcQ/Q32HVdpYIraHOWOMAbBlbtIwpEI/I+lHbsgvxikpGmelp0s0H9y2yZUt5HtZAGjPcl2IYnGwax7R/ZlPGTdyMKqMpaowi8z2OnFhtCW2EAR2WgMUP/o6Fx7WvHrVkIgDlOdl0Roit4nh9+ftg5Yudfxv5xtiexL42sPqiWlH+wb1Ki+NBuqXWc64l//adlZZq4BKiNw2ZKUgvFTPvJvHeXaRlO+vfNTIPriyBqwFkBYidd4tdUmMxDMMwTHNAqh5s23qHa8t9ZStIqB4x/nyKmjqzyYlQAGualmT/tYHfbXleNpZoSos6JSkJVGbABcK/YzfDFYIsgahwvLezfHsh9GKuvLmeCAXoS/h/SxZla5TnZstUTcf/+xgdefpeSkUaKY0iFFb9yAnT9EfYMwzDMEwzRgpRz9Dw6rQ+Dt4SgUiLnDRDRsg7Y+uyIYDQ9gwJ0ymIqoQIyrEYCY9gnKIzJ3RbrSGQgnoNcIgPLvpLUI9+Mg+qo/GNaSvzcuJvNSCGAzp3Jw8b3TxgWUXuUF3XWdzr0EEjxXXur/O+MwzDMEzzRipPCIrg/sOqLUoOAhHW8AeFNbSh8lg6A1xLrzD9fk4QQJZSF2EbHBWH1NIfWULWlVexINoLr8goChk8UgpwR4Egopgrb7LaP2V6qtj2ypHzQKBZxIQLmuziimEYhmEcxVm1hDyMkROn2zWqugYEl0BIhI+a6LRt3AbDzY28w4UQ1SlKkMTdkhWuNCONinUEQAEI/uA+g8gzwHxAh61AcIcOGUMB3XopLfaj+r1HU+z8W8k70vqWt4dfAIUOHePU4DcI31YXXynTdjEMwzAMo49zZjshoAJ79KPwMcjnaT/rFuqKt7n2LlnysLlsW3qGhukW9LCImk35VFVFRaeP6a6mBPEWgJr9Dr7uHv4BFDX1ErvmzoQrQQvxnq1mzqvO46kF2Yf7SvEtDqrbHAhcEnB+CKBiGIZhGEY/dfaPYUGLGHd+9TajrWJUiILgfkModsEd5NPSOTVxXQVP/yCZT1IPlSUlVJ6vXpIQEdy6qylBlHXvq7sqkFFkINFl19vFvQPR660vu646i4BONw4I2IhxUzXlZLUFJNGPvvwG8mvjfFcAhmEYhmkq1HNkxMSP6N+o6bOlpcsIEGGwFEULYaI3grwp4O7rS15h+gQgxKasOqQSOY98ncVndKZsCgmTQUrOdIWARRTpi+AzacgiqVg02918r7Rq6vWzrQEVl6Kmz5GC1hFgOz7mqluktZ9hGIZhGOOozvQQo+GjJlHbG/4j0/NoFRUQDhA/EBJhw8c1fX9QMyA7gEyHpWNLHNbO0vTUehUiEJxUcOSAxoTq58B982ntuOAzcyCHZuyC2ynq/Et0LWQgGuFrGSsEnhZ/UGsggr7VzCt1W6YtAytzH3mOzc3KzzAMwzCOQCa0V/6tCoRQ4fFDsiZ4wdGDdWrM14Bt/ICuvWREvH+7TroEWJNEXNLs7RspedkXuspXBvcfSq1nL6iTagl5LBO+fF9XonYIQGwbB8I/tAEpz8+j7E1r5LVAxSk1EMgWNmwshY2YYPcgI1l/HqVEf/7GrNuDVmSe0EnTKXzkRLnQYBiGYRjGdqwK0dpUlZVS0ZmTcqsYJSwxOcNHzk+IT80BJc2EwpNHKOGzd3UJIFxHVECq7c4Aa2jCV+9TRUG+0mKdwJ79pL+mM6PHrVGWmUbFiWdkv0H1Ke+oaFknHtv5RrfgtVKceJqSvv9Md0WqGpBAHyVY7V2ZimEYhmGaO7qEKKOdspwsiv9kMRUnnFZarIMUWrHzbz8b8APhn7z8a8resgFHss0asKa2mnU1hfQfxpbpWiA9VuaGlbJsJzIUWAPi2L9zDwofPVn6vDpaLDMMwzBMc4SFqINA8FHSd0sod882pcU6sGDGYEu9R195XJxwiuI/fZvKsjPlsRZgvYuZd7PDAnUaO7DGZv27lvL2bZc+ubhPNeCaIR8o/EuRvxRBTwzDMAzDOA4Wog4C/omZ6/6ktD+XWayYVBsEd7WYMlOmLSLx+/jdDPEe1mrQ1wBf3ahpsyls5AS24GkEQrSqvNxwhgiGYRiGYYzDasVBQAgi0bmewBYIVlhBERBWdPo45ezYpFmEAuS2DOrZj0WoDty9fViEMgzDMEwDwYrFgcDXU+8WOYRocfwpylj3h66UTRCfQb0HkKeTEtgzDMMwDMPYCgtRBwIR6hvTVjnSRmlGOiV89QHlH9yrtGgDuTeD+w5hayjDMAzDMI0GVi0OBBHs/u06S99N7VRReW62ri15WZGoZ3/yimihNDAMwzAMw7g+LEQdiRCIfu06kmeQY8uceoVFUnD/Ic22khXDMAzDMI0TFqIOxjsi6mxeUIcgxG5wn4Hk06K10sAwDMMwDNM4YCHqYNy8fci/Q1eHWSt9WrSi0MGjyc1Tz/Y/wzAMwzBMw8NC1MEgeCigSw+ZKN3eQNyGDBxBXpFRSgvDMAzDMEzjgYWoE0BEu1/bjsqR/fBpGUPB/YdypDzDMAzDMI0SVjBOwN3Hl4L7DZUlPO2Fm5eXrKDkxXlDGYZhGIZppLAQdRL+HbuQX5sOypHtBHTsRkG9+stgJYZhGIZhmMYIC1En4eEXQKFDRkvrqK14BARS2MiJ5OEfqLQwDMMwDMM0PliIOgskne/WmwK69lQaDCLeJ6T/MAro3F1pYBiGYRiGaZywEHUi8BGNGDOFPEPClBb9+LaOldZQN08vpYVhGIZhGKZxwkLUyfi26UDhoycbyvvp4edPkROnkzeX8mQYhmEYpgnAQtTJINVS2PBxFDpkjLj62i+//L0R4ymwRz8OUGIYhmEYpknAQrQBcPf2oRZTLqaQAcO1iUohQkOHjqGIcedzBSWGYRiGYZoMblUC5d+Mk6kqL6eszesofdXPVFGQr7TWBX6lkePPp7DRk8ndy1tpZRiGYRiGafywEHUBKgoLKHf3Vso/uIfKsjJES5VM9xTQrbeMkPcKj6z+QYZhGIZhmCYEC1GGYRiGYRimQWAfUYZhGIZhGKZBYCHKMAzDMAzDNABE/x/2nH13ciBkdAAAAABJRU5ErkJggg==\"","module.exports = 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\"","module.exports = \"data:image/svg+xml;base64,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\"","module.exports = \"data:image/svg+xml;base64,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\"","module.exports = require(\"sharedb/lib/client\");","module.exports = require(\"jquery-ui-dist/jquery-ui\");","module.exports = require(\"cytoscape-edgehandles\");","module.exports = require(\"cytoscape-edge-editing\");","module.exports = require(\"cytoscape-fcose\");","module.exports = require(\"cytoscape-node-editing\");","module.exports = require(\"cytoscape-undo-redo\");","module.exports = require(\"cytoscape-panzoom\");","module.exports = (function()\n{\n var styleSheet = [\n {\n selector: 'node',\n style:\n {\n 'text-valign': 'center',\n 'text-halign': 'center',\n 'color': '#1e2829',\n 'width': function (ele)\n {\n return ele.data('w') || 0;\n },\n 'height': function (ele)\n {\n return ele.data('h') || 0;\n },\n 'background-color': 'white',\n 'shape': function(ele)\n {\n return parentNodeShapeFunc( ele );\n },\n 'border-width': function(ele)\n {\n return borderWidthFunction( ele );\n },\n 'border-color': function(ele)\n {\n return nodeBorderColorFunction(ele);\n },\n 'font-size': 14\n }\n },\n {\n selector: 'node[name]',\n style: {\n 'label': 'data(name)'\n }\n },\n {\n selector: 'node:parent',\n style:\n {\n 'shape': function(ele)\n {\n return parentNodeShapeFunc( ele );\n },\n 'text-valign': function(ele)\n {\n return 'bottom';\n },\n 'text-margin-y' : 2,\n 'padding-left': function(ele){ return compoundPaddingFunction(ele); },\n 'padding-right': function(ele){ return compoundPaddingFunction(ele); },\n 'padding-bottom': function(ele){ return compoundPaddingFunction(ele); },\n 'padding-top': function(ele){ return compoundPaddingFunction(ele); },\n 'background-opacity': 0.5,\n 'border-width': function(ele)\n {\n return parentBorderWidthFunction( ele );\n },\n 'border-color': function(ele)\n {\n return nodeBorderColorFunction(ele);\n },\n 'background-color': function(ele){\n return nodeBackgroundColorFunction(ele);\n }\n }\n },\n {\n selector: 'edge',\n style:\n {\n 'arrow-scale': 1.7,\n 'curve-style': 'bezier',\n 'text-background-color': '#EEEEEE',\n 'text-background-opacity': 0,\n 'target-arrow-shape': function( ele )\n {\n return edgeTargetArrowTypeHandler(ele);\n },\n 'width': 1,\n 'line-color': function( ele )\n {\n return edgeColorHandler(ele);\n },\n 'target-arrow-color': function( ele )\n {\n return edgeColorHandler(ele);\n },\n 'line-style': function(ele)\n {\n return edgeLineTypeHandler(ele);\n },\n 'opacity': 1,\n\n }\n },\n {\n selector: 'edge[name]',\n style: {\n 'label': function(edge) {\n const label = edge.data('name');\n if (label === \"\") {\n return label;\n }\n //https://github.com/cytoscape/cytoscape.js/issues/2329\n return (label + \"\\n \\u2060\"); \n },\n 'text-wrap': 'wrap',\n 'edge-text-rotation': 'autorotate',\n 'text-background-opacity': '0'\n }\n },\n\n // some style for the Edge Handles !!!\n\n {\n selector: '.eh-handle',\n style: {\n 'background-color': '#1abc9c',\n 'width': 12,\n 'height': 12,\n 'shape': 'ellipse',\n 'overlay-opacity': 0,\n 'border-width': 12, // makes the handle easier to hit\n 'border-opacity': 0\n }\n },\n\n {\n selector: '.eh-hover',\n css: {\n 'background-color': '#1abc9c'\n }\n },\n\n {\n selector: '.eh-source',\n css: {\n 'border-width': 2,\n 'border-color': '#1abc9c'\n }\n },\n\n {\n selector: '.eh-target',\n css: {\n 'border-width': 2,\n 'background-color': '#1abc9c',\n 'border-color': '#1abc9c'\n }\n },\n\n {\n selector: '.eh-preview, .eh-ghost-edge',\n css: {\n 'line-color': '#1abc9c',\n 'target-arrow-color': '#1abc9c',\n 'source-arrow-color': '#1abc9c'\n }\n },\n\n {\n selector: '.highlightedEdge',\n style:\n {\n 'width': 3.5,\n 'border-width':4,\n 'line-color' : '#1abc9c' ,\n 'target-arrow-color': '#1abc9c',\n 'arrow-scale': 2\n }\n },\n {\n selector: '.highlightedNode',\n style:\n {\n 'border-width': function(ele)\n {\n return highlightedBorderWidthFunction( ele );\n },\n 'border-color': '#1abc9c',\n 'background-color': '#fff',\n }\n },\n {\n selector: '.invalidGene',\n style:\n {\n 'border-width': 2,\n 'border-color': '#e94332',\n 'color': '#e94332'\n }\n },\n {\n // The css properties when a node is highlighted and an invalid gene\n selector: '.invalidGeneHighlight',\n style:\n {\n 'border-width': 3,\n 'font-weight' : 'bold',\n 'border-color': '#e94332',\n 'color': '#e94332',\n }\n },\n {\n selector: 'node:selected',\n style:\n {\n 'border-width': function(ele)\n {\n return selectedBorderWidthFunction( ele );\n },\n 'border-color' : '#ffc90e', /*#f1c40f'*/\n }\n },\n {\n selector: '.highlightedNode:selected, .invalidGeneHighlight:selected',\n style:\n {\n 'border-width': function(ele)\n {\n return selectedHighlightedBorderWidthFunction( ele );\n },\n }\n },\n {\n selector: 'edge:selected',\n style:\n {\n 'width' : 3,\n 'line-color' : '#ffc90e',\n 'target-arrow-color': '#ffc90e'\n }\n },\n ];\n\n\n\n var compoundPaddingFunction = function( ele )\n {\n switch (ele._private.data['type'])\n {\n case \"FAMILY\": return 5;\n case \"COMPLEX\": return '5'; \n case \"COMPARTMENT\": return 10;\n case \"PROCESS\": return 10;\n default: return 5;\n }\n };\n\n var contentFunction = function( ele )\n {\n if (ele._private.data.name) {\n return ele._private.data.name;\n }\n return 'newNode';\n };\n\n var vTextPositionFunction = function( ele )\n {\n switch (ele._private.data['type'])\n {\n case \"GENE\": return 'center';\n case \"FAMILY\": return 'top';\n case \"COMPLEX\": return 'top';\n case \"COMPARTMENT\": return 'top';\n default: return 'center';\n }\n };\n\n var borderWidthFunction = function( ele )\n {\n switch (ele._private.data['type'])\n {\n case \"GENE\": return 1;\n case \"PROCESS\": return 0;\n case \"FAMILY\": return 2;\n case \"COMPARTMENT\": return 4;\n default: return 1;\n }\n };\n\n var parentBorderWidthFunction = function( ele )\n {\n switch (ele._private.data['type'])\n {\n case \"GENE\": return 1;\n case \"PROCESS\": return 0;\n case \"FAMILY\": return 2;\n case \"COMPLEX\": return 1;\n case \"COMPARTMENT\": return 4;\n default: return 1;\n }\n };\n\n var highlightedBorderWidthFunction = function( ele )\n {\n switch (ele._private.data['type'])\n {\n case \"GENE\": return 3;\n case \"PROCESS\": return 1;\n case \"FAMILY\": return 4;\n case \"COMPARTMENT\": return 6;\n default: return 3;\n }\n };\n\n var selectedBorderWidthFunction = function( ele )\n {\n switch (ele._private.data['type'])\n {\n case \"GENE\": return 2;\n case \"PROCESS\": return 1;\n case \"FAMILY\": return 3;\n case \"COMPARTMENT\": return 5;\n default: return 2;\n }\n };\n var selectedHighlightedBorderWidthFunction = function( ele )\n {\n switch (ele._private.data['type'])\n {\n case \"GENE\": return 3;\n case \"PROCESS\": return 1;\n case \"FAMILY\": return 4;\n case \"COMPARTMENT\": return 6;\n default: return 3;\n }\n };\n\n\n var parentNodeShapeFunc = function( ele )\n {\n switch (ele._private.data['type'])\n {\n case \"GENE\": return \"roundrectangle\";\n case \"PROCESS\": return \"roundrectangle\";\n case \"FAMILY\": return \"rectangle\";\n case \"COMPARTMENT\": return \"roundrectangle\";\n case \"COMPLEX\": return \"rectangle\";\n default: return \"roundrectangle\";\n }\n };\n\n var nodeBackgroundColorFunction = function( ele )\n {\n return \"#fff\";\n };\n\n var nodeBorderColorFunction = function( ele )\n {\n switch (ele._private.data['type'])\n {\n case \"GENE\": return \"#00000a\";\n case \"FAMILY\": return \"#a3a3a3\";\n case \"COMPLEX\": return \"#000000\";\n case \"COMPARTMENT\": return \"#000000\";\n default: return \"#000000\";\n }\n };\n\n var edgeColorHandler = function( ele )\n {\n return \"#1b1b1b\";\n };\n\n var edgeTargetArrowTypeHandler = function( ele )\n {\n switch (ele._private.data['type']){\n case \"ACTIVATES\": return \"triangle\";\n case \"INHIBITS\": return \"tee\";\n case \"INDUCES\": return \"triangle\";\n case \"REPRESSES\": return \"tee\";\n case \"BINDS\": return \"none\";\n default: return \"none\";\n }\n };\n\n var edgeLineTypeHandler = function( ele )\n {\n switch (ele._private.data['type']){\n case \"ACTIVATES\": return \"solid\";\n case \"INHIBITS\": return \"solid\";\n case \"INDUCES\": return \"dashed\";\n case \"REPRESSES\": return \"dashed\";\n case \"BINDS\": return \"solid\";\n default: return \"solid\";\n }\n };\n\n return styleSheet;\n})();\n","var panzoomOptions =\n{\n zoomFactor: 0.05, // zoom factor per zoom tick\n zoomDelay: 45, // how many ms between zoom ticks\n minZoom: 0.1, // min zoom level\n maxZoom: 10, // max zoom level\n fitPadding: 50, // padding when fitting\n panSpeed: 10, // how many ms in between pan ticks\n panDistance: 10, // max pan distance per tick\n panDragAreaSize: 75, // the length of the pan drag box in which the vector for panning is calculated (bigger = finer control of pan speed and direction)\n panMinPercentSpeed: 0.25, // the slowest speed we can pan by (as a percent of panSpeed)\n panInactiveArea: 8, // radius of inactive area in pan drag box\n panIndicatorMinOpacity: 0.5, // min opacity of pan indicator (the draggable nib); scales from this to 1.0\n zoomOnly: false, // a minimal version of the ui only with zooming (useful on systems with bad mousewheel resolution)\n fitSelector: undefined, // selector of elements to fit\n animateOnFit: function(){ // whether to animate on fit\n return false;\n },\n fitAnimationDuration: 1000, // duration of animation on fit\n\n // icon class names\n sliderHandleIcon: 'fa fa-minus',\n zoomInIcon: 'fa fa-plus',\n zoomOutIcon: 'fa fa-minus',\n resetIcon: 'fa fa-expand'\n};\n\nmodule.exports = panzoomOptions;\n","module.exports = require(\"cytoscape-navigator\");","module.exports = require(\"cytoscape-context-menus\");","module.exports = require(\"konva\");","module.exports = require(\"cytoscape-view-utilities\");","module.exports = require(\"cytoscape-grid-guide\");","module.exports = require(\"cytoscape-popper\");","module.exports = require(\"cytoscape-layout-utilities\");","module.exports = require(\"@datastructures-js/max-heap\");","import { IPathwayInfo } from \"../managers/FileOperationsManager\";\n\nexport default class SaveLoadUtility{\n //Exports given json graph(based on cy.export()) into a string\n static exportGraph(pathwayDetails: IPathwayInfo, cy, edgeEditing)\n {\n var returnString = pathwayDetails.pathwayTitle + '\\n\\n';\n returnString += pathwayDetails.pathwayDetails +'\\n\\n';\n\n //Get nodes and edges\n var nodes = cy.nodes();\n var edges = cy.edges();\n\n //Prepare Meta Line\n returnString += '--NODE_NAME\\tNODE_ID\\tNODE_TYPE\\tPARENT_ID\\tPOSX\\tPOSY\\tWIDTH\\tHEIGHT--'+'\\n';\n\n if (nodes)\n {\n for (let i = 0; i < nodes.length; i++)\n {\n returnString += this.exportNode(nodes[i]);\n }\n }\n\n //Put a blank line between nodes and edges\n returnString += '\\n';\n returnString += '--EDGE_ID\\tSOURCE\\tTARGET\\tEDGE_TYPE\\tINTERACTION_PUBMED_ID\\tEDGE_NAME\\tEDGE_BENDS\\tEDGE_CURVE_STYLE\\n';\n\n if (edges) {\n //Write edges\n for (let i = 0; i < edges.length; i++)\n {\n var edgeID = edges[i].data('id');\n var edgeType = edges[i].data('type');\n var source = edges[i].data('source');\n var target = edges[i].data('target');\n var pubmedIDs = edges[i].data('pubmedIDs');\n var pubmedString = \"\";\n var edgeName = (edges[i].data('name')) ? edges[i].data('name') : \"\";\n var edgeCurveStyle = edges[i].css('curve-style');\n\n var numberOfAnchorPoints = 0;\n var anchors = edgeEditing.getAnchorsAsArray(edges[i])\n if (anchors !== undefined)\n numberOfAnchorPoints = anchors.length/2;\n var anchorPointPositions = \"\";\n for (var j = 0; j < numberOfAnchorPoints; j++)\n {\n anchorPointPositions += \"(\" + anchors[2*j] + \";\" +\n anchors[2*j+1] + \")\";\n }\n\n if (pubmedIDs != undefined) {\n for (var j = 0; j < pubmedIDs.length; j++)\n {\n pubmedString += pubmedIDs[j];\n if (j != pubmedIDs.length - 1)\n pubmedString += \";\"\n }\n }\n\n returnString += edgeID + '\\t' +\n source + '\\t' +\n target + '\\t' +\n edgeType + '\\t' +\n pubmedString + '\\t' +\n edgeName + '\\t' +\n anchorPointPositions + '\\t' + \n edgeCurveStyle + '\\n';\n }\n }\n\n //Finally return a string that includes whole graph lovely and peacefully :)\n return returnString;\n }\n static exportAsSIFNX(cy: any)\n {\n let returnString = \"\";\n\n //Get nodes and edges\n const nodes = cy.nodes();\n const edges = cy.edges();\n const nodeMap = {};\n //Put a blank line between nodes and edges\n returnString += '\\n';\n returnString += 'PARTICIPANT\\tPARTICIPANT_TYPE\\tPARENT_ID\\tPOSX\\tPOSY\\tWIDTH\\tHEIGHT'+'\\n';\n\n if (nodes)\n {\n for (var i = 0; i < nodes.length; i++)\n {\n returnString += this.exportNode(nodes[i]);\n\n nodeMap[nodes[i].id()] = nodes[i];\n }\n }\n\n //Put a blank line between nodes and edges\n returnString += '\\n';\n returnString += 'PARTICIPANT_A\\tPARTICIPANT_B\\tTYPE\\tPUBMED_IDS\\n';\n\n \n if (edges) {\n //Write edges\n for (var i = 0; i < edges.length; i++)\n {\n var edgeType = edges[i].data(\"type\");\n var source = edges[i].data(\"source\");\n var target = edges[i].data(\"target\");\n var edgeName = edges[i].data(\"name\");\n var pubmedIDs = edges[i].data(\"pubmedIDs\");\n var pubmedString = \"\";\n\n if (pubmedIDs != undefined) {\n for (var j = 0; j < pubmedIDs.length; j++)\n {\n pubmedString += pubmedIDs[j];\n if (j != pubmedIDs.length - 1)\n pubmedString += \";\"\n }\n }\n\n returnString += nodeMap[source].data(\"name\") + '\\t' +\n nodeMap[target].data(\"name\") + '\\t' +\n edgeType + '\\t' +\n pubmedString + '\\t' +\n edgeName + '\\n';\n }\n }\n\n //Finally return a string that includes whole graph lovely and peacefully :)\n return returnString;\n }\n static exportNode(node)\n {\n //Node specific data fields\n var nodeName = node.data(\"name\");\n var parentID = node.data(\"parent\");\n var nodeID = node.data(\"id\");\n var pos = node.position();\n var nodeType = node.data(\"type\");\n var nodeW = node.data(\"w\");\n var nodeH = node.data(\"h\");\n\n //Check if node has a parent, if not set parent id -1\n if (node.data(\"parent\"))\n {\n parentID = node.data(\"parent\");\n }\n else\n {\n parentID = -1;\n }\n\n // Write a line for a node\n return nodeName + '\\t' +\n nodeID + '\\t' +\n nodeType + '\\t' +\n parentID + '\\t' +\n parseInt(pos.x) + '\\t' +\n parseInt(pos.y) + '\\t' +\n nodeW + '\\t' +\n nodeH + '\\n';\n }\n static parseGraph(graph, isArray) {\n\n const allEles = [];\n const nodes = [];\n const edges = [];\n\n // By lines\n // Match all new line character representations\n var seperator = /\\r?\\n|\\r/;\n var lines = (isArray) ? graph : graph.split(seperator);\n var edgesStartIndex = -1;\n var title = lines[0];\n var description = lines[2];\n\n // In old version description used to expand in multiple lines\n // graphDataIndex holds the line index where the first --NODE_NAME occurs and is used later to load nodes\n let graphDataIndex = 3;\n let isFound = false;\n while (graphDataIndex < lines.length) {\n if (lines[graphDataIndex].includes(\"--NODE_NAME\")) {\n isFound = true;\n break;\n }\n description += \"\\n\" + lines[graphDataIndex];\n graphDataIndex++;\n }\n graphDataIndex++;\n // TODO AMENDMENT\n if(!isFound){\n graphDataIndex = 2;\n }\n //TODO Legacy pathways workaround\n if (lines[0].includes(\"--NODE_NAME\")) {\n graphDataIndex = 1;\n title = \"New Pathway\";\n description = \"\";\n }\n\n // start from first line skip node meta data\n for (var i = graphDataIndex; i < lines.length; i++) {\n // If we encounter a blank line, that means we need to parse edges from now on !\n // so skip blank line and edge meta line\n if (lines[i].length == 0 || lines[i] === \"\") {\n edgesStartIndex = i + 2;\n break;\n }\n\n //Fetch a line for nodes\n var lineData = lines[i].split('\\t');\n var nodeName = lineData[0];\n var nodeID = lineData[1];\n var nodeType = lineData[2];\n var parentID = lineData[3];\n var posX = (lineData.length > 4) ? lineData[4] : \"0\";\n var posY = (lineData.length > 5) ? lineData[5] : \"0\";\n var nodeW = (lineData.length > 7) ? lineData[6] : (nodeType === 'PROCESS') ? (nodeName.length * 6 + 24) : \"150\";\n var nodeH = (lineData.length > 7) ? lineData[7] : (nodeType === 'PROCESS') ? \"24\" : \"52\";\n\n if(nodeName === \" \" || nodeName === \"\"){\n //nodeName = \"No Name \" + (i + 1);\n }\n\n\n var newNode = {\n group: 'nodes',\n data:\n {\n id: nodeID,\n name: nodeName,\n type: nodeType,\n w: nodeW,\n h: nodeH,\n parent: -1\n },\n position:\n {\n x: parseInt(posX),\n y: parseInt(posY)\n }\n };\n\n if (parentID != '-1') {\n newNode.data.parent = parentID;\n }\n nodes.push(newNode);\n }\n //Read edges\n for (let i = edgesStartIndex; i < lines.length; i++) {\n //If we reach EOF we break loop\n if (lines[i].length == 0) {\n break;\n }\n\n var lineData = lines[i].split('\\t');\n var edgeID = lineData[0];\n var edgeSource = lineData[1];\n var edgeTarget = lineData[2];\n var edgeType = lineData[3];\n var pubmedIDs = (lineData.length > 4) ? lineData[4].split(';') : [];\n var label = (lineData.length > 5) ? lineData[5] : '';\n var anchorPoints = (lineData.length > 6) ? lineData[6] : '';\n var edgeCurveStyle = (lineData.length > 7) ? lineData[7] : '';\n\n var anchorPointPositions = [];\n if (anchorPoints) {\n var anchorPair = anchorPoints.split(')'); //The last element of anchorPair array is \"\"\n for (var j = 0; j < anchorPair.length - 1; j++) {\n var separatorIndex = anchorPair[j].indexOf(\";\");\n var x = anchorPair[j].substring(1, separatorIndex);\n var y = anchorPair[j].substring(separatorIndex + 1, anchorPair[j].length);\n anchorPointPositions.push({x: parseFloat(x), y: parseFloat(y)});\n }\n }\n\n var edgeData = {\n id: edgeID,//((isFound) ? edgeID : i - edgesStartIndex),\n type: edgeType,//((isFound) ? edgeType : edgeTarget),\n source: edgeSource,//((isFound) ? edgeSource : edgeID),\n target: edgeTarget,//((isFound) ? edgeTarget : edgeSource),\n pubmedIDs: pubmedIDs,\n name: label,\n }\n\n if (edgeCurveStyle === \"unbundled-bezier\") {\n edgeData['controlPointPositions'] = anchorPointPositions;\n }\n else {\n edgeData['bendPointPositions'] = anchorPointPositions;\n }\n\n const newEdge = {\n group: 'edges', \n data: edgeData\n };\n edges.push(newEdge);\n }\n return {title: title, description: description, nodes: nodes, edges: edges};\n }\n}\n","import { saveAs } from 'file-saver';\nimport { action, computed, makeObservable, observable } from 'mobx';\nimport SaveLoadUtility from '../utils/SaveLoadUtility';\nimport EditorActionsManager from './EditorActionsManager.js';\n\nexport interface IPathwayInfo{\n pathwayTitle: string;\n pathwayDetails: string;\n}\n\nexport default class FileOperationsManager{\n\n @observable\n pathwayInfo: IPathwayInfo;\n\n constructor(){\n makeObservable(this);\n this.pathwayInfo = {pathwayTitle: \"New Pathway\", pathwayDetails: \"\"};\n }\n\n\n @computed get\n getPathwayInfo(){\n return this.pathwayInfo;\n }\n\n @action\n setPathwayInfo(other: IPathwayInfo){\n this.pathwayInfo = other;\n }\n \n // see http://stackoverflow.com/questions/16245767/creating-a-blob-from-a-base64-string-in-javascript\n b64toBlob(b64Data, contentType, sliceSize = 512)\n {\n contentType = contentType || '';\n\n var byteCharacters = atob(b64Data);\n var byteArrays = [];\n\n for (var offset = 0; offset < byteCharacters.length; offset += sliceSize) {\n var slice = byteCharacters.slice(offset, offset + sliceSize);\n\n var byteNumbers = new Array(slice.length);\n for (var i = 0; i < slice.length; i++) {\n byteNumbers[i] = slice.charCodeAt(i);\n }\n\n var byteArray = new Uint8Array(byteNumbers);\n\n byteArrays.push(byteArray);\n }\n\n var blob = new Blob(byteArrays, {type: contentType});\n return blob;\n };\n\n saveAsJPEG(cy: any)\n {\n const graphData = cy.jpeg();\n // this is to remove the beginning of the pngContent: data:img/png;base64,\n const b64data = graphData.substr(graphData.indexOf(\",\") + 1);\n const imageData = this.b64toBlob(b64data, \"image/jpeg\");\n const blob = new Blob([imageData]);\n const fileName = this.pathwayInfo.pathwayTitle + \".jpg\"\n saveAs(blob, fileName);\n };\n\n saveAsSVG(editor: EditorActionsManager){\n const returnString: any = editor.exportSVG();\n const fileName = this.pathwayInfo.pathwayTitle + \".svg\"\n const blob = new Blob([returnString], {type: \"text/plain;charset=utf-8\"});\n saveAs(blob, fileName);\n }\n\n saveAsPNG(cy: any)\n {\n const graphData = cy.png();\n // this is to remove the beginning of the pngContent: data:img/png;base64,\n const b64data = graphData.substr(graphData.indexOf(\",\") + 1);\n const imageData = this.b64toBlob(b64data, \"image/png\");\n const blob = new Blob([imageData]);\n const fileName = this.pathwayInfo.pathwayTitle + \".png\"\n saveAs(blob, fileName);\n };\n \n\n saveGraph(isSIFNX: boolean, editor: EditorActionsManager)\n {\n const pathwayData = this.pathwayInfo;\n const returnString = (isSIFNX) ? SaveLoadUtility.exportAsSIFNX(editor.cy):\n SaveLoadUtility.exportGraph(pathwayData, editor.cy, editor.edgeEditing);\n const blob = new Blob([returnString], {type: \"text/plain;charset=utf-8\"});\n const fileName = pathwayData.pathwayTitle + \".txt\";\n saveAs(blob, fileName);\n };\n}","import _ from \"lodash\";\n\nexport default class GridOptionsManager\n{\n\n static defaultGridGuideOptions = \n {\n // On/Off Modules\n /* From the following four snap options, at most one should be true at a given time */\n snapToGridOnRelease: false, // Snap to grid on release\n snapToGridDuringDrag: false, // Snap to grid during drag\n snapToAlignmentLocationOnRelease: false, // Snap to alignment location on release\n snapToAlignmentLocationDuringDrag: false, // Snap to alignment location during drag\n distributionGuidelines: false, // Distribution guidelines\n geometricGuideline: false, // Geometric guidelines\n initPosAlignment: false, // Guideline to initial mouse position\n centerToEdgeAlignment: false, // Center to edge alignment\n resize: false, // Adjust node sizes to cell sizes\n parentPadding: false, // Adjust parent sizes to cell sizes by padding\n drawGrid: false, // Draw grid background\n\n // General\n gridSpacing: 20, // Distance between the lines of the grid.\n\n // Draw Grid\n zoomDash: true, // Determines whether the size of the dashes should change when the drawing is zoomed in and out if grid is drawn.\n panGrid: true, // Determines whether the grid should move then the user moves the graph if grid is drawn.\n gridStackOrder: -1, // Namely z-index\n gridColor: '#dedede', // Color of grid lines\n lineWidth: 1.0, // Width of grid lines\n\n // Guidelines\n guidelinesStackOrder: 4, // z-index of guidelines\n guidelinesTolerance: 5.00, // Tolerance distance for rendered positions of nodes' interaction.\n guidelinesStyle: { // Set ctx properties of line. Properties are here:\n strokeStyle: \"#4286f4\", // color of geometric guidelines\n geometricGuidelineRange: 750, // range of geometric guidelines\n range: 500, // max range of distribution guidelines\n minDistRange: 10, // min range for distribution guidelines\n distGuidelineOffset: 10, // shift amount of distribution guidelines\n horizontalDistColor: \"#4286f4\", // color of horizontal distribution alignment\n verticalDistColor: \"#4286f4\", // color of vertical distribution alignment\n initPosAlignmentColor: \"#34495E\", // color of alignment to initial mouse location\n lineDash: [6, 8], // line style of geometric guidelines\n horizontalDistLine: [0, 0], // line style of horizontal distribution guidelines\n verticalDistLine: [0, 0], // line style of vertical distribution guidelines\n initPosAlignmentLine: [0, 0], // line style of alignment to initial mouse position\n },\n\n // Parent Padding\n parentSpacing: -1 // -1 to set paddings of parents to gridSpacing\n };\n currentProperties: any;\n cy: any;\n constructor(cy: any)\n {\n this.cy = cy;\n\n this.currentProperties = {};\n this.changeParameters(GridOptionsManager.defaultGridGuideOptions);\n\n }\n\n changeParameters(params)\n {\n this.currentProperties = _.clone(params);\n this.refreshGridOptionsExtension();\n }\n\n getCurrentOptions()\n {\n return this.currentProperties;\n }\n\n getDefaultOptions()\n {\n return GridOptionsManager.defaultGridGuideOptions;\n }\n\n setSnapToGuidelines(state)\n {\n this.currentProperties.geometricGuideline = state;\n this.currentProperties.snapToAlignmentLocationDuringDrag = state;\n this.currentProperties.distributionGuidelines = state;\n this.refreshGridOptionsExtension();\n //this.appManager.gridOptionsView.changeParameters();\n }\n\n setShowGrid(state)\n {\n this.currentProperties.drawGrid = state;\n this.currentProperties.snapToGridDuringDrag = state;\n this.refreshGridOptionsExtension();\n }\n\n refreshGridOptionsExtension()\n {\n this.cy.gridGuide(this.currentProperties);\n }\n\n //TODO expose individual functions related for changing parameters from toolbar here\n\n}\n","import EditorActionsManager from \"./EditorActionsManager\";\n\nexport default class ViewOperationsManager{\n movedNodes: any[];\n editor: EditorActionsManager;\n cy: any;\n\n constructor(editor: EditorActionsManager,cy: any)\n {\n this.cy = cy;\n this.editor = editor;\n this.movedNodes = [];\n }\n\n //TODO use align function from cytoscape.js-grid-guide extension\n handleNodeAlignment(param)\n {\n var tmpNodes = this.editor.selectedNodeStack;\n var nodes = this.cy.collection();\n var nodeMap = {};\n this.movedNodes = [];\n\n for (const key in tmpNodes)\n {\n nodes = nodes.add(tmpNodes[key]);\n }\n\n nodes.forEach(function(node)\n {\n if (node.isParent())\n {\n nodeMap[node.id()] = node;\n }\n });\n\n\n if (nodes.length > 0)\n {\n var firstSelected = nodes[0];\n var firstBbox = firstSelected.boundingBox();\n //OuterHeight variable added due to miscalculation of boundingBox function in pathwaymapper\n var firstOuterHeight = firstSelected.outerHeight();\n var self = this;\n nodes.forEach(function(node,index)\n {\n if (index == 0)\n {\n return ;\n }\n\n //If parent of selected node is in selection do nothing !\n if (nodeMap[node.parent().id()] == null)\n {\n var newPosition = self.calculateNewPosition(param, node, firstBbox, firstOuterHeight);\n //Recursively traverse leaf nodes\n self.changePosition(node,0,0,newPosition);\n }\n });\n this.editor.handleChangePositionByAlignment(self.movedNodes);\n }\n }\n\n /*\n Determine new position according to the alignment\n node that node.position works on center positions thats why all calculations\n are performed accordingly\n */\n calculateNewPosition(param, node, referenceBbox, referenceOuterHeight)\n {\n var currentPos = node.position();\n var currentBbox = node.boundingBox();\n var newPosition;\n //This parameter is used to move the compounds less upwards when they contain label\n var moveParam = node.isParent() ? node.outerHeight() - ((currentBbox.h - node.outerHeight())/2) - ((node.outerHeight() - node.height())/2) : node.height();\n //This param is used only when the node is parent, for simple nodes is 0\n var labelHeight = node.isParent()? currentBbox.h - node.outerHeight(): 0;\n\n if (param === 'vLeft')\n {\n newPosition = {x: referenceBbox.x1+currentBbox.w/2, y: currentPos.y};\n }\n else if (param === 'vCen')\n {\n newPosition = {x: referenceBbox.x1+referenceBbox.w/2, y: currentPos.y};\n }\n else if (param === 'vRight')\n {\n newPosition = {x: referenceBbox.x2-currentBbox.w/2, y: currentPos.y};\n }\n else if (param === 'hTop')\n {\n newPosition = {x: currentPos.x, y: referenceBbox.y1 + currentBbox.h/2};\n }\n //Checks for the case where compounds don't have names (name isn't taken in consideration in that case)\n else if (param === 'hMid' && node.isParent() && node.data('name') == \"\")\n {\n newPosition = {x: currentPos.x, y: referenceBbox.y1 + referenceBbox.h/2};\n }\n else if (param === 'hMid' )\n {\n newPosition = {x: currentPos.x, y: referenceBbox.y1 + referenceOuterHeight/2 + labelHeight/2};\n }\n //Checks for the case where compounds don't have names (name isn't taken in consideration in that case)\n else if (param === 'hBot' && node.isParent() && node.data('name') == \"\")\n {\n newPosition = {x: currentPos.x, y: referenceBbox.y2 - currentBbox.h/2};\n }\n else if (param === 'hBot')\n {\n newPosition = {x: currentPos.x, y: referenceBbox.y1 + referenceOuterHeight - moveParam/2};\n }\n else {\n console.log('Error: wrong alignment name ' + param);\n return;\n }\n\n return newPosition;\n }\n\n //Recursively move leaf nodes\n changePosition(node, dx, dy, newPos)\n {\n if (node.isParent())\n {\n var childNodes = node.children();\n var parentBbox = node.boundingBox();\n var self = this;\n childNodes.forEach(function(childNode, index)\n {\n var childBbox = childNode.boundingBox();\n var _dx = -(parentBbox.x1 - childBbox.x1)-parentBbox.w/2+childBbox.w/2;\n var _dy = -(parentBbox.y1 - childBbox.y1)-parentBbox.h/2+childBbox.h/2;\n\n //If further compound node is found, set position accordingly\n if (childNode.isParent())\n {\n self.changePosition(childNode, 0, 0, {x: newPos.x+_dx, y:newPos.y+_dy});\n }\n else\n {\n self.changePosition(childNode, _dx, _dy, newPos);\n }\n\n });\n }\n else\n {\n //Move locally and let editor actions manager know a move happened\n //If in collaborative mode editor actions manager will update collaborative model\n var position =\n {\n x: newPos.x+dx,\n y: newPos.y+dy\n };\n\n this.movedNodes.push({node: node, nextPosition: position, oldPosition: null});\n }\n }\n\n}\n","import React from 'react';\nimport { Modal } from 'react-bootstrap';\nimport { EModalType } from '../ui/react-pathway-mapper';\ninterface IAboutModalProps{\n show: boolean;\n handleClose: Function;\n}\n\nexport default class AboutModal extends React.Component {\n\n constructor(props: IAboutModalProps){\n super(props);\n }\n\n render(){\n\n\n return(\n \n {this.props.handleClose(EModalType.ABOUT)}}\n >\n \n About\n \n \n

PathwayMapper 2.2

\n
\n \"\"\n
\n
\n \"\"\n
\n
\n

i-Vis information Visualization Lab

\n

Bilkent University, Ankara, Turkey

\n
\n
\n

Memorial Sloan-Kettering Cancer Center

\n

New York, USA

\n
\n
\n \n https://github.com/iVis-at-Bilkent/pathway-mapper\n \n \n\n )\n\n\n }\n\n}\n","import { RGBAColor, shapeToSvg } from 'oncoprintjs';\nimport React from 'react';\nimport { Modal } from 'react-bootstrap';\n// @ts-ignore\nimport openImage from \"../images/toolbar/edit.svg\";\n// @ts-ignore\nimport layoutImage from \"../images/toolbar/layout-cose.svg\";\n// @ts-ignore\nimport savePNGImage from \"../images/toolbar/save_png.svg\";\n// @ts-ignore\nimport saveSVGImage from \"../images/toolbar/save_svg.svg\";\nimport { EModalType } from '../ui/react-pathway-mapper';\n// @ts-ignore\nconst addSelImage = require(\"../images/toolbar/add-selected.svg\");\n// @ts-ignore\nconst addAllImage = require(\"../images/toolbar/add-all.svg\");\n\n\ninterface ICBioHelpModalProps{\n show: boolean;\n handleClose: (modalId: EModalType) => void;\n patientView ?: boolean;\n}\n\n// https://github.com/cBioPortal/cbioportal-frontend/blob/29a93c5e992ca1affd3d027355015164ae3602bd/src/shared/lib/Colors.ts\nconst CNA_COLOR_AMP = '#ff0000';\nconst CNA_COLOR_HOMDEL = '#0000ff';\nconst DEFAULT_GREY = '#bebebe';\nconst MUT_COLOR_MISSENSE = '#008000';\nconst MUT_COLOR_MISSENSE_PASSENGER = '#53D400';\nconst MUT_COLOR_INFRAME = '#993404';\nconst MUT_COLOR_INFRAME_PASSENGER = '#a68028';\nconst MUT_COLOR_TRUNC = '#000000';\nconst MUT_COLOR_TRUNC_PASSENGER = '#708090';\nconst MUT_COLOR_FUSION = '#8B00C9';\nconst MUT_COLOR_PROMOTER = '#00B7CE';\nconst MUT_COLOR_OTHER = '#cf58bc';\nconst MUT_COLOR_GERMLINE = '#FFFFFF';\n\nexport function hexToRGBA(str: string): [number, number, number, number] {\n const r = parseInt(str[1] + str[2], 16);\n const g = parseInt(str[3] + str[4], 16);\n const b = parseInt(str[5] + str[6], 16);\n return [r, g, b, 1];\n}\n\n// always used shape\nconst defaultShape = {\n type: 'rectangle',\n fill: hexToRGBA(DEFAULT_GREY),\n x: 0,\n y: 0,\n width: 6,\n height: 20,\n stroke: [0,0,0,0] as RGBAColor,\n 'stroke-width': 0\n};\n\nconst labels = [\n 'Amplification',\n 'Deep Deletion',\n 'Fusion',\n 'Germline Mutation',\n 'Missense Mutation (putative driver)',\n 'Missense Mutation (unknown significance)',\n 'Other Mutation',\n 'Promoter Mutation',\n 'Truncating Mutation (putative driver)',\n 'Truncating Mutation (unknown significance)',\n 'Inframe Mutation (putative driver)',\n 'Inframe Mutation (unknown significance)'\n];\n\n// conditional shapes\nconst shapeBank = [\n {\n type: 'rectangle',\n fill: hexToRGBA(CNA_COLOR_AMP),\n x: 0,\n y: 0,\n width: 6,\n height: 20\n },\n {\n type: 'rectangle',\n fill: hexToRGBA(CNA_COLOR_HOMDEL),\n x: 0,\n y: 0,\n width: 6,\n height: 20\n },\n {\n type: 'rectangle',\n fill: hexToRGBA(MUT_COLOR_FUSION),\n x: 0,\n y: 4,\n width: 6,\n height: 12\n },\n {\n type: 'rectangle',\n fill: hexToRGBA(MUT_COLOR_GERMLINE),\n x: 0,\n y: 8.75,\n width: 6,\n height: 1.6\n },\n {\n type: 'rectangle',\n fill: hexToRGBA(MUT_COLOR_MISSENSE),\n x: 0,\n y: 6.66,\n width: 6,\n height: 6.66\n },\n {\n type: 'rectangle',\n fill: hexToRGBA(MUT_COLOR_MISSENSE_PASSENGER),\n x: 0,\n y: 6.66,\n width: 6,\n height: 6.66\n },\n {\n type: 'rectangle',\n fill: hexToRGBA(MUT_COLOR_OTHER),\n x: 0,\n y: 6.66,\n width: 6,\n height: 6.66\n },\n {\n type: 'rectangle',\n fill: hexToRGBA(MUT_COLOR_PROMOTER),\n x: 0,\n y: 6.66,\n width: 6,\n height: 6.66\n },\n {\n type: 'rectangle',\n fill: hexToRGBA(MUT_COLOR_TRUNC),\n x: 0,\n y: 6.66,\n width: 6,\n height: 6.66\n },\n {\n type: 'rectangle',\n fill: hexToRGBA(MUT_COLOR_TRUNC_PASSENGER),\n x: 0,\n y: 6.66,\n width: 6,\n height: 6.66\n },\n {\n type: 'rectangle',\n fill: hexToRGBA(MUT_COLOR_INFRAME),\n x: 0,\n y: 6.66,\n width: 6,\n height: 6.66\n },\n {\n type: 'rectangle',\n fill: hexToRGBA(MUT_COLOR_INFRAME_PASSENGER),\n x: 0,\n y: 6.66,\n width: 6,\n height: 6.66\n },\n];\n\nexport default class CBioHelpModal extends React.Component{\n\n\n constructor(props: ICBioHelpModalProps){\n super(props);\n }\n\n generateOncoprintLegend() {\n const svgNameSpace = 'http://www.w3.org/2000/svg'\n const svgElement = document.createElementNS(svgNameSpace, 'svg')\n\n const legendEleWidth = 280\n \n const cellWidth = 6\n const cellHeight = 23\n const cellVerticalPadding = 15\n const cellMarginRight = cellWidth + 3\n\n shapeBank.forEach((shape, index) => {\n const offsetX = (index % 3) * (legendEleWidth)\n const textOffsetX = offsetX + cellMarginRight\n const offsetY = Math.floor(index / 3) * (cellHeight + cellVerticalPadding)\n const textOffsetY = offsetY + 15\n const g = document.createElementNS(svgNameSpace, 'g')\n if (!shape[\"stroke\"]) {\n shape[\"stroke\"] = [0,0,0,0];\n shape[\"stroke-width\"] = 0;\n }\n g.appendChild(shapeToSvg(defaultShape, offsetX, offsetY))\n g.appendChild(shapeToSvg(shape, offsetX, offsetY))\n \n const text = document.createElementNS(svgNameSpace, 'text');\n text.setAttributeNS(null, 'x', textOffsetX.toString());\n text.setAttributeNS(null, 'y', textOffsetY.toString());\n text.setAttributeNS(null, 'font-size', '12');\n text.setAttributeNS(null, 'font-family', 'Arial');\n var textNode = document.createTextNode(labels[index]);\n text.appendChild(textNode)\n\n g.appendChild(text);\n svgElement.appendChild(g)\n });\n\n svgElement.setAttribute(\n 'width', '840')\n svgElement.setAttribute(\n 'height','175')\n svgElement.style.paddingTop = '20px'\n // This is important you need to include this to succesfully render in cytoscape.js!\n svgElement.setAttribute('xmlns', svgNameSpace)\n \n return svgElement\n }\n\n render(){\n\n const legendPadding = '45px';\n\n return( \n {this.props.handleClose(EModalType.CHELP)}}>\n \n PathwayMapper cBioPortal Edition 2.2\n \n {(!this.props.patientView &&\n \n

\n PathwayMapper shows you your genes of interest with the alteration frequencies of selected genetic profiles of the chosen study overlaid on a TCGA pathway using a white to red color scale (the more frequently altered a gene is, the more red it's shown). All available TCGA pathways are ranked with the aim to choose the pathway that matches your interest the most. By default we display the pathway with highest ranking with the default ranking options but you may look at your genes of interest in the context of other pathways as well by choosing from the pathway table. \n
\n
\n Refer to the documentation here for the notation used.\n
\n
\n To search for a particular pathway of your interest, use the search field on top of the pathway table. To switch to another pathway, click on the button in the associated row of the pathway table. Ranking criteria might be changed by changing the options at the bottom of the table. \n
\n
\n The buttons on top of the pathway are:\n

    \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n
    Save as PNG
    Save as SVG
    Perform layout: Layout is recalculated taking current node positions into account
    Add selected genes to query: You may select additional genes from the pathway by left clicking (Shift + left click to add more genes)
    Add all valid genes to query: All valid gene symbols will be added to the query; others will be ignored
    Edit pathway: Edit both the topology and the geometry of the current pathway with the full blown PathwayMapper editor
    \n
\n

\n
)\n },\n {(this.props.patientView &&\n \n

\n PathwayMapper shows you your genes of interest with the mutation types, copy number alterations and fusions of selected genetic profiles of the chosen study overlaid on a TCGA pathway using the OncoPrint color scheme. All available TCGA pathways are ranked with the aim to choose the pathway that matches your interest the most. By default we display the pathway with the highest number of genes of interest matching the ones in a pathway but you may look at your genes of interest in the context of other pathways as well by choosing from the pathway table. \n
\n
\n Refer to the documentation here for the notation used.\n
\n
\n Genetic alteration legend:\n
\n

\n
\n

Putative driver and unknown significance annotations are based on data from OncoKB and CancerHotspots.org.

\n
\n To search for a particular pathway of your interest, use the search field on top of the pathway table. To switch to another pathway, click on the button in the associated row of the pathway table.\n
\n
\n The buttons on top of the pathway are:\n
    \n \n \n \n \n \n \n \n \n \n \n
    Save as PNG
    Save as SVG
    Perform layout: Layout is recalculated taking current node positions into account
    \n
\n

\n
\n )}\n
\n\n );\n }\n\n}\n","import { makeObservable, observable } from 'mobx';\nimport { observer } from 'mobx-react';\nimport React from 'react';\nimport { Button, Checkbox, Col, ControlLabel, Form, FormControl, Row, Modal } from 'react-bootstrap';\nimport GridOptionsManager from '../managers/GridOptionsManager';\nimport { EModalType } from '../ui/react-pathway-mapper';\nimport PathwayActions from '../utils/PathwayActions';\ninterface IGridSettingsProps{\n show: boolean;\n handleClose: Function;\n pathwayActions: PathwayActions;\n}\n\nexport enum EGridType{\n GRID,\n GUIDE,\n NONE\n}\n\n@observer\nexport default class GridSettings extends React.Component{\n\n\n\n @observable\n private gridSize: number;\n \n @observable\n private guideColor: string;\n\n private defaultSettings = GridOptionsManager.defaultGridGuideOptions;\n\n @observable\n private enabledType: EGridType;\n constructor(props: IGridSettingsProps){\n super(props);\n makeObservable(this);\n \n this.gridSize = this.defaultSettings.gridSpacing;\n this.guideColor = this.defaultSettings.guidelinesStyle.strokeStyle;\n }\n\n setEnabledType(newType: EGridType){\n if(newType === this.enabledType){\n this.enabledType = EGridType.NONE;\n return;\n }\n\n this.enabledType = newType;\n }\n\n render(){\n\n return(\n {this.enabledType = this.props.pathwayActions.enabledType;}}\n onHide={() => {\n this.props.handleClose(EModalType.GRID);\n }}>\n \n \n Grid Settings\n \n \n \n
\n \n \n Enable Grids:\n \n\n \n {this.setEnabledType(EGridType.GRID);}}>\n \n \n \n \n Enable Guidelines:\n \n\n \n {this.setEnabledType(EGridType.GUIDE);}}>\n \n \n \n \n Grid Size:\n \n\n \n {this.gridSize = e.target.value;}}/>\n \n \n \n \n Guideline Color:\n \n\n \n {this.guideColor = e.target.value;}}/>\n \n \n
\n
\n\n \n \n \n
\n );\n\n\n } \n}","import React from 'react';\nimport {Modal, Button} from 'react-bootstrap';\nimport { EModalType } from '../ui/react-pathway-mapper';\n\ninterface IConfirmationModalProps{\n show: boolean;\n handleClose: (modalId: EModalType) => void;\n}\n\nexport default class ConfirmationModal extends React.Component{\n\n static pendingFunction: Function;\n\n constructor(props: IConfirmationModalProps){\n super(props);\n\n }\n\n render(){\n\n\n return(\n {this.props.handleClose(EModalType.CONFIRMATION);}}\n >\n \n Confirmation\n \n \n
\n All unsaved changes will be lost. Do you want to continue?\n
\n
\n \n \n \n\n \n \n );\n }\n}","import _ from \"lodash\";\nimport { IColorValueMap } from \"../ui/react-pathway-mapper\";\nimport GraphUtilities from \"../utils/GraphUtilities\";\nimport EditorActionsManager from \"./EditorActionsManager\";\n\nlet sharedb;\nlet socket;\nlet connection;\n\nexport default class ShareDBManager {\n\n readonly NODEMAP_NAME = 'nodes';\n readonly EDGEMAP_NAME = 'edges';\n readonly LAYOUT_PROPS_NAME = 'layoutProperties';\n readonly GLOBAL_OPTS_NAME = 'globalOptions';\n //For storing genomic data information per gene\n readonly GENOMIC_DATA_MAP_NAME = 'genomicDataMap';\n //For storing visibility information of genomic data according to the cancer type\n readonly VISIBLE_GENOMIC_DATA_MAP_NAME = 'visibleGenomicDataMapByType';\n readonly GENOMIC_DATA_GROUP_NAME = 'genomicDataGroupList';\n readonly GENOMIC_DATA_GROUP_COUNT = 'genomicDataGroupCount';\n readonly GENOMIC_DATA_COLOR_SCHEME_NAME = 'genomicDataColorScheme';\n \n doc: any;\n postFileLoad: any;\n editor: EditorActionsManager;\n constructor(postFileLoadCallback) {\n //Doc data maps names and keys\n this.postFileLoad = postFileLoadCallback;\n };\n\n\n\n getDoc(){\n return this.doc;\n }\n\n setEditor(editor: EditorActionsManager){\n this.editor = editor;\n }\n\n //Applies any given sharDB opeation to shared document and notifies other clients\n applyShareDBOperation(op) {\n this.doc.submitOp(op, this.shareDBError);\n };\n\n //Clears genomic data in shared document and notifies other clients\n clearShareDBGenomicData() {\n var ops = [];\n var genomicMap = this.doc.data[this.GENOMIC_DATA_MAP_NAME];\n var visMap = this.doc.data[this.VISIBLE_GENOMIC_DATA_MAP_NAME];\n var genomicDataGroupMap = this.doc.data[this.GENOMIC_DATA_GROUP_NAME];\n var genomicDataGroupCount = this.doc.data[this.GENOMIC_DATA_GROUP_COUNT];\n //Reset all genomic maps\n for (const key of Object.keys(genomicMap)) {\n ops.push({p: [this.GENOMIC_DATA_MAP_NAME, key], od: genomicMap[key]});\n }\n for (const key of Object.keys(visMap)) {\n ops.push({p: [this.VISIBLE_GENOMIC_DATA_MAP_NAME, key], od: visMap[key]});\n }\n for (const key of Object.keys(genomicDataGroupMap)) {\n ops.push({p: [this.GENOMIC_DATA_GROUP_NAME, key], od: genomicDataGroupMap[key]});\n }\n //Reset genomic data group count to 0\n ops.push({p: [this.GENOMIC_DATA_GROUP_COUNT], na: -genomicDataGroupCount});\n this.doc.submitOp(ops, this.shareDBError);\n };\n\n /*\n * Updates shared document object\n * @param mapName: map name of the object\n * @param objectKey: key of the object\n * @param object: new object\n *\n */\n updateShareDBObject(mapName, objectKey, object) {\n this.doc.submitOp([{\n p: [mapName, objectKey],\n od: this.doc.data[mapName][objectKey],\n oi: object\n }], this.shareDBError);\n };\n\n /*\n * Inserts a new shared document object\n * @param mapName: map name of the object\n * @param objectKey: key of the object\n * @param object: new object\n *\n */\n insertShareDBObject(mapName, objectKey, object) {\n this.doc.submitOp([{p: [mapName, objectKey], oi: object}], this.shareDBError);\n };\n\n /*\n * Deletes a shared document object\n * @param mapName: map name of the object\n * @param objectKey: key of the object\n *\n */\n deleteShareDBObject(mapName, objectKey) {\n this.doc.submitOp([{p: [mapName, objectKey], od: this.doc.data[mapName][objectKey]}], this.shareDBError);\n };\n\n //Initializes layout properties of the shared document\n initializeShareDBLayoutProperties() {\n this.doc.submitOp([{\n p: [this.LAYOUT_PROPS_NAME, 0],\n li: [this.editor.layoutProperties]\n }], this.shareDBError);\n };\n\n //Initializes global options of the shared document\n initializeShareDBGlobalOptions() {\n this.doc.submitOp([{\n p: [this.GLOBAL_OPTS_NAME, 0],\n li: [this.editor.getGlobalOptions()]\n }], this.shareDBError);\n };\n\n /*\n * Updates layout properties of the shared document and notifies other clients\n * @param object: new layout properties object\n *\n */\n updateShareDBLayoutProperties(object) {\n this.doc.submitOp([{\n p: [this.LAYOUT_PROPS_NAME, 0],\n ld: this.doc.data[this.LAYOUT_PROPS_NAME][0],\n li: object\n }], this.shareDBError);\n };\n\n /*\n * Updates global options of the shared document and notifies other clients\n * @param object: new global options object\n *\n */\n updateShareDBGlobalOptions(object) {\n this.doc.submitOp([{\n p: [this.GLOBAL_OPTS_NAME, 0],\n ld: this.doc.data[this.GLOBAL_OPTS_NAME][0],\n li: object\n }], this.shareDBError);\n };\n\n updateShareDBGenomicDataOverlayColorScheme(object : IColorValueMap) {\n this.doc.submitOp([{\n p: [this.GENOMIC_DATA_COLOR_SCHEME_NAME, 0],\n ld: this.doc.data[this.GENOMIC_DATA_COLOR_SCHEME_NAME][0],\n li: object\n }], this.shareDBError);\n };\n\n //Increments shared data group count\n //Use this function to increment and keep the group count synchronized\n incrementShareDBGroupCount() {\n this.doc.submitOp([{p: [this.GENOMIC_DATA_GROUP_COUNT], na: 1}], this.shareDBError);\n };\n\n //Checks whether given operation is a replace or add/delete operation\n isShareDBReplaceEvent(op) {\n return (op.hasOwnProperty(\"oi\") && op.hasOwnProperty(\"od\"))\n || (op.hasOwnProperty(\"li\") && op.hasOwnProperty(\"ld\"));\n };\n\n /*\n * Gets the initial value of the shared document\n * without this function shared document values cannot be reached\n */\n initializeSharedDBDoc() {\n this.doc.subscribe();\n };\n\n shareDBError(err) {\n if (err) {\n console.error(err);\n }\n };\n\n initShareDB() {\n sharedb = require('sharedb/lib/client');\n socket = new WebSocket('ws://' + window.location.host);\n connection = new sharedb.Connection(socket);\n\n var self = this;\n\n var id = this.getParam('id');\n\n var loadFileCallback = function () {\n self.onFileLoaded();\n };\n\n //Creates new shared db document and initializes values\n var createNewDocument = () => {\n var new_id = self.getCustomObjId();\n var data = {\n nodes: {},\n edges: {},\n layoutProperties: [this.editor.layoutProperties],\n globalOptions: [this.editor.getGlobalOptions()],\n genomicDataMap: {},\n visibleGenomicDataMapByType: {},\n genomicDataGroupList: {},\n genomicDataGroupCount: 0,\n genomicDataColorScheme: [{\n '-100' : \"#0000ff\",\n '0' : \"#ffffff\",\n '100' : \"#ff0000\"\n }]\n };\n window.history.pushState(null, null, '?id=' + new_id);\n self.doc = connection.get('cy', new_id);\n self.doc.create(data, loadFileCallback);\n };\n\n //Check if id exists in parameters\n //If exists open the shared document\n if (id) {\n // Check any document exists with given id\n this.doc = connection.get('cy', id);\n this.doc.fetch(function (err) {\n if (err)\n throw err;\n\n if (self.doc.type === null) {\n createNewDocument();\n return;\n }\n self.doc.subscribe(loadFileCallback);\n });\n }\n else {\n //Create new shared document\n createNewDocument();\n }\n };\n\n /*\n * After a file has been initialized and loaded, we can access the\n * document. We will wire up the data in shared document to the UI.\n *\n */\n onFileLoaded() {\n this.initializeSharedDBDoc();\n this.syncInitialSharedDocData();\n this.initSharedDocEventHandlers();\n\n this.postFileLoad();\n };\n\n /*\n * Synchronizes initial data in the shared document to\n * client's application.\n */\n syncInitialSharedDocData() {\n var self = this;\n var nodeMap = self.doc.data[this.NODEMAP_NAME];\n var edgeMap = self.doc.data[this.EDGEMAP_NAME];\n var shareDBLayoutProperties = self.doc.data[this.LAYOUT_PROPS_NAME][0];\n var globalOptions = self.doc.data[this.GLOBAL_OPTS_NAME][0];\n var genomicDataMap = self.doc.data[this.GENOMIC_DATA_MAP_NAME];\n var visDataMap = self.doc.data[this.VISIBLE_GENOMIC_DATA_MAP_NAME];\n var groupedGenomicDataMap = self.doc.data[this.GENOMIC_DATA_GROUP_NAME];\n var groupedGenomicDataCount = self.doc.data[this.GENOMIC_DATA_GROUP_COUNT];\n let genomicDataColorScheme = self.doc.data[this.GENOMIC_DATA_COLOR_SCHEME_NAME][0];\n\n var invalidGenes = [];\n var highlightedGenes = [];\n var invalidHighlightedGenes = [];\n var hiddenGenes = [];\n for (const key of Object.keys(nodeMap)) {\n var tmpNode = nodeMap[key];\n var tmpNodeId = tmpNode.id;\n\n if (tmpNode.isInvalidGene && tmpNode.isHighlighted) {\n invalidHighlightedGenes.push(tmpNodeId);\n }\n else if (tmpNode.isInvalidGene) {\n invalidGenes.push(tmpNodeId);\n }\n else if (tmpNode.isHighlighted) {\n highlightedGenes.push(tmpNodeId);\n }\n if (tmpNode.isHidden) {\n hiddenGenes.push(tmpNodeId);\n }\n }\n var highlightedEdges = [];\n for (const key of Object.keys(edgeMap)) {\n var tmpEdge = edgeMap[key];\n var tmpEdgeId = tmpEdge.id;\n if (tmpEdge.isHighlighted) {\n highlightedEdges.push(tmpEdgeId);\n }\n }\n\n //TODO Workaround for legacy pathways\n\n // Workaround for backward compatibility of legacy pathways\n // Addition of pubmed id field on server if legacy collaborative\n // pathways does not have !\n for (const key of Object.keys(edgeMap)) {\n const tmpEdge = edgeMap[key];\n\n if (tmpEdge.pubmedIDs == undefined \n || tmpEdge.name == undefined \n || tmpEdge.bendPoint == undefined \n || tmpEdge.anchorPoints == undefined\n || tmpEdge.edgeCurveStyle == undefined) {\n const pubmedIDs = (tmpEdge.pubmedIDs == undefined) ? [] : tmpEdge.pubmedID;\n const edgeLabel = (tmpEdge.name == undefined) ? \"\" : tmpEdge.name;\n let anchorPoints = [];\n if (tmpEdge.bendPoint) {\n anchorPoints = tmpEdge.bendPoint;\n }\n else if (tmpEdge.anchorPoints) {\n anchorPoints = tmpEdge.anchorPoints;\n }\n const edgeCurveStyle = tmpEdge.edgeCurveStyle ? tmpEdge.edgeCurveStyle : \"bezier\";\n\n const param = {\n type: tmpEdge.type,\n source: tmpEdge.source,\n id: self.getCustomObjId(),\n target: tmpEdge.target,\n pubmedID: pubmedIDs,\n name: edgeLabel,\n anchorPoints: anchorPoints,\n edgeCurveStyle: edgeCurveStyle\n };\n\n const newEdge: any = self.edgeInitializer(param);\n\n\n const tmpEdgeID = tmpEdge.id;\n const newEdgeID = newEdge.id;\n\n const ops = [\n {p: [self.EDGEMAP_NAME, tmpEdgeID], od: tmpEdge},\n {p: [self.EDGEMAP_NAME, newEdgeID], oi: newEdge}\n ]\n self.applyShareDBOperation(ops);\n }\n\n }\n\n //Add real time nodes to local graph\n this.editor.addNewElementsLocally(nodeMap, edgeMap);\n //Adds different type of highlight to nodes and hides if their property is hidden\n this.editor.highlightElementsInitially(invalidHighlightedGenes, invalidGenes, highlightedGenes, highlightedEdges, hiddenGenes);\n\n //Update layout properties & global options!!\n if (shareDBLayoutProperties.name == \"cose-bilkent\") {\n shareDBLayoutProperties.name = \"fcose\";\n this.updateLayoutProperties(shareDBLayoutProperties);\n }\n this.editor.updateLayoutPropertiesCallback({li: shareDBLayoutProperties});\n this.editor.changeGlobalOptions({li: globalOptions});\n\n //Sync already available genomic data !\n\n if (!groupedGenomicDataMap) {\n\n self.insertShareDBObject(self.GENOMIC_DATA_MAP_NAME, '0', []);\n for (const key of Object.keys(visDataMap)) {\n var currentMap = _.clone(groupedGenomicDataMap['0']);\n // currentMap.push(visibilityMapKeys[key]);\n self.updateShareDBObject(self.GENOMIC_DATA_MAP_NAME, '0', currentMap);\n }\n }\n\n if (!groupedGenomicDataCount) {\n var count = self.doc.data[self.GENOMIC_DATA_GROUP_COUNT];\n var op = [{\n p: [self.GENOMIC_DATA_GROUP_COUNT],\n na: -count\n }];\n self.applyShareDBOperation(op);\n groupedGenomicDataCount = self.doc.data[self.GENOMIC_DATA_GROUP_COUNT];\n }\n\n if (!genomicDataColorScheme) {\n self.insertShareDBObject(self.GENOMIC_DATA_COLOR_SCHEME_NAME, '0', this.editor.getGenomicDataOverlayColorScheme());\n genomicDataColorScheme = self.doc.data[self.GENOMIC_DATA_COLOR_SCHEME_NAME]['0'];\n }\n\n this.editor.updateGenomicDataColorSchemeHandler({li: genomicDataColorScheme});\n\n for (const key_g of Object.keys(genomicDataMap)) {\n this.editor.genomicDataOverlayManager.genomicDataMap[key_g] =\n genomicDataMap[key_g];\n\n }\n\n for (const key_g of Object.keys(groupedGenomicDataMap)) {\n this.editor.genomicDataOverlayManager.groupedGenomicDataMap[key_g] =\n groupedGenomicDataMap[key_g];\n const data = groupedGenomicDataMap[key_g];\n if(data.length !== 1){\n console.log(\"Grouped genomic data expected to be of length 1 (from sync)\");\n }\n data.forEach((profileId: any) => {this.editor.addToProfiles(profileId)});\n }\n\n for (const key_g of Object.keys(visDataMap)) {\n this.editor.genomicDataOverlayManager.visibleGenomicDataMapByType[key_g] =\n visDataMap[key_g];\n this.editor.adjustVisibilityShareDB(key_g, visDataMap[key_g]);\n \n }\n\n //Does not seem necessary for not but just for sake of completeness\n this.editor.genomicDataOverlayManager.groupedGenomicDataCount = groupedGenomicDataCount;\n\n this.editor.genomicDataOverlayManager.showGenomicData();\n this.editor.genomicDataOverlayManager.notifyObservers();\n this.editor.cy.style().update();\n this.editor.cy.fit(50);\n };\n\n /*\n * Initialize event listeners for any operation coming from shareDB\n *\n */\n initSharedDocEventHandlers () {\n\n var self = this;\n\n //Setup event handlers for maps\n var nodeAddRemoveHandler = function (op) {\n self.editor.shareDBNodeAddRemoveEventCallBack(op);\n };\n\n var edgeAddRemoveHandler = function (op) {\n self.editor.shareDBEdgeAddRemoveEventCallBack(op);\n };\n\n var genomicDataAddRemoveHandler = function (op) {\n self.editor.shareDBGenomicDataHandler(op);\n };\n\n var genomicDataVisibilityChangeHandler = function (op) {\n self.editor.shareDBGenomicDataVisibilityHandler(op);\n self.checkShareDBGenomicData();\n };\n\n var genomicDataGroupChangeHandler = function (op) {\n self.editor.shareDBGenomicDataGroupChangeHandler(op);\n };\n\n var updateElementHandler = function (op) {\n self.editor.updateElementCallback(op);\n };\n\n var updateLayoutPropsHandler = function (op) {\n self.editor.updateLayoutPropertiesCallback(op);\n };\n\n var updateGlobalOptionsHandler = function (op) {\n self.editor.changeGlobalOptions(op);\n };\n\n var updateGenomicDataColorSchemeHandler = function (op) {\n self.editor.updateGenomicDataColorSchemeHandler(op);\n }\n\n\n //Event listeners for maps\n this.doc.on('op', function (op, source) {\n for (var i = 0; i < op.length; i++) {\n var handleOp = op[i];\n var path = handleOp.p[0];\n var isReplaceEvent = self.isShareDBReplaceEvent(handleOp);\n\n if (!isReplaceEvent) {\n if (path === self.NODEMAP_NAME) {\n nodeAddRemoveHandler(handleOp);\n }\n else if (path === self.EDGEMAP_NAME) {\n edgeAddRemoveHandler(handleOp);\n }\n else if (path === self.GENOMIC_DATA_MAP_NAME) {\n genomicDataAddRemoveHandler(handleOp);\n }\n else if (path === self.VISIBLE_GENOMIC_DATA_MAP_NAME) {\n genomicDataVisibilityChangeHandler(handleOp);\n }\n else if (path === self.GENOMIC_DATA_GROUP_NAME) {\n genomicDataGroupChangeHandler(handleOp);\n }\n }\n else { //Then it is update event\n if (path === self.NODEMAP_NAME) {\n updateElementHandler(handleOp);\n }\n else if (path === self.EDGEMAP_NAME) {\n updateElementHandler(handleOp);\n }\n else if (path === self.LAYOUT_PROPS_NAME) {\n updateLayoutPropsHandler(handleOp);\n }\n else if (path === self.GLOBAL_OPTS_NAME) {\n updateGlobalOptionsHandler(handleOp);\n }\n else if (path === self.GENOMIC_DATA_COLOR_SCHEME_NAME) {\n updateGenomicDataColorSchemeHandler(handleOp);\n }\n }\n }\n });\n };\n\n /*\n * Make sure that genomic cloud data is syncronized\n */\n checkShareDBGenomicData () {\n\n var self = this;\n var genomicDataMap = self.doc.data[this.GENOMIC_DATA_MAP_NAME];\n var visDataMap = self.doc.data[this.VISIBLE_GENOMIC_DATA_MAP_NAME];\n var groupedGenomicDataMap = self.doc.data[this.GENOMIC_DATA_GROUP_NAME];\n var groupedGenomicDataCount = self.doc.data[this.GENOMIC_DATA_GROUP_COUNT];\n\n for (var key in genomicDataMap) {\n this.editor.genomicDataOverlayManager.genomicDataMap[key] =\n genomicDataMap[key];\n }\n\n for (var key in visDataMap) {\n this.editor.genomicDataOverlayManager.visibleGenomicDataMapByType[key] =\n visDataMap[key];\n }\n\n for (var key in groupedGenomicDataMap) {\n this.editor.genomicDataOverlayManager.groupedGenomicDataMap[key] =\n groupedGenomicDataMap[key];\n }\n this.editor.genomicDataOverlayManager.groupedGenomicDataCount = groupedGenomicDataCount;\n this.editor.genomicDataOverlayManager.showGenomicData();\n this.editor.genomicDataOverlayManager.notifyObservers();\n };\n \n /*\n * Gets the first empty index from the shared document\n * genomic data group count and increments counter by 1\n *\n */\n\n getEmptyGroupID() {\n var returnCount = this.doc.data[this.GENOMIC_DATA_GROUP_COUNT];\n this.incrementShareDBGroupCount();\n return returnCount;\n };\n\n /*\n * Gets the first empty index from the shared document\n * Initializes & inserts a new genomic data\n * by group id or group name\n *\n */\n groupGenomicData(cancerNames, inGroupId) {\n var genomicGroupMap = this.doc.data[this.GENOMIC_DATA_GROUP_NAME];\n var genomicVisMap = this.doc.data[this.VISIBLE_GENOMIC_DATA_MAP_NAME];\n\n var groupID = \"\" + inGroupId;\n var currentGroup = [];\n\n if (genomicGroupMap.hasOwnProperty(groupID))\n currentGroup = _.clone(genomicGroupMap[groupID]);\n\n for (var i in cancerNames) {\n if (!genomicVisMap.hasOwnProperty(cancerNames[i]))\n currentGroup.push(cancerNames[i]);\n }\n\n // If group id already exists change existing object\n if (genomicGroupMap.hasOwnProperty(groupID)) {\n this.updateShareDBObject(this.GENOMIC_DATA_GROUP_NAME, groupID, currentGroup);\n }\n else {\n //Insert new group\n this.insertShareDBObject(this.GENOMIC_DATA_GROUP_NAME, groupID, currentGroup);\n }\n\n };\n\n //Clears genomic data on shared document\n clearGenomicData() {\n this.clearShareDBGenomicData();\n };\n\n addGenomicData(geneData) {\n var genomicMap = this.doc.data[this.GENOMIC_DATA_MAP_NAME];\n\n //Iterate over all genmoic data which is mapped by geneSymbol to list of alteration values\n //that are also mapped by cancer name and associated value\n var ops = [];\n for (var geneSymbol in geneData) {\n var genomicMapEntry = {};\n if (genomicMap.hasOwnProperty(geneSymbol))\n genomicMapEntry = _.clone(genomicMap[geneSymbol]);\n\n for (var cancerType in geneData[geneSymbol]) {\n if (!(cancerType in genomicMapEntry))\n genomicMapEntry[cancerType] = parseInt(geneData[geneSymbol][cancerType]).toFixed(2);\n }\n ops.push({\n p: [this.GENOMIC_DATA_MAP_NAME, geneSymbol],\n oi: genomicMapEntry\n });\n }\n this.applyShareDBOperation(ops);\n };\n\n addGenomicVisibilityData(visMap) {\n var ops = [];\n for (var cancerStudy in visMap) {\n ops.push({\n p: [this.VISIBLE_GENOMIC_DATA_MAP_NAME, cancerStudy],\n oi: visMap[cancerStudy]\n });\n }\n this.applyShareDBOperation(ops);\n };\n\n changeVisibility(nodesToHide, isHidden) {\n var self = this;\n var nodeMap = self.doc.data[this.NODEMAP_NAME];\n\n nodesToHide.forEach(function (ele) {\n var nodeID = ele.id();\n if (nodeMap.hasOwnProperty(nodeID)) {\n var realTimeNode = nodeMap[nodeID];\n realTimeNode.isHidden = isHidden;\n self.updateShareDBObject(self.NODEMAP_NAME, nodeID, realTimeNode);\n }\n });\n };\n\n changeHighlight(elementsToHighlight, isHighlighted) {\n var self = this;\n var nodeMap = self.doc.data[this.NODEMAP_NAME];\n var edgeMap = self.doc.data[this.EDGEMAP_NAME];\n\n elementsToHighlight.forEach(function (ele) {\n var elementID = ele.id();\n if (nodeMap.hasOwnProperty(elementID)) {\n var realTimeNode = nodeMap[elementID];\n realTimeNode.isHighlighted = isHighlighted;\n self.updateShareDBObject(self.NODEMAP_NAME, elementID, realTimeNode);\n }\n if (edgeMap.hasOwnProperty(elementID)) {\n var realTimeEdge = edgeMap[elementID];\n realTimeEdge.isHighlighted = isHighlighted;\n self.updateShareDBObject(self.EDGEMAP_NAME, elementID, realTimeEdge);\n }\n });\n };\n\n addNewNode(nodeData, posData) {\n var realTimeGeneratedID = this.getCustomObjId();\n var params = {\n name: nodeData.name,\n type: nodeData.type,\n id: realTimeGeneratedID,\n parent: nodeData.parent,\n w: nodeData.w,\n h: nodeData.h,\n minWidth: nodeData.minWidth,\n minWidthBiasLeft: nodeData.minWidthBiasLeft,\n minWidthBiasRight: nodeData.minWidthBiasRight,\n minHeight: nodeData.minHeight,\n minHeightBiasTop: nodeData.minHeightBiasTop,\n minHeightBiasBottom: nodeData.minHeightBiasBottom\n };\n\n //Ensures new node is compatible with the other nodes\n var newNode = this.nodeInitializer(params);\n if (posData) {\n newNode.x = posData.x;\n newNode.y = posData.y;\n }\n this.insertShareDBObject(this.NODEMAP_NAME, realTimeGeneratedID, newNode);\n };\n\n addNewEdge(edgeData) {\n var realTimeGeneratedID = this.getCustomObjId();\n var params = {\n type: edgeData.type,\n id: realTimeGeneratedID,\n source: edgeData.source,\n target: edgeData.target,\n pubmedIDs: edgeData.pubmedIDs,\n name: edgeData.name,\n anchorPoints: edgeData.anchorPoints\n };\n\n //Ensures new edge is compatible with the other edge\n var newEdge = this.edgeInitializer(params);\n this.insertShareDBObject(this.EDGEMAP_NAME, realTimeGeneratedID, newEdge);\n };\n\n reconnectEdge = function(sourceID, targetID, edgeData) {\n var edgeMap = this.doc.data[this.EDGEMAP_NAME];\n var edge = edgeMap[edgeData.id];\n var edgeID = edge.id;\n\n edge.source = sourceID;\n edge.target = targetID;\n\n if(edgeMap.hasOwnProperty(edgeID)) {\n this.updateShareDBObject(this.EDGEMAP_NAME, edgeID, edge);\n }\n else {\n throw new Error('Element does not exist in Real Time');\n }\n };\n\n\n removeElement (elementID) {\n var edgeMap = this.doc.data[this.EDGEMAP_NAME];\n var nodeMap = this.doc.data[this.NODEMAP_NAME];\n\n if (nodeMap.hasOwnProperty(elementID)) {\n this.deleteShareDBObject(this.NODEMAP_NAME, elementID);\n }\n else if (edgeMap.hasOwnProperty(elementID)) {\n this.deleteShareDBObject(this.EDGEMAP_NAME, elementID);\n }\n else {\n throw new Error('Element does not exist in Real Time');\n }\n };\n\n moveElement (ele) {\n var nodeMap = this.doc.data[this.NODEMAP_NAME];\n\n var elementID = ele.id();\n var newPos = ele.position();\n\n if (nodeMap.hasOwnProperty(elementID)) {\n var tmpNode = nodeMap[elementID];\n tmpNode.x = newPos.x;\n tmpNode.y = newPos.y;\n this.updateShareDBObject(this.NODEMAP_NAME, elementID, tmpNode);\n }\n else {\n throw new Error('Element does not exist in nodes !!! ');\n }\n };\n\n //This function is used for movements of all selected elements wrt alignment selected\n changeElementsPositionByAlignment (coll) {\n var self = this;\n var nodeMap = self.doc.data[this.NODEMAP_NAME];\n\n coll.forEach(function (ele) {\n var elementID = ele.node.id();\n if (nodeMap.hasOwnProperty(elementID)) {\n var tmpNode = nodeMap[elementID];\n tmpNode.x = ele.nextPosition.x;\n tmpNode.y = ele.nextPosition.y;\n self.updateShareDBObject(self.NODEMAP_NAME, elementID, tmpNode);\n }\n else {\n throw new Error('Element does not exist in nodes !!! ');\n }\n });\n };\n\n resizeElement (ele, previousWidth, previousHeight) {\n var nodeMap = this.doc.data[this.NODEMAP_NAME];\n\n var elementID = ele.id();\n var newWidth = ele.width();\n var newHeight = ele.height();\n var currentX = ele.position('x');\n var currentY = ele.position('y');\n\n if (nodeMap.hasOwnProperty(elementID)) {\n var tmpNode = nodeMap[elementID];\n tmpNode.x = currentX + newWidth - previousWidth;\n tmpNode.y = currentY + newHeight - previousHeight;\n tmpNode.w = newWidth;\n tmpNode.h = newHeight;\n this.updateShareDBObject(this.NODEMAP_NAME, elementID, tmpNode);\n }\n else {\n throw new Error('Element does not exist in nodes !!! ');\n }\n };\n\n setSizeOfElement (ele, newWidth, newHeight) {\n var nodeMap = this.doc.data[this.NODEMAP_NAME];\n\n var elementID = ele.id();\n\n if (nodeMap.hasOwnProperty(elementID)) {\n var tmpNode = nodeMap[elementID];\n tmpNode.w = newWidth;\n tmpNode.h = newHeight;\n this.updateShareDBObject(this.NODEMAP_NAME, elementID, tmpNode);\n }\n else {\n throw new Error('Element does not exist in nodes !!! ');\n }\n };\n\n resizeCompound (ele, minWidth, minWidthBiasLeft, minWidthBiasRight, minHeight, minHeightBiasTop, minHeightBiasBottom) {\n var nodeMap = this.doc.data[this.NODEMAP_NAME];\n\n var elementID = ele.id();\n var currentX = ele.position('x');\n var currentY = ele.position('y');\n\n if (nodeMap.hasOwnProperty(elementID)) {\n var tmpNode = nodeMap[elementID];\n tmpNode.x = currentX;\n tmpNode.y = currentY;\n tmpNode.minWidth = minWidth;\n tmpNode.minWidthBiasLeft = minWidthBiasLeft;\n tmpNode.minWidthBiasRight = minWidthBiasRight;\n tmpNode.minHeight = minHeight;\n tmpNode.minHeightBiasTop = minHeightBiasTop;\n tmpNode.minHeightBiasBottom = minHeightBiasBottom;\n this.updateShareDBObject(this.NODEMAP_NAME, elementID, tmpNode);\n }\n else {\n throw new Error('Element does not exist in nodes !!! ');\n }\n };\n\n changeNodePositionsShareDB (nodes) {\n var self = this;\n var nodeMap = self.doc.data[self.NODEMAP_NAME];\n\n nodes.forEach(function (ele) {\n var nodeID = ele.id();\n if (nodeMap.hasOwnProperty(nodeID)) {\n var realTimeNode = nodeMap[nodeID];\n realTimeNode.x = ele.position('x');\n realTimeNode.y = ele.position('y');\n self.updateShareDBObject(self\n .NODEMAP_NAME, nodeID, realTimeNode);\n }\n else {\n throw new Error('Element does not exist in nodes !!! ');\n }\n });\n };\n\n changeHighlightInvalidGenes (nodeIDs, isInvalid) {\n var nodeMap = this.doc.data[this.NODEMAP_NAME];\n\n //TODO check compound operation inside or outside of for ?\n for (var i in nodeIDs) {\n var nodeID = nodeIDs[i];\n if (nodeMap.hasOwnProperty(nodeID)) {\n var collaborativeNode = nodeMap[nodeID];\n collaborativeNode.isInvalidGene = isInvalid;\n this.updateShareDBObject(this.NODEMAP_NAME, nodeID, collaborativeNode);\n }\n }\n\n };\n\n addPubmedIDs (edgeID, pubmedIDs) {\n var edgeMap = this.doc.data[this.EDGEMAP_NAME];\n\n\n if (edgeMap.hasOwnProperty(edgeID)) {\n var tmpEdge = edgeMap[edgeID];\n var nonDuplicateArray = [];\n for (var i = 0; i < pubmedIDs.length; i++) {\n if (tmpEdge.pubmedIDs.indexOf(pubmedIDs[i]) < 0) {\n nonDuplicateArray.push(pubmedIDs[i]);\n }\n }\n tmpEdge.pubmedIDs = tmpEdge.pubmedIDs.concat(nonDuplicateArray);\n this.updateShareDBObject(this.EDGEMAP_NAME, edgeID, tmpEdge);\n }\n else {\n throw new Error('Edge does not exist in real time !!! ');\n }\n };\n\n removePubmedID(edgeID, pubmedIDs) {\n var edgeMap = this.doc.data[this.EDGEMAP_NAME];\n\n if (edgeMap.hasOwnProperty(edgeID)) {\n var tmpEdge = edgeMap[edgeID];\n var removedIndices = [];\n for (var i = 0; i < pubmedIDs.length; i++) {\n var tmpID = pubmedIDs[i];\n var index = tmpEdge.pubmedIDs.indexOf(tmpID);\n if (index >= 0) {\n removedIndices.push(index);\n }\n }\n for (var i = 0; i < removedIndices.length; i++) {\n tmpEdge.pubmedIDs.remove(removedIndices[i]);\n }\n this.updateShareDBObject(this.EDGEMAP_NAME, edgeID, tmpEdge);\n\n }\n else {\n throw new Error('Edge does not exist in real time !!! ');\n }\n };\n\n updateEdgeAnchorPoints(edgeID, anchorPointsArray, edgeCurveStyle) {\n\n var edgeMap = this.doc.data[this.EDGEMAP_NAME];\n \n if (edgeMap.hasOwnProperty(edgeID)) {\n var tmpEdge = edgeMap[edgeID];\n tmpEdge.anchorPoints = anchorPointsArray;\n tmpEdge.edgeCurveStyle = edgeCurveStyle;\n this.updateShareDBObject(this.EDGEMAP_NAME, edgeID, tmpEdge);\n }\n else {\n throw new Error('Edge does not exist in real time !!! ');\n }\n };\n\n changeName(ele, newName) {\n var nodeMap = this.doc.data[this.NODEMAP_NAME];\n var edgeMap = this.doc.data[this.EDGEMAP_NAME];\n\n var elementID = ele.id();\n\n if (ele.isNode()) {\n if (nodeMap.hasOwnProperty(elementID)) {\n var tmpNode = nodeMap[elementID];\n tmpNode.name = newName;\n this.updateShareDBObject(this.NODEMAP_NAME, elementID, tmpNode);\n }\n else {\n throw new Error('Element does not exist in nodes !!! ');\n }\n }\n else {\n if (edgeMap.hasOwnProperty(elementID)) {\n var tmpEdge = edgeMap[elementID];\n tmpEdge.name = newName;\n this.updateShareDBObject(this.EDGEMAP_NAME, elementID, tmpEdge);\n }\n else {\n throw new Error('Element does not exist in edges !!! ');\n }\n }\n };\n\n changeParent(rootNode, newParentId, connectedEdges) {\n var self = this;\n var nodeLookupTable = {};\n\n function traverseFromRoot(rootNode, parId) {\n /*\n remove outermost node,\n create new real time node with given parentId,\n pass id of this real time node to children,\n repeat in a recursive manner\n after that restore the edges that dissapear by removed nodes\n during change parent\n */\n\n var refNode = rootNode.nodeRef;\n var children = rootNode.children;\n var newParentId = parId;\n\n if (refNode) {\n var refNodeId = refNode.id();\n var nodeData = refNode.data();\n var posData = refNode.position();\n var currentWidth = refNode.data('w');\n var currentHeight = refNode.data('h');\n\n var newNodeData =\n {\n name: nodeData.name,\n type: nodeData.type,\n x: posData.x,\n y: posData.y,\n w: currentWidth,\n h: currentHeight,\n parent: -1\n };\n\n if (parId) {\n newNodeData.parent = parId;\n }\n\n self.removeElement(refNodeId);\n var newNode = self.nodeInitializer(newNodeData);\n var newNodeId = newNode.id;\n self.insertShareDBObject(self.NODEMAP_NAME, newNodeId, newNode);\n newParentId = newNodeId;\n nodeLookupTable[refNodeId] = newNodeId;\n }\n\n for (const childNode of children) {\n traverseFromRoot(childNode, newParentId);\n }\n }\n\n //Begin traversing from given root node\n traverseFromRoot(rootNode, newParentId);\n\n //Restore edges that dissapear by the change parent operation\n //TODO compound operations ?\n connectedEdges.forEach(function (edge, index) {\n var edgeData = edge.data();\n self.removeElement(edge.id());\n\n var newSource = nodeLookupTable[edgeData.source];\n var newTarget = nodeLookupTable[edgeData.target];\n\n if (newSource) {\n edgeData.source = newSource;\n }\n\n if (newTarget) {\n edgeData.target = newTarget;\n }\n\n self.addNewEdge(edgeData);\n });\n };\n\n removeAllElements() {\n var nodeMap = this.doc.data[this.NODEMAP_NAME];\n var edgeMap = this.doc.data[this.EDGEMAP_NAME];\n var ops = [];\n\n //Remove all real time nodes\n for (const key of Object.keys(nodeMap)) {\n ops.push({\n p: [this.NODEMAP_NAME, key],\n od: nodeMap[key]\n });\n }\n\n //Remove all real time edges\n for (const key of Object.keys(edgeMap)) {\n ops.push({\n p: [this.EDGEMAP_NAME, key],\n od: edgeMap[key]\n });\n }\n\n this.applyShareDBOperation(ops);\n };\n\n loadGraph(nodes, edges) {\n var self = this;\n this.removeAllElements();\n\n //Function that traverses graph tree recursively.\n var oldIdNewIdMap = {};\n\n function traverseTree(node, newParentId) {\n node.data.x = node.position.x;\n node.data.y = node.position.y;\n\n //Update parent !\n if (newParentId) {\n var parent = node.data.parent;\n if (parent) {\n node.data.parent = newParentId;\n }\n }\n\n //Create new real time node\n var newNodeId = self.getCustomObjId();\n var params = node.data;\n oldIdNewIdMap[params.id] = newNodeId;\n var newNode = self.nodeInitializer(params);\n newNode.id = newNodeId;\n\n self.insertShareDBObject(self.NODEMAP_NAME, newNodeId, newNode);\n\n //If node has children recursively traverse sub graphs and update parent field of child nodes\n if (node.children.length > 0) {\n for (const tmpNode of node.children) {\n traverseTree(tmpNode, newNodeId);\n }\n }\n }\n\n //Create graph hierarchy from given list of flat nodes\n var tree = GraphUtilities.createGraphHierarchyRealTime(nodes);\n //Traverse from root nodes of tree\n for (const rootLevelNode of tree) {\n traverseTree(rootLevelNode, undefined);\n }\n\n /*\n Create real time edges, update the source and target fields, since new ids will be generated for the nodes in\n real time\n */\n for (const edge of edges) {\n edge.data.source = oldIdNewIdMap[edge.data.source];\n edge.data.target = oldIdNewIdMap[edge.data.target];\n\n var edgeCurveStyle = \"bezier\";\n if (edge.data.bendPointPositions && edge.data.bendPointPositions.length > 0) {\n edge.data['anchorPoints'] = edge.data['bendPointPositions'];\n delete edge.data['bendPointPositions'];\n edgeCurveStyle = \"segments\";\n }\n else if (edge.data.controlPointPositions && edge.data.controlPointPositions.length > 0) {\n edge.data['anchorPoints'] = edge.data['controlPointPositions'];\n delete edge.data['controlPointPositions'];\n edgeCurveStyle = \"unbundled-bezier\";\n }\n\n var params = edge.data;\n params.edgeCurveStyle = edgeCurveStyle;\n var newEdgeID = self.getCustomObjId();\n params.id = newEdgeID;\n \n var newEdge = self.edgeInitializer(params);\n self.insertShareDBObject(self.EDGEMAP_NAME, newEdgeID, newEdge);\n }\n };\n\n mergeGraph (nodes, edges) {\n var self = this;\n var nodeMap = self.doc.data[this.NODEMAP_NAME];\n\n var realTimeNodeMap = nodeMap;\n var realTimeNodeLookupTable = {};\n var realTimeNodeNameLookupTable = {};\n var oldIdNewIdMap = {};\n\n //Create lookup table for real time nodes\n //items are stored in an array in the resulting array of nodeMap.items()\n // [0] - id, [1] - object\n for (var i in realTimeNodeMap) {\n var nodeMapItem = realTimeNodeMap[i];\n realTimeNodeLookupTable[nodeMapItem.id] = nodeMapItem;\n realTimeNodeNameLookupTable[nodeMapItem.name] = nodeMapItem;\n }\n\n //Recursive traverse definition\n function traverseTree(node, newParentId) {\n //Search by name !\n //We have not found a node that exist in the graph, add normally\n if (!(node.data.name in realTimeNodeNameLookupTable)) {\n node.data.x = node.position.x;\n node.data.y = node.position.y;\n\n //Update parent !\n if (newParentId) {\n var parent = node.data.parent;\n if (parent) {\n node.data.parent = newParentId;\n }\n }\n\n //Create new real time node\n var newNodeId = self.getCustomObjId();\n oldIdNewIdMap[node.data.id] = newNodeId;\n var newNode = self.nodeInitializer(node.data);\n newNode.id = newNodeId;\n self.insertShareDBObject(self.NODEMAP_NAME, newNodeId, newNode);\n\n //If node has children recursively traverse sub graphs and update parent field of child nodes\n if (node.children.length > 0) {\n for (const tmpNode of node.children) {\n traverseTree(tmpNode, newNodeId);\n }\n }\n }\n // At this point there exists another node in the graph with the same name as 'node'\n // we need to update parent field of children of this node if any\n else {\n var sameNameNode = realTimeNodeNameLookupTable[node.data.name];\n var sameNodeId = sameNameNode.id;\n oldIdNewIdMap[node.data.id] = sameNodeId;\n\n //If node has children recursively traverse sub graphs and update parent field of child nodes\n if (node.children.length > 0) {\n for (const tmpNode of node.children) {\n traverseTree(tmpNode, sameNodeId);\n }\n }\n }\n }\n\n //Traverse from root nodes of tree\n var tree = GraphUtilities.createGraphHierarchyRealTime(nodes);\n for (const rootLevelNode of tree) {\n traverseTree(rootLevelNode, rootLevelNode.data.id);\n }\n\n /*\n Create real time edges, update the source and target fields, since new ids will be generated for the nodes in\n real time\n */\n var ops = [];\n for (const edge of edges) {\n edge.data.source = oldIdNewIdMap[edge.data.source];\n edge.data.target = oldIdNewIdMap[edge.data.target];\n var newEdge = self.edgeInitializer(edge.data);\n var newEdgeID = this.getCustomObjId();\n newEdge.id = newEdgeID;\n ops.push({\n p: [self.EDGEMAP_NAME, newEdgeID],\n oi: newEdge\n });\n }\n self.applyShareDBOperation(ops);\n };\n\n updateLayoutProperties (newLayoutProperties) {\n this.updateShareDBLayoutProperties(newLayoutProperties);\n };\n\n updateGlobalOptions (newOptions) {\n this.updateShareDBGlobalOptions(newOptions);\n };\n\n updateGenomicDataOverlayColorScheme(newColorScheme: IColorValueMap) {\n this.updateShareDBGenomicDataOverlayColorScheme(newColorScheme);\n }\n\n /*\n * Creates graph hierarchy from given flat list of nodes list, nodes list is assumed to have parent-child\n * relationship by a field 'parent' which represents to the id of the parent node This function is specific\n * for the needs of TCGA Pathway Curation Tool 04/07/2016\n *\n * @param nodes {array}: flat list of nodes of a graph\n * @return {array}: Tree representation in array, entries are root level nodes. node.children gives children nodes\n * of each node in the returned array.\n * a node in corresponding level.\n *\n * */\n createGraphHierarchy (nodes) {\n //Some arrays and maps for creating graph hierarchy\n var tree = [];\n var mappedArr = {};\n\n // First map the nodes of the array to an object -> create a hash table.\n for (var i = 0, len = nodes.length; i < len; i++) {\n var arrElem = nodes[i];\n mappedArr[arrElem.data.id] = arrElem;\n mappedArr[arrElem.data.id].children = [];\n }\n\n for (const id of Object.keys(mappedArr)) {\n var mappedElem = mappedArr[id];\n\n // If the element is not at the root level, add it to its parent array of children.\n if (mappedElem.data.parent) {\n mappedArr[mappedElem.data.parent].children.push(mappedElem);\n }\n // If the element is at the root level, add it to first level elements array.\n else {\n tree.push(mappedElem);\n }\n }\n return tree;\n };\n\n //Makes sure that edge is compatible with edges in shared document\n edgeInitializer (params) {\n var edge: any = {};\n edge.id = params.id || this.getCustomObjId();\n edge.type = params.type || \"undefined\";\n edge.source = params.source || \"undefined\";\n edge.target = params.target || \"undefined\";\n edge.name = params.name || \"\";\n edge.isHighlighted = params.isHighlighted || false;\n edge.anchorPoints = params.anchorPoints || [];\n edge.edgeCurveStyle = params.edgeCurveStyle || \"bezier\"\n\n if (params.pubmedIDs) {\n if (edge.pubmedIDs == undefined) {\n edge.pubmedIDs = [];\n }\n if(params.pubmedIDs.length > 0)\n edge.pubmedIDs.push(params.pubmedIDs);\n }\n else {\n edge.pubmedIDs = [];\n }\n\n if (params.anchorPoints) {\n if (edge.anchorPoints == undefined) {\n edge.anchorPoints = [];\n }\n // legacy workaround\n if (Array.isArray(params.anchorPoints[0])) {\n edge.anchorPoints = params.anchorPoints[0];\n }\n else {\n edge.anchorPoints = params.anchorPoints;\n }\n }\n else {\n edge.anchorPoints = [];\n }\n return edge;\n };\n\n //Makes sure that node is compatible with nodes in shared document\n nodeInitializer(params) {\n var node: any = {};\n node.id = params.id || this.getCustomObjId();\n node.name = params.name || \"undefined\";\n node.type = params.type || \"undefined\";\n node.parent = params.parent || \"undefined\";\n node.x = params.x || \"undefined\";\n node.y = params.y || \"undefined\";\n node.w = params.w || \"undefined\";\n node.h = params.h || \"undefined\";\n node.minWidth = params.minWidth || 0;\n node.minWidthBiasLeft = params.minWidth || 0;\n node.minWidthBiasRight = params.minWidth || 0;\n node.minHeight = params.minWidth || 0;\n node.minHeightBiasTop = params.minWidth || 0;\n node.minHeightBiasBottom = params.minWidth || 0;\n node.isHidden = params.isHidden || false;\n node.isInvalidGene = params.isInvalidGene || false;\n node.isHighlighted = params.isHighlighted || false;\n return node;\n };\n\n //Makes sure that layout properties is compatible with layout properties in shared document\n layoutPropertiesInitializer (params) {\n var layoutProperties: any = {};\n layoutProperties.name = params.name || 'undefined';\n layoutProperties.nodeRepulsion = params.nodeRepulsion || 'undefined';\n // this.nodeOverlap = params.nodeOverlap || 'undefined';\n layoutProperties.idealEdgeLength = params.idealEdgeLength || 'undefined';\n layoutProperties.edgeElasticity = params.edgeElasticity || 'undefined';\n layoutProperties.nestingFactor = params.nestingFactor || 'undefined';\n layoutProperties.gravity = params.gravity || 'undefined';\n layoutProperties.numIter = params.numIter || 'undefined';\n layoutProperties.tile = params.tile || 'undefined';\n layoutProperties.animate = params.animate || 'undefined';\n layoutProperties.randomize = params.randomize || false;\n layoutProperties.gravityRangeCompound = params.gravityRangeCompound || 'undefined';\n layoutProperties.gravityCompound = params.gravityCompound || 'undefined';\n layoutProperties.gravityRange = params.gravityRange || 'undefined';\n layoutProperties.tilingPaddingVertical = params.tilingPaddingVertical || 'undefined';\n layoutProperties.tilingPaddingHorizontal = params.tilingPaddingHorizontal || 'undefined';\n layoutProperties.initialEnergyOnIncremental = params.initialEnergyOnIncremental || 'undefined';\n return layoutProperties;\n };\n\n //Makes sure that global options is compatible with global options in shared document\n globalOptionsInitializer (params) {\n var globalOptions: any = {};\n globalOptions.zoomLevel = params.zoomLevel || 'undefined';\n globalOptions.panLevel = params.panLevel || 'undefined';\n return globalOptions;\n };\n\n //Create unique ID for elements\n getCustomObjId () {\n // see http://stackoverflow.com/a/8809472\n // we need to take care of our own IDs because the ones automatically generated by cytoscape (also UUID)\n // don't comply with xsd:SID type that must not begin with a number\n // Public Domain/MIT\n var d = Date.now();\n if (typeof performance !== 'undefined' && typeof performance.now === 'function') {\n d += performance.now(); //use high-precision timer if available\n }\n return 'xxxxxxxx-xxxx-4xxx-yxxx-xxxxxxxxxxxx'.replace(/[xy]/g, function (c) {\n var r = (d + Math.random() * 16) % 16 | 0;\n d = Math.floor(d / 16);\n return (c === 'x' ? r : (r & 0x3 | 0x8)).toString(16);\n });\n };\n\n getParam (urlParam) {\n const regExp = new RegExp(urlParam + '=(.*?)($|&)', 'g');\n let match: any = window.location.search.match(regExp);\n if (match && match.length) {\n match = match[0];\n match = match.replace(urlParam + '=', '').replace('&', '');\n } else {\n match = null;\n }\n return match;\n };\n\n}\n","/**\n * Created by istemi on 27.09.2016.\n */\n\nexport default class GraphUtilities {\n \n \n static createGraphHierarchy(nodes)\n {\n //Some arrays and maps for creating graph hierarchy\n var tree = [];\n var mappedArr = {};\n\n // First map the nodes of the array to an object -> create a hash table.\n for (var i = 0, len = nodes.length; i < len; i++)\n {\n var arrElem = nodes[i];\n mappedArr[arrElem.id()] = arrElem;\n mappedArr[arrElem.id()].childNodes = [];\n }\n\n for (var id in mappedArr)\n {\n var mappedElem = mappedArr[id];\n\n // If the element is not at the root level, add it to its parent array of children.\n if (mappedElem.parent().length > 0)\n {\n mappedArr[mappedElem.parent().id()].childNodes.push(mappedElem);\n }\n // If the element is at the root level, add it to first level elements array.\n else\n {\n tree.push(mappedElem);\n }\n }\n return tree;\n };\n\n /*\n * Creates graph hierarchy from given flat list of nodes list, nodes list is assumed to have parent-child\n * relationship by a field 'parent' which represents to the id of the parent node This function is specific\n * for the needs of TCGA Pathway Curation Tool 04/07/2016\n *\n * @param nodes {array}: flat list of nodes of a graph\n * @return {array}: Tree representation in array, entries are root level nodes. node.children gives children nodes\n * of each node in the returned array.\n * a node in corresponding level.\n *\n * */\n static createGraphHierarchyRealTime(nodes)\n {\n //Some arrays and maps for creating graph hierarchy\n var tree = [];\n var mappedArr = {};\n\n // First map the nodes of the array to an object -> create a hash table.\n for (var i = 0, len = nodes.length; i < len; i++)\n {\n var arrElem = nodes[i];\n mappedArr[arrElem.data.id] = arrElem;\n mappedArr[arrElem.data.id].children = [];\n }\n for (var id in mappedArr)\n {\n var mappedElem = mappedArr[id];\n\n // If the element is not at the root level, add it to its parent array of children.\n if (mappedElem.data.parent != -1)\n {\n mappedArr[mappedElem.data.parent].children.push(mappedElem);\n }\n // If the element is at the root level, add it to first level elements array.\n else\n {\n tree.push(mappedElem);\n }\n }\n return tree;\n };\n}","import EditorActionsManager from \"../managers/EditorActionsManager\";\nimport GraphUtilities from \"../utils/GraphUtilities\";\n\nexport default class SVGExporter {\n SVGNameSpace = \"http://www.w3.org/2000/svg\";\n svg = document.createElementNS(this.SVGNameSpace, \"svg\");\n NODE_FILL_COLOR = \"rgb(255,255,255)\";\n FAMILY_FILL_COLOR = \"rgb(255,255,255)\";\n FAMILY_STROKE_COLOR = \"rgb(204,204,204)\";\n NODE_STROKE_COLOR = \"rgb(0,0,0)\";\n COMPARTMENT_STROKE_WIDTH = 2;\n NODE_STROKE_WIDTH = 1;\n NODE_OPACITY = 0.5;\n ROUNDING_FACTOR = 6;\n GENOMICDATA_LABEL_Y_OFFSET = -15;\n EDGE_ARROW_SCALE = 1.7;\n EDGE_WIDTH = 1;\n T_ARROW_HEAD_WIDTH = 2 * this.EDGE_ARROW_SCALE;\n T_ARROW_HEAD_HEIGHT = 8 * this.EDGE_ARROW_SCALE;\n TRIANGLE_ARROW_HEAD_HEIGHT = 8 * this.EDGE_ARROW_SCALE;\n TRIANGLE_ARROW_HEAD_WIDTH = 8 * this.EDGE_ARROW_SCALE;\n DASH_PARAMETERS = \"5, 3\";\n COMPOUND_MARGIN = 8;\n NODE_FONT_SIZE = 14;\n\n edgeEditing: any;\n editor: EditorActionsManager;\n constructor(edgeEditing: any, editor: EditorActionsManager) {\n this.edgeEditing = edgeEditing;\n this.editor = editor;\n }\n\n resetSVG() {\n this.svg = document.createElementNS(this.SVGNameSpace, \"svg\");\n }\n\n exportGraph(nodes, edges) {\n //Reset SVG\n this.resetSVG();\n this.svg.setAttribute(\"version\", \"1.1\");\n this.svg.setAttribute(\"xmlns\", \"http://www.w3.org/2000/svg\");\n //Set viewport of output SVG\n var cyBounds = this.editor.cy.extent();\n this.svg.setAttribute(\n \"viewBox\",\n cyBounds.x1 + \" \" + cyBounds.y1 + \" \" + cyBounds.w + \" \" + cyBounds.h\n );\n\n var self = this;\n var nodeMap = {};\n\n var nodeTree = GraphUtilities.createGraphHierarchy(nodes);\n var traverseFunction = function(node) {\n //Create SVG for current node\n nodeMap[node.id()] = node;\n var genomicDataSVG = self.editor.getGenomicDataSVG(node).children;\n var oncoprintDataSVG = self.editor.getOncoprintDataSVG(node);\n self.svg.appendChild(self.createRect(node));\n var labelOffset =\n (genomicDataSVG && genomicDataSVG.length > 0) ||\n oncoprintDataSVG.outerHTML !== \"\"\n ? self.GENOMICDATA_LABEL_Y_OFFSET\n : 0;\n self.svg.appendChild(self.createNodeLabel(node, labelOffset));\n\n //Append Genomic Data SVG\n if (genomicDataSVG) {\n while (genomicDataSVG.length > 0) {\n var elemSVG = genomicDataSVG[0];\n var nodePosition = node.position();\n var svgX = elemSVG.getAttribute(\"x\");\n var svgY = elemSVG.getAttribute(\"y\");\n elemSVG.setAttribute(\n \"x\",\n nodePosition.x - node.width() / 2 + parseFloat(svgX)\n );\n elemSVG.setAttribute(\n \"y\",\n nodePosition.y - node.height() / 2 + parseFloat(svgY)\n );\n self.svg.appendChild(elemSVG);\n }\n }\n //Append Oncoprint Data SVG\n else if (oncoprintDataSVG.outerHTML !== \"\") {\n var nodePosition = node.position();\n\n const width = parseInt(oncoprintDataSVG.getAttribute(\"width\"));\n const height = parseInt(oncoprintDataSVG.getAttribute(\"height\"));\n const verticalPadding = 8;\n\n const y =\n nodePosition.y + node.height() / 2 - (height + verticalPadding);\n oncoprintDataSVG.setAttribute(\"x\", nodePosition.x - width / 2);\n oncoprintDataSVG.setAttribute(\"y\", y);\n self.svg.appendChild(oncoprintDataSVG);\n }\n\n //Traverse children\n if (node.childNodes) {\n for (var i in node.childNodes) {\n traverseFunction(node.childNodes[i]);\n }\n }\n };\n\n //Traverse node hierarchy\n for (var i in nodeTree) {\n var rootLevelNode = nodeTree[i];\n traverseFunction(rootLevelNode);\n }\n\n edges.forEach(function(edge) {\n self.drawEdge(edge);\n });\n\n return this.svg.outerHTML;\n }\n\n drawEdge(edge) {\n const sourceEndpoint = edge.sourceEndpoint();\n const targetEndpoint = edge.targetEndpoint();\n const targetArrowShape = edge.style(\"target-arrow-shape\");\n const lineStyle = edge.style(\"line-style\");\n const curveStyle = edge.style(\"curve-style\");\n const anchorPoints = curveStyle === \"segments\" ? \n edge.segmentPoints() : \n edge.controlPoints();\n\n const labelElement = this.createEdgeLabel(edge);\n if (labelElement) {\n this.svg.appendChild(labelElement);\n }\n\n let lastAnchor = {\n x: sourceEndpoint.x,\n y: sourceEndpoint.y\n }\n let edgeEndpoint = {\n x: targetEndpoint.x,\n y: targetEndpoint.y\n };\n\n if (anchorPoints && anchorPoints.length > 0) {\n lastAnchor = {\n x: anchorPoints[anchorPoints.length - 1].x,\n y: anchorPoints[anchorPoints.length - 1].y\n }\n }\n\n var unitV = this.unitVector({\n x: targetEndpoint.x - lastAnchor.x,\n y: targetEndpoint.y - lastAnchor.y,\n });\n var inverseUnitV = this.scale(unitV, -1);\n\n var targetX = targetEndpoint.x;\n var targetY = targetEndpoint.y;\n\n //Draw Triangle arrow head\n if (targetArrowShape === \"triangle\") {\n targetX =\n targetEndpoint.x +\n this.TRIANGLE_ARROW_HEAD_HEIGHT * inverseUnitV.x;\n targetY =\n targetEndpoint.y +\n this.TRIANGLE_ARROW_HEAD_HEIGHT * inverseUnitV.y;\n\n var point1Vector = this.rotateVector(unitV, Math.PI / 2);\n var point2Vector = this.rotateVector(unitV, -Math.PI / 2);\n\n point1Vector = this.scale(\n point1Vector,\n this.TRIANGLE_ARROW_HEAD_WIDTH / 2\n );\n point2Vector = this.scale(\n point2Vector,\n this.TRIANGLE_ARROW_HEAD_WIDTH / 2\n );\n\n var point1X = targetX + point1Vector.x;\n var point1Y = targetY + point1Vector.y;\n\n var point2X = targetX + point2Vector.x;\n var point2Y = targetY + point2Vector.y;\n\n edgeEndpoint = {\n x: (point1X + point2X) / 2,\n y: (point1Y + point2Y) / 2\n }\n\n var polySVG = document.createElementNS(this.SVGNameSpace, \"polygon\");\n polySVG.setAttribute(\n \"points\",\n point1X +\n \",\" +\n point1Y +\n \",\" +\n point2X +\n \",\" +\n point2Y +\n \",\" +\n targetEndpoint.x +\n \",\" +\n targetEndpoint.y\n );\n\n this.svg.appendChild(polySVG);\n }\n //Draw T type arrow head\n else if (targetArrowShape === \"tee\") {\n targetX =\n targetEndpoint.x \n targetY =\n targetEndpoint.y \n\n //Calculate T shape points\n var point1Vector = this.rotateVector(unitV, Math.PI / 2);\n var point2Vector = this.rotateVector(unitV, -Math.PI / 2);\n point1Vector = this.scale(point1Vector, this.T_ARROW_HEAD_HEIGHT / 2);\n point2Vector = this.scale(point2Vector, this.T_ARROW_HEAD_HEIGHT / 2);\n\n var point1X = targetX + point1Vector.x;\n var point1Y = targetY + point1Vector.y;\n var point2X = targetX + point2Vector.x;\n var point2Y = targetY + point2Vector.y;\n\n edgeEndpoint = {\n x: (point1X + point2X) / 2,\n y: (point1Y + point2Y) / 2\n }\n\n //Draw edge arrow line here !\n var lineSVG = document.createElementNS(this.SVGNameSpace, \"line\");\n lineSVG.setAttribute(\"x1\", point1X);\n lineSVG.setAttribute(\"y1\", point1Y);\n lineSVG.setAttribute(\"x2\", point2X);\n lineSVG.setAttribute(\"y2\", point2Y);\n lineSVG.setAttribute(\"stroke-width\", this.T_ARROW_HEAD_WIDTH.toString());\n lineSVG.setAttribute(\"stroke\", \"black\");\n this.svg.appendChild(lineSVG);\n }\n \n // no anchors means a single line connecting source and target end points\n if (!anchorPoints || anchorPoints.length < 1) {\n const lineSVG = document.createElementNS(this.SVGNameSpace, \"line\");\n lineSVG.setAttribute(\"x1\", sourceEndpoint.x);\n lineSVG.setAttribute(\"y1\", sourceEndpoint.y);\n lineSVG.setAttribute(\"x2\", edgeEndpoint.x);\n lineSVG.setAttribute(\"y2\", edgeEndpoint.y);\n lineSVG.setAttribute(\"stroke-width\", this.EDGE_WIDTH.toString());\n lineSVG.setAttribute(\"stroke\", \"black\");\n if (lineStyle === \"dashed\") {\n lineSVG.setAttribute(\"stroke-dasharray\", this.DASH_PARAMETERS);\n }\n this.svg.appendChild(lineSVG);\n }\n else if (curveStyle === \"unbundled-bezier\" || curveStyle === \"bezier\") {\n const pathSVG = document.createElementNS(this.SVGNameSpace, \"path\");\n let pathPoints: string[] = [];\n\n for (let i = 0; i < anchorPoints.length; i++) {\n if (i === 0) {\n pathPoints.push(\"M\" + sourceEndpoint.x + \",\" + sourceEndpoint.y);\n pathPoints.push(\"Q\" + anchorPoints[i].x + \",\" + anchorPoints[i].y);\n if (anchorPoints.length === 1) {\n pathPoints.push(edgeEndpoint.x + \",\" + edgeEndpoint.y);\n }\n else {\n const furtherEndPoint = {\n x: (anchorPoints[i].x + anchorPoints[i+1].x) / 2,\n y: (anchorPoints[i].y + anchorPoints[i+1].y) / 2 \n }\n pathPoints.push(furtherEndPoint.x + \",\" + furtherEndPoint.y);\n }\n }\n else {\n if (i < anchorPoints.length - 1) {\n const furtherEndPoint = {\n x: (anchorPoints[i].x + anchorPoints[i+1].x) / 2,\n y: (anchorPoints[i].y + anchorPoints[i+1].y) / 2 \n }\n pathPoints.push(\"T\" + furtherEndPoint.x + \",\" + furtherEndPoint.y);\n }\n else {\n pathPoints.push(\"T\" + edgeEndpoint.x + \",\" + edgeEndpoint.y);\n }\n }\n }\n pathSVG.setAttribute(\n 'd',\n pathPoints.join(\" \")\n );\n pathSVG.setAttribute('stroke-width', this.EDGE_WIDTH.toString());\n pathSVG.setAttribute('stroke', 'black');\n if (lineStyle === \"dashed\") {\n pathSVG.setAttribute(\"stroke-dasharray\", this.DASH_PARAMETERS);\n }\n pathSVG.setAttribute('fill', 'none');\n this.svg.appendChild(pathSVG);\n }\n // anchors means polyline\n else {\n const polylineSVG = document.createElementNS(this.SVGNameSpace, \"polyline\");\n let polylinePoints: string[] = [];\n\n for (let i = 0; i < anchorPoints.length; i++) {\n if (i === 0) {\n polylinePoints.push(sourceEndpoint.x + \",\" + sourceEndpoint.y);\n polylinePoints.push(anchorPoints[i].x + \",\" + anchorPoints[i].y);\n if (anchorPoints.length === 1) {\n polylinePoints.push(edgeEndpoint.x + \",\" + edgeEndpoint.y);\n }\n }\n else if (i === anchorPoints.length - 1) {\n polylinePoints.push(anchorPoints[i].x + \",\" + anchorPoints[i].y);\n polylinePoints.push(edgeEndpoint.x + \",\" + edgeEndpoint.y);\n }\n else {\n polylinePoints.push(anchorPoints[i].x + \",\" + anchorPoints[i].y);\n }\n }\n polylineSVG.setAttribute(\n 'points',\n polylinePoints.join(\" \")\n );\n polylineSVG.setAttribute('stroke-width', this.EDGE_WIDTH.toString());\n polylineSVG.setAttribute('stroke', 'black');\n if (lineStyle === \"dashed\") {\n lineSVG.setAttribute(\"stroke-dasharray\", this.DASH_PARAMETERS);\n }\n polylineSVG.setAttribute('fill', 'none');\n this.svg.appendChild(polylineSVG);\n }\n \n }\n\n createRect(node) {\n var nodeRectangle = document.createElementNS(this.SVGNameSpace, \"rect\");\n var nodePosition = node.position();\n if (node.isParent()) {\n nodeRectangle.setAttribute(\n \"x\",\n nodePosition.x - node.width() / 2 - this.COMPOUND_MARGIN / 2 + \"\"\n );\n nodeRectangle.setAttribute(\n \"y\",\n nodePosition.y - node.height() / 2 - this.COMPOUND_MARGIN / 2 + \"\"\n );\n nodeRectangle.setAttribute(\"width\", node.width() + this.COMPOUND_MARGIN);\n nodeRectangle.setAttribute(\n \"height\",\n node.height() + this.COMPOUND_MARGIN\n );\n } else {\n nodeRectangle.setAttribute(\"x\", nodePosition.x - node.width() / 2 + \"\");\n nodeRectangle.setAttribute(\"y\", nodePosition.y - node.height() / 2 + \"\");\n nodeRectangle.setAttribute(\"width\", node.width());\n nodeRectangle.setAttribute(\"height\", node.height());\n }\n\n nodeRectangle = this.createStyleForNodes(node, nodeRectangle);\n\n return nodeRectangle;\n }\n\n createNodeLabel(node, genomicDataOffset) {\n var verticalTextOffset = 5;\n var nodePosition = node.position();\n var svgText = document.createElementNS(this.SVGNameSpace, \"text\");\n\n if (node.isParent()) {\n verticalTextOffset = 20;\n svgText.setAttribute(\"x\", nodePosition.x);\n svgText.setAttribute(\n \"y\",\n nodePosition.y + node.height() / 2 + verticalTextOffset\n );\n } else {\n svgText.setAttribute(\"x\", nodePosition.x);\n svgText.setAttribute(\n \"y\",\n nodePosition.y + verticalTextOffset + genomicDataOffset\n );\n }\n\n svgText.setAttribute(\"font-family\", \"Arial\");\n svgText.setAttribute(\"text-anchor\", \"middle\");\n svgText.setAttribute(\"font-size\", this.NODE_FONT_SIZE.toString());\n svgText.innerHTML = node.data(\"name\");\n return svgText;\n }\n\n createStyleForNodes(node, nodeRectangle) {\n var nodeType = node.data().type;\n var strokeWidth = node.css(\"border-width\") || this.NODE_STROKE_WIDTH;\n var strokeColor = this.NODE_STROKE_COLOR;\n var fillColor = this.NODE_FILL_COLOR;\n var opacity = this.NODE_OPACITY;\n var strokeOpacity = 1;\n\n if (nodeType == \"GENE\" || nodeType == \"COMPARTMENT\") {\n nodeRectangle.setAttribute(\"rx\", this.ROUNDING_FACTOR);\n nodeRectangle.setAttribute(\"ry\", this.ROUNDING_FACTOR);\n\n if (nodeType == \"COMPARTMENT\")\n strokeWidth = this.COMPARTMENT_STROKE_WIDTH;\n }\n\n if (nodeType == \"PROCESS\") {\n opacity = 0;\n strokeOpacity = 0;\n }\n\n if (nodeType == \"FAMILY\") {\n fillColor = this.FAMILY_FILL_COLOR;\n strokeColor = this.FAMILY_STROKE_COLOR;\n }\n\n var styleString =\n \"stroke-width:\" +\n strokeWidth +\n \";\" +\n \"stroke:\" +\n strokeColor +\n \";\" +\n \"fill-opacity:\" +\n opacity +\n \";\" +\n \"fill:\" +\n fillColor +\n \";\" +\n \"stroke-opacity:\" +\n strokeOpacity +\n \";\";\n\n nodeRectangle.setAttribute(\"style\", styleString);\n\n return nodeRectangle;\n }\n\n createEdgeLabel(edge) {\n const labelText = edge.data(\"name\");\n \n if (labelText === \"\") {\n return undefined;\n }\n const svgTextElement = document.createElementNS(this.SVGNameSpace, \"text\");\n\n const fontSize = edge.style(\"font-size\");\n const fontFamily = edge.style(\"font-family\");\n\n // get rotation angle in degrees for transform: rotate()\n const labelRotationAngle = this.getEdgeLabelRotationAngle(edge);\n const lineHeight = edge._private.rscratch.labelLineHeight;\n\n // adjust margins to compensate for the label hack (see stylesheet)\n const dx = (lineHeight / 4) * Math.sin(edge._private.rscratch.labelAngle);\n const dy = (lineHeight / 4) * Math.cos(edge._private.rscratch.labelAngle);\n\n const labelPos = {\n x: edge._private.rscratch.labelX + dx,\n y: edge._private.rscratch.labelY - dy\n }\n\n svgTextElement.setAttribute('x', labelPos.x.toString());\n svgTextElement.setAttribute('y', labelPos.y.toString());\n svgTextElement.setAttribute(\"font-family\", fontFamily);\n svgTextElement.setAttribute(\"text-anchor\", \"middle\");\n svgTextElement.setAttribute(\"font-size\", fontSize);\n\n svgTextElement.innerHTML = labelText;\n\n // adjusting for autorotate option\n // https://developer.mozilla.org/en-US/docs/Web/SVG/Attribute/transform#rotate \n svgTextElement.setAttribute(\n \"transform\", \n \"rotate(\" + \n labelRotationAngle +\n \" \" +\n labelPos.x.toString() +\n \" \" +\n labelPos.y.toString()+\n \")\");\n\n return svgTextElement;\n }\n\n getEdgeLabelRotationAngle(edge) {\n const labelAngle = edge._private.rscratch.labelAngle;\n\n if (!labelAngle) {\n return 0;\n }\n\n return this.toDegrees(labelAngle);\n }\n\n toDegrees(radians) {\n const pi = Math.PI;\n return radians * (180/pi);\n }\n\n unitVector(v) {\n var inverseLength = 1 / Math.sqrt(v.x * v.x + v.y * v.y);\n\n return {\n x: v.x * inverseLength,\n y: v.y * inverseLength,\n };\n }\n\n rotateVector(v, radians) {\n var newX = v.x * Math.cos(radians) - v.y * Math.sin(radians);\n var newY = v.x * Math.sin(radians) + v.y * Math.cos(radians);\n\n return { x: newX, y: newY };\n }\n\n scale(v, scalar) {\n var newX = v.x * scalar;\n var newY = v.y * scalar;\n\n return { x: newX, y: newY };\n }\n}\n","import $ from \"jquery\";\nimport { GeneticAlterationRuleSet, shapeToSvg } from \"oncoprintjs\";\nimport tippy from \"tippy.js\";\nimport \"tippy.js/dist/tippy.css\"; // optional for styling\nimport { IColorValueMap } from \"../ui/react-pathway-mapper\";\n\ninterface Color {\n r: number;\n g: number;\n b: number;\n}\n\ninterface ValueColorPair {\n value: number;\n color: Color;\n}\nexport default class GenomicDataOverlayManager {\n public genomicDataMap: {};\n public visibleGenomicDataMapByType: {};\n public groupedGenomicDataCount: number;\n public groupedGenomicDataMap: {};\n public patientData: any;\n private DEFAULT_VISIBLE_GENOMIC_DATA_COUNT: number;\n private observers: any[];\n private cy: any;\n private colorScheme: IColorValueMap;\n\n constructor(cy: any) {\n this.cy = cy;\n this.genomicDataMap = {};\n this.patientData = {};\n this.visibleGenomicDataMapByType = {};\n this.groupedGenomicDataMap = {};\n this.groupedGenomicDataCount = 0;\n this.DEFAULT_VISIBLE_GENOMIC_DATA_COUNT = 6;\n this.colorScheme = {\n \"-100\": \"#0000ff\",\n \"0\": \"#ffffff\",\n \"100\": \"#ff0000\",\n };\n // Observer-observable pattern related stuff\n this.observers = [];\n }\n\n getEmptyGroupID() {\n const oldCount = this.groupedGenomicDataCount;\n this.groupedGenomicDataCount++;\n return oldCount;\n }\n\n addGenomicDataLocally(genomicData, groupID) {\n this.parseGenomicData(genomicData, groupID);\n this.showGenomicData();\n this.notifyObservers();\n }\n\n preparePortalGenomicDataShareDB(genomicData) {\n const geneMap = {};\n const visMap = {};\n\n for (const cancerKey in genomicData) {\n for (const geneSymbol in genomicData[cancerKey]) {\n geneMap[geneSymbol] = {};\n geneMap[geneSymbol][cancerKey] = genomicData[cancerKey][geneSymbol];\n }\n\n visMap[cancerKey] = true;\n }\n\n return {\n genomicDataMap: geneMap,\n visibilityMap: visMap,\n };\n }\n\n addGenomicData(data) {\n this.genomicDataMap = data;\n }\n\n removeGenomicVisData() {\n this.visibleGenomicDataMapByType = {};\n }\n\n addGenomicDataWithGeneSymbol(geneSymbol, data) {\n this.genomicDataMap[geneSymbol] = data;\n }\n\n addGenomicGroupData(groupID, data) {\n this.groupedGenomicDataMap[groupID] = data;\n }\n\n addPortalGenomicData(data, groupID) {\n for (const cancerStudy of Object.keys(data)) {\n this.visibleGenomicDataMapByType[cancerStudy] = true;\n // Group current cancer study according to the groupID\n if (this.groupedGenomicDataMap[groupID] === undefined) {\n this.groupedGenomicDataMap[groupID] = [];\n }\n\n this.groupedGenomicDataMap[groupID].push(cancerStudy);\n\n var cancerData = data[cancerStudy];\n\n for (const geneSymbol of Object.keys(cancerData)) {\n if (this.genomicDataMap[geneSymbol] === undefined)\n this.genomicDataMap[geneSymbol] = {};\n\n this.genomicDataMap[geneSymbol][cancerStudy] = data[cancerStudy][\n geneSymbol\n ].toFixed\n ? data[cancerStudy][geneSymbol].toFixed(2)\n : data[cancerStudy][geneSymbol];\n }\n }\n //This parameter is used as flag for PatientView PathwayMapper Functions\n if (data[\"PatientView\"] == 1) {\n this.patientData = data;\n this.showPatientData();\n } else {\n this.showGenomicData();\n }\n this.notifyObservers();\n }\n\n clearAllGenomicData = function() {\n this.genomicDataMap = {};\n this.visibleGenomicDataMapByType = {};\n this.groupedGenomicDataMap = {};\n this.groupedGenomicDataCount = 0;\n };\n\n removeGenomicData() {\n this.genomicDataMap = {};\n }\n\n removeGenomicDataWithGeneSymbol(geneSymbol) {\n this.genomicDataMap[geneSymbol] = {};\n }\n\n addGenomicVisData(key, data) {\n this.visibleGenomicDataMapByType[key] = data;\n }\n\n prepareGenomicDataShareDB = function(genomicData) {\n const genomicDataMap = {};\n const cancerTypes = [];\n const visibleGenomicDataMapByType = {};\n\n // By lines\n const lines = genomicData.split(\"\\n\");\n // First line is meta data !\n const metaLineColumns = lines[0].split(\"\\t\");\n\n // Parse cancer types\n for (let i = 1; i < metaLineColumns.length; i++) {\n cancerTypes.push(metaLineColumns[i]);\n // Update initially visible genomic data boxes !\n if (i - 1 < this.DEFAULT_VISIBLE_GENOMIC_DATA_COUNT) {\n visibleGenomicDataMapByType[cancerTypes[i - 1]] = true;\n } else {\n visibleGenomicDataMapByType[cancerTypes[i - 1]] = false;\n }\n }\n\n // parse genomic data\n for (let i = 1; i < lines.length; i++) {\n // EOF check\n if (lines[i].length === 0) {\n break;\n }\n\n // Split each line by tab and parse genomic data content\n const lineContent = lines[i].split(\"\\t\");\n const geneSymbol = lineContent[0];\n\n // If current gene entry is not in genomic data map create new hashmap entry\n if (!(geneSymbol in genomicDataMap)) {\n genomicDataMap[geneSymbol] = {};\n }\n\n // Add each entry of genomic data\n for (let j = 1; j < lineContent.length; j++) {\n genomicDataMap[geneSymbol][cancerTypes[j - 1]] = lineContent[j];\n }\n }\n\n const returnObj = {\n genomicDataMap: genomicDataMap,\n visibilityMap: visibleGenomicDataMapByType,\n };\n\n return returnObj;\n };\n\n updateGenomicDataVisibility = function(_key, isVisible) {\n if (_key in this.visibleGenomicDataMapByType) {\n this.visibleGenomicDataMapByType[_key] = isVisible;\n }\n };\n\n hideGenomicData = function() {\n\n this.cy.nodes('[type=\"GENE\"]').forEach(node => {\n node.data('w', this.getRequiredWidthForGenomicData(0));\n })\n\n this.cy\n .style()\n .selector('node[type=\"GENE\"]')\n .style(\"text-margin-y\", 0)\n .style(\"background-image\", function(ele) {\n const dataURI = \"data:image/svg+xml;utf8,\";\n return dataURI;\n })\n .update();\n };\n\n countVisibleGenomicDataByType() {\n // Count the genomic data that will be displayed on nodes' body\n let genomicDataBoxCount = 0;\n for (let cancerType in this.visibleGenomicDataMapByType) {\n if (this.visibleGenomicDataMapByType[cancerType]) {\n genomicDataBoxCount++;\n }\n }\n\n return genomicDataBoxCount;\n }\n\n generateSVGForNode(ele) {\n const genomicDataBoxCount = this.countVisibleGenomicDataByType();\n\n // Experimental data overlay part !\n const dataURI = \"data:image/svg+xml;utf8,\";\n const svgNameSpace = \"http://www.w3.org/2000/svg\";\n\n const nodeLabel = ele.data(\"name\");\n // If there is no genomic data for this node return !\n if (!(nodeLabel in this.genomicDataMap)) {\n return dataURI;\n }\n\n const eleBBox = ele.boundingBox();\n const reqWidth = this.getRequiredWidthForGenomicData(genomicDataBoxCount);\n const overlayRecBoxW = reqWidth - 10;\n const overlayRecBoxH = 25;\n const svg: any = document.createElementNS(svgNameSpace, \"svg\");\n // It seems this should be set according to the node size !\n svg.setAttribute(\"width\", reqWidth);\n svg.setAttribute(\"height\", eleBBox.h);\n // This is important you need to include this to succesfully render in cytoscape.js!\n svg.setAttribute(\"xmlns\", svgNameSpace);\n\n // Overlay Data Rect\n const overLayRectBBox = {\n w: overlayRecBoxW,\n h: overlayRecBoxH,\n x: reqWidth / 2 - overlayRecBoxW / 2,\n y: eleBBox.h / 2 + overlayRecBoxH / 2 - 18,\n };\n\n const genomicFrequencyData = this.genomicDataMap[nodeLabel];\n\n let maxGenomicDataBoxCount = /*(genomicDataBoxCount > 3) ? 3:*/ genomicDataBoxCount;\n let genomicBoxCounter = 0;\n\n for (let i in this.groupedGenomicDataMap) {\n for (let j in this.groupedGenomicDataMap[i]) {\n const cancerType = this.groupedGenomicDataMap[i][j];\n if (!this.visibleGenomicDataMapByType[cancerType]) {\n continue;\n }\n\n if (genomicFrequencyData[cancerType] !== undefined) {\n genomicDataRectangleGenerator(\n overLayRectBBox.x +\n (genomicBoxCounter * overLayRectBBox.w) / maxGenomicDataBoxCount,\n overLayRectBBox.y,\n overLayRectBBox.w / maxGenomicDataBoxCount,\n overLayRectBBox.h,\n genomicFrequencyData[cancerType],\n svg,\n this.colorScheme\n );\n } else {\n genomicDataRectangleGenerator(\n overLayRectBBox.x +\n (genomicBoxCounter * overLayRectBBox.w) / maxGenomicDataBoxCount,\n overLayRectBBox.y,\n overLayRectBBox.w / maxGenomicDataBoxCount,\n overLayRectBBox.h,\n null,\n svg,\n this.colorScheme\n );\n }\n\n genomicBoxCounter++;\n }\n }\n\n function hexToRGB(hex: string) {\n var result = /^#?([a-f\\d]{2})([a-f\\d]{2})([a-f\\d]{2})$/i.exec(hex);\n\n return result\n ? {\n r: parseInt(result[1], 16),\n g: parseInt(result[2], 16),\n b: parseInt(result[3], 16),\n }\n : null;\n }\n\n function swap(a, b) {\n let temp = a;\n a = b;\n b = temp;\n }\n\n function findValueColorInterval(\n colorScheme: IColorValueMap,\n value: number\n ): { lower: ValueColorPair; upper: ValueColorPair } {\n const pairs = Object.entries(colorScheme)\n .map(([value, color]) => {\n return {\n value: Number(value),\n color: hexToRGB(color),\n };\n })\n .sort((o1, o2) => {\n return o1.value - o2.value;\n });\n\n if (value < pairs[0].value) {\n return {\n lower: {\n value: -Infinity,\n color: pairs[0].color,\n },\n upper: {\n value: pairs[0].value,\n color: pairs[0].color,\n },\n };\n } else if (value > pairs[pairs.length - 1].value) {\n return {\n lower: {\n value: pairs[pairs.length - 1].value,\n color: pairs[pairs.length - 1].color,\n },\n upper: {\n value: Infinity,\n color: pairs[pairs.length - 1].color,\n },\n };\n } else {\n for (let i = 0; i < pairs.length - 1; i++) {\n if (value >= pairs[i].value && value < pairs[i + 1].value) {\n return {\n lower: {\n value: pairs[i].value,\n color: pairs[i].color,\n },\n upper: {\n value: pairs[i + 1].value,\n color: pairs[i + 1].color,\n },\n };\n }\n }\n\n return {\n lower: {\n value: -Infinity,\n color: pairs[0].color,\n },\n upper: {\n value: Infinity,\n color: pairs[pairs.length - 1].color,\n },\n };\n }\n }\n\n /**\n * Map the percentage value to r,g,b values using a log scale, i.e instead of taking the ratio linearly by taking differences\n * between the lower and upper color r,g,b values, take the differences between their Math.log values. This makes the color\n * scale up to the upper value much quicker, i.e in a 0-100 mapping a value of 20 doesn't map to 1/5 way between two colors\n * but closer to half way. This is done because high numbers in alteration values are extremely rare and even small numbers\n * are usually significant.\n */\n function getMappedColor(\n lowerColor: Color,\n upperColor: Color,\n lowerValue: number,\n upperValue: number,\n percent: number\n ): Color {\n const up = Math.log(1 + upperValue);\n const low = Math.log(1 + lowerValue);\n const p = Math.log(1 + (percent >= 0 ? percent : percent * -1));\n\n // arbitrary value used to slow down the scaling of log instead of getting too much into math\n const scalingFactor = percent >= 0 ? 0.8 : 1.2;\n\n const ratio = ((p - low) / (up - low)) * scalingFactor;\n\n return {\n r: lowerColor.r + ratio * (upperColor.r - lowerColor.r),\n g: lowerColor.g + ratio * (upperColor.g - lowerColor.g),\n b: lowerColor.b + ratio * (upperColor.b - lowerColor.b),\n };\n }\n\n function genomicDataRectangleGenerator(\n x,\n y,\n w,\n h,\n percent,\n parentSVG,\n colorScheme\n ) {\n const limits = findValueColorInterval(colorScheme, Number(percent));\n let color: Color = { r: 255, g: 255, b: 255 };\n if (limits.lower.value === -Infinity) {\n color = limits.upper.color;\n } else if (limits.upper.value === Infinity) {\n color = limits.lower.color;\n } else {\n let upperValue = limits.upper.value;\n let lowerValue = limits.lower.value;\n let upperColor = limits.upper.color;\n let lowerColor = limits.lower.color;\n\n if (lowerValue < 0 && upperValue <= 0) {\n lowerValue *= -1;\n upperValue *= -1;\n swap(lowerValue, upperValue);\n } else if (lowerValue < 0 && upperValue > 0) {\n upperValue += lowerValue * -1;\n lowerValue = 0;\n }\n\n color = getMappedColor(\n lowerColor,\n upperColor,\n lowerValue,\n upperValue,\n Number(percent)\n );\n }\n\n let colorString = \"\";\n if (percent) {\n colorString = `rgb(${Math.round(color.r)}, ${Math.round(\n color.g\n )}, ${Math.round(color.b)})`;\n // Rectangle Part\n const overlayRect = document.createElementNS(svgNameSpace, \"rect\");\n overlayRect.setAttribute(\"x\", x);\n overlayRect.setAttribute(\"y\", y);\n overlayRect.setAttribute(\"width\", w);\n overlayRect.setAttribute(\"height\", h);\n overlayRect.setAttribute(\n \"style\",\n \"stroke-width:1;stroke:rgb(0,0,0);opacity:1;fill:\" + colorString + \";\"\n );\n\n // Text Part\n if (percent[0] === \"-\") {\n percent = percent.substr(1);\n }\n const textPercent =\n percent < 0.5 && percent > 0 ? \"<0.5\" : Number(percent).toFixed(1);\n const text = percent == -101 ? \"N/P\" : textPercent + \"%\";\n const fontSize = 14;\n const textLength = text.length;\n const xOffset = w / 2 - textLength * 4;\n const yOffset = fontSize / 3;\n\n const svgText = document.createElementNS(svgNameSpace, \"text\");\n svgText.setAttribute(\"x\", x + xOffset);\n svgText.setAttribute(\"y\", y + h / 2 + yOffset);\n svgText.setAttribute(\"font-family\", \"Arial\");\n svgText.setAttribute(\"font-size\", fontSize + \"\");\n svgText.innerHTML = text;\n\n parentSVG.appendChild(overlayRect);\n parentSVG.appendChild(svgText);\n } else {\n colorString = \"rgb(210,210,210)\";\n\n // Rectangle Part\n const overlayRect = document.createElementNS(svgNameSpace, \"rect\");\n overlayRect.setAttribute(\"x\", x);\n overlayRect.setAttribute(\"y\", y);\n overlayRect.setAttribute(\"width\", w);\n overlayRect.setAttribute(\"height\", h);\n overlayRect.setAttribute(\n \"style\",\n \"stroke-width:1;stroke:rgb(0,0,0);opacity:1;fill:\" + colorString + \";\"\n );\n\n parentSVG.appendChild(overlayRect);\n }\n }\n\n return svg;\n }\n\n // Just an utility function to calculate required width for genes for genomic data !\n getRequiredWidthForGenomicData(genomicDataBoxCount) {\n const term = genomicDataBoxCount > 3 ? genomicDataBoxCount - 3 : 0;\n return 150 + term * 35;\n }\n\n updateColorScheme(colorValueMap: IColorValueMap) {\n this.colorScheme = colorValueMap;\n }\n\n showGenomicData() {\n const self = this;\n\n const genomicDataBoxCount = this.countVisibleGenomicDataByType();\n\n if (genomicDataBoxCount < 1) {\n // Hide all genomic data and return\n this.hideGenomicData();\n return;\n }\n\n this.cy.nodes('[type=\"GENE\"]').forEach(node => {\n node.data('w', this.getRequiredWidthForGenomicData(genomicDataBoxCount));\n });\n\n this.cy\n .style()\n .selector('node[type=\"GENE\"]')\n .style(\"text-margin-y\", function(ele) {\n const nodeLabel = ele.data(\"name\");\n // If there is no genomic data for this node return !\n if (!(nodeLabel in self.genomicDataMap)) {\n return 0;\n }\n\n // Else shift label in Y axis\n return -15;\n })\n .style(\"background-image\", function(ele) {\n const x = encodeURIComponent(self.generateSVGForNode(ele).outerHTML);\n if (x === \"undefined\") {\n return \"none\";\n }\n const dataURI = \"data:image/svg+xml;utf8,\" + x;\n return dataURI;\n })\n .update();\n }\n\n parseGenomicData(genomicData, groupID) {\n this.genomicDataMap = this.genomicDataMap || {};\n this.visibleGenomicDataMapByType = this.visibleGenomicDataMapByType || {};\n this.groupedGenomicDataMap = this.groupedGenomicDataMap || {};\n const cancerTypes = [];\n\n // By lines\n const lines = genomicData.split(\"\\n\");\n // First line is meta data !\n const metaLineColumns = lines[0].split(\"\\t\");\n\n // Parse cancer types\n for (let i = 1; i < metaLineColumns.length; i++) {\n cancerTypes.push(metaLineColumns[i]);\n const visibleGenomicDataCount = Object.keys(this.visibleGenomicDataMapByType).length;\n // Update initially visible genomic data boxes !\n if (visibleGenomicDataCount < this.DEFAULT_VISIBLE_GENOMIC_DATA_COUNT) {\n this.visibleGenomicDataMapByType[cancerTypes[i - 1]] = true;\n } else {\n this.visibleGenomicDataMapByType[cancerTypes[i - 1]] = false;\n }\n\n if (this.groupedGenomicDataMap[groupID] === undefined) {\n this.groupedGenomicDataMap[groupID] = [];\n }\n this.groupedGenomicDataMap[groupID].push(cancerTypes[i - 1]);\n }\n\n // parse genomic data\n for (let i = 1; i < lines.length; i++) {\n // EOF check\n if (lines[i].length === 0) {\n break;\n }\n\n // Split each line by tab and parse genomic data content\n const lineContent = lines[i].split(\"\\t\");\n const geneSymbol = lineContent[0];\n\n // If current gene entry is not in genomic data map create new map\n if (!(geneSymbol in this.genomicDataMap)) {\n this.genomicDataMap[geneSymbol] = {};\n }\n\n // Add each entry of genomic data\n for (let j = 1; j < lineContent.length; j++) {\n this.genomicDataMap[geneSymbol][cancerTypes[j - 1]] = lineContent[j];\n }\n }\n }\n\n // Simple observer-observable pattern for views!!!!!\n registerObserver(observer) {\n this.observers.push(observer);\n }\n\n notifyObservers() {\n for (const observer of this.observers) {\n observer.notify();\n }\n }\n\n //This method is needed to calculate the alteration Types for each gene\n getAlterationCountForPatient(geneData) {\n let count = 0;\n for (let altType in geneData) {\n count++;\n }\n return count;\n }\n\n //These methods are created to be used in CbioPortal PatientView they are not used\n //in ResultView Page or PathwayMapper Editor\n\n showPatientData() {\n const self = this;\n\n const data = this.patientData;\n\n // const genomicDataBoxCount = 3 //this.countVisibleGenomicDataByType(); //CHANGE\n const genomicDataBoxCount = data.geneticTrackData\n ? data.geneticTrackData.length\n : 3;\n if (genomicDataBoxCount < 1) {\n // Hide all genomic data and return\n this.hideGenomicData();\n return;\n }\n\n this.cy\n .style()\n .selector('node[type=\"GENE\"]')\n // It used to change the width of nodes only locally\n .style(\"width\", (ele) => {\n return this.getRequiredWidthForGenomicData(genomicDataBoxCount);\n })\n .style(\"text-margin-y\", function(ele) {\n const nodeLabel = ele.data(\"name\");\n\n // If there is no genomic data for this node return !\n if (!(nodeLabel in data)) {\n return 0;\n }\n\n // Else shift label in Y axis\n return -15;\n })\n .style(\"background-image\", function(ele) {\n const x = encodeURIComponent(\n // self.generateSVGForPatientNode(ele, data).outerHTML\n self.generateOncoprintForPatientNode(ele).outerHTML\n );\n if (x === \"undefined\") {\n return \"none\";\n }\n const dataURI = \"data:image/svg+xml;utf8,\" + x;\n return dataURI;\n })\n .update();\n\n this.cy.on(\"mouseover\", 'node[type=\"GENE\"]', function(event) {\n const node = event.target || event.cyTarget;\n const nodeLabel = node.data(\"name\");\n if (!data[nodeLabel]) {\n return;\n }\n\n let ref = node.popperRef();\n let dummyDomEle = document.createElement(\"div\");\n document.body.appendChild(dummyDomEle);\n\n let tip = tippy(dummyDomEle, {\n // tippy props:\n getReferenceClientRect: ref.getBoundingClientRect, // https://atomiks.github.io/tippyjs/v6/all-props/#getreferenceclientrect\n trigger: \"manual\", // mandatory, we cause the tippy to show programmatically.\n placement: \"bottom\",\n interactive: true,\n theme: \"cbioportal\",\n // your own custom props\n // content prop can be used when the target is a single element https://atomiks.github.io/tippyjs/v6/constructor/#prop\n content: () => {\n let content = self\n .generateHTMLContentForNodeTooltip(node, data)\n .get(0);\n\n return content;\n },\n onHidden(instance) {\n instance.destroy();\n dummyDomEle.remove();\n },\n });\n\n node.one(\"showqtipevent\", function() {\n tip.show();\n });\n\n node.on(\"mouseout\", function() {\n if (dummyDomEle && dummyDomEle[\"_tippy\"]) {\n tip.hide();\n }\n });\n\n node.trigger(\"showqtipevent\");\n });\n }\n\n //Every mutation type has a unique color coded. This method is used to retrieve the colors\n getOncoprintColors(selectedGene) {\n const oncoprintColors = {\n Missense_Mutation: \"rgb(0,128,0)\",\n inframe: \"#993404\",\n truncating: \"#000000\",\n Fusion: \"rgb(139,0,201)\",\n AMP: \"rgb(255,0,0)\",\n gain: \"#ffb6c1\",\n heatloss: \"#8fd8d8\",\n homdel: \"rgb(0,0,255)\",\n DeepDel: \"rgb(0,0,255)\",\n \"5'Flank\": \"rgb(207,88,188)\",\n in_frame_del: \"rgb(166,128,40)\",\n };\n\n if (oncoprintColors[selectedGene] !== undefined) {\n return oncoprintColors[selectedGene];\n } else {\n //Types are not on the list corresponds to black\n return \"rgb(0,0,0)\";\n }\n }\n generateSVGForPatientNode(ele, patientData) {\n //Here we should use the parameter patientData when calculating the expressions\n const genomicDataBoxCount = this.countVisibleGenomicDataByType();\n // Experimental data overlay part !\n const dataURI = \"data:image/svg+xml;utf8,\";\n const svgNameSpace = \"http://www.w3.org/2000/svg\";\n //nodeLabel refers to the nodeLabels in the overlay data\n const nodeLabel = ele.data(\"name\");\n // If there is no genomic data for this node return !\n if (!(nodeLabel in patientData)) {\n return dataURI;\n }\n //this parameter refers to the count of alteration types for each gene\n const alterationBoxCount = this.getAlterationCountForPatient(\n patientData[nodeLabel]\n );\n\n const eleBBox = ele.boundingBox();\n const svg: any = document.createElementNS(svgNameSpace, \"svg\");\n //this parameter is set to 12 since there are 12 different possiblities for types\n const term = alterationBoxCount > 12 ? alterationBoxCount - 12 : 0;\n const reqWidth = 150 + term * 35;\n\n const overlayRecBoxW = reqWidth - 10;\n const overlayRecBoxH = 25;\n\n // It seems this should be set according to the node size !\n svg.setAttribute(\"width\", reqWidth);\n svg.setAttribute(\"height\", eleBBox.h);\n // This is important you need to include this to succesfully render in cytoscape.js!\n svg.setAttribute(\"xmlns\", svgNameSpace);\n\n // Overlay Data Rect\n const overLayRectBBox = {\n w: overlayRecBoxW,\n h: overlayRecBoxH,\n x: reqWidth / 2 - overlayRecBoxW / 2,\n y: eleBBox.h / 2 + overlayRecBoxH / 2 - 18,\n };\n let genomicBoxCounter = 0;\n //required width is calculated for each gene since box count is different for each gene\n for (let j in patientData[nodeLabel]) {\n const genomicAlterationData = patientData[nodeLabel];\n const alterationType = j;\n\n if (!this.visibleGenomicDataMapByType[nodeLabel]) {\n continue;\n }\n //get the color string corresponding to the alterationType\n let colorString = this.getOncoprintColors(alterationType);\n\n if (genomicAlterationData[alterationType] !== undefined) {\n genomicDataRectangleGeneratorPatient(\n overLayRectBBox.x +\n (genomicBoxCounter * overLayRectBBox.w) / alterationBoxCount,\n overLayRectBBox.y,\n overLayRectBBox.w / alterationBoxCount,\n overLayRectBBox.h,\n 100,\n svg,\n alterationType,\n colorString\n );\n } else {\n genomicDataRectangleGeneratorPatient(\n overLayRectBBox.x +\n (genomicBoxCounter * overLayRectBBox.w) / alterationBoxCount,\n overLayRectBBox.y,\n overLayRectBBox.w / alterationBoxCount,\n overLayRectBBox.h,\n null,\n svg,\n \"\",\n null\n );\n }\n\n genomicBoxCounter++;\n }\n //This function differs from genomicRectangleGenerator. genomicDataRectangleGeneratorPatient\n //has an extra parameter text. In patient view alterationTypes of genes are displayed instead of\n //alteration percentage. Hence a text is sent to this method which is alterationType\n function genomicDataRectangleGeneratorPatient(\n x,\n y,\n w,\n h,\n percent,\n parentSVG,\n text,\n colorString\n ) {\n if (percent) {\n const isNegativePercent = percent < 0;\n // Rectangle Part\n const overlayRect = document.createElementNS(svgNameSpace, \"rect\");\n overlayRect.setAttribute(\"x\", x);\n overlayRect.setAttribute(\"y\", y);\n overlayRect.setAttribute(\"width\", w);\n overlayRect.setAttribute(\"height\", h);\n overlayRect.setAttribute(\n \"style\",\n \"stroke-width:1;stroke:rgb(0,0,0);opacity:1;fill:\" + colorString + \";\"\n );\n\n // Text Part\n const fontSize = 14;\n const textLength = 4;\n const xOffset = w / 2 - textLength * 4;\n const yOffset = fontSize / 3;\n\n const svgText = document.createElementNS(svgNameSpace, \"text\");\n if (colorString === \"rgb(0,0,0)\") {\n svgText.setAttribute(\"fill\", \"white\");\n }\n svgText.setAttribute(\"x\", x + xOffset);\n svgText.setAttribute(\"y\", y + h / 2 + yOffset);\n\n svgText.setAttribute(\"font-family\", \"Arial\");\n svgText.setAttribute(\"font-size\", fontSize + \"\");\n\n //first 4 letters of the alterationTypes are used\n svgText.innerHTML = text.substring(0, 4);\n parentSVG.appendChild(overlayRect);\n parentSVG.appendChild(svgText);\n } else {\n //Normally\n colorString = \"rgb(210,210,210)\";\n }\n }\n\n return svg;\n }\n\n generateOncoprintForPatientNode(ele) {\n // const dataURI = 'data:image/svg+xml;utf8,'\n // nodeLabel refers to the nodeLabels in the overlay data\n const patientData = this.patientData;\n const nodeLabel = ele.data(\"name\");\n const genomicData = patientData[nodeLabel];\n\n const svgNameSpace = \"http://www.w3.org/2000/svg\";\n const svgElement: any = document.createElementNS(svgNameSpace, \"svg\");\n\n if (!genomicData) {\n return { outerHTML: \"\" };\n }\n\n const ruleset = new GeneticAlterationRuleSet(\n genomicData.geneticTrackRuleSetParams\n );\n const cellWidth = 6;\n const cellPadding = 3;\n const cellHeight = 23;\n const cellVerticalPadding = 8;\n\n const universalShapes = ruleset.getUniversalShapes(cellWidth, cellHeight);\n\n const specificShapesPerDatum = ruleset.getSpecificShapesForDatum(\n genomicData.geneticTrackData,\n cellWidth,\n cellHeight\n );\n\n const shapesPerDatum = specificShapesPerDatum.map((specificShapes) =>\n universalShapes.concat(specificShapes)\n );\n\n shapesPerDatum.forEach((shapes, index) => {\n const offsetX = index * (cellWidth + cellPadding); // width + padding\n const offsetY = cellVerticalPadding;\n const g = document.createElementNS(svgNameSpace, \"g\");\n shapes.forEach((shape) =>\n g.appendChild(shapeToSvg(shape, offsetX, offsetY))\n );\n svgElement.appendChild(g);\n });\n\n // It seems this should be set according to the node size !\n svgElement.setAttribute(\n \"width\",\n ((cellWidth + cellPadding) * shapesPerDatum.length).toString()\n );\n svgElement.setAttribute(\n \"height\",\n (cellHeight + cellVerticalPadding).toString()\n );\n // This is important you need to include this to succesfully render in cytoscape.js!\n svgElement.setAttribute(\"xmlns\", svgNameSpace);\n\n return svgElement;\n }\n\n // Mapping of alteration type keys to strings\n // See: https://github.com/cBioPortal/cbioportal-frontend/blob/442e108208846255feb1ed5b309218cd44927fb9/src/shared/components/oncoprint/TooltipUtils.ts#L599\n getCNADisplayString(alterationTypeKey: number) {\n const disp_cna: { [integerCN: string]: string } = {\n \"-2\": \"HOMODELETED\",\n \"-1\": \"HETLOSS\",\n \"1\": \"GAIN\",\n \"2\": \"AMPLIFIED\",\n };\n return disp_cna[alterationTypeKey];\n }\n\n generateSvgIconForSample(iconColor: string, iconText: string) {\n var html =\n '' +\n '' +\n '' +\n \"\" +\n '' +\n '' +\n iconText +\n \"\" +\n \"\" +\n \"\";\n\n return html;\n }\n\n generateHTMLContentForNodeTooltip(ele, patientData) {\n const tooltipMaxHeight = \"200px\";\n const tooltipMaxWidth = \"200px\";\n const marginBetweenSamples = \"10px\";\n const sampleIconColorMap = patientData.sampleColors;\n const sampleIndexMap = patientData.sampleIndex;\n\n const nodeLabel = ele.data(\"name\");\n const data = patientData[nodeLabel];\n\n // Outer wrapper for the entire tooltip\n var wrapper = $(\"
\");\n wrapper.css({\n \"max-width\": tooltipMaxWidth,\n \"max-height\": tooltipMaxHeight,\n \"word-wrap\": \"break-word\",\n \"overflow-y\": \"auto\",\n });\n\n data.geneticTrackData.forEach((sample, sampleIndex) => {\n const sampleId = sample.sample;\n const iconColor = sampleIconColorMap[sampleId];\n const iconText = (sampleIndexMap[sampleId] + 1).toString();\n const sampleIconSvgHTML = this.generateSvgIconForSample(\n iconColor,\n iconText\n );\n\n const margin = sampleIndex > 0 ? marginBetweenSamples : \"0px\";\n\n // Inner wrapper for a single sample\n var sampleWrapper = $(\"
\");\n sampleWrapper.css({\n \"margin-top\": margin,\n });\n\n const sampleData = sample.data;\n var mutationInfo = [];\n var cnaInfo = [];\n var fusionInfo = [];\n sampleData.forEach((data) => {\n const geneSymbol = data.gene.hugoGeneSymbol;\n\n if (\n sample.disp_mut &&\n data.proteinChange &&\n data.mutationType !== \"Fusion\"\n ) {\n const proteinChange = data.proteinChange;\n mutationInfo.push({\n gene: geneSymbol,\n proteinChange: proteinChange,\n });\n }\n\n if (sample.disp_cna && data.alteration) {\n const cnaLabelKey = data.alteration;\n const cnaLabel = this.getCNADisplayString(cnaLabelKey);\n cnaInfo.push({\n gene: geneSymbol,\n cnaLabel: cnaLabel,\n });\n }\n\n if (\n sample.disp_fusion &&\n data.proteinChange &&\n data.mutationType === \"Fusion\"\n ) {\n const proteinChange = data.proteinChange;\n fusionInfo.push({\n gene: geneSymbol,\n proteinChange: proteinChange,\n });\n }\n });\n // Prepare HTML for tooltip\n var mutationInfoHTML = mutationInfo.length > 0 ? \"Mutation: \" : \"\";\n var cnaInfoHTML = cnaInfo.length > 0 ? \"CNA: \" : \"\";\n var fusionInfoHTML = fusionInfo.length > 0 ? \"Fusion: \" : \"\";\n\n mutationInfo.forEach((mutation, index) => {\n mutationInfoHTML +=\n \"\" + mutation.gene + \" \" + mutation.proteinChange + \"\";\n if (index !== mutationInfo.length - 1) {\n mutationInfoHTML += \", \";\n } else {\n mutationInfoHTML += \"
\";\n }\n });\n\n cnaInfo.forEach((cna, index) => {\n cnaInfoHTML += \"\" + cna.gene + \" \" + cna.cnaLabel + \"\";\n if (index !== cnaInfo.length - 1) {\n cnaInfoHTML += \", \";\n } else {\n cnaInfoHTML += \"
\";\n }\n });\n\n fusionInfo.forEach((fusion, index) => {\n fusionInfoHTML +=\n \"\" + fusion.gene + \" \" + fusion.proteinChange + \"\";\n if (index !== fusionInfo.length - 1) {\n fusionInfoHTML += \", \";\n } else {\n fusionInfoHTML += \"
\";\n }\n });\n const sampleIdHTML = \" \" + sampleId + \"\" + \"
\";\n sampleWrapper.append(\n $(\n \"
\" +\n sampleIconSvgHTML +\n sampleIdHTML +\n mutationInfoHTML +\n cnaInfoHTML +\n fusionInfoHTML +\n +\"
\"\n )\n );\n wrapper.append(sampleWrapper);\n });\n\n return wrapper;\n }\n}\n","import autobind from \"autobind-decorator\";\nimport { action, makeObservable, observable } from \"mobx\";\nimport LayoutProperties, { ILayoutProperties } from \"../modals/LayoutProperties\";\nimport { IColorValueMap, IProfileMetaData } from \"../ui/react-pathway-mapper\";\nimport CBioPortalAccessor from \"../utils/CBioPortalAccessor\";\nimport SVGExporter from \"../utils/SVGExporter\";\nimport GenomicDataOverlayManager from \"./GenomicDataOverlayManager\";\nimport ShareDBManager from \"./ShareDBManager\";\n\nconst _ = require('lodash');\n\nexport default class EditorActionsManager{\n\n public static defaultLayoutProperties: ILayoutProperties =\n {\n name: 'fcose',\n nodeRepulsion: 4500,\n idealEdgeLength: 50,\n edgeElasticity: 0.45,\n nestingFactor: 0.1,\n gravity: 0.25,\n numIter: 2500,\n tile: true,\n animate: true,\n randomize: false,\n gravityRangeCompound: 1.5,\n // Gravity force (constant) for compounds\n gravityCompound: 1.0,\n // Gravity range (constant)\n gravityRange: 3.8,\n // Amount of vertical space to put between degree zero nodes during tiling (can also be a function)\n tilingPaddingVertical: 10,\n // Amount of horizontal space to put between degree zero nodes during tiling (can also be a function)\n tilingPaddingHorizontal: 10,\n // Initial cooling factor for incremental layout\n initialEnergyOnIncremental: 0.5,\n animationDuration: 2000,\n animationEasing: 'cubic-bezier(0.17,0.72,0.41,0.98)',\n };\n \n public cy: any;\n public genomicDataOverlayManager: GenomicDataOverlayManager;\n public edgeEditing: any;\n public selectedNodeStack: any;\n public layoutProperties: ILayoutProperties;\n \n private FIT_CONSTANT: number;\n private observers: any[];\n private svgExporter: SVGExporter;\n private undoRedoManager: any;\n private isCbioPortal: boolean;\n private isCollaborative: boolean;\n private shareDBManager: ShareDBManager;\n private portalAccessor: CBioPortalAccessor;\n private viewUtilities: any;\n\n @observable\n private profiles: IProfileMetaData[];\n\n @observable\n private genomicDataOverlayColorScheme: IColorValueMap;\n\n private colorSchemeChangeCallback: (IColorValueMap) => void;\n\n constructor(isCollaborative: boolean, shareDBManager: any, cyInst: any, isCBioPortal: boolean,\n undoRedoManager: any, portalAccessor: CBioPortalAccessor, profiles: IProfileMetaData[],\n genomicDataOverlayColorScheme: IColorValueMap, colorSchemeChangeCallback: (IColorValueMap) => void)\n {\n // Set cy instance and set real time manager reference if collaborative mode\n makeObservable(this);\n this.cy = cyInst;\n this.isCollaborative = isCollaborative;\n this.isCbioPortal = isCBioPortal;\n this.profiles = profiles;\n this.genomicDataOverlayColorScheme = genomicDataOverlayColorScheme;\n this.colorSchemeChangeCallback = colorSchemeChangeCallback;\n \n const edgeEditingOptions = {\n bendPositionsFunction: function(ele) {\n return ele.data('bendPointPositions');\n },\n // A function parameter to get control point positions, should return positions of control points\n controlPositionsFunction: function(ele) {\n return ele.data('controlPointPositions');\n },\n // whether the anchor editing operations are undoable (requires cytoscape-undo-redo.js)\n undoable: true,\n // the size of bend shape is obtained by multipling width of edge with this parameter\n anchorShapeSizeFactor: 6,\n // whether to start the plugin in the enabled state\n enabled: !this.isCbioPortal,\n \n handleReconnectEdge: this.isCollaborative ? \n this.reconnectEdge.bind(this) :\n undefined,\n\n enableMultipleAnchorRemovalOption: true\n };\n \n this.edgeEditing = this.cy.edgeEditing(edgeEditingOptions);\n this.portalAccessor = portalAccessor;\n if(this.isCollaborative) {\n this.shareDBManager = shareDBManager;\n }\n\n this.FIT_CONSTANT = 50;\n\n this.layoutProperties = _.clone(EditorActionsManager.defaultLayoutProperties);\n this.observers = [];\n this.genomicDataOverlayManager = new GenomicDataOverlayManager(this.cy);\n this.svgExporter = new SVGExporter(this.edgeEditing, this);\n\n this.selectedNodeStack = {};\n this.undoRedoManager = undoRedoManager;\n this.undoRedoManager.action(\"changePositions\", this.doChangePosition, this.undoChangePosition);\n this.undoRedoManager.action(\"changeNodeSize\", this.doChangeNodeSize, this.undoChangeNodeSize);\n this.undoRedoManager.action(\"changeCompoundSize\", this.doChangeCompoundSize, this.undoChangeCompoundSize);\n this.undoRedoManager.action(\"changeName\", this.doChangename, this.undoChangeName);\n this.undoRedoManager.action(\"hideNode\", this.doHide, this.undoHide);\n this.undoRedoManager.action(\"showAllNodes\", this.doShow, this.undoShow);\n // HighlightOthers is the type of highlight from the menu and by searching, while highlightInvalidGenes is for only invalid genes\n this.undoRedoManager.action(\"highlightInvalidGenes\", this.doHighlightInvalidGenes, this.undoHighlightInvalidGenes);\n this.undoRedoManager.action(\"removeHighlightInvalidGenes\", this.undoHighlightInvalidGenes, this.doHighlightInvalidGenes);\n this.undoRedoManager.action(\"highlightOthers\", this.doHighlight, this.undoHighlight);\n this.undoRedoManager.action(\"removeOtherHighlight\", this.undoHighlight, this.doHighlight);\n\n };\n\n @action.bound\n setProfile(index: number, profile: IProfileMetaData) {\n this.profiles[index] = profile;\n }\n\n @action.bound\n addProfile(profile: IProfileMetaData) {\n this.profiles.push(profile);\n }\n\n @action.bound\n removeProfiles() {\n this.profiles.length = 0;\n }\n\n @action.bound\n setGenomicDataOverlayColorScheme(scheme: IColorValueMap) {\n this.genomicDataOverlayColorScheme = scheme;\n }\n\n @autobind\n setViewUtilities(viewUtilitiesRef: any) {\n this.viewUtilities = viewUtilitiesRef;\n }\n\n getGenomicDataOverlayColorScheme() : IColorValueMap {\n return this.genomicDataOverlayColorScheme;\n }\n\n handleChangePositionByAlignment(movedNodeArr: any)\n {\n if (this.isCollaborative)\n this.shareDBManager.changeElementsPositionByAlignment(movedNodeArr);\n else\n this.undoRedoManager.do(\"changePositions\", movedNodeArr)\n };\n\n /*\n * Undo redo for changing positions of nodes via programatically (node.position)\n * **/\n doChangePosition(movedNodes: any)\n {\n const newMovedNodes = [];\n\n for(let i = 0; i < movedNodes.length; i++)\n {\n const currentNodePosition =\n {\n x: movedNodes[i].node.position().x,\n y: movedNodes[i].node.position().y\n };\n newMovedNodes.push({node: movedNodes[i].node, oldPosition: currentNodePosition, nextPosition: movedNodes[i].nextPosition});\n movedNodes[i].node.position(movedNodes[i].nextPosition);\n }\n\n return newMovedNodes;\n };\n\n undoChangePosition(movedNodes: any)\n {\n var newMovedNodes = [];\n\n for(var i = 0; i < movedNodes.length; i++)\n {\n var currentNodePosition =\n {\n x: movedNodes[i].node.position().x,\n y: movedNodes[i].node.position().y\n };\n newMovedNodes.push({node: movedNodes[i].node, oldPosition: movedNodes[i].oldPosition, nextPosition: currentNodePosition});\n movedNodes[i].node.position(movedNodes[i].oldPosition);\n }\n\n return newMovedNodes;\n };\n\n changeNodePositionsByArrows(selectedNodes: any)\n {\n if (this.isCollaborative)\n this.shareDBManager.changeNodePositionsShareDB(selectedNodes);\n //node-editing extension already deals for the movement in local mode\n };\n\n /*\n * Undo redo for changing size of nodes\n * **/\n doChangeNodeSize (args: any)\n {\n args.ele.data('w', args.newWidth);\n args.ele.data('h', args.newHeight);\n\n return args;\n };\n\n undoChangeNodeSize(args: any)\n {\n args.ele.data('w', args.oldWidth);\n args.ele.data('h', args.oldHeight);\n return args;\n };\n\n /*\n * Undo redo for changing size of compounds\n * **/\n doChangeCompoundSize(args: any)\n {\n args.ele.style('min-width', args.newMinWidth);\n args.ele.style('min-width-bias-left', args.newMinWidthBiasLeft);\n args.ele.style('min-width-bias-right', args.newMinWidthBiasRight);\n args.ele.style('min-height', args.newMinHeight);\n args.ele.style('min-height-bias-top', args.newMinHeightBiasTop);\n args.ele.style('min-height-bias-bottom', args.newMinHeightBiasBottom);\n\n return args;\n };\n\n undoChangeCompoundSize(args: any)\n {\n if (args.oldMinWidth == undefined)\n {\n args.ele.style('min-width', 0);\n args.ele.style('min-width-bias-left', 0);\n args.ele.style('min-width-bias-right', 0);\n\n }\n else {\n args.ele.style('min-width', args.oldMinWidth);\n args.ele.style('min-width-bias-left', args.oldMinWidthBiasLeft);\n args.ele.style('min-width-bias-right', args.oldMinWidthBiasRight);\n }\n if (args.oldMinHeight == undefined)\n {\n args.ele.style('min-height', 0);\n args.ele.style('min-height-bias-top', 0);\n args.ele.style('min-height-bias-bottom', 0);\n }\n else {\n args.ele.style('min-height', args.oldMinHeight);\n args.ele.style('min-height-bias-top', args.oldMinHeightBiasTop);\n args.ele.style('min-height-bias-bottom', args.oldMinHeightBiasBottom);\n }\n\n return args;\n };\n\n changeName(ele: any, newName: any)\n {\n if (this.isCollaborative)\n {\n this.shareDBManager.changeName(ele, newName);\n }\n else\n {\n this.changeNameCy(ele, newName);\n }\n };\n\n changeNameCy(ele: any, newName: any)\n {\n var currentName = ele.data('name');\n var args = {ele: ele, oldName: currentName, newName: newName};\n this.undoRedoManager.do('changeName', args);\n };\n\n /*\n * Undo redo for changing name of nodes\n * **/\n doChangename(args: any)\n {\n\n var currentName = args.ele.data('name');\n var newArgs = {ele: args.ele, newName: args.newName, oldName: currentName};\n args.ele.data('name', args.newName);\n\n return newArgs;\n };\n\n undoChangeName(args: any)\n {\n\n var currentName = args.ele.data('name');\n var newArgs = {ele: args.ele, newName: args.newName, oldName: currentName};\n args.ele.data('name', args.oldName);\n\n return newArgs;\n };\n\n hideSelectedNodes()\n {\n //Hides the selected elements\n var sel = this.cy.nodes(\":selected\");\n var nodesToHide = sel;\n var b = true;\n //Hides the parents if they have no children\n sel.parent().each((parent: any) =>\n {\n b=true;\n parent.children().each(function(ch: any)\n {\n if (!ch.selected())\n {\n if (ch.visible()) b=false;\n }\n }\n );\n if (b) nodesToHide = nodesToHide.add(parent);\n });\n this.cy.elements(\":selected\").unselect();\n if (this.isCollaborative)\n this.shareDBManager.changeVisibility(nodesToHide, true);\n else\n this.undoRedoManager.do('hideNode', nodesToHide);\n };\n\n /*\n * Undo redo for hiding nodes\n * **/\n @autobind\n doHide(args: any)\n {\n this.viewUtilities.hide(args);\n return args;\n };\n\n @autobind\n undoHide(args: any)\n {\n this.viewUtilities.show(args);\n return args;\n };\n\n showAllNodes()\n {\n var hid = this.cy.nodes(\":hidden\");\n if (this.isCollaborative)\n this.shareDBManager.changeVisibility(hid, false);\n else\n this.undoRedoManager.do('showAllNodes', hid);\n };\n\n /*\n * Undo redo for showing all nodes\n * **/\n @autobind\n doShow(args: any)\n {\n this.viewUtilities.show(args);\n return args;\n };\n\n @autobind\n undoShow(args: any)\n {\n this.viewUtilities.hide(args);\n return args;\n };\n\n highlightElementsInitially(invalidHighlightedGenesIDs: string[], invalidGenesIDs: string[],\n highlightedGenesIDs: string[], highlightedEdgesIDs: string[], hiddenGenesIDs: string[])\n {\n for (var i in invalidHighlightedGenesIDs)\n {\n this.cy.$('#'+invalidHighlightedGenesIDs[i]).addClass('invalidGeneHighlight');\n }\n for (var i in invalidGenesIDs)\n {\n this.cy.$('#'+invalidGenesIDs[i]).addClass('invalidGene');\n }\n for (var i in highlightedGenesIDs)\n {\n this.cy.$('#'+highlightedGenesIDs[i]).addClass('highlightedNode');\n }\n for (var i in highlightedEdgesIDs)\n {\n this.cy.$('#'+highlightedEdgesIDs[i]).addClass('highlightedEdge');\n }\n for (var i in hiddenGenesIDs)\n {\n this.viewUtilities.hide(this.cy.$('#'+hiddenGenesIDs[i]))\n }\n };\n\n validateGenes()\n {\n var geneSymbols = this.getGeneSymbols();\n this.portalAccessor.validateGenes(geneSymbols, this);\n }\n\n //Get all gene symbols\n getGeneSymbols()\n {\n var geneSymbols: any[] = [];\n this.cy.nodes().forEach( function (gene: any)\n {\n if(gene.data().type === \"GENE\")\n geneSymbols.push(gene.data().name);\n });\n return geneSymbols;\n }\n\n\n highlightInvalidGenes(validGeneSymbols: any)\n {\n if (this.isCollaborative)\n {\n var invalidGenes: any[] = [];\n this.cy.nodes().forEach( function (gene: any)\n {\n if(gene.data().type === \"GENE\")\n {\n var geneName = gene.data().name;\n if(validGeneSymbols.indexOf(geneName) < 0)\n invalidGenes.push(gene.id());\n }\n });\n this.shareDBManager.changeHighlightInvalidGenes(invalidGenes, true);\n // TODO: Amendment by Ziya\n /*\n if (invalidGenes.length > 0)\n this.notificationManager.createNotification(\"Invalid genes are highlighted\",\"fail\");\n else\n this.notificationManager.createNotification(\"All gene symbols are valid\",\"success\");*/\n }\n else\n {\n var highlightedGenes = this.cy.collection();\n this.cy.nodes().forEach( function (gene: any)\n {\n if(gene.data().type === \"GENE\")\n {\n var geneName = gene.data().name;\n if(validGeneSymbols.indexOf(geneName) < 0)\n highlightedGenes = highlightedGenes.add(gene);\n }\n });\n // TODO: Amendment by Ziya\n /*\n if (highlightedGenes.size() > 0)\n this.notificationManager.createNotification(\"Invalid genes are highlighted\",\"fail\");\n else\n this.notificationManager.createNotification(\"All gene symbols are valid\",\"success\");*/\n\n var nodesToAddInvalidHighlight = this.cy.collection();\n highlightedGenes.forEach(function(ele: any){\n if (!ele.hasClass('invalidGeneHighlight') && !ele.hasClass('invalidGene'))\n nodesToAddInvalidHighlight = nodesToAddInvalidHighlight.union(ele);\n });\n this.undoRedoManager.do('highlightInvalidGenes', nodesToAddInvalidHighlight);\n }\n }\n\n removeInvalidGeneHighlights(actions: any[])\n {\n if (this.isCollaborative)\n {\n var geneIDs: any[] = [];\n this.cy.nodes().forEach( function (gene: any)\n {\n if(gene.data().type === \"GENE\")\n {\n if(gene.hasClass('invalidGeneHighlight') || gene.hasClass('invalidGene'))\n geneIDs.push(gene.id());\n }\n });\n this.shareDBManager.changeHighlightInvalidGenes(geneIDs, false);\n }\n else\n {\n var nodesToRemoveInvalidHighlight = this.cy.collection();\n this.cy.nodes().forEach(function(ele: any){\n if (ele.hasClass('invalidGeneHighlight') || ele.hasClass('invalidGene'))\n nodesToRemoveInvalidHighlight = nodesToRemoveInvalidHighlight.union(ele);\n });\n actions.push({name: \"removeHighlightInvalidGenes\", param: nodesToRemoveInvalidHighlight});\n // this.undoRedoManager.do('removeHighlightInvalidGenes', nodesToRemoveInvalidHighlight);\n }\n }\n\n doHighlightInvalidGenes(args: any)\n {\n args.each(function(n: any)\n {\n if(n.hasClass('highlightedNode'))\n {\n n.removeClass('highlightedNode');\n n.addClass(\"invalidGeneHighlight\");\n }\n else\n n.addClass(\"invalidGene\");\n });\n return args;\n };\n\n undoHighlightInvalidGenes(args: any)\n {\n args.each(function(n: any)\n {\n if(n.hasClass('invalidGeneHighlight'))\n {\n n.removeClass('invalidGeneHighlight');\n n.addClass(\"highlightedNode\");\n }\n else\n n.removeClass(\"invalidGene\");\n });\n return args;\n }\n\n highlightSelected()\n {\n var sel = this.cy.elements(\":selected\");\n sel.unselect();\n var elementsToHighlight = this.cy.collection();\n sel.forEach(function(ele: any){\n if (!ele.hasClass('invalidGeneHighlight') && !ele.hasClass('highlightedNode') && !ele.hasClass('highlightedEdge'))\n elementsToHighlight = elementsToHighlight.union(ele);\n });\n if (this.isCollaborative)\n this.shareDBManager.changeHighlight(elementsToHighlight, true);\n else\n this.undoRedoManager.do('highlightOthers', elementsToHighlight);\n };\n\n highlightNeighbors()\n {\n var sel = this.cy.elements(\":selected\");\n var neighbors = sel.neighborhood();\n neighbors = neighbors.union(sel);\n neighbors.unselect();\n var elementsToHighlight = this.cy.collection();\n neighbors.forEach(function(ele: any){\n if (!ele.hasClass('invalidGeneHighlight') && !ele.hasClass('highlightedNode') && !ele.hasClass('highlightedEdge'))\n elementsToHighlight = elementsToHighlight.union(ele);\n });\n if (this.isCollaborative)\n this.shareDBManager.changeHighlight(elementsToHighlight, true);\n else\n this.undoRedoManager.do('highlightOthers', elementsToHighlight);\n };\n\n highlightBySearch(args: any[])\n {\n if (this.isCollaborative)\n this.shareDBManager.changeHighlight(args, true);\n else\n this.undoRedoManager.do('highlightOthers', args);\n };\n\n removeOtherHighlight(actions: any[])\n {\n var nodesToRemoveHighlight = this.cy.collection();\n //TODO cytoscape selectors may provide more handy functionality instead of iterating over !\n this.cy.elements().forEach(function(ele: any){\n if (ele.hasClass('highlightedNode') || ele.hasClass('highlightedEdge') || ele.hasClass('invalidGeneHighlight'))\n nodesToRemoveHighlight = nodesToRemoveHighlight.add(ele);\n });\n\n if (this.isCollaborative)\n this.shareDBManager.changeHighlight(nodesToRemoveHighlight, false);\n else\n actions.push({name: \"removeOtherHighlight\", param: nodesToRemoveHighlight});\n // this.undoRedoManager.do('removeOtherHighlight', nodesToRemoveHighlight);\n };\n\n /*\n * Undo redo for highlighting of nodes\n * **/\n doHighlight(args: any)\n {\n args.each(function(n: any)\n {\n if (n.isEdge())\n n.addClass(\"highlightedEdge\");\n else\n {\n if(n.hasClass('invalidGene'))\n {\n n.removeClass(\"invalidGene\");\n n.addClass(\"invalidGeneHighlight\");\n }\n else\n n.addClass(\"highlightedNode\");\n }\n });\n return args;\n };\n\n undoHighlight(args: any)\n {\n args.each(function(n: any)\n {\n if (n.isEdge())\n n.removeClass(\"highlightedEdge\");\n else\n {\n if(n.hasClass('invalidGeneHighlight'))\n {\n n.removeClass(\"invalidGeneHighlight\");\n n.addClass(\"invalidGene\");\n }\n else\n n.removeClass(\"highlightedNode\");\n }\n });\n return args;\n };\n\n removeAllHighlight()\n {\n let actions: any[] = [];\n this.removeInvalidGeneHighlights(actions);\n this.removeOtherHighlight(actions);\n this.cy.undoRedo().do(\"batch\", actions);\n };\n\n postLayout()\n {\n if (this.isCollaborative)\n {\n //Previously this.cy.nodes() was sent as an argument in moveElements function but it caused a problem when\n // the compound node was moved before the child nodes\n var movedNodes = this.cy.collection();\n var parentNodes = this.cy.collection();\n this.cy.nodes().forEach(function(node: any)\n {\n if (!node.isParent())\n movedNodes = movedNodes.add(node);\n else\n parentNodes = parentNodes.add(node);\n });\n this.moveElements(movedNodes);\n this.moveElements(parentNodes);\n\n var newState = {\n zoomLevel: this.cy.zoom(),\n panLevel: this.cy.pan()\n };\n this.updateGlobalOptions(newState);\n }\n };\n\n /*\n * Gets the first empty index from the list in cloud model\n * **/\n getEmptyGroupID()\n {\n if(this.isCollaborative)\n return this.shareDBManager.getEmptyGroupID();\n else\n return this.genomicDataOverlayManager.getEmptyGroupID();\n };\n\n /*\n * Gets the first empty index from the list in cloud model\n * **/\n groupGenomicData(cancerNames: any[], groupID: string)\n {\n return this.shareDBManager.groupGenomicData(cancerNames, groupID);\n };\n\n addPubmedIDs(edge: any, pubmedIDs: number[])\n {\n if (this.isCollaborative)\n {\n this.shareDBManager.addPubmedIDs(edge.id(), pubmedIDs);\n }\n else\n {\n var pubmedArray = edge.data('pubmedIDs');\n var validPubmedIDs = _.filter(pubmedIDs, function(id: number){\n return !isNaN(id);\n });\n pubmedArray.push.apply(pubmedArray,validPubmedIDs);\n edge.data('pubmedIDs', _.uniq(pubmedArray));\n }\n }\n\n removePubmedID(edge: any, pubmedIDs: number[])\n {\n if (this.isCollaborative)\n {\n this.shareDBManager.removePubmedID(edge.id(), pubmedIDs);\n }\n else\n {\n var pubmedArray = edge.data('pubmedIDs');\n edge.data('pubmedIDs', _.difference(pubmedArray, pubmedIDs));\n }\n }\n\n updateEdgeAnchorPoints(edge: any)\n {\n if (this.isCollaborative)\n {\n var edgeCurveStyle = edge.css('curve-style')\n var numberOfAnchorPoints = 0;\n var anchors = this.edgeEditing.getAnchorsAsArray(edge);\n if (anchors !== undefined)\n numberOfAnchorPoints = anchors.length / 2;\n var anchorPointsArray = [];\n for (var j = 0; j < numberOfAnchorPoints; j++)\n {\n anchorPointsArray.push(\n {\n x: anchors[2*j],\n y: anchors[2*j+1]\n }\n );\n } \n this.shareDBManager.updateEdgeAnchorPoints(edge.id(), anchorPointsArray, edgeCurveStyle);\n }\n }\n\n //Related to order the nodes according to the selection of user\n pushSelectedNodeStack(ele: any)\n {\n this.selectedNodeStack[ele.id()] = ele;\n }\n\n removeElementFromSelectedNodeStack(ele: any)\n {\n var nodeID = ele.id();\n if (nodeID in this.selectedNodeStack)\n delete this.selectedNodeStack[ele.id()];\n }\n\n clearSelectedNodeStack()\n {\n this.selectedNodeStack = {};\n }\n\n exportSVG()\n {\n return this.svgExporter.exportGraph(this.cy.nodes(), this.cy.edges());\n }\n\n //Simple observer-observable pattern for views!!!!!\n registerObserver(observer: any)\n {\n this.observers.push(observer);\n };\n\n notifyObservers()\n {\n for (var i in this.observers)\n {\n var observer = this.observers[i];\n observer.notify();\n }\n };\n\n registerGenomicDataObserver(observer: any)\n {\n this.genomicDataOverlayManager.registerObserver(observer);\n }\n\n updateGenomicDataVisibility(dataMap: any)\n {\n if(this.isCollaborative)\n {\n //TODO compound OP\n // this.shareDBManager.clearGenomicVisData();\n this.shareDBManager.addGenomicVisibilityData(dataMap);\n }\n else\n {\n for (var _key in dataMap)\n {\n this.genomicDataOverlayManager.updateGenomicDataVisibility(_key, dataMap[_key]);\n }\n this.genomicDataOverlayManager.showGenomicData();\n }\n }\n\n updateGenomicDataColorScheme(colorValueMap: IColorValueMap)\n {\n this.setGenomicDataOverlayColorScheme(colorValueMap);\n \n if(this.isCollaborative)\n {\n this.shareDBManager.updateGenomicDataOverlayColorScheme(colorValueMap);\n }\n else\n {\n this.genomicDataOverlayManager.updateColorScheme(colorValueMap);\n this.genomicDataOverlayManager.showGenomicData();\n }\n }\n\n //Global options related functions, zoom etc..\n getGlobalOptions()\n {\n return {\n zoomLevel: this.cy.zoom(),\n panLevel: this.cy.pan()\n };\n }\n\n changeGlobalOptions(op: any)\n {\n var globalOptions = op.li;\n this.cy.zoom(globalOptions.zoomLevel);\n this.cy.pan(globalOptions.panLevel);\n }\n\n updateGlobalOptions(newOptions: any)\n {\n if(this.isCollaborative)\n this.shareDBManager.updateGlobalOptions(newOptions);\n }\n\n //Layout properties related functions\n saveLayoutProperties(newLayoutProps: any)\n {\n if(this.isCollaborative)\n {\n // Call a real time function that updated real time object and\n // its callback (updateLayoutPropertiesCallback) will handle sync of this object\n // across collaborators\n this.shareDBManager.updateLayoutProperties(newLayoutProps);\n }\n else\n {\n this.layoutProperties = _.clone(newLayoutProps);\n }\n };\n\n updateLayoutPropertiesCallback(op: any)\n {\n var newLayoutProps = op.li;\n this.layoutProperties = _.clone(newLayoutProps);\n LayoutProperties.layoutProperties = _.clone(this.layoutProperties);\n //Notify observers to reflect changes on colalborative object to the views\n this.notifyObservers();\n };\n\n performLayout()\n {\n this.undoRedoManager.do(\"layout\", {options: this.layoutProperties, eles: null, zoom: this.cy.zoom(), pan: this.cy.pan()});\n };\n\n //Node Related Functions\n addNode(nodeData: any, posData: any)\n {\n if (this.isCollaborative)\n {\n this.addNewNodeToShareDB(nodeData, posData);\n }\n else\n {\n this.addNodetoCy(nodeData,posData);\n }\n };\n\n addNodes(nodes: any[])\n {\n for (var i in nodes)\n {\n this.addNode(nodes[i].data, nodes[i].position);\n }\n };\n\n addNodesCy(nodes: any[])\n {\n var nodeArr: any[] = [];\n for (var i in nodes)\n {\n var nodeData = nodes[i].data;\n var posData = nodes[i].position;\n\n var newNode =\n {\n group: \"nodes\",\n data: nodeData,\n position: {}\n };\n\n if (nodeData.parent === undefined )\n {\n delete newNode.data.parent;\n }\n\n if (posData)\n {\n newNode.position =\n {\n x: posData.x,\n y: posData.y\n }\n }\n nodeArr[i] = newNode;\n }\n\n this.cy.add(nodeArr);\n this.cy.nodes().updateCompoundBounds();\n\n };\n\n addNodetoCy(nodeData: any, posData: any)\n {\n var newNode =\n {\n group: \"nodes\",\n data: nodeData,\n position: {}\n };\n\n if (nodeData.parent === undefined )\n {\n delete newNode.data.parent;\n }\n\n if (posData)\n {\n newNode.position =\n {\n x: posData.x,\n y: posData.y\n }\n }\n\n //his.cy.add(newNode);\n this.cy.nodes().updateCompoundBounds();\n this.undoRedoManager.do(\"add\", newNode);\n };\n\n shareDBNodeAddRemoveEventCallBack(op: any)\n {\n //Get real time node object and sync it to node addition or removal\n var isRemove = Object.keys(op)[1] === 'od';\n var node = op.oi || op.od;\n //Removal Operation\n if (isRemove)\n {\n var nodeID = op.p[1];\n //Remove element from existing graph\n var cyEle = this.cy.$(\"#\" + nodeID);\n this.removeElementCy(cyEle);\n this.cy.nodes().updateCompoundBounds();\n }\n //Addition Operation\n else\n {\n this.addNewNodeLocally(node);\n }\n };\n\n addNewNodeLocally(realtimeNode: any)\n {\n var nodeData =\n {\n id: realtimeNode.id,\n type: realtimeNode.type,\n name: realtimeNode.name,\n parent: realtimeNode.parent,\n w: realtimeNode.w,\n h: realtimeNode.h\n };\n\n if (realtimeNode.x != \"undefined\" && realtimeNode.y != \"undefined\")\n {\n this.addNodetoCy(nodeData, {x: realtimeNode.x, y: realtimeNode.y});\n }\n else\n {\n // TODO: Amendment by Ziya\n this.addNodetoCy(nodeData, null);\n }\n\n this.cy.nodes().updateCompoundBounds();\n };\n\n addNewNodeToShareDB(nodeData: any, posData: any)\n {\n this.shareDBManager.addNewNode(nodeData,posData);\n };\n\n //Edge related functions\n addEdge(edgeData: any)\n {\n if (this.isCollaborative)\n {\n this.addNewEdgeShareDB(edgeData);\n }\n else\n {\n this.addNewEdgetoCy(edgeData);\n }\n };\n\n addEdges(edges: any[])\n {\n for (var i in edges)\n {\n this.addEdge(edges[i].data);\n }\n };\n\n addEdgesCy(edges: any[])\n {\n const newEdges = [];\n\n\n for (var i in edges)\n {\n const newEdge =\n {\n group: \"edges\",\n data: edges[i].data\n };\n newEdges.push(newEdge);\n }\n this.cy.add(newEdges);\n };\n\n addNewEdgeShareDB(edgeData: any)\n {\n this.shareDBManager.addNewEdge(edgeData);\n };\n\n addNewEdgetoCy(edgeData: any)\n {\n var newEdge =\n {\n group: \"edges\",\n data: edgeData\n };\n this.undoRedoManager.do(\"add\", newEdge);\n };\n\n shareDBEdgeAddRemoveEventCallBack(op: any)\n {\n\n //Get real time node object and sync it to node addition or removal\n var isRemove = Object.keys(op)[1] === 'od';\n var edge = op.oi || op.od;\n\n //Removal Operation\n if (isRemove)\n {\n var edgeID = op.p[1];\n //Remove element from existing graph\n var cyEle = this.cy.$(\"#\" + edgeID);\n this.removeElementCy(cyEle);\n }\n //Addition Operation\n else\n {\n this.addNewEdgeLocally(edge);\n }\n };\n\n addNewElementsLocally(realTimeNodeArray: any[], realTimeEdgeArray: any[])\n {\n const nodeList: any[] = [];\n const nodeMap: any = {};\n\n for (var i in realTimeNodeArray)\n {\n var realTimeNode = realTimeNodeArray[i];\n\n var nodeID = realTimeNode.id;\n\n //Added for backward compatibility when width was not defined\n var nodeWidth = (realTimeNode.w == undefined) ? 150 : realTimeNode.w ;\n var nodeHeight = (realTimeNode.h == undefined) ? 52 : realTimeNode.h ;\n var compoundMinWidth = (realTimeNode.minWidth == undefined) ? 0 : realTimeNode.minWidth ;\n var compoundMinWidthBiasLeft = (realTimeNode.minWidthBiasLeft == undefined) ? 0 : realTimeNode.minWidthBiasLeft ;\n var compoundMinWidthBiasRight = (realTimeNode.minWidthBiasRight == undefined) ? 0 : realTimeNode.minWidthBiasRight ;\n var compoundMinHeight = (realTimeNode.minHeight == undefined) ? 0 : realTimeNode.minHeight ;\n var compoundMinHeightBiasTop = (realTimeNode.minHeightBiasTop == undefined) ? 0 : realTimeNode.minHeightBiasTop ;\n var compoundMinHeightBiasBottom = (realTimeNode.minHeightBiasBottom == undefined) ? 0 : realTimeNode.minHeightBiasBottom;\n\n const nodeData =\n {\n group: 'nodes',\n // TODO: Amendment by Ziya\n position: {},\n data:\n {\n id: nodeID,\n type: realTimeNode.type,\n name: realTimeNode.name,\n parent: realTimeNode.parent,\n w: nodeWidth,\n h: nodeHeight\n },\n style:\n {\n 'min-width': compoundMinWidth,\n 'min-width-bias-left': compoundMinWidthBiasLeft,\n 'min-width-bias-right': compoundMinWidthBiasRight,\n 'min-height': compoundMinHeight,\n 'min-height-bias-top': compoundMinHeightBiasTop,\n 'min-height-bias-bottom': compoundMinHeightBiasBottom\n }\n };\n\n if (nodeData.data.parent === undefined )\n {\n delete nodeData.data.parent;\n }\n\n if (realTimeNode.x && realTimeNode.y)\n {\n nodeData.position =\n {\n x: realTimeNode.x,\n y: realTimeNode.y\n }\n }\n\n nodeMap[nodeID] = nodeData;\n nodeList.push(nodeData);\n }\n\n var edgeList = [];\n for (var i in realTimeEdgeArray)\n {\n var edge = realTimeEdgeArray[i];\n var edgeID = edge.id;\n\n //If source and and target is somehow lost in remote model do not create this edge\n if(!(edge.source in nodeMap && edge.target in nodeMap))\n continue\n\n var tmpData = {\n id: edgeID,\n type: edge.type,\n source: edge.source,\n target: edge.target,\n pubmedIDs: edge.pubmedIDs,\n name: edge.name,\n }\n\n if (edge.edgeCurveStyle == \"unbundled-bezier\") {\n tmpData['controlPointPositions'] = edge.anchorPoints;\n }\n else {\n tmpData['bendPointPositions'] = edge.anchorPoints;\n }\n\n var edgeData =\n {\n group: 'edges',\n data: tmpData\n };\n\n edgeList.push(edgeData);\n }\n\n this.cy.add(nodeList);\n this.cy.add(edgeList);\n\n this.edgeEditing.initAnchorPoints(this.cy.edges());\n\n this.cy.nodes().updateCompoundBounds();\n }\n\n addNewEdgeLocally(edge: any)\n {\n var edgeData ={\n id: edge.id,\n type: edge.type,\n source: edge.source,\n target: edge.target,\n pubmedIDs: edge.pubmedIDs,\n name: edge.name\n };\n if (edge.edgeCurveStyle == \"unbundled-bezier\") {\n edgeData['controlPointPositions'] = edge.anchorPoints;\n }\n else {\n edgeData['bendPointPositions'] = edge.anchorPoints;\n }\n this.addNewEdgetoCy(edgeData);\n this.edgeEditing.initAnchorPoints(this.cy.getElementById( edge.id ));\n };\n\n reconnectEdge(sourceID: string, targetID: string, edgeData: any) {\n\n if(this.isCollaborative){\n var edge = this.cy.getElementById(edgeData.id);\n this.reconnectEdgeInShareDB(sourceID, targetID, edgeData);\n }\n else{\n var location = {\n source: sourceID,\n target: targetID\n };\n\n var edge = this.cy.getElementById(edgeData.id);\n edge.move(location);\n }\n\n return this.cy.getElementById(edgeData.id);\n };\n\n reconnectEdgeInShareDB(sourceID: string, targetID: string, edgeData: any) {\n this.shareDBManager.reconnectEdge(sourceID, targetID, edgeData);\n };\n\n //Removal functions\n removeElement(ele: any)\n {\n if (this.isCollaborative)\n {\n this.removeElementsFromShareDB(ele);\n }\n else\n {\n this.removeElementsCy(ele);\n }\n };\n\n removeElementCy(ele: any)\n {\n this.undoRedoManager.do(\"remove\", ele);\n };\n\n removeElementsCy(ele: any)\n {\n this.undoRedoManager.do(\"remove\", ele);\n };\n\n removeElementsFromShareDB(eles: any[])\n {\n var self = this;\n eles.forEach(function (ele)\n {\n self.shareDBManager.removeElement(ele.id());\n });\n };\n\n removeElementFromShareDB(ele: any)\n {\n this.shareDBManager.removeElement(ele.id());\n };\n\n changeParents(eles: any[], newParentId: string)\n {\n if(this.isCollaborative)\n {\n this.changeParentShareDB(eles, newParentId);\n }\n else\n {\n var parentData = newParentId ? newParentId : null;\n\n // Old manual way to change parents in local mode\n //this.changeParentCy(eles, newParentId);\n\n //Save element's previous width & height in dim array\n const dim : any[]= [];\n const id : any[]= [];\n eles.forEach(function (ele: any)\n {\n var parameters =\n {\n id: ele.id(),\n width: ele.data(\"w\"),\n height: ele.data(\"h\")\n };\n dim.push(parameters);\n id.push(ele.id());\n });\n\n const parentElem = this.cy.getElementById(parentData);\n var param = {\n firstTime: true,\n parentData: parentData, // It keeps the newParentId (Just an id for each nodes for the first time)\n nodes: eles,\n posDiffX: (!parentData) ? 0 : parentElem.position('x') - eles[0].position('x'),\n posDiffY: (!parentData) ? 0 : parentElem.position('y') - eles[0].position('y')\n };\n this.undoRedoManager.do('changeParent', param);\n\n //The elements after change parent operation are different so we find them by using the saved ids\n // and add them to the collection\n var collection = this.cy.collection();\n for (var i in id)\n {\n var elementById = this.cy.getElementById(id[i]);\n collection = collection.add(elementById);\n }\n //Set their previous size to the new elements in the collection\n collection.forEach(function (ele: any, i: number)\n {\n if (ele.id() == dim[i].id)\n ele.data(\"w\", dim[i].width);\n ele.data(\"h\", dim[i].height);\n });\n }\n };\n\n changeParentShareDB (eles: any, newParentId: string)\n {\n\n var classRef = this;\n function getTopLevelParents(eles: any[])\n {\n var tpMostNodes = classRef.cy.collection();\n const parentMap : any = {};\n\n //Get all parents\n eles.forEach(function (node)\n {\n if(node.isParent())\n parentMap[node.id()] = node;\n });\n\n //Get all parents\n eles.forEach(function (node)\n {\n var nodeParent = node.parent();\n\n if(parentMap[nodeParent.id()] === undefined)\n tpMostNodes = tpMostNodes.union(node);\n });\n\n return tpMostNodes;\n }\n\n\n class NodeObj{\n public nodeRef: any;\n public children: any;\n constructor(nodeObj: any){\n this.nodeRef = nodeObj;\n this.children = [];\n }\n }\n var connectedEdges = eles.connectedEdges();\n // Traverses given elements and constructs subgraph relations\n // creates a nested structure into rootnodeObj\n function traverseNodes(eles: any[], rootNodeObj: any)\n {\n eles.forEach(function (ele)\n {\n connectedEdges = connectedEdges.union(ele.connectedEdges());\n\n if(ele.isParent())\n {\n rootNodeObj.children.push(new NodeObj(ele));\n var lengthOfChildrenArray = rootNodeObj.children.length;\n traverseNodes(ele.children(), rootNodeObj.children[lengthOfChildrenArray-1]);\n }\n else\n {\n rootNodeObj.children.push(new NodeObj(ele));\n }\n });\n }\n\n //Create new collection\n var topMostNodes = getTopLevelParents(eles);\n\n var rootNodeR = new NodeObj(null);\n\n traverseNodes(topMostNodes, rootNodeR);\n this.shareDBManager.changeParent(rootNodeR, newParentId, connectedEdges);\n };\n\n changeParentCy(eles: any[], newParentId: string)\n {\n let lockedNodes: any = {};\n const self = this;\n\n function removeNodes(nodes: any)\n {\n //Get removed edges first\n let removedEles = nodes.connectedEdges().remove();\n const children = nodes.children();\n\n if (children != null && children.length > 0)\n {\n children.forEach(function(childNode: any)\n {\n lockedNodes[childNode.id()] = true;\n });\n\n removedEles = removedEles.union(removeNodes(children));\n }\n\n removedEles = removedEles.union(nodes.remove());\n self.cy.nodes().updateCompoundBounds();\n return removedEles;\n }\n\n\n var removedEles = removeNodes(eles);\n this.undoRedoManager.do(\"remove\", removedEles);\n\n for (var i = 0; i < removedEles.length; i++)\n {\n var removedNode = removedEles[i];\n\n //Just alter the parent id of corresponding nodes !\n if (removedNode.isEdge() || lockedNodes[removedNode.id()])\n {\n continue;\n }\n\n removedNode._private.data.parent = newParentId;\n if(removedNode._private.parent){\n delete removedNode._private.parent;\n }\n }\n\n self.cy.add(removedEles);\n this.undoRedoManager.do(\"add\", removedEles);\n self.cy.nodes().updateCompoundBounds();\n };\n\n moveElements(eles: any[])\n {\n var classRef = this;\n //Sync movement to real time api\n if(this.isCollaborative)\n {\n eles.forEach(function (ele: any)\n {\n classRef.shareDBManager.moveElement(ele);\n });\n }\n };\n\n resizeElements(ele: any)\n {\n if(this.isCollaborative) {\n if (!ele.isParent()) {\n var previousWidth = ele.width();\n var previousHeight = ele.height();\n //Sync movement to real time api\n this.shareDBManager.resizeElement(ele, previousWidth, previousHeight);\n }\n else {\n var minWidth = ele.style('min-width');\n var minWidthBiasLeft = ele.style('min-width-bias-left');\n var minWidthBiasRight = ele.style('min-width-bias-right');\n var minHeight = ele.style('min-height');\n var minHeightBiasTop = ele.style('min-height-bias-top');\n var minHeightBiasBottom = ele.style('min-height-bias-bottom');\n\n //Sync movement to real time api\n this.shareDBManager.resizeCompound(ele, minWidth, minWidthBiasLeft, minWidthBiasRight, minHeight, minHeightBiasTop, minHeightBiasBottom);\n }\n }\n };\n\n mergeGraph(nodes: any[], edges: any[])\n {\n if (this.isCollaborative)\n {\n //Collaborative usage\n this.shareDBManager.mergeGraph(nodes,edges);\n }\n else\n {\n //Local usage file load\n this.mergeGraphCy(nodes,edges);\n }\n this.fitGraph();\n };\n\n mergeGraphCy(nodes: any[], edges: any[])\n {\n //Define arrays and maps\n const nodesToBeAdded = [];\n const edgesToBeAdded = [];\n const nodeMap : any= {};\n\n //Iterate over nodes and find nodes that does not exist in current graph by looking their name\n for (var index in nodes)\n {\n var ele = nodes[index];\n nodeMap[ele.data.id] = ele;\n\n if (this.cy.filter('node[name = \"'+ele.data.name+'\"]').length <= 0)\n {\n nodesToBeAdded.push(ele);\n }\n }\n\n this.cy.add(nodesToBeAdded);\n\n //Iterate over all edges\n for (var index in edges)\n {\n //Get corresponding source and target node in merge file\n var ele = edges[index];\n var sourceNode = nodeMap[ele.data.source];\n var targetNode = nodeMap[ele.data.target];\n\n //Check if there are nodes with same name in current graph\n var cySourceNode = this.cy.nodes('[name=\"'+sourceNode.data.name+'\"]');\n var targetNode = this.cy.nodes('[name=\"'+targetNode.data.name+'\"]');\n\n if (cySourceNode.length > 0)\n {\n ele.data.source = cySourceNode.id();\n }\n\n if (targetNode.length > 0)\n {\n ele.data.target = targetNode.id();\n }\n\n if (targetNode.length < 0 && cySourceNode.length < 0 ) {\n continue;\n }\n\n var edgesBtw = this.cy.filter('edge[source = \"'+cySourceNode.id()+'\"][target = \"'+targetNode.id()+'\"]');\n\n //We assume there could be one edge between source and target node with same type\n var isFound = false;\n edgesBtw.forEach(function(edge: any)\n {\n if (edge.data().type == ele.data.type)\n {\n isFound = true;\n return false;\n }\n //TODO: AMENDMENT by Ziya\n return true;\n });\n\n if (!isFound)\n {\n delete ele.data.id;\n edgesToBeAdded.push(ele);\n }\n }\n\n this.cy.add(edgesToBeAdded);\n };\n\n fitGraph()\n {\n if(this.isCollaborative)\n {\n this.cy.fit(this.FIT_CONSTANT);\n var newState =\n {\n zoomLevel: this.cy.zoom(),\n panLevel: this.cy.pan()\n };\n this.updateGlobalOptions(newState);\n }\n else\n {\n this.cy.fit(this.FIT_CONSTANT);\n }\n }\n\n loadFile(nodes: any[], edges: any[])\n {\n if (this.isCollaborative)\n {\n //Real time load graph\n this.loadfileShareDB(nodes, edges);\n }\n else\n {\n //Local usage file load\n this.loadFileCy(nodes,edges);\n }\n \n this.edgeEditing.initAnchorPoints(this.cy.edges());\n \n this.fitGraph();\n };\n\n loadFileCy(nodes: any[], edges: any[])\n {\n //Remove all elements\n this.removeElementCy(this.cy.elements());\n\n this.addNodesCy(nodes);\n this.addEdgesCy(edges);\n };\n\n loadfileShareDB(nodes: any[], edges: any[])\n {\n this.shareDBManager.loadGraph(nodes,edges);\n };\n\n removeAllElements()\n {\n if (this.isCollaborative)\n {\n this.shareDBManager.removeAllElements();\n }\n else\n {\n this.cy.remove(this.cy.elements());\n }\n };\n\n updateHighlight(ele: any, isHighlighted: boolean)\n {\n if (isHighlighted)\n this.undoRedoManager.do('highlightOthers', ele);\n else\n this.undoRedoManager.do('removeOtherHighlight', ele);\n };\n\n\n @autobind\n updateVisibility(ele: any, isHidden: boolean)\n {\n if (isHidden)\n this.viewUtilities.hide(ele);\n else\n this.viewUtilities.show(ele);\n };\n\n updateElementCallback(op: any)\n {\n var ele = op.oi;\n var eleID = ele.id;\n var cyEle = this.cy.$(\"#\" + eleID);\n this.changeNameCy(cyEle, ele.name);\n\n if (cyEle.isNode())\n {\n //Width and height of simple nodes and compounds is changed differently\n if (cyEle.isParent())\n {\n cyEle.style(\"min-width\", ele.minWidth);\n cyEle.style(\"min-width-bias-left\", ele.minWidthBiasLeft);\n cyEle.style(\"min-width-bias-right\", ele.minWidthBiasRight);\n cyEle.style(\"min-height\", ele.minHeight);\n cyEle.style(\"min-height-bias-top\", ele.minHeightBiasTop);\n cyEle.style(\"min-height-bias-bottom\", ele.minHeightBiasBottom);\n }\n else\n {\n cyEle.data('w', ele.w);\n cyEle.data('h', ele.h);\n //Position is changed only for simple nodes because the\n //position of compounds is defined by simple nodes' position\n cyEle.position({x: ele.x, y: ele.y});\n }\n\n this.updateVisibility(cyEle, ele.isHidden);\n this.updateHighlight(cyEle, ele.isHighlighted);\n\n if(ele.isInvalidGene)\n {\n this.doHighlightInvalidGenes(cyEle);\n }\n else\n {\n this.undoHighlightInvalidGenes(cyEle);\n }\n }\n else if(cyEle.isEdge())\n {\n var pubmedArray = ele.pubmedIDs;\n cyEle.data('pubmedIDs', pubmedArray);\n this.updateHighlight(cyEle, ele.isHighlighted);\n\n var anchorPoints = ele.anchorPoints;\n\n //If edge is reconnected\n if ( ele.source !== cyEle.source().id() || ele.target !== cyEle.target().id()){\n var location = {\n source: ele.source,\n target: ele.target\n };\n cyEle.move(location);\n //make sure that bend points are same\n this.edgeEditing.initAnchorPoints(cyEle);\n }\n else {\n if (ele.edgeCurveStyle === \"bezier\") {\n const anchors = this.edgeEditing.getAnchorsAsArray(cyEle);\n if (anchors && anchors.length > 0) {\n for (let i = 0; i < anchors.length / 2; i++) {\n this.edgeEditing.deleteSelectedAnchor(cyEle, 0);\n }\n }\n }\n else if (ele.edgeCurveStyle === \"unbundled-bezier\") {\n cyEle.data('controlPointPositions', anchorPoints);\n }\n else {\n cyEle.data('bendPointPositions', anchorPoints);\n }\n \n this.edgeEditing.initAnchorPoints(cyEle);\n }\n }\n };\n\n getGenomicDataSVG(node: any)\n {\n // @ts-ignore\n return this.genomicDataOverlayManager.generateSVGForNode(node);\n }\n\n getOncoprintDataSVG(node: any) \n {\n return this.genomicDataOverlayManager.generateOncoprintForPatientNode(node);\n }\n\n removeGenomicData()\n {\n if(this.isCollaborative)\n {\n this.shareDBManager.clearGenomicData();\n }\n else\n {\n // TODO wrap this in afunction in genomic data overlay manager\n this.genomicDataOverlayManager.clearAllGenomicData();\n this.genomicDataOverlayManager.hideGenomicData();\n this.genomicDataOverlayManager.notifyObservers();\n }\n\n }\n\n addGenomicData(genomicData: any)\n {\n const groupID = this.getEmptyGroupID();\n\n if(this.isCollaborative)\n {\n var parsedGenomicData = this.genomicDataOverlayManager.prepareGenomicDataShareDB(genomicData);\n this.shareDBManager.addGenomicData(parsedGenomicData.genomicDataMap);\n this.shareDBManager.groupGenomicData(Object.keys(parsedGenomicData.visibilityMap),\n groupID);\n \n let currentVisibleGenomicDataCount = this.genomicDataOverlayManager.countVisibleGenomicDataByType();\n Object.keys(parsedGenomicData.visibilityMap).forEach(study => {\n if (parsedGenomicData.visibilityMap[study] && (currentVisibleGenomicDataCount >= 6)) {\n parsedGenomicData.visibilityMap[study] = false;\n }\n else if(parsedGenomicData.visibilityMap[study]) {\n currentVisibleGenomicDataCount++;\n }\n });\n\n this.shareDBManager.addGenomicVisibilityData(parsedGenomicData.visibilityMap);\n }\n else\n {\n this.genomicDataOverlayManager.addGenomicDataLocally(genomicData, groupID);\n }\n }\n\n adjustVisibilityShareDB(profileId: string, isEnabled: boolean){\n const targetProfileIndex = this.profiles.map(profile => profile.profileId).indexOf(profileId);\n this.setProfile(targetProfileIndex, {\n ...this.profiles[targetProfileIndex],\n enabled: isEnabled\n }); \n }\n\n addToProfiles(profileId: string){\n // Check if this profile already exists\n if(this.profiles.map(profile => profile.profileId).includes(profileId)){\n return;\n }\n\n this.addProfile({\n profileId: profileId, \n enabled: true\n });\n }\n\n addPortalGenomicData(genomicData: any, groupID: any)\n {\n \n if(this.isCollaborative)\n {\n var parsedGenomicData = this.genomicDataOverlayManager.preparePortalGenomicDataShareDB(genomicData);\n this.shareDBManager.addGenomicData(parsedGenomicData.genomicDataMap);\n this.shareDBManager.groupGenomicData(Object.keys(parsedGenomicData.visibilityMap),\n groupID);\n this.shareDBManager.addGenomicVisibilityData(parsedGenomicData.visibilityMap);\n }\n else\n {\n this.genomicDataOverlayManager.addPortalGenomicData(genomicData, groupID);\n }\n }\n\n shareDBGenomicDataHandler(op: any)\n {\n var isRemove = Object.keys(op)[1] === 'od';\n var newData = op.oi;\n var geneSymbol = op.p[1];\n\n\n if(!isRemove)\n {\n this.genomicDataOverlayManager.addGenomicDataWithGeneSymbol(geneSymbol, newData);\n\n }\n // Removal\n else\n {\n this.genomicDataOverlayManager.removeGenomicDataWithGeneSymbol(geneSymbol);\n }\n }\n\n\n shareDBGenomicDataGroupChangeHandler(op: any)\n {\n\n var isRemove = Object.keys(op)[1] === 'od';\n var data = op.oi;\n var key = op.p[1];\n\n // Addition\n if(!isRemove)\n {\n this.genomicDataOverlayManager.addGenomicGroupData(key, data);\n if(data.length !== 1){\n console.log(\"Grouped genomic data expected to be of length 1\");\n }\n data.forEach((profileId: any) => {this.addToProfiles(profileId)});\n }\n // //Removal\n // else\n // {\n //\n // }\n this.genomicDataOverlayManager.showGenomicData();\n this.genomicDataOverlayManager.notifyObservers();\n }\n\n shareDBGenomicDataVisibilityHandler(op: any)\n {\n var data = op.oi;\n var key = op.p[1];\n var isRemove = Object.keys(op)[1] === 'od';\n // Addition\n if(!isRemove)\n {\n this.genomicDataOverlayManager.addGenomicVisData(key, data);\n\n this.adjustVisibilityShareDB(key, data);\n }\n // Removal\n else\n {\n this.genomicDataOverlayManager.removeGenomicVisData();\n this.removeProfiles();\n }\n\n this.genomicDataOverlayManager.showGenomicData();\n this.genomicDataOverlayManager.notifyObservers();\n }\n\n updateGenomicDataColorSchemeHandler(op: any)\n {\n let colorScheme = op.li;\n \n this.setGenomicDataOverlayColorScheme(colorScheme);\n\n this.colorSchemeChangeCallback(colorScheme);\n \n this.genomicDataOverlayManager.updateColorScheme(colorScheme);\n this.genomicDataOverlayManager.showGenomicData();\n this.genomicDataOverlayManager.notifyObservers();\n }\n\n resizeNodesToContent(nodes: any[])\n {\n if(this.isCollaborative)\n {\n const visibleNumberOfData = this.genomicDataOverlayManager.countVisibleGenomicDataByType();\n const labelWithData = 148 + (visibleNumberOfData-3) * 36;\n const rt = this.shareDBManager;\n nodes.forEach(function( ele ){\n if (!ele.isParent())\n {\n var newWidth = 150;\n var newHeight = 52;\n if (ele.data('name') != \"\")\n {\n var labelLength = ele.style('label').length*10 + 6;\n newWidth = labelLength;\n newHeight = 24;\n }\n if (ele.data('type') !== \"PROCESS\" && visibleNumberOfData > 0)\n {\n newHeight = 52;\n if (visibleNumberOfData < 4)\n {\n if (150 > newWidth)\n newWidth = 150;\n }\n else\n {\n if (labelWithData > newWidth)\n newWidth = labelWithData;\n }\n }\n rt.setSizeOfElement(ele, newWidth, newHeight);\n }\n else\n {\n //Set the minWidth, minHeight and other properties of compound to 0\n rt.resizeCompound(ele, 0, 0, 0, 0, 0, 0);\n }\n });\n }\n else\n {\n const ur = this.cy.undoRedo();\n const actions: any[] = [];\n\n const visibleNumberOfData = this.genomicDataOverlayManager.countVisibleGenomicDataByType();\n const labelWithData = 150 + (visibleNumberOfData-3) * 36;\n nodes.forEach(function( ele: any){\n if (!ele.isParent())\n {\n let newWidth = 150;\n let newHeight = 52;\n if (ele.data('name') != \"\") {\n var labelLength = ele.style('label').length * 6 + 24;\n newWidth = labelLength;\n newHeight = 24;\n }\n if (ele.data('type') !== \"PROCESS\" && \n visibleNumberOfData > 0) {\n \n newHeight = 52;\n if (visibleNumberOfData < 4) {\n if (150 > newWidth)\n newWidth = 150;\n }\n else {\n if (labelWithData > newWidth)\n newWidth = labelWithData;\n }\n }\n const args = {\n ele: ele,\n oldWidth: ele.width(),\n newWidth: newWidth,\n oldHeight: ele.height(),\n newHeight: newHeight\n };\n actions.push({name: \"changeNodeSize\", param: args});\n }\n else\n {\n const args = {\n ele: ele,\n oldMinWidth: ele.style(\"min-width\"),\n newMinWidth: 0,\n oldMinWidthBiasLeft: ele.style(\"min-width-bias-left\"),\n newMinWidthBiasLeft: 0,\n oldMinWidthBiasRight: ele.style(\"min-width-bias-right\"),\n newMinWidthBiasRight: 0,\n oldMinHeight: ele.style(\"min-height\"),\n newMinHeight: 0,\n oldMinHeightBiasTop: ele.style(\"min-height-bias-top\"),\n newMinHeightBiasTop: 0,\n oldMinHeightBiasBottom: ele.style(\"min-height-bias-bottom\"),\n newMinHeightBiasBottom: 0\n };\n actions.push({name: \"changeCompoundSize\", param: args});\n }\n });\n\n ur.do(\"batch\", actions);\n }\n this.cy.nodeEditing('get').refreshGrapples();\n };\n\n\n\n}\n","import _ from \"lodash\";\nimport { action, makeObservable, observable } from \"mobx\";\nimport { observer } from \"mobx-react\";\nimport React from \"react\";\nimport {\n Button,\n Checkbox,\n Col,\n ControlLabel,\n Form,\n FormControl,\n InputGroup,\n Modal\n} from \"react-bootstrap\";\nimport EditorActionsManager from \"../managers/EditorActionsManager\";\nimport { EModalType } from \"../ui/react-pathway-mapper\";\nimport PathwayActions from \"../utils/PathwayActions\";\n\ninterface ILayoutPropertiesProps {\n show: boolean;\n handleClose: (modelId: EModalType) => void;\n pathwayActions: PathwayActions;\n}\n\nexport interface ILayoutProperties {\n name: string;\n animationDuration: number;\n animationEasing: string;\n nodeRepulsion: number;\n idealEdgeLength: number;\n edgeElasticity: number;\n nestingFactor: number;\n gravity: number;\n numIter: number;\n gravityRangeCompound: number;\n gravityCompound: number;\n gravityRange: number;\n tilingPaddingVertical: number;\n tilingPaddingHorizontal: number;\n initialEnergyOnIncremental: number;\n tile: boolean;\n animate: boolean;\n randomize: boolean;\n}\n\n@observer\nexport default class LayoutProperties extends React.Component<\n ILayoutPropertiesProps\n> {\n static layoutProperties: ILayoutProperties;\n\n @observable\n internalLayoutProperties: ILayoutProperties;\n\n constructor(props: ILayoutPropertiesProps) {\n super(props);\n makeObservable(this);\n this.internalLayoutProperties = _.clone(\n EditorActionsManager.defaultLayoutProperties\n );\n LayoutProperties.layoutProperties = _.clone(EditorActionsManager.defaultLayoutProperties);\n }\n\n @action.bound\n updateInternalLayoutProperty(property: string, val: boolean | number) {\n this.internalLayoutProperties[property] = val;\n }\n\n render() {\n\n return (\n {\n this.internalLayoutProperties = _.clone(LayoutProperties.layoutProperties);\n }}\n onHide={() => {\n this.internalLayoutProperties = _.clone(LayoutProperties.layoutProperties);\n this.props.handleClose(EModalType.LAYOUT);\n }}\n >\n \n \n Layout Properties\n \n \n \n
\n \n \n Node Repulsion:\n \n\n \n {\n this.updateInternalLayoutProperty(\"nodeRepulsion\", Number(e.target.value));\n }}\n />\n \n \n \n \n Ideal Edge Length:\n \n\n \n {\n this.updateInternalLayoutProperty(\"idealEdgeLength\", Number(e.target.value));\n }}\n />\n \n \n \n \n Edge Elasticity:\n \n\n \n {\n this.updateInternalLayoutProperty(\"edgeElasticity\", Number(e.target.value));\n }}\n />\n \n \n \n \n Nesting Factor:\n \n\n \n {\n this.updateInternalLayoutProperty(\"nestingFactor\", Number(e.target.value));\n }}\n />\n \n \n \n \n Gravity:\n \n\n \n {\n this.updateInternalLayoutProperty(\"gravity\", Number(e.target.value));\n }}\n />\n \n \n \n \n Gravity Range:\n \n\n \n {\n this.updateInternalLayoutProperty(\"gravityRange\", Number(e.target.value));\n }}\n />\n \n \n \n \n Compound Gravity:\n \n\n \n {\n this.updateInternalLayoutProperty(\"gravityCompound\", Number(e.target.value));\n }}\n />\n \n \n \n \n Compound Gravity Range:\n \n\n \n {\n this.updateInternalLayoutProperty(\"gravityRangeCompound\", Number(e.target.value));\n }}\n />\n \n \n \n \n Number of Iterations:\n \n\n \n {\n this.updateInternalLayoutProperty(\"numIter\", Number(e.target.value));\n }}\n />\n \n \n \n \n Tiling Vertical Padding:\n \n\n \n {\n this.updateInternalLayoutProperty(\"tilingPaddingVertical\", Number(e.target.value));\n }}\n />\n \n \n \n \n Tiling Horizontal Padding:\n \n\n \n {\n this.updateInternalLayoutProperty(\"tilingPaddingHorizontal\", Number(e.target.value));\n }}\n />\n \n \n \n \n Tile Disconnected:\n \n\n \n {\n this.updateInternalLayoutProperty(\"tile\", !this.internalLayoutProperties.tile);\n }}\n >\n \n \n \n \n Animate:\n \n\n \n {\n this.updateInternalLayoutProperty(\"animate\",!this.internalLayoutProperties.animate);\n }}\n >\n \n \n \n \n Incremental:\n \n\n \n {\n this.updateInternalLayoutProperty(\"randomize\", !this.internalLayoutProperties.randomize);\n }}\n >\n \n \n \n \n Incremental Cooling Factor:\n \n\n \n {\n this.updateInternalLayoutProperty(\"initialEnergyOnIncremental\", Number(e.target.value));\n }}\n />\n \n \n
\n
\n\n \n {\n LayoutProperties.layoutProperties = _.clone(this.internalLayoutProperties);\n this.props.pathwayActions.setLayoutProperties(\n LayoutProperties.layoutProperties\n );\n this.props.handleClose(EModalType.LAYOUT);\n }}\n >\n Save\n \n\n {\n this.internalLayoutProperties = _.clone(\n EditorActionsManager.defaultLayoutProperties\n );\n LayoutProperties.layoutProperties = _.clone(this.internalLayoutProperties);\n this.props.pathwayActions.setLayoutProperties(\n this.internalLayoutProperties\n );\n }}\n >\n Default\n \n \n \n );\n }\n}\n","import { observer } from 'mobx-react';\nimport React from 'react';\nimport { Button, Col, ControlLabel, Form, FormControl, InputGroup, Modal } from 'react-bootstrap';\nimport { IPathwayInfo } from '../managers/FileOperationsManager';\nimport { EModalType } from '../ui/react-pathway-mapper';\nimport PathwayActions from '../utils/PathwayActions';\n\ninterface IPathwayDetailsModalProps{\n show: boolean;\n handleClose: Function;\n pathwayActions: PathwayActions;\n}\n\n@observer\nexport default class PathwayDetailsModal extends React.Component{\n\n pathwayInfo: IPathwayInfo;\n\n constructor(props: IPathwayDetailsModalProps){\n super(props);\n }\n\n render(){\n\n this.pathwayInfo = this.props.pathwayActions.getPathwayInfo;\n\n return(\n\n {this.props.handleClose(4)}}>\n \n Pathway Properties\n \n \n
\n\n \n \n Pathway Title:\n \n \n {this.pathwayInfo.pathwayTitle = e.target.value;}}value={this.pathwayInfo.pathwayTitle}/>\n \n \n\n \n \n Pathway Description:\n \n \n \n \n \n\n
\n
\n\n \n \n \n
\n\n )\n\n }\n}","import autobind from \"autobind-decorator\";\nimport { action, makeObservable, observable } from \"mobx\";\nimport { observer } from \"mobx-react\";\nimport React from \"react\";\nimport { Button, Col, Modal, Row } from \"react-bootstrap\";\nimport { EModalType, IColorValueMap } from \"../ui/react-pathway-mapper\";\n\nconst addButtonImg = require(\"../images/add.svg\");\nconst deleteButtonImg = require(\"../images/delete-simple.svg\");\n\ninterface IValueColorObj {\n value: string;\n color: string;\n}\n\ninterface IProfilesColorSchemeModalProps {\n show: boolean;\n handleClose: (modalId: EModalType) => void;\n colorValueMapping: IColorValueMap;\n handleColorMappingChange: (colorMapping: IColorValueMap) => void;\n}\n\n@observer\nexport default class ProfilesColorSchemeModal extends React.Component<\n IProfilesColorSchemeModalProps,\n {}\n> {\n @observable\n colorMappings: IValueColorObj[];\n\n @observable\n showUniqueValuesWarningModal: boolean;\n\n constructor(props: IProfilesColorSchemeModalProps) {\n super(props);\n makeObservable(this);\n this.initColorMappings();\n }\n\n componentDidUpdate(prevProps) {\n if (prevProps.show === false && this.props.show === true) {\n this.initColorMappings();\n }\n }\n\n initColorMappings() {\n this.colorMappings = Object.entries(this.props.colorValueMapping)\n .map(([value, color]) => {\n return {\n value: value,\n color: color,\n };\n })\n .sort((o1, o2) => {\n return Number(o1.value) - Number(o2.value);\n });\n }\n\n @action.bound\n handleColorChange(index: number, color: string) {\n this.colorMappings[index].color = color;\n }\n\n @action.bound\n handleValueChange(index: number, value: string) {\n this.colorMappings[index].value = value;\n }\n\n @action.bound\n addDefaultColorMapping() {\n this.colorMappings.push({ value: \"0\", color: \"#ffffff\" });\n }\n\n @action.bound\n removeColorMapping(index: number) {\n this.colorMappings.splice(index, 1);\n }\n\n @action.bound\n setDefaultColorMapping() {\n this.colorMappings = [\n { value: \"-100\", color: \"#0000ff\" },\n { value: \"0\", color: \"#ffffff\" },\n { value: \"100\", color: \"#ff0000\" },\n ];\n }\n\n @action.bound\n setShowUniqueValuesWarningModal(val: boolean) {\n this.showUniqueValuesWarningModal = val;\n }\n\n @autobind\n handleSaveColorScheme(): boolean {\n const mapping = {};\n this.colorMappings.forEach((pair) => {\n mapping[pair.value] = pair.color;\n });\n\n if (Object.keys(mapping).length < 2) {\n this.setShowUniqueValuesWarningModal(true);\n return false;\n } else {\n this.props.handleColorMappingChange(mapping);\n return true;\n }\n }\n\n @autobind\n close() {\n this.props.handleClose(EModalType.PROFILES_COLOR_SCHEME);\n }\n\n render() {\n const mappingElements = this.colorMappings.map((mapping, index) => (\n \n \n \n {\n const value = event.target.value;\n this.handleValueChange(index, value);\n }}\n >\n \n \n {\n const color = event.target.value;\n this.handleColorChange(index, color);\n }}\n />\n \n \n 2 ? \"icon-enabled\" : \"icon-disabled\")\n }\n title={\"Remove\"}\n onClick={() => {\n this.removeColorMapping(index);\n }}\n >\n \n \n \n ));\n\n return (\n {\n this.close();\n }}\n bsSize=\"small\"\n >\n \n Study Data Overlay Color Scheme\n \n\n \n \n \n \n \n \n \n \n \n \n \n
\n {mappingElements}\n \n\n this.setShowUniqueValuesWarningModal(false)}\n bsSize=\"small\"\n >\n \n \n Warning \n \n \n \n

Please set at least two unique value-color mappings.

\n
\n \n {\n this.setShowUniqueValuesWarningModal(false);\n }}\n >\n OK\n \n \n \n
\n\n \n {\n this.close();\n }}\n >\n Cancel\n \n {\n this.setDefaultColorMapping();\n }}\n >\n Default\n \n {\n const close = this.handleSaveColorScheme();\n if (close) {\n this.close();\n }\n }}\n >\n Save\n \n \n \n );\n }\n}\n","import { action, computed, makeObservable, observable } from \"mobx\";\nimport { observer } from \"mobx-react\";\nimport React from \"react\";\nimport { Button, Modal } from \"react-bootstrap\";\nimport EditorActionsManager from \"../managers/EditorActionsManager\";\nimport { EModalType, IProfileMetaData } from \"../ui/react-pathway-mapper\";\ninterface IProfilesModalProps {\n profiles: IProfileMetaData[];\n editor: EditorActionsManager;\n show: boolean;\n handleClose: Function;\n handleProfileLabelClicked: (index: number) => void;\n enabledProfileCountLimit: number;\n}\n\n@observer\nexport default class ProfilesModal extends React.Component<\n IProfilesModalProps,\n {}\n> {\n\n\n @observable\n showEnabledProfileWarningModal: boolean = false;\n\n constructor(props: IProfilesModalProps) {\n super(props);\n\n makeObservable(this);\n }\n\n @action\n setShowEnabledProfileWarningModal(val: boolean) {\n this.showEnabledProfileWarningModal = val;\n }\n\n @computed get profileEnabledMap() {\n\n const enabledProfiles: IProfileMetaData[] = [];\n this.props.profiles.forEach(profile => {\n if (profile.enabled && enabledProfiles.length < this.props.enabledProfileCountLimit) {\n enabledProfiles.push(profile);\n }\n });\n\n const profileEnabledMap = {};\n this.props.profiles.forEach((profile: IProfileMetaData) => {\n const enabled = enabledProfiles.indexOf(profile) > -1;\n profileEnabledMap[profile.profileId] = enabled;\n });\n return profileEnabledMap;\n }\n\n handleProfileLabelClicked(index: number) {\n this.props.handleProfileLabelClicked(index);\n }\n\n render() {\n const profileLabels = this.props.profiles.map(\n (profile: IProfileMetaData, i: number) => (\n \n {\n const enabledProfileCount = this.props.profiles.filter(profile => profile.enabled).length;\n if (this.props.profiles[i].enabled || enabledProfileCount < this.props.enabledProfileCountLimit) {\n this.handleProfileLabelClicked(i);\n this.props.editor.updateGenomicDataVisibility(\n this.profileEnabledMap\n );\n }\n else {\n this.setShowEnabledProfileWarningModal(true);\n }\n }}\n style={{\n cursor: \"pointer\",\n margin: \"10px\"\n }}\n bsStyle={this.props.profiles[i].enabled ? \"primary\" : \"default\"}\n >\n {profile.profileId}\n \n \n )\n );\n\n return (\n {\n this.props.handleClose(EModalType.PROFILES);\n }}\n >\n \n Genomic Data Set(s) to Show\n \n \n {profileLabels.length > 0 ? (\n profileLabels\n ) : (\n

There is currently no data to show

\n )}\n this.setShowEnabledProfileWarningModal(false)}>\n \n \n Warning\n \n \n \n

At most 6 data sets can be displayed at the same time, please disable some other data set before enabling this.

\n
\n \n {\n this.setShowEnabledProfileWarningModal(false);\n }}>\n OK\n \n \n \n
\n \n );\n }\n}\n","import React from 'react';\nimport { EModalType } from '../ui/react-pathway-mapper';\nimport {Modal} from 'react-bootstrap';\ninterface IQuickHelpModalProps{\n show: boolean;\n handleClose: (modalId: EModalType) => void;\n}\n\nexport default class QuickHelpModal extends React.Component{\n\n constructor(props: IQuickHelpModalProps){\n super(props);\n }\n\n render(){\n\n\n return(\n {this.props.handleClose(EModalType.HELP)}}>\n \n Quick Help\n \n \n
    \n
  • To add a node: Drag and drop from node palette
  • \n
  • To add an interaction: Click on interaction type; then click on small circle on source node and release on target node
  • \n
  • To add a node into a container (family, complex, compartment or process): Drag the node into its container node or select nodes to be contained and right click on container node and choose \"Add Selected Into This\"
  • \n
  • To delete nodes/interactions: Select and perform Edit > Delete Selected
  • \n
  • To overlay experiment data: Select Alteration % > Load From cBioPortal...
  • \n
\n
\n\n
\n\n );\n }\n\n\n}","import _ from \"lodash\";\nimport { toast } from 'react-toastify';\nimport EditorActionsManager from \"../managers/EditorActionsManager\";\n\n\nexport default class CBioPortalAccessor{\n static readonly CNA_GAIN = 2;\n\n static readonly GET_ALL_CANCER_STUDIES_URL = \"https://www.cbioportal.org/webservice.do?cmd=getCancerStudies\";\n static readonly GET_GENETIC_PROFILES_URL = \"https://www.cbioportal.org/webservice.do?cmd=getGeneticProfiles&cancer_study_id=\";\n static readonly GET_PROFILE_DATA_URL = \"https://www.cbioportal.org/webservice.do?cmd=getProfileData\";\n static readonly MRNA_EXP_STUDY_NAME = \"_mrna_median_Zscores\";\n static readonly CNA_EXP_STUDY_NAME = \"_gistic\";\n static readonly VALIDATE_GENES_URL = 'https://www.cbioportal.org/api/genes/fetch?geneIdType=HUGO_GENE_SYMBOL&projection=ID'\n static readonly MUTATION_EXP_STUDY_NAME = \"_mutations\";\n\n static readonly CNA_DELETION = -2;\n static readonly Z_SCORE_UPPER_THRESHOLD = 2;\n static readonly Z_SCORE_LOWER_THRESHOLD = -2;\n \n static readonly MUTATION = \"Mutation\";\n static readonly GENE_EXPRESSION = \"Gene Expression\";\n static readonly CNA = \"Copy Number Alteration\";\n\n getDataTypes(){\n return [CBioPortalAccessor.MUTATION, CBioPortalAccessor.GENE_EXPRESSION, CBioPortalAccessor.CNA];\n }\n\n /*\n * Retrieves all cancer studies from cBioPortal\n * **/\n fetchCancerStudies(callbackFunction)\n {\n var cancerStudies = {};\n var request = new XMLHttpRequest();\n request.onreadystatechange = function ()\n {\n if(request.readyState === XMLHttpRequest.DONE && request.status === 200)\n {\n // By lines\n // Match all new line character representations\n var seperator = /\\r?\\n|\\r/;\n var lines = request.responseText.split(seperator);\n\n // start from first line skip node meta data\n for(var i = 1; i < lines.length; i++)\n {\n if (lines[i].length <= 0)\n continue;\n\n var lineData = lines[i].split('\\t');\n cancerStudies[lineData[0]] = lineData;\n }\n callbackFunction(cancerStudies);\n }\n else if (request.readyState === XMLHttpRequest.DONE && request.status !== 200)\n {\n toast.error(\"Could not retrieve studies!\");\n }\n };\n request.open(\"GET\", CBioPortalAccessor.GET_ALL_CANCER_STUDIES_URL);\n request.send();\n };\n\n /**\n * Retrieves all genetic profiles for given cancerStudy from cBioPortal\n */\n getSupportedGeneticProfiles(cancerStudy, callbackFunction)\n {\n var outData = {};\n var request = new XMLHttpRequest();\n var self = this;\n request.onreadystatechange = function ()\n {\n if(request.readyState === XMLHttpRequest.DONE && request.status === 200)\n {\n // By lines\n // Match all new line character representations\n var seperator = /\\r?\\n|\\r/;\n var lines = request.responseText.split(seperator);\n\n // start from first line skip node meta data\n for(var i = 1; i < lines.length; i++)\n {\n if (lines[i].length <= 0)\n continue;\n\n var lineData = lines[i].split('\\t');\n var cancerProfileName = lineData[0];\n if(self.isSupportedCancerProfile(cancerProfileName))\n {\n outData[cancerProfileName] = lineData;\n }\n }\n\n callbackFunction(outData);\n }\n else if (request.readyState === XMLHttpRequest.DONE && request.status !== 200)\n {\n console.error(\"Error retrieving studies\");\n }\n };\n request.open(\"GET\", CBioPortalAccessor.GET_GENETIC_PROFILES_URL + cancerStudy);\n request.send();\n };\n\n isSupportedCancerProfile(cancerProfileName: string)\n {\n return (cancerProfileName.endsWith(CBioPortalAccessor.MRNA_EXP_STUDY_NAME) ||\n cancerProfileName.endsWith(CBioPortalAccessor.CNA_EXP_STUDY_NAME) ||\n cancerProfileName.endsWith(CBioPortalAccessor.MUTATION_EXP_STUDY_NAME));\n };\n\n static getDataType(cancerProfileName: string)\n {\n if ( cancerProfileName.endsWith(this.MRNA_EXP_STUDY_NAME))\n {\n return this.GENE_EXPRESSION;\n }\n else if ( cancerProfileName.endsWith(this.CNA_EXP_STUDY_NAME))\n {\n return this.CNA;\n }\n else if ( cancerProfileName.endsWith(this.MUTATION_EXP_STUDY_NAME))\n {\n return this.MUTATION;\n }\n\n return \"\";\n }\n \n\n calcAlterationPercentages(paramLines, geneticProfileId, callbackFunction)\n {\n // By lines\n // Match all new line character representations\n const seperator = /\\r?\\n|\\r/;\n const lines = paramLines.split(seperator);\n let startIndex = 0;\n\n //Find starting index of actual data skip commented lines\n for (const i in lines)\n {\n if(!lines[i].startsWith('#'))\n {\n startIndex = parseInt(i);\n break;\n }\n }\n\n //Total number of tumor samples in the response\n const tumorSamples = lines[startIndex].split('\\t');\n const numOfTumorSamples = tumorSamples.length - 2;\n const outData: {} = {};\n outData[geneticProfileId] = {};\n\n const geneticProfileType = CBioPortalAccessor.getDataType(geneticProfileId);\n // skip meta line and iterate over tumor sample data\n for(let i = startIndex + 1; i < lines.length; i++)\n {\n if (lines[i].length <= 0)\n continue;\n\n //Iterate over samples for each gene to calculate profile data\n const lineData: string[] = lines[i].split('\\t');\n let profileDataAlteration = 0;\n for(let j = 2; j < lineData.length; j++)\n {\n if(lineData[j] !== 'NaN')\n {\n if( geneticProfileType === CBioPortalAccessor.MUTATION )\n profileDataAlteration++;\n else if ( (geneticProfileType === CBioPortalAccessor.CNA) \n && ( parseInt(lineData[j]) === CBioPortalAccessor.CNA_GAIN || parseInt(lineData[j]) === CBioPortalAccessor.CNA_DELETION ) ){\n profileDataAlteration++;\n }\n else if ( (geneticProfileType === CBioPortalAccessor.GENE_EXPRESSION) \n && (parseFloat(lineData[j]) >= CBioPortalAccessor.Z_SCORE_UPPER_THRESHOLD \n || parseFloat(lineData[j]) <= CBioPortalAccessor.Z_SCORE_LOWER_THRESHOLD)){\n profileDataAlteration++;\n }\n }\n }\n\n //\n outData[geneticProfileId][lineData[1]] = ( profileDataAlteration / numOfTumorSamples ) * 100;\n }\n\n callbackFunction(outData);\n }\n\n\n /*\n *\n * Retrieves profile data associated with the parameters below from cBioPortal\n * @params\n {\n caseSetId: \"gbm_tcga\",\n geneticProfileId: \"gbm_tcga_mutations\",\n genes: [\"BRCA1\", \"BRCA2\", \"TP53\"]\n }\n * */\n getProfileData(params, callbackFunction)\n {\n //params\n //caseSetId, geneticProfileId, genes\n\n const outData = {};\n const request = new XMLHttpRequest();\n const self = this;\n request.onreadystatechange = function ()\n {\n if(request.readyState === XMLHttpRequest.DONE && request.status === 200)\n {\n self.calcAlterationPercentages(request.responseText, params.geneticProfileId, callbackFunction);\n toast.success(params.geneticProfileId + \" has been succesfully loaded from cBioPortal.\");\n }\n };\n\n //Create query URL\n let queryURL = CBioPortalAccessor.GET_PROFILE_DATA_URL;\n //Fetch sequenced case list !!\n queryURL += \"&case_set_id=\" + params.caseSetId + \"_sequenced\";\n queryURL += \"&genetic_profile_id=\" + params.geneticProfileId;\n queryURL += \"&gene_list=\";\n let isFirst = true;\n for(const gene of params.genes)\n {\n if(!isFirst){\n queryURL += \"+\";\n } else {\n isFirst = false;\n }\n queryURL += gene;\n \n }\n request.open(\"GET\", queryURL);\n request.send();\n };\n\n validateGenes(nodeSymbols, editor: EditorActionsManager)\n {\n const request = new XMLHttpRequest();\n const self = this;\n\n request.onreadystatechange = function ()\n {\n if(request.readyState === XMLHttpRequest.DONE && request.status === 200)\n {\n const validGeneSymbols = JSON.parse(request.responseText);\n const validGeneArray = _.map(validGeneSymbols, function(object)\n {\n return object.hugoGeneSymbol;\n });\n editor.highlightInvalidGenes(validGeneArray);\n }\n };\n const queryURL = CBioPortalAccessor.VALIDATE_GENES_URL;\n request.open(\"POST\", queryURL);\n request.setRequestHeader(\"Content-type\", \"application/json\");\n request.send(JSON.stringify(nodeSymbols));\n }\n}\n","import autobind from \"autobind-decorator\";\nimport { action, computed, makeObservable, observable } from \"mobx\";\nimport { observer } from \"mobx-react\";\nimport React from \"react\";\nimport {\n Button,\n Checkbox,\n FormControl,\n ListGroup,\n ListGroupItem,\n Modal,\n} from \"react-bootstrap\";\nimport { EModalType, IDataTypeMetaData } from \"../ui/react-pathway-mapper\";\nimport CBioPortalAccessor from \"../utils/CBioPortalAccessor\";\n\ninterface IStudyModalProps {\n show: boolean;\n loadFromCBio: Function;\n handleClose: Function;\n}\n\n@observer\nexport default class StudyModal extends React.Component {\n @observable\n dataTypes: { [dataType: string]: IDataTypeMetaData } = {};\n\n @observable\n dataTypeFetchResultsReady: boolean = false;\n\n currentlySelectedItemIndex = -1;\n\n @observable\n selectedStudies: {\n data: any[];\n dataTypes: { [dataType: string]: IDataTypeMetaData };\n }[] = [];\n\n checkboxModalPosition: {\n bottom: number;\n } = {\n bottom: 0,\n };\n\n @observable\n selectedDataTypesPerStudy: string[] = [];\n\n @observable\n itemArray: any[] = [];\n\n @observable\n searchQuery: string = \"\";\n\n @observable\n showDataTypeSelectionModal = false;\n\n @observable\n studyListItemCheckboxChecked: boolean[] = [];\n\n @observable\n selectedStudyData: any[];\n\n @observable\n portalAccessor: CBioPortalAccessor;\n\n constructor(props: IStudyModalProps) {\n super(props);\n makeObservable(this);\n this.selectedStudyData = [];\n this.portalAccessor = new CBioPortalAccessor();\n this.fetchStudy();\n }\n\n @action.bound\n setDataTypeFetchResultsReady(ready: boolean) {\n this.dataTypeFetchResultsReady = ready;\n }\n\n @action.bound\n setItemArray(itemArray: any[]) {\n this.itemArray = itemArray;\n }\n\n @action.bound\n setSearchQuery(query: string) {\n this.searchQuery = query;\n }\n\n @action.bound\n setSelectedStudyData(data: any[]) {\n this.selectedStudyData = data;\n }\n\n @action.bound\n setDataTypeProperties(dataType: string, properties: IDataTypeMetaData) {\n this.dataTypes[dataType] = properties;\n }\n\n @action.bound\n initStudyListItemCheckboxChecked(studyCount: number) {\n this.studyListItemCheckboxChecked = Array(studyCount).fill(false);\n }\n\n @action.bound\n initSelectedDataTypesPerStudy(studyCount: number) {\n this.selectedDataTypesPerStudy = Array(studyCount).fill(\"\");\n }\n\n @action.bound\n toggleStudyListItemCheckboxChecked(studyIndex: number) {\n this.studyListItemCheckboxChecked[studyIndex] = !this\n .studyListItemCheckboxChecked[studyIndex];\n }\n\n @action.bound\n addSelectedStudy(selectedStudy: {\n data: any[];\n dataTypes: { [dataType: string]: IDataTypeMetaData };\n }) {\n this.selectedStudies.push(selectedStudy);\n }\n\n @action.bound\n removeSelectedStudy(selectedStudyData: any[]) {\n this.selectedStudies = this.selectedStudies.filter(\n (study) => study.data[0] != selectedStudyData[0]\n );\n }\n\n @action.bound\n clearSelectedStudies() {\n this.selectedStudies = [];\n }\n\n @action.bound\n setShowDataTypeSelectionModal(show: boolean) {\n this.showDataTypeSelectionModal = show;\n }\n\n @action.bound\n clearStudyCheckboxesChecked() {\n const length = this.studyListItemCheckboxChecked.length;\n this.studyListItemCheckboxChecked = Array(length).fill(false);\n }\n\n @action.bound\n clearSelectedDataTypesPerStudy() {\n const length = this.studyListItemCheckboxChecked.length;\n this.selectedDataTypesPerStudy = Array(length).fill(\"\");\n }\n\n @action.bound\n unselectDataTypesForStudy(index: number) {\n this.selectedDataTypesPerStudy[index] = \"\";\n }\n\n preparePortalAccess(studyId: string) {\n this.setDataTypeFetchResultsReady(false);\n this.portalAccessor.getSupportedGeneticProfiles(studyId, (data) => {\n this.disableAllDataTypes();\n // Iterate through profiles\n for (const profile of Object.keys(data)) {\n const type = CBioPortalAccessor.getDataType(profile);\n if (type !== \"\") {\n this.setDataTypeProperties(type, {\n ...this.dataTypes[type],\n enabled: true,\n profile: profile,\n });\n setTimeout(() => this.setDataTypeFetchResultsReady(true), 500);\n }\n }\n });\n }\n\n disableAllDataTypes() {\n for (const dataType of Object.keys(this.dataTypes)) {\n this.setDataTypeProperties(dataType, {\n enabled: false,\n checked: false,\n profile: undefined,\n });\n }\n }\n\n fetchStudy() {\n this.portalAccessor.getDataTypes().forEach((dataType) => {\n this.setDataTypeProperties(dataType, {\n enabled: false,\n checked: false,\n profile: undefined,\n });\n });\n\n this.portalAccessor.fetchCancerStudies((cancerStudies: any) => {\n let temp = [];\n for (const studyTitle in cancerStudies) {\n if (!cancerStudies.hasOwnProperty(studyTitle)) {\n continue;\n }\n const studyData = cancerStudies[studyTitle];\n temp.push(studyData);\n }\n const numOfStudies = temp.length;\n this.initStudyListItemCheckboxChecked(numOfStudies);\n this.initSelectedDataTypesPerStudy(numOfStudies);\n\n this.setItemArray(temp);\n });\n }\n\n @autobind\n resetModal() {\n this.disableAllDataTypes();\n this.setSelectedStudyData([]);\n this.clearSelectedStudies();\n this.clearStudyCheckboxesChecked();\n this.clearSelectedDataTypesPerStudy();\n this.currentlySelectedItemIndex = -1;\n this.searchQuery = \"\";\n }\n\n @autobind\n handleCheckboxClick(dataType) {\n this.setDataTypeProperties(dataType, {\n ...this.dataTypes[dataType],\n checked: !this.dataTypes[dataType].checked,\n });\n }\n\n @computed\n get selectedStudyDataTitle() {\n if (this.selectedStudyData.length > 1) {\n return this.selectedStudyData[1] || \"Choose study\";\n } else {\n return \"Choose study\";\n }\n }\n\n render() {\n\n return (\n {\n this.props.handleClose(EModalType.STUDY);\n this.resetModal();\n }}\n >\n \n Profile Data from cBioPortal\n \n \n \n

Select Cancer Study

\n
\n this.setSearchQuery(event.target.value)}\n />\n \n \n {this.itemArray.length < 1 ? (\n Fetching studies from cBioPortal...\n ) : (\n this.itemArray\n .map((item, index) => {\n return { item: item, index: index };\n })\n .filter((obj) =>\n obj.item[1]\n .toLowerCase()\n .includes(this.searchQuery.toLowerCase())\n )\n .map((obj) => {\n const item = obj.item;\n const index = obj.index;\n\n const studyTitle = item[1];\n const studyId = item[0];\n return (\n \n {\n const boundingRect = document\n .getElementById(\"listgroupitem\" + index)\n .getBoundingClientRect();\n const modalMargin = 30;\n this.checkboxModalPosition = {\n bottom: boundingRect.bottom - modalMargin,\n };\n this.setSelectedStudyData(item);\n this.preparePortalAccess(studyId);\n this.toggleStudyListItemCheckboxChecked(index);\n this.currentlySelectedItemIndex = index;\n\n if (this.studyListItemCheckboxChecked[index]) {\n this.setShowDataTypeSelectionModal(true);\n } else {\n this.removeSelectedStudy(item);\n this.unselectDataTypesForStudy(index);\n }\n }}\n >\n {studyTitle}\n \n {this.selectedDataTypesPerStudy[index] != \"\" && (\n \n {this.selectedDataTypesPerStudy[index]}\n \n )}\n \n );\n })\n )}\n \n
\n
\n

\n Warning: At most six different data sets will be overlayed on the genes. You can toggle which ones are to be displayed via \"Alteration %\" {\">\"} \"View Settings\" menu.\n

\n
\n {\n this.setShowDataTypeSelectionModal(false);\n }}\n >\n \n {this.dataTypeFetchResultsReady === false ? (\n Fetching data types from cBioPortal...\n ) : (\n Object.keys(this.dataTypes).map((dataType: string) => {\n return (\n {\n this.handleCheckboxClick(dataType);\n }}\n checked={this.dataTypes[dataType].checked}\n >\n {dataType}\n \n );\n })\n )}\n \n \n {\n const currentDataTypes = { ...this.dataTypes };\n const selectedCount = Object.keys(currentDataTypes).filter(\n (dataType) => {\n return currentDataTypes[dataType].checked;\n }\n ).length;\n if (selectedCount == 0) {\n this.studyListItemCheckboxChecked[\n this.currentlySelectedItemIndex\n ] = false;\n }\n this.setShowDataTypeSelectionModal(false);\n }}\n >\n Cancel\n \n {\n const currentDataTypes = { ...this.dataTypes };\n this.addSelectedStudy({\n data: this.selectedStudyData,\n dataTypes: currentDataTypes,\n });\n this.selectedDataTypesPerStudy[\n this.currentlySelectedItemIndex\n ] = Object.keys(currentDataTypes)\n .filter((dataType) => {\n return currentDataTypes[dataType].checked;\n })\n .join(\", \");\n this.setShowDataTypeSelectionModal(false);\n }}\n >\n Add\n \n \n \n \n\n \n {\n this.selectedStudies.forEach((study) => {\n this.props.loadFromCBio(study.dataTypes, study.data);\n });\n this.props.handleClose(EModalType.STUDY);\n this.resetModal();\n }}\n >\n Load Data\n \n \n \n );\n }\n}\n","import autobind from \"autobind-decorator\";\nimport { action, makeObservable, observable } from \"mobx\";\nimport { observer } from \"mobx-react\";\nimport React from 'react';\nimport { Checkbox, DropdownButton, MenuItem } from \"react-bootstrap\";\nimport PathwayActions from '../utils/PathwayActions.js';\nimport { IPathwayMapperTable } from \"./react-pathway-mapper\";\n\ninterface IRankingProps{\n pathwayActions: PathwayActions;\n bestPathwaysAlgos: any[][];\n tableComponent: (data: IPathwayMapperTable[], selectedPathway: string, onPathwaySelect: (pathway: string) => void) => JSX.Element;\n patientView ?: boolean;\n}\n\nconst TCGA_PANCAN_PATHWAY_NAMES = [\n \"Cell Cycle\", \n \"HIPPO\", \n \"MYC\",\n \"NOTCH\",\n \"NRF2\",\n \"PI3K\",\n \"RTK-RAS\",\n \"TGF-Beta\",\n \"TP53\",\n \"WNT\"\n];\n\n\n@observer\nexport default class Ranking extends React.Component{\n @observable\n bestPathways: any[];\n\n @observable\n shownPathways: any[];\n\n @observable\n dropDownTitle: string;\n\n @observable\n selectedPathway: string;\n isPercentageMatch: number;\n isAlterationEnabled: number;\n\n @observable\n considerOnlyTCGAPanPathways: boolean;\n\n @observable\n isExpanded: boolean;\n\n readonly COUNT_PERC_EXPLANATION = \"Whether we should favor the number of genes of interest matching the ones in a pathway or the percentage of such genes in that pathway. For instance, suppose genes of interest are A, B, and C, and the pathway contains genes B, C, D, and E. When we consider count, the score is 2 (for the two genes that match). However, when we consider percentage the score will be 50% as 2 of the 4 genes in the pathway are among genes of interest.\";\n readonly ALTERATION_EXPLANATION = \"When this is checked, each matching gene will not directly contribute to the score as 1 unit but with the alteration frequency percentage of that gene. For instance, suppose genes of interest are A, B, and C with alteration frequencies of 0.5, 0.2, and 0.3, respectively, and the pathway contains genes B, C, D, and E. When this is option isn't checked, the score will be 2 for match count and 50% for the match percentage. However, when this option is checked, the scores will be 0.2+0.3=0.5 and (0.2+0.3)/4=12.5% for match count and percentage, respectively.\";\n readonly TCGA_PANCAN_EXPLANATION = \"The pathways listed above were retrieved from PathwayMapper. When this option is checked, only the pathways under TCGA > PanCanAtlas will be shown. Uncheck to show all.\";\n\n constructor(props: IRankingProps){\n super(props);\n makeObservable(this);\n \n this.isPercentageMatch = 0;\n this.isAlterationEnabled = 0;\n this.considerOnlyTCGAPanPathways = true;\n this.dropDownTitle = \"Match count\";\n this.isExpanded = false;\n this.setBestPathwayMethod(0);\n this.selectedPathway = this.shownPathways[0].pathwayName;\n }\n\n @autobind\n setBestPathwayMethod(i: number){\n this.bestPathways = this.props.bestPathwaysAlgos[i];\n this.filterBestPathwaysByTCGAPanPathways();\n }\n\n @autobind\n onPathwayClick(pathway: string){\n this.selectedPathway = pathway;\n this.props.pathwayActions.changePathway(this.selectedPathway);\n }\n\n @autobind\n onApplyClick(){\n // Mapping from dropdown + checkbox selection to pathway method.\n this.setBestPathwayMethod(2 * this.isAlterationEnabled + this.isPercentageMatch);\n }\n\n @action.bound \n filterBestPathwaysByTCGAPanPathways() {\n this.shownPathways = this.bestPathways.filter((data: any) => {\n if (this.considerOnlyTCGAPanPathways) {\n return TCGA_PANCAN_PATHWAY_NAMES.indexOf(data.pathwayName) > -1;\n }\n return true;\n });\n // change selected pathway if we are filtered and doesn't exist\n if (this.considerOnlyTCGAPanPathways \n && TCGA_PANCAN_PATHWAY_NAMES.indexOf(this.selectedPathway) < 0) {\n this.selectedPathway = this.shownPathways[0].pathwayName;\n this.props.pathwayActions.changePathway(this.selectedPathway);\n }\n }\n\n @action.bound\n toggleConsiderOnlyTCGAPanPathways() {\n this.considerOnlyTCGAPanPathways = !this.considerOnlyTCGAPanPathways;\n this.filterBestPathwaysByTCGAPanPathways();\n }\n\n\n componentDidMount(): void {\n this.props.pathwayActions.changePathway(this.selectedPathway);\n }\n\n render(){\n const lengthThreshold = 13;\n \n return (\n
\n\n {/*\n
\n  Pathways\n
*/}\n\n { this.props.tableComponent &&\n this.props.tableComponent(\n this.shownPathways.map((data: any) => ({\n name: data.pathwayName, score: data.score, genes: data.genesMatched\n })),\n this.selectedPathway,\n this.onPathwayClick)\n }\n {\n
\n \n Show TCGA PanCancer Atlas pathways only  \n \n \n \n
\n }\n {(!this.props.patientView &&\n
\n {\n
\n \n  Ranking options\n \n
\n }\n
\n \n {this.isPercentageMatch = 0; this.dropDownTitle = \"Match count\"; this.onApplyClick();} }>Match count\n {this.isPercentageMatch = 1; this.dropDownTitle = \"Match percentage\"; this.onApplyClick();}}>Match percentage\n \n   \n
\n\n {this.isAlterationEnabled = (this.isAlterationEnabled === 1) ? 0 : 1; this.onApplyClick();}}\n style={{fontSize: \"13px\", marginTop: \"18px\", bottom: \"4px\"}}>\n Consider alteration frequency  \n \n \n
\n
\n )}\n
\n \n );\n \n }\n\n \n}\n","import { makeObservable, observable } from \"mobx\";\nimport { observer } from \"mobx-react\";\nimport React from 'react';\n// @ts-ignore\nimport openImage from \"../images/toolbar/edit.svg\";\n// @ts-ignore\nimport layoutImage from \"../images/toolbar/layout-cose.svg\";\n// @ts-ignore\nimport savePNGImage from \"../images/toolbar/save_png.svg\";\n// @ts-ignore\nimport saveSVGImage from \"../images/toolbar/save_svg.svg\";\nimport EditorActionsManager from \"../managers/EditorActionsManager\";\nimport { EModalType, IAlterationData } from '../ui/react-pathway-mapper';\nimport PathwayActions from '../utils/PathwayActions';\n// @ts-ignore\nconst addSelImage = require(\"../images/toolbar/add-selected.svg\");\n// @ts-ignore\nconst addAllImage = require(\"../images/toolbar/add-all.svg\");\n// @ts-ignore\nconst aboutImage = require(\"../images/toolbar/about.svg\");\n\n\ninterface IToolbarProps {\n pathwayActions: PathwayActions;\n selectedPathway: string;\n alterationData: IAlterationData;\n handleOpen: (modalId: number) => void;\n genes: any[];\n validGenes: any;\n showMessage: (message: string) => void;\n pathwayGenes: string[];\n onAddGenes: (selectedGenes: string[]) => void;\n patientView ?: boolean;\n}\n\n@observer\nexport default class Toolbar extends React.Component{\n\n\n @observable\n selectedGenes: string[];\n\n @observable\n private editor: EditorActionsManager;\n constructor(props: IToolbarProps){\n super(props);\n makeObservable(this);\n\n this.selectedGenes = [];\n }\n\n \n render(){\n\n\n const studyQuery = \"q=\" + JSON.stringify(this.props.alterationData) + \"&g=\" + this.props.genes.map(gene => gene.hugoGeneSymbol).join(\"+\");\n return (\n
\n {this.props.pathwayActions.saveAs(\"PNG\");}}/>\n\n {this.props.pathwayActions.saveAs(\"SVG\");}}/>\n\n \n {(!this.props.patientView && [\n {\n this.selectedGenes = this.props.pathwayActions.getSelectedNodes()\n .filter((node: any) => node.data().type === \"GENE\")\n .map((node: any) => node.data().name as string);\n\t const noneGeneList = this.props.pathwayActions.getSelectedNodes()\n .filter((node: any) => node.data().type !== \"GENE\")\n .map((node: any) => node.data().name as string);\n const invalidGenes: string[] = [];\n\t let message = \"\";\n if(noneGeneList.length > 0){\n message += \"Selection contains nodes that are not genes: \" + noneGeneList.join(', ') + \". \";\n }\n\n this.selectedGenes.forEach((gene: string) => {\n if(!this.props.validGenes.hasOwnProperty(gene)){\n invalidGenes.push(gene);\n }\n });\n\n if(invalidGenes.length === 0){\n\n if(this.selectedGenes.length > 0 && noneGeneList.length === 0){\n this.props.onAddGenes(this.selectedGenes);\n }\n } else {\n\t message += \"Following gene symbols are invalid or already in gene list: \" + invalidGenes.join(\", \") + \".\";\n }\n\n\t if(message.length > 0) {\n\t this.props.showMessage(message);\n\t }\n }}/>\n ,\n \n {\n\n this.selectedGenes = this.props.pathwayGenes.filter((gene: string) => {\n return this.props.validGenes.hasOwnProperty(gene);\n });\n \n if(this.selectedGenes.length > 0){\n this.props.onAddGenes(this.selectedGenes);\n }\n }}/>,\n \n\n {{window.open(\"http://pathwaymapper.org/?pathwayName=\" + this.props.selectedPathway +\"&\"+ studyQuery )}}}/>\n ])}\n {this.props.handleOpen(EModalType.CHELP); }}/>\n \n
);\n }\n}\n","import autobind from \"autobind-decorator\";\nimport { action, computed, makeObservable, observable } from \"mobx\";\nimport EditorActionsManager from \"../managers/EditorActionsManager\";\nimport FileOperationsManager, {\n IPathwayInfo\n} from \"../managers/FileOperationsManager\";\nimport GridOptionsManager from \"../managers/GridOptionsManager\";\nimport ViewOperationsManager from \"../managers/ViewOperationsManager\";\nimport ConfirmationModal from \"../modals/ConfirmationModal\";\nimport { EGridType } from \"../modals/GridSettings\";\nimport { ILayoutProperties } from \"../modals/LayoutProperties\";\nimport {\n EModalType, IPathwayData, IProfileMetaData\n} from \"../ui/react-pathway-mapper\";\nimport SaveLoadUtility from \"./SaveLoadUtility\";\n\nexport default class PathwayActions {\n @observable\n selectedPathway: string;\n fileManager: FileOperationsManager;\n editor: EditorActionsManager;\n undoRedoManager: any;\n pathwayHandler: (pathwayName: string) => void;\n handleOpen: (modalId: EModalType) => void;\n eh: any;\n profiles: IProfileMetaData[];\n gridOptionsManager: GridOptionsManager;\n\n uploader: any;\n merger: any;\n isCBioPortal: boolean;\n isCollaborative: boolean;\n viewOperationsManager: ViewOperationsManager;\n overlayUploader: any;\n\n @observable\n enabledType: EGridType;\n\n constructor(\n pathwayHandler: (pathwayName: string) => void,\n profiles: IProfileMetaData[],\n fileManager: FileOperationsManager,\n handleOpen: (modalId: EModalType) => void,\n isCBioPortal: boolean,\n isCollaborative: boolean\n ) {\n makeObservable(this);\n this.pathwayHandler = pathwayHandler;\n this.profiles = profiles;\n this.fileManager = fileManager;\n this.handleOpen = handleOpen;\n this.isCBioPortal = isCBioPortal;\n this.isCollaborative = isCollaborative;\n this.enabledType = EGridType.NONE;\n }\n\n @action.bound\n addProfile(profile: IProfileMetaData) {\n this.profiles.push(profile);\n }\n\n @action.bound\n clearProfiles() {\n this.profiles.length = 0;\n }\n\n emphasizeQueryGenes(queryGenes: string[]) {\n if (this.editor)\n this.editor.cy.nodes().forEach((node: any) => {\n const nodeName = node.data().name;\n const nodeType = node.data().type;\n if (queryGenes.includes(nodeName) && nodeType === \"GENE\") {\n node.style({ \"border-width\": \"4px\", \"font-weight\": \"bold\" });\n }\n });\n }\n\n getSelectedNodes() {\n return this.editor.cy.nodes(\":selected\");\n }\n\n setLayoutProperties(layoutProperties: ILayoutProperties) {\n this.editor.saveLayoutProperties(layoutProperties);\n }\n\n doesCyHaveElements() {\n return this.editor.cy.elements().length > 0;\n }\n\n @autobind\n toggleGrid(isEnabled: boolean) {\n this.gridOptionsManager.setSnapToGuidelines(false);\n this.gridOptionsManager.setShowGrid(isEnabled);\n }\n\n @autobind\n toggleGuide(isEnabled: boolean) {\n this.gridOptionsManager.setSnapToGuidelines(isEnabled);\n this.gridOptionsManager.setShowGrid(false);\n }\n\n adjustGridSettings(gridSize: number, color: string) {\n this.gridOptionsManager.currentProperties.gridSpacing = gridSize;\n this.gridOptionsManager.currentProperties.guidelinesStyle.strokeStyle = color;\n this.gridOptionsManager.currentProperties.guidelinesStyle.horizontalDistColor = color;\n this.gridOptionsManager.currentProperties.guidelinesStyle.verticalDistColor = color;\n }\n\n @autobind\n resizeToContent() {\n this.editor.resizeNodesToContent(this.editor.cy.nodes());\n }\n\n @autobind\n align(param: string) {\n this.viewOperationsManager.handleNodeAlignment(param);\n }\n\n @autobind\n onChangeFile(e: any, isMerge: boolean) {\n const file = e.target.files[0] as File;\n this.processFile(file, isMerge);\n //Can't load the same file twice in a row without this\n e.target.value = \"\";\n }\n\n uploadOverlay() {\n this.overlayUploader.click();\n }\n\n overlayFromText(file: File) {\n // Create a new FormData object.\n const formData = new FormData();\n formData.append(\"graphFile\", file);\n const request = new XMLHttpRequest();\n request.onreadystatechange = () => {\n if (\n request.readyState === XMLHttpRequest.DONE &&\n request.status === 200\n ) {\n const linesOfData = request.responseText.split(\"\\n\");\n if (linesOfData.length > 0) {\n const profileIdsFromFile = linesOfData[0].split(\"\\t\").slice(1);\n profileIdsFromFile.forEach(id =>\n this.addProfile({ profileId: id, enabled: true })\n );\n } else {\n console.log(\"Error: No valid data\");\n }\n this.editor.addGenomicData(request.responseText);\n }\n };\n request.open(\"POST\", \"/loadGraph\");\n request.send(formData);\n }\n\n @autobind\n upload() {\n if (this.editor.cy.elements().length > 0) {\n this.handleOpen(EModalType.CONFIRMATION);\n ConfirmationModal.pendingFunction = () => {\n this.uploader.click();\n };\n } else {\n this.uploader.click();\n }\n }\n\n @autobind\n merge() {\n this.merger.click();\n }\n\n setOverlayUploader(inputRef: any) {\n this.overlayUploader = inputRef;\n }\n\n @autobind\n setUploaders(inputRef: any, isMerge: boolean) {\n if (isMerge) this.merger = inputRef;\n else this.uploader = inputRef;\n }\n\n @computed\n get getPathwayInfo() {\n return this.fileManager.getPathwayInfo;\n }\n\n @autobind\n setPathwayInfo(other: IPathwayInfo) {\n this.fileManager.setPathwayInfo(other);\n }\n\n @autobind\n undo() {\n this.undoRedoManager.undo();\n }\n\n @autobind\n redo() {\n this.undoRedoManager.redo();\n }\n\n @autobind\n export(isSIFNX: boolean) {\n //this.editor.cy.remove('.eh-handle');\n this.eh.hide();\n this.fileManager.saveGraph(isSIFNX, this.editor);\n }\n\n @autobind\n resetUndoStack() {\n this.undoRedoManager.reset();\n }\n\n @autobind\n newPathway() {\n const commitNewPathway = () => {\n this.editor.removeAllElements();\n this.fileManager.setPathwayInfo({\n pathwayTitle: \"New Pathway\",\n pathwayDetails: \"\"\n });\n //this.removeAllData()\n this.resetUndoStack();\n this.pathwayHandler(\"Dummy\");\n };\n\n if (this.editor.cy.elements().length > 0) {\n this.handleOpen(EModalType.CONFIRMATION);\n ConfirmationModal.pendingFunction = commitNewPathway;\n } else {\n commitNewPathway();\n }\n }\n\n @autobind\n changePathway(pathwayName: string) {\n this.pathwayHandler(pathwayName);\n\n if (!this.isCBioPortal) {\n this.fileManager.setPathwayInfo({\n pathwayTitle: pathwayName,\n pathwayDetails: \"\",\n });\n // At the beginning changePathway is called editor is not ready hence removeData shall not be called\n if (this.editor) {\n //this.removeAllData()\n this.resetUndoStack();\n }\n }\n }\n\n @autobind\n highlightNeighbours() {\n this.editor.highlightNeighbors();\n }\n\n @autobind\n highlightSelected() {\n this.editor.highlightSelected();\n }\n\n @autobind\n validateGenes() {\n this.editor.validateGenes();\n }\n\n @autobind\n showAll() {\n this.editor.showAllNodes();\n }\n\n @autobind\n hideSelected() {\n this.editor.hideSelectedNodes();\n }\n\n @autobind\n deleteSelected() {\n const selectedEles = this.editor.cy.elements(\":selected\");\n this.editor.removeElement(selectedEles);\n }\n\n @autobind\n addEdge(edgeTypeIndex: number) {\n // @ts-ignore\n window.edgeAddingMode = edgeTypeIndex + 1;\n if (edgeTypeIndex === -1) {\n this.eh.disable();\n this.eh.hide();\n return;\n } else {\n // @ts-ignore\n this.eh.enable();\n }\n }\n\n @autobind\n changeNodeName(oldName: string, newName: string) {\n const cyNode = this.editor.cy.$('[name=\"' + oldName + '\"]')[0];\n this.editor.changeName(cyNode, newName);\n }\n\n @autobind\n addNode(nodeType) {\n const nodeData = {\n type: nodeType.toUpperCase(),\n name: \"New \" + nodeType,\n w: \"150\",\n h: \"52\"\n };\n const extent = this.editor.cy.extent();\n const posData = {\n x: (extent.x1 + extent.x2) / 2,\n y: (extent.y1 + extent.y2) / 2\n };\n\n this.editor.addNode(nodeData, posData);\n this.pathwayHandler(\"Additional Pathway\");\n }\n\n @autobind\n searchGene(geneName: string) {\n const selector = \"node[name @*= '\" + geneName + \"']\";\n const nodesContainingSearchedGene = this.editor.cy.filter(selector);\n let nodesToSelect = this.editor.cy.collection();\n nodesContainingSearchedGene.forEach(function(ele, index) {\n if (\n !ele.hasClass(\"highlightedNode\") &&\n !ele.hasClass(\"invalidGeneHighlight\")\n )\n nodesToSelect = nodesToSelect.union(ele);\n });\n this.editor.highlightBySearch(nodesToSelect);\n }\n\n @autobind\n removeAllData() {\n this.editor.removeGenomicData();\n this.clearProfiles();\n }\n\n @autobind\n removeAllHighlight() {\n this.editor.removeAllHighlight();\n }\n\n @autobind\n processFile(file: File, isMerge: boolean) {\n // Create a new FormData object.\n const formData = new FormData();\n formData.append(\"graphFile\", file);\n const request = new XMLHttpRequest();\n request.onreadystatechange = () => {\n if (request.readyState === XMLHttpRequest.DONE) {\n if (request.status === 200) {\n const pathwayData: IPathwayData = SaveLoadUtility.parseGraph(\n request.responseText,\n false\n );\n\n if (isMerge) {\n this.editor.mergeGraph(pathwayData.nodes, pathwayData.edges);\n const graphJSON = this.editor.cy.json();\n\n //TODO change file name maybe, probabyly not necessary ?\n // Pathway nodes and edges are now combination of both previous and new pathway.\n pathwayData.nodes = graphJSON.elements.nodes; //this.editor.cy.nodes().map((node) => ({data: node.data()}));\n pathwayData.edges = graphJSON.elements.edges; //this.editor.cy.edges().map((edge) => ({data: edge.data()}));\n pathwayData.title = \"Additional Pathway\";\n } else {\n this.editor.loadFile(pathwayData.nodes, pathwayData.edges);\n this.fileManager.setPathwayInfo({\n pathwayTitle: pathwayData.title,\n pathwayDetails: pathwayData.description\n });\n }\n\n this.pathwayHandler(pathwayData.title + \"_imported\");\n this.resetUndoStack();\n } else {\n console.error(\n \"Error processing file: \" +\n request.readyState +\n request.responseText\n );\n }\n }\n };\n request.open(\"POST\", \"/loadGraph\");\n request.send(formData);\n }\n\n @autobind\n saveAs(type: string) {\n if (type === \"SVG\") {\n this.fileManager.saveAsSVG(this.editor);\n } else if (type === \"PNG\") {\n this.fileManager.saveAsPNG(this.editor.cy);\n } else if (type === \"JPEG\") {\n this.fileManager.saveAsJPEG(this.editor.cy);\n }\n }\n\n @autobind\n editorHandler(\n editor,\n eh,\n undoRedoManager,\n viewOperationsManager: ViewOperationsManager,\n gridOptionsManager: GridOptionsManager\n ) {\n this.editor = editor;\n this.eh = eh;\n this.undoRedoManager = undoRedoManager;\n this.viewOperationsManager = viewOperationsManager;\n this.gridOptionsManager = gridOptionsManager;\n }\n\n @autobind\n exists(profileId: string){\n\n let exists = false;\n this.profiles.forEach((profile: IProfileMetaData) => {\n if(profile.profileId === profileId){\n exists = true;\n }\n });\n\n return exists;\n }\n\n @autobind\n loadSampleData() {\n const data =\n \"gene\\tlung\\tovarian\\tbreast\\n\" +\n \"PTEN\\t-7\\t-20\\t10\\n\" +\n \"NF1\\t-12\\t-4\\t30\\n\" +\n \"PIK3CA\\t18\\t40\\t-50\\n\" +\n \"KRAS\\t11\\t-5\\t0\\n\" +\n \"ZIYA\\t0\\t-2\\t0\\n\" +\n \"AKT1\\t3\\t30\\t-10\\n\" +\n \"AKT2\\t6\\t-3\\t20\\n\" +\n \"AKT3\\t6\\t-3\\t20\\n\" +\n \"\\n\";\n\n if (this.exists(\"lung\") || this.exists(\"ovarian\") || this.exists(\"breast\")) {\n return;\n } \n\n this.editor.addGenomicData(data);\n\n if (!this.isCollaborative) {\n this.addProfile({ profileId: \"lung\", enabled: this.profiles.length < 6 ? true : false });\n this.addProfile({ profileId: \"ovarian\", enabled: this.profiles.length < 6 ? true : false });\n this.addProfile({ profileId: \"breast\", enabled: this.profiles.length < 6 ? true : false });\n }\n \n }\n\n @autobind\n performLayout() {\n this.editor.performLayout();\n }\n}\n","import { makeObservable, observable } from \"mobx\";\nimport { observer } from \"mobx-react\";\nimport React from \"react\";\nimport { Button, ButtonGroup, ButtonToolbar, FormControl, FormGroup, Glyphicon, InputGroup, Navbar } from \"react-bootstrap\";\n// @ts-ignore\nimport aboutSvg from '../images/toolbar/about.svg';\n// @ts-ignore\nimport ahbSvg from '../images/toolbar/align/align-horizontal-bottom.svg';\n// @ts-ignore\nimport ahmSvg from '../images/toolbar/align/align-horizontal-middle.svg';\n// @ts-ignore\nimport ahtSvg from '../images/toolbar/align/align-horizontal-top.svg';\n// @ts-ignore\nimport avcSvg from '../images/toolbar/align/align-vertical-center.svg';\n// @ts-ignore\nimport avlSvg from '../images/toolbar/align/align-vertical-left.svg';\n// @ts-ignore\nimport avrSvg from '../images/toolbar/align/align-vertical-right.svg';\n// @ts-ignore\nimport deleteSvg from '../images/toolbar/delete-simple.svg';\n// @ts-ignore\nimport gridSvg from '../images/toolbar/grid.svg';\n// @ts-ignore\nimport guideSvg from '../images/toolbar/guidelines.svg';\n// @ts-ignore\nimport hideSvg from '../images/toolbar/hide-selected.svg';\n// @ts-ignore\nimport layoutSvg from '../images/toolbar/layout-cose.svg';\n// @ts-ignore\nimport layoutPropSvg from '../images/toolbar/layout-properties.svg';\n// @ts-ignore\nimport loadSvg from '../images/toolbar/load.svg';\n// @ts-ignore\nimport newSvg from '../images/toolbar/new.svg';\n// @ts-ignore\nimport portalSvg from '../images/toolbar/portal.svg';\n// @ts-ignore\nimport helpSvg from '../images/toolbar/quick-help.svg';\n// @ts-ignore\nimport redoSvg from '../images/toolbar/redo.svg';\n// @ts-ignore\nimport saveSvg from '../images/toolbar/save.svg';\n// @ts-ignore\nimport setingsSvg from '../images/toolbar/settings.svg';\n// @ts-ignore\nimport showSvg from '../images/toolbar/show-all.svg';\n// @ts-ignore\nimport undoSvg from '../images/toolbar/undo.svg';\nimport { EGridType } from \"../modals/GridSettings\";\nimport PathwayActions from \"../utils/PathwayActions\";\nimport { EModalType } from \"./react-pathway-mapper\";\n\n\ninterface IButtonbarProps {\n pathwayActions: PathwayActions;\n handleOpen: (modelId: EModalType) => void;\n}\n\ninterface ISVGFunction{\n svg: any;\n function: () => void;\n tooltip: string; \n isFocused?: boolean;\n}\n\n\n@observer\nexport default class Buttonbar extends React.Component{\n\n\n @observable\n private searchedGene: string;\n\n\n constructor(props: IButtonbarProps) {\n super(props);\n makeObservable(this);\n \n this.searchedGene = \"\";\n this.props.pathwayActions.enabledType = EGridType.NONE;\n }\n\n setEnabledType(newType: EGridType){\n if(newType === this.props.pathwayActions.enabledType){\n this.props.pathwayActions.enabledType = EGridType.NONE;\n } else {\n this.props.pathwayActions.enabledType = newType;\n }\n\n // Enabled type calculated\n\n if(this.props.pathwayActions.enabledType === EGridType.GRID){\n this.props.pathwayActions.toggleGrid(true);\n }\n else if(this.props.pathwayActions.enabledType === EGridType.GUIDE){\n this.props.pathwayActions.toggleGuide(true);\n } else {\n this.props.pathwayActions.toggleGrid(false); // This will disable both.\n }\n }\n render() {\n \n const fileFunctions: ISVGFunction[] = [\n {svg: newSvg, function: this.props.pathwayActions.newPathway, tooltip: \"New Pathway\"},\n {svg: loadSvg, function: this.props.pathwayActions.upload, tooltip: \"Import Pathway\" },\n {svg: saveSvg, function: () => {this.props.pathwayActions.export(false)}, tooltip: \"Export Pathway\"}];\n \n const modFunctions: ISVGFunction[] = [\n {svg: deleteSvg, function: this.props.pathwayActions.deleteSelected, tooltip: \"Delete Selected\"}];\n\n if(!this.props.pathwayActions.isCollaborative){\n modFunctions.push({svg: undoSvg, function: () => {this.props.pathwayActions.undo();}, tooltip: \"Undo\"},\n {svg: redoSvg, function: () => {this.props.pathwayActions.redo();}, tooltip: \"Redo\"});\n }\n const alignFunctions: ISVGFunction[] = [\n {svg: ahtSvg, function: () => {this.props.pathwayActions.align(\"hTop\");}, tooltip: \"Align Horizontal Top\"},\n {svg: ahmSvg, function: () => {this.props.pathwayActions.align(\"hMid\");}, tooltip: \"Align Horizontal Middle\"},\n {svg: ahbSvg, function: () => {this.props.pathwayActions.align(\"hBot\");}, tooltip: \"Align Horizontal Bottom\"},\n {svg: avlSvg, function: () => {this.props.pathwayActions.align(\"vLeft\");}, tooltip: \"Align Vertical Left\"},\n {svg: avcSvg, function: () => {this.props.pathwayActions.align(\"vCen\");}, tooltip: \"Align Vertical Center\"},\n {svg: avrSvg, function: () => {this.props.pathwayActions.align(\"vRight\");}, tooltip: \"Align Vertical Right\"}];\n \n const utilFunctions: ISVGFunction[] = [\n {isFocused: this.props.pathwayActions.enabledType === EGridType.GRID, svg: gridSvg, function: () => {this.setEnabledType(EGridType.GRID);}, tooltip: \"Enable Grid: Show and snap to grid\"},\n {isFocused: this.props.pathwayActions.enabledType === EGridType.GUIDE, svg: guideSvg, function: () => {this.setEnabledType(EGridType.GUIDE);}, tooltip: \"Enable Guidelines: Enable and snap to alignment guidelines\"}];\n\n const visibilityFunctions: ISVGFunction[] = [\n {svg: hideSvg, function: () => {this.props.pathwayActions.hideSelected();}, tooltip: \"Hide Selected\"},\n {svg: showSvg, function: () => {this.props.pathwayActions.showAll();}, tooltip: \"Show All\"}];\n\n const layoutFunctions: ISVGFunction[] = [\n {svg: layoutSvg, function: () => {this.props.pathwayActions.performLayout();}, tooltip: \"Perform Layout\"},\n {svg: layoutPropSvg, function: () => {this.props.handleOpen(EModalType.LAYOUT);}, tooltip: \"Layout Properties\"}];\n\n const portalFunctions: ISVGFunction[] = [\n {svg: portalSvg, function: () => {this.props.handleOpen(EModalType.STUDY);}, tooltip: \"Fetch Genomic Data From cBioPortal\"},\n {svg: setingsSvg, function: () => {this.props.handleOpen(EModalType.PROFILES);}, tooltip: \"Genomic Data Visibility Settings\"}];\n\n const infoFunctions: ISVGFunction[] = [\n {svg: helpSvg, function: () => {this.props.handleOpen(EModalType.HELP);}, tooltip: \"Quick Help\"},\n {svg: aboutSvg, function: () => {this.props.handleOpen(EModalType.ABOUT);}, tooltip: \"About\"}];\n \n const allFunctions = [fileFunctions, modFunctions, alignFunctions, utilFunctions, visibilityFunctions, portalFunctions, layoutFunctions, infoFunctions];\n\n \n return (\n \n \n { allFunctions.map((functions, index) =>\n \n { functions.map((svg: ISVGFunction, index) => \n (\n )\n )\n }\n )\n }\n \n \n \n { this.searchedGene = e.target.value;}}\n placeholder=\"Search Genes...\"\n onKeyPress={(e: any) => { if (e.key !== \"Enter\") return; this.props.pathwayActions.searchGene(this.searchedGene) }} />\n {this.props.pathwayActions.searchGene(this.searchedGene)}}\n style={{cursor: 'pointer'}}\n >\n \n \n \n \n \n \n \n )\n }\n\n}\n","import { EModalType } from \"../ui/react-pathway-mapper\";\nimport EditorActionsManager from \"./EditorActionsManager\";\n\nexport default class ContextMenuManager {\n private cy: any;\n private editor: EditorActionsManager;\n private handleOpen: (modalId: EModalType) => void;\n private undoRedoManager: any;\n private isCollaborative: any;\n constructor(cy: any, editor: EditorActionsManager,\n handleOpen: (modalId: EModalType) => void, undoRedoManager: any,\n isCollaborative: boolean){\n this.cy = cy;\n this.editor = editor;\n this.handleOpen = handleOpen;\n this.undoRedoManager = undoRedoManager;\n this.isCollaborative = isCollaborative;\n this.init();\n }\n\n init() {\n const classRef = this;\n\n const ctxMenus = this.cy.scratch('cycontextmenus') ? \n this.cy.contextMenus('get') :\n this.cy.contextMenus();\n\n let menuItems = [\n {\n id: 'deleteSelected',\n content: 'Delete Selected',\n coreAsWell: true,\n onClickFunction: () => {\n const selectedEles = this.cy.elements(':selected');\n classRef.editor.removeElement(selectedEles);\n },\n disabled: false, \n hasTrailingDivider: false,\n },\n {\n id: 'hideSelected',\n content: 'Hide Selected',\n coreAsWell: true,\n onClickFunction: function () {\n classRef.editor.hideSelectedNodes();\n },\n disabled: false,\n hasTrailingDivider: false, \n },\n {\n id: 'loadFromCBioPortal',\n content: 'Load From cBioPortal...', \n coreAsWell: true,\n onClickFunction: () => {\n this.handleOpen(EModalType.STUDY);\n },\n disabled: false,\n hasTrailingDivider: false,\n },\n //Context menu items when clicking on nodes/compounds\n {\n id: 'remove', \n content: 'Delete', \n selector: 'node, edge',\n onClickFunction: function (event) {\n var ele = event.target;\n // The function to be executed on click\n var selectedElements = classRef.cy.nodes(':selected').union(ele);\n classRef.editor.removeElement(selectedElements);\n },\n disabled: false,\n hasTrailingDivider: false, \n coreAsWell: false \n },\n {\n id: 'addSelected',\n content: 'Add Selected Into This', \n selector: 'node',\n onClickFunction: function (event)\n {\n var ele = event.target;\n var selectedNodes = classRef.cy.nodes(':selected');\n var containerType = ele.data('type');\n var validNodes = classRef.cy.collection();\n\n //Do nothing if node is GENE\n if (ele._private.data['type'] === 'GENE' || selectedNodes.size() < 1) {\n return;\n }\n //Prevent actions like adding root node to children & addition to itself\n else\n {\n var notValid = false;\n selectedNodes.forEach(function (tmpNode, i)\n {\n if (ele.id() == tmpNode.id()) {\n notValid = true;\n return false;\n }\n\n if (tmpNode.isParent()) {\n notValid = classRef.isChildren(tmpNode, ele);\n if (notValid) {\n return false;\n }\n }\n\n return true;\n });\n\n if (notValid) {\n return;\n }\n }\n\n\n selectedNodes.forEach(function (tmpNode, i)\n {\n\n if(containerType == \"FAMILY\" || containerType == \"COMPLEX\")\n {\n if(tmpNode.data('type') != \"COMPARTMENT\" && tmpNode.data('type') != \"PROCESS\")\n {\n validNodes = validNodes.add(tmpNode);\n }\n }\n else\n {\n validNodes = validNodes.add(tmpNode);\n }\n\n });\n\n var compId = ele.id();\n classRef.editor.changeParents(validNodes, compId);\n //Unselecting nodes to remove them from selectedNodeStack\n selectedNodes.unselect();\n\n },\n disabled: false,\n hasTrailingDivider: false, \n coreAsWell: false \n },\n {\n id: 'removeSelected',\n content: 'Remove Selected From Parent', \n selector: 'node',\n onClickFunction: function (event) {\n const ele = event.target;\n const selectedNodes = classRef.cy.nodes(':selected');\n\n let notValid = false;\n selectedNodes.forEach(function (tmpNode, i) {\n\n if (tmpNode.isParent()) {\n notValid = classRef.isChildren(tmpNode, ele);\n if (notValid) {\n return false;\n }\n }\n\n return true;\n });\n\n if (notValid) {\n return;\n }\n\n classRef.editor.changeParents(selectedNodes, null);\n //Unselecting nodes to remove them from selectedNodeStack\n selectedNodes.unselect();\n },\n disabled: false, \n hasTrailingDivider: false,\n coreAsWell: false \n },\n {\n id: 'performLayout', \n content: 'Perform Layout', \n coreAsWell: true,\n onClickFunction: () => {\n this.editor.performLayout();\n },\n disabled: false, \n hasTrailingDivider: false, \n }\n\n ];\n let nonCollabItems = [ \n //Context menu items when clicking on blank space\n {\n id: 'undoAction', \n content: 'Undo', \n coreAsWell: true,\n onClickFunction: () => {\n this.undoRedoManager.undo();\n },\n disabled: false, \n hasTrailingDivider: false, \n },\n {\n id: 'redoAction',\n content: 'Redo',\n coreAsWell: true,\n onClickFunction: () => {\n this.undoRedoManager.redo();\n },\n disabled: false,\n hasTrailingDivider: false,\n }\n ];\n\n if(!this.isCollaborative){\n menuItems = menuItems.concat(nonCollabItems);\n }\n ctxMenus.appendMenuItems(menuItems);\n }\n\n //TODO better move this to another class\n //Utility function to check whether query node is children of given node\n isChildren(node, queryNode)\n {\n var parent = queryNode.parent()[0];\n while(parent)\n {\n if (parent.id() == node.id()) {\n return true;\n }\n parent = parent.parent()[0];\n }\n return false;\n }\n}\n","import tippy from 'tippy.js';\nimport 'tippy.js/dist/tippy.css'; // optional for styling\nimport EditorActionsManager from \"./EditorActionsManager\";\nexport default class QtipManager{\n private cy: any;\n private editor: any;\n constructor(cy: any, editor: EditorActionsManager)\n {\n this.cy = cy;\n this.editor = editor;\n }\n\n generateEdgeQtip(edge) {\n const self = this;\n const pubmedURL = 'https://www.ncbi.nlm.nih.gov/pubmed/';\n const pubmedData = edge.data('pubmedIDs');\n\n const wrapper = document.createElement('div');\n\n // header\n const header = document.createElement('div');\n header.classList.add('row', 'node-tooltip-header');\n header.innerHTML = \"INTERACTION DETAILS\";\n\n wrapper.append(header);\n\n // edge label input\n const textInputWrapper = document.createElement('div');\n textInputWrapper.classList.add('col-xs-6', 'inputCol');\n\n const inputElement = document.createElement('input');\n inputElement.type = 'text';\n inputElement.value = edge.data('name');\n inputElement.classList.add('form-control');\n\n inputElement.addEventListener(\"change\", function(event) {\n // @ts-ignore\n const value = event.target.value;\n self.editor.changeName(edge, value);\n });\n\n textInputWrapper.appendChild(inputElement);\n\n const edgeLabelRowElement = document.createElement('div');\n edgeLabelRowElement.classList.add('row', 'geneDetails');\n const colElement = document.createElement('div');\n colElement.classList.add('col-xs-6', 'qtipLabel');\n colElement.innerHTML = \"Label:\";\n\n edgeLabelRowElement.appendChild(colElement);\n edgeLabelRowElement.appendChild(textInputWrapper);\n\n wrapper.appendChild(edgeLabelRowElement);\n \n wrapper.appendChild(document.createElement('hr'));\n\n // pubmed id input\n const pubmedTextInputWrapper = document.createElement('div');\n pubmedTextInputWrapper.classList.add('col-xs-6', 'inputCol');\n\n const pubmedIdInputElement = document.createElement('input');\n pubmedIdInputElement.type = 'text';\n pubmedIdInputElement.classList.add('form-control');\n\n pubmedIdInputElement.addEventListener(\"change\", function(event) {\n // @ts-ignore\n const value = event.target.value;\n const pubmedIdsToAdd = value.split(';');\n \n // @ts-ignore\n event.target.value = \"\";\n\n self.editor.addPubmedIDs(edge, pubmedIdsToAdd);\n\n const pubmedIds = edge.data(\"pubmedIDs\")\n generatePubmedLinks(pubmedIds);\n });\n\n pubmedTextInputWrapper.appendChild(pubmedIdInputElement);\n\n const pubmedIdRowElement = document.createElement('div');\n pubmedIdRowElement.classList.add('row', 'geneDetails');\n const pubmedIdColElement = document.createElement('div');\n pubmedIdColElement.classList.add('col-xs-6', 'qtipLabel');\n pubmedIdColElement.innerHTML = \"Add Pubmed ID(s):\";\n\n pubmedIdRowElement.appendChild(pubmedIdColElement);\n pubmedIdRowElement.appendChild(pubmedTextInputWrapper);\n\n wrapper.appendChild(pubmedIdRowElement);\n\n if (pubmedData.length > 0) {\n generatePubmedLinks(pubmedData);\n }\n\n function generatePubmedLinks(argData) {\n if (document.getElementsByClassName(\"pubmedIDList\").length > 0) {\n document.getElementsByClassName(\"pubmedIDList\").item(0).remove();\n }\n const pubmedIdListWrapper = document.createElement('div');\n pubmedIdListWrapper.classList.add(\"pubmedIDList\");\n\n pubmedIdListWrapper.appendChild(document.createElement('hr'));\n\n const pubmedIdLabel = document.createElement('label');\n pubmedIdLabel.classList.add(\"col-xs-12\", \"pubmedIDLabel\");\n pubmedIdLabel.innerHTML = \"Pubmed IDs\";\n\n pubmedIdListWrapper.appendChild(pubmedIdLabel);\n\n for (var key in argData)\n {\n if(!argData.hasOwnProperty(key)){\n continue;\n }\n const pubmedId = argData[key];\n\n if (isNaN(pubmedId))\n continue;\n\n const pubmedIdListElement = document.createElement('div');\n\n const pubmedIdRemoveButton = document.createElement('i');\n pubmedIdRemoveButton.classList.add('fa', 'fa-times', 'qtipRemovePmedID');\n pubmedIdRemoveButton.setAttribute('aria-hidden', 'true');\n pubmedIdRemoveButton.setAttribute('pubmedId', pubmedId);\n\n pubmedIdRemoveButton.addEventListener(\"click\", function(event) {\n (event.target as HTMLElement).parentElement.remove();\n const pubmedId = (event.target as HTMLElement).getAttribute('pubmedId');\n self.editor.removePubmedID(edge, [pubmedId]);\n const pubmedIds = edge.data('pubmedIDs');\n if (pubmedIds.length === 0) {\n document.getElementsByClassName(\"pubmedIDList\").item(0).remove();\n }\n });\n \n const pubmedContent = document.createElement('div');\n const pubmedIdLabel = document.createElement('label');\n const pubmedIdLink = document.createElement('a');\n pubmedIdLink.setAttribute('target', '_blank');\n const pubmedLink = pubmedURL + pubmedId;\n pubmedIdLink.setAttribute('href', pubmedLink);\n pubmedIdLink.innerHTML = pubmedId.toString();\n\n pubmedIdLabel.appendChild(pubmedIdLink);\n pubmedContent.appendChild(pubmedIdLabel);\n pubmedContent.appendChild(pubmedIdRemoveButton);\n pubmedIdListElement.appendChild(pubmedContent);\n\n pubmedIdListWrapper.appendChild(pubmedIdListElement);\n }\n if (edge.data('pubmedIDs').length > 0) {\n wrapper.appendChild(pubmedIdListWrapper);\n }\n }\n\n wrapper.classList.add(\"tooltip-text-style\");\n return wrapper;\n }\n\n generateNodeQtip(node) {\n const self = this;\n\n const header = document.createElement('div');\n header.classList.add('row', 'node-tooltip-header');\n header.innerHTML = node.data('type').toUpperCase() + \" DETAILS\";\n\n const textInputWrapper = document.createElement('div');\n textInputWrapper.classList.add('col-xs-8', 'inputCol');\n\n const inputElement = document.createElement('input');\n inputElement.type = 'text';\n inputElement.value = node.data('name');\n inputElement.classList.add('form-control');\n\n inputElement.addEventListener(\"change\", function(event) {\n // @ts-ignore\n const value = event.target.value;\n self.editor.changeName(node, value);\n });\n\n textInputWrapper.appendChild(inputElement);\n\n const wrapper = document.createElement('div');\n const rowElement = document.createElement('div');\n rowElement.classList.add('row', 'geneDetails');\n const colElement = document.createElement('div');\n colElement.classList.add('col-xs-4', 'qtipLabel');\n colElement.innerHTML = \"Name:\";\n\n rowElement.appendChild(colElement);\n rowElement.appendChild(textInputWrapper);\n\n wrapper.append(header);\n wrapper.append(rowElement);\n\n if (node.data('type') === \"GENE\") {\n const buttonWrapper = document.createElement('div');\n buttonWrapper.classList.add('row', 'centerText', 'geneDetails');\n \n const button = document.createElement('button');\n button.type = 'button';\n button.classList.add('btn', 'btn-default');\n button.innerHTML = \"My Cancer Genome\";\n button.addEventListener(\"click\", function (event) {\n event.preventDefault();\n const name = node.data('name');\n window.open(\"https://www.mycancergenome.org/content/gene/\" + name);\n })\n\n buttonWrapper.append(button);\n wrapper.append(buttonWrapper)\n }\n\n wrapper.classList.add(\"tooltip-text-style\");\n return wrapper;\n }\n\n addQtipToElements(eles)\n {\n const self = this;\n eles.forEach(function(ele)\n {\n let ref = ele.popperRef();\n let dummyDomEle = document.createElement('div');\n document.body.appendChild(dummyDomEle);\n let tip = tippy(dummyDomEle, { // tippy props:\n getReferenceClientRect: ref.getBoundingClientRect, // https://atomiks.github.io/tippyjs/v6/all-props/#getreferenceclientrect\n trigger: 'manual', // mandatory, we cause the tippy to show programmatically.\n placement: 'bottom',\n interactive: true,\n theme: 'pathwaymapper',\n // your own custom props\n // content prop can be used when the target is a single element https://atomiks.github.io/tippyjs/v6/constructor/#prop\n content: () => {\n let content = ele.isNode() ? \n self.generateNodeQtip(ele) :\n self.generateEdgeQtip(ele);\n \n return content;\n },\n onHidden(instance) {\n instance.destroy();\n dummyDomEle.remove();\n }\n });\n \n self.cy.one(\"pan zoom\", function() {\n if (dummyDomEle && dummyDomEle[\"_tippy\"]) {\n tip.hide();\n }\n });\n\n ele.one(\"showqtipevent\", function() {\n tip.show();\n });\n });\n }\n\n\n //Utility Functions\n capitalizeFirstLetter(string)\n {\n return string.charAt(0).toUpperCase() + string.slice(1);\n }\n\n\n}\n","import cytoscape from 'cytoscape';\nimport $ from \"jquery\";\nimport 'jquery-ui-dist/jquery-ui';\nimport EditorActionsManager from \"../managers/EditorActionsManager\";\n\n\nexport default class DragDropNodeAddPlugin {\n\n\n\n pathwayHandler: (pathwayName: string) => void;\n\n private cy: any;\n private editor: EditorActionsManager;\n\n constructor(editor: EditorActionsManager, cy: any, pathwayHandler: (pathwayName: string) => void)\n {\n this.editor = editor;\n this.cy = cy;\n this.pathwayHandler = pathwayHandler;\n this.initNodeAdd();\n }\n\n //TODO JQUERY IS IGNORED\n initNodeAdd()\n {\n var nodeAddClass = this;\n var defaults = {\n height: 30, //height of the icon container\n width: 30, //width of the icon container\n padding: 5, //padding of the icon container(from right & top)\n backgroundColorDiv: '#fbfbfb', //background color of the icon container\n borderColorDiv: '#fff', //border color of the icon container\n borderWidthDiv: '0px', //border width of the icon container\n borderRadiusDiv: '5px', //border radius of the icon container\n\n icon: '', //icon class name\n\n nodeParams: function(){\n // return element object to be passed to cy.add() for adding node\n return {};\n }\n };\n\n const self = this;\n\n // @ts-ignore\n $.fn.cytoscapeNodeadd = function(params: any) {\n var options = $.extend(true, {}, defaults, params);\n var fn = params;\n\n var functions = {\n destroy: function() {\n var $this = $(this);\n\n $this.find(\".ui-cytoscape-nodeadd\").remove();\n },\n init: function()\n {\n return $(this).each(function()\n {\n var components = options.components;\n for (const component of components)\n {\n var dragContainer = component.container;\n //var explanationText = component.explanationText;\n\n var $nodeadd = $('
');\n dragContainer.append($nodeadd);\n var $nodeDragHandle = $('
\\\n \\\n \\\n \\\n
');\n $nodeadd.append($nodeDragHandle);\n\n $nodeDragHandle.bind(\"mousedown\", function(e: any)\n {\n e.stopPropagation(); // don't trigger dragging of nodeadd\n e.preventDefault(); // don't cause text selection\n });\n\n //Setup UI\n dragContainer.find(\".ui-cytoscape-nodeadd-nodediv\").css({\n background: options.backgroundColorDiv,\n border: options.borderWidthDiv + ' solid ' + options.borderColorDiv,\n 'border-radius': options.borderRadiusDiv\n });\n\n //Init Draggable\n dragContainer.find(\"#ui-cytoscape-nodeadd-icon\").draggable({\n helper: \"clone\",\n cursor: \"pointer\"\n });\n }\n\n // @ts-ignore TODO: AMENDMENT ATTENTION\n var $container = $(this);\n //Init Droppable\n // @ts-ignore TODO: Droppable is ignored\n $container.droppable({\n activeClass: \"ui-state-highlight\",\n // accept: \"#ui-cytoscape-nodeadd-icon\",\n drop: function(event: any, ui: any) {\n $container.removeClass(\"ui-state-highlight\");\n\n var currentOffset = $container.offset();\n var relX = event.pageX - currentOffset.left;\n var relY = event.pageY - currentOffset.top;\n\n var nodeType = $(ui.helper).attr('nodeType').toUpperCase();\n\n var cy = nodeAddClass.cy;\n\n //Hold a map for parents and candidate parent nodes for this addition\n var nodeMap = {};\n var parentMap = {};\n //Loop through nodes for hit testing about drag position on canvas\n cy.nodes().forEach(function(node: any)\n {\n var nodeBbox = node.renderedBoundingBox();\n //Rectangle point test\n if ( (relX <= nodeBbox.x2 && relX >= nodeBbox.x1) && (relY <= nodeBbox.y2 && relY >= nodeBbox.y1) && node.data().type != 'GENE' )\n {\n //If node has a children put an entry to the parentMap\n if (node.children().length > 0)\n {\n parentMap[node.id()] = true;\n }\n\n //If parent of this node is already added to the node map remove it, since our candidate is in deeper level !\n if (parentMap[node._private.data.parent])\n {\n delete nodeMap[node._private.data.parent];\n }\n\n //Add an entry to node map\n nodeMap[node.id()] = node;\n }\n });\n\n //Check if any parent found, if so set parent field\n var parent = nodeMap[Object.keys(nodeMap)[0]];\n var nodeData = {w: \"0\", h: \"100\", parent: 0, type: nodeType, name:'New '+ $(ui.helper).attr('nodeType')};\n if (parent)\n {\n if(parent.data().type == \"FAMILY\" || parent.data().type == \"COMPLEX\")\n {\n if(nodeType != \"COMPARTMENT\" && nodeType != \"PROCESS\")\n {\n nodeData.parent = parent.id();\n }\n }\n else\n {\n nodeData.parent = parent.id();\n }\n }\n if (nodeType === \"PROCESS\") {\n nodeData.w = \"100\";\n nodeData.h = \"35\";\n }\n else {\n nodeData.w = \"150\";\n nodeData.h = \"52\";\n }\n\n //Adjust position according to the zoom level and pan !\n //To set rendered position !!!\n //TODO refactor this !\n relX = relX / cy.zoom() + cy.extent().x1;\n relY = relY / cy.zoom() + cy.extent().y1;\n nodeAddClass.editor.addNode(nodeData,{x: relX,y: relY});\n self.pathwayHandler(\"Additional Pathway\");\n\n }\n });\n\n });\n }\n };\n\n if (functions[fn]) {\n return functions[fn].apply(this, Array.prototype.slice.call(arguments, 1));\n } else if (typeof fn == 'object' || !fn) {\n return functions.init.apply(this, arguments);\n } else {\n $.error(\"No such function `\" + fn + \"` for jquery.cytoscapenodeadd\");\n }\n\n return $(this);\n };\n\n // @ts-ignore\n $.fn.cynodeadd = $.fn.cytoscapeNodeadd;\n try{\n /* Adding as an extension to the core functionality of cytoscape.js*/\n cytoscape('core', 'nodeadd', function(options: any) {\n\n // @ts-ignore\n $(this.container()).cytoscapeNodeadd(options);\n });\n } catch(err){\n console.log(err);\n }\n }\n\n\n\n\n}\n","import autobind from \"autobind-decorator\";\nimport cytoscape from 'cytoscape';\nimport $ from \"jquery\";\nimport { observer } from \"mobx-react\";\nimport React from 'react';\nimport pathways from \"../data/pathways.json\";\n// @ts-ignore\nimport compartmentImg from \"../images/nodes/compartment.svg\";\n// @ts-ignore\nimport complexImg from \"../images/nodes/complex.svg\";\n// @ts-ignore\nimport familyImg from \"../images/nodes/family.svg\";\n// @ts-ignore\nimport geneImg from \"../images/nodes/gene.svg\";\n// @ts-ignore\nimport processImg from \"../images/nodes/process.svg\";\n// @ts-ignore\nimport resizeCue from '../images/resizeCue.svg';\nimport ContextMenuManager from \"../managers/ContextMenuManager\";\nimport EditorActionsManager from \"../managers/EditorActionsManager\";\nimport QtipManager from \"../managers/QtipManager\";\nimport ShareDBManager from \"../managers/ShareDBManager\";\nimport ViewOperationsManager from \"../managers/ViewOperationsManager\";\nimport CBioPortalAccessor from \"../utils/CBioPortalAccessor\";\nimport DragDropNodeAddPlugin from \"../utils/DragDropNodeAddPlugin\";\nimport SaveLoadUtility from \"../utils/SaveLoadUtility\";\nimport { EModalType, IColorValueMap, IProfileMetaData } from './react-pathway-mapper';\n\n// @ts-ignore\nwindow.$ = $;\n\nconst edgeHandles = require('cytoscape-edgehandles');\nconst edgeEditing = require('cytoscape-edge-editing');\nconst fcose = require('cytoscape-fcose');\nconst nodeEditing = require('cytoscape-node-editing');\nconst undoRedo = require('cytoscape-undo-redo');\nconst panzoom = require('cytoscape-panzoom');\nconst styleSheet = require('../utils/GraphStyleSheet.tsx');\nconst panzoomOpts = require('../utils/PanzoomOptions.tsx');\nconst navigator = require('cytoscape-navigator');\nconst contextMenus = require('cytoscape-context-menus');\nconst konva = require('konva');\nconst viewUtilities = require('cytoscape-view-utilities');\nconst gridGuide = require('cytoscape-grid-guide');\nconst popper = require('cytoscape-popper');\nconst layoutUtilities = require('cytoscape-layout-utilities');\n\ntype PathwayMapperType = {\n isCollaborative: boolean;\n isCbioPortal: boolean;\n editorHandler: Function;\n selectedPathway: string;\n setActiveEdge: Function;\n profiles: IProfileMetaData[];\n pathwayHandler: (pathwayName: string) => void;\n handleOpen: (modalId: EModalType) => void;\n onPathwayChangeCompleted: () => void;\n genomicDataOverlayColorScheme: IColorValueMap;\n colorSchemeChangeCallback: (IColorValueMap) => void;\n};\n@observer\nexport default class CytoscapeArea extends React.Component{\n private cy:any;\n private cyDiv: HTMLDivElement | undefined;\n private editor: EditorActionsManager;\n private edgeAddingMode: any;\n private viewOperationsManager: ViewOperationsManager;\n private qtipManager: QtipManager;\n private genomicDataExplorerView: any;\n private pathwayDetailsView: any;\n private viewUtilities: any;\n private isCollaborative: boolean;\n private isCbioPortal: boolean;\n private shareDBManager: ShareDBManager;\n private cxtMenuManager: ContextMenuManager;\n private dragDropNodeAddManager: DragDropNodeAddPlugin;\n private undoRedoManager: any;\n private portalAccessor: CBioPortalAccessor;\n private isMountedFirst = true;\n private eh: any;\n private lastSelectedEdge: any;\n\n\n constructor (props: PathwayMapperType) {\n super(props);\n this.isCollaborative = props.isCollaborative;\n this.edgeAddingMode = 0;\n this.isCbioPortal = props.isCbioPortal;\n }\n\n componentWillUpdate(nextProps: PathwayMapperType) {\n\n if (this.props.selectedPathway !== nextProps.selectedPathway) {\n this.getPathway(nextProps.selectedPathway);\n }\n \n }\n\n componentDidUpdate(prevProps: PathwayMapperType) {\n if (this.isCbioPortal && \n prevProps.selectedPathway !== this.props.selectedPathway) {\n this.props.onPathwayChangeCompleted();\n }\n }\n\n // This method only opens pathways that are available in pathway.json. Namely, imported or merged pathways are not opened via this method.\n // Yet, they individually call parsing method.\n getPathway(selectedPathway: string){\n\n if(!selectedPathway || selectedPathway === '') return;\n\n const data = pathways[selectedPathway];\n\n // It might be non-existent due to pathway being created using collaborative mode, or pathway loaded elsewhere (import vs.)\n if(!data){ \n return;\n }\n // TODO Problematic const data = pathways[\"../samples/BLCA-2014-RTK-RAS-PI(3)K-pathway.txt\"];\n\n const parsedGraph = SaveLoadUtility.parseGraph(data, true);\n\n\n const allEles = parsedGraph;\n this.editor.loadFile(allEles.nodes, allEles.edges);\n }\n\n render(){\n return (
\n
\n
\n
);\n }\n\n componentDidMount(): void {\n if(this.isMountedFirst){\n this.init();\n this.isMountedFirst = false;\n }\n this.getPathway(this.props.selectedPathway);\n }\n\n @autobind\n cyDivHandler(div:HTMLDivElement){\n this.cyDiv = div;\n }\n\n init(){\n\n // Create portal accessor\n this.portalAccessor = new CBioPortalAccessor();\n\n // Initializes cytoscape\n this.initCyJS();\n // Initialize cytoscape based handlers here\n this.initCyHandlers();\n this.initKeyboardHandlers();\n this.initUndoRedoFunctionality();\n this.initCBioPortalFunctionalities();\n this.placePanzoomAndOverlay();\n\n //this.appManager = this;\n }\n\n placePanzoomAndOverlay(){\n //TODO place navigator !!!\n var offset = 5;\n // @ts-ignore\n var topCy = $(this.cyDiv).offset().top;\n //var bottomCy = $('.cyContainer').offset().bottom;\n // @ts-ignore\n var leftCy = $(this.cyDiv).offset().left;\n //var rightCy = $('.cyContainer').offset().right;\n // @ts-ignore\n var heightCy = $(this.cyDiv).outerHeight();\n // @ts-ignore\n var widthCy = $(this.cyDiv).outerWidth();\n var heightNavigator = $('.cytoscape-navigator-wrapper').outerHeight();\n var widthNavigator = $('.cytoscape-navigator-wrapper').outerWidth();\n\n if(!this.isCbioPortal) {\n \n $('.cytoscape-navigator-wrapper').css('top', heightCy + topCy - heightNavigator - offset + 16);\n $('.cytoscape-navigator-wrapper').css('left', widthCy + leftCy - widthNavigator - offset + 24 - 0.5 + 0.35);\n }\n else {\n $('.cytoscape-navigator-wrapper').css('bottom', 10.5);\n $('.cytoscape-navigator-wrapper').css('right', 0);\n }\n $('.cytoscape-navigator-wrapper').css('z-index', 1039);\n\n //Relative is used so that its position depends on the below properties\n $('.cy-panzoom').css('position', 'relative');\n $('.cy-panzoom').css('top', 2);\n $('.cy-panzoom').css('left', widthCy - 51);\n $('.cy-panzoom').css('z-index', 1039);\n //Makes the width of panzoom container to 0\n $('.cy-panzoom').css('width', 200);\n }\n\n getPathwayData() {\n return this.pathwayDetailsView.getPathwayData();\n }\n\n initCyJS() {\n \n try {\n panzoom(cytoscape, $); // register extension\n } catch(err){\n console.log(err);\n }\n try { \n navigator(cytoscape); // register extension\n } catch(err){\n console.log(err);\n }\n try { \n gridGuide(cytoscape, $); // register extension\n } catch(err){\n console.log(err);\n }\n try { \n undoRedo(cytoscape); // register extension\n } catch(err){\n console.log(err);\n }\n try { \n contextMenus(cytoscape, $); // register extension\n } catch(err){\n console.log(err);\n }\n try { \n nodeEditing(cytoscape, $, konva); // register extension\n } catch(err){\n console.log(err);\n }\n try { \n edgeEditing(cytoscape, $, konva); // register extension\n } catch(err){\n console.log(err);\n }\n try { \n viewUtilities(cytoscape, $); // register extension\n } catch(err){\n console.log(err);\n }\n try { \n edgeHandles(cytoscape, $);\n } catch(err){\n console.log(err);\n }\n try {\n popper(cytoscape);\n } catch (err) {\n console.log(err);\n }\n try {\n fcose(cytoscape);\n } catch (err) {\n console.log(err);\n }\n try {\n layoutUtilities(cytoscape);\n } catch (err) {\n console.log(err);\n }\n\n this.cy = cytoscape({\n container: this.cyDiv,\n boxSelectionEnabled: true,\n autounselectify: false,\n wheelSensitivity: 0.1,\n style: styleSheet,\n textureOnViewport: false,\n motionBlur: true,\n layout: {name: 'preset'}\n });\n\n this.edgeAddingMode = 0;\n // var allEles = SaveLoadUtilities.parseGraph(sampleGraph);\n\n this.undoRedoManager = this.cy.undoRedo();\n // Create Manager Classes\n this.shareDBManager = new ShareDBManager(() => {\n const dbDoc = this.shareDBManager.getDoc();\n });\n this.editor = new EditorActionsManager(this.isCollaborative,\n this.shareDBManager,\n this.cy,\n this.isCbioPortal,\n this.undoRedoManager,\n this.portalAccessor,\n this.props.profiles,\n this.props.genomicDataOverlayColorScheme,\n this.props.colorSchemeChangeCallback);\n this.shareDBManager.setEditor(this.editor);\n if(this.isCollaborative){\n this.shareDBManager.initShareDB();\n }\n\n this.qtipManager = new QtipManager(this.cy, this.editor);\n \n this.cxtMenuManager = new ContextMenuManager(this.cy, \n this.editor,\n this.props.handleOpen, \n this.undoRedoManager, \n this.props.isCollaborative);\n \n this.dragDropNodeAddManager = new DragDropNodeAddPlugin(this.editor, this.cy, this.props.pathwayHandler);\n\n // Initialize panzoom\n this.cy.panzoom(panzoomOpts);\n\n this.cy.layoutUtilities({\n desiredAspectRatio: this.cy.width() / this.cy.height()\n });\n\n // Node Add initialization\n this.cy.nodeadd(\n {\n // Once the explanationText is cast to uppercase they will be node types\n components:\n [\n {\n container: $('#simpleNodeDiv'),\n nodeType: 'Gene',\n icon: geneImg\n },\n {\n container: $('#familyNodeDiv'),\n nodeType: 'Family',\n icon: familyImg\n },\n {\n container: $('#complexNodeDiv'),\n nodeType: 'Complex',\n icon: complexImg\n },\n {\n container: $('#compartmentNodeDiv'),\n nodeType: 'Compartment',\n icon: compartmentImg\n },\n {\n container: $('#processNodeDiv'),\n nodeType: 'Process',\n icon: processImg\n }\n ]\n\n });\n const self = this;\n const edgeHandleDefaults ={\n preview: true, // whether to show added edges preview before releasing selection\n stackOrder: 4, // Controls stack order of edgehandles canvas element by setting it's z-index\n handleSize: 10, // the size of the edge handle put on nodes\n handleColor: '#1abc9c', // the colour of the handle and the line drawn from it\n handleLineType: 'ghost', // can be 'ghost' for real edge, 'straight' for a straight line, or 'draw' for a draw-as-you-go line\n handleLineWidth: 1, // width of handle line in pixels\n handleNodes: 'node', // selector/filter function for whether edges can be made from a given node\n hoverDelay: 1, // time spend over a target node before it is considered a target selection\n cxt: false, // whether cxt events trigger edgehandles (useful on touch)\n enabled: false, // whether to start the extension in the enabled state\n toggleOffOnLeave: true, // whether an edge is cancelled by leaving a node (true), or whether you need to go over again to cancel (false; allows multiple edges in one pass)\n edgeType: function( sourceNode, targetNode ) {\n // can return 'flat' for flat edges between nodes or 'node' for intermediate node between them\n // returning null/undefined means an edge can't be added between the two nodes\n return 'flat';\n },\n handlePosition: function( node ){\n return 'middle top'; // sets the position of the handle in the format of \"X-AXIS Y-AXIS\" such as \"left top\", \"middle top\"\n },\n loopAllowed: function( node ) {\n // for the specified node, return whether edges from itself to itself are allowed\n return false;\n },\n nodeLoopOffset: -50, // offset for edgeType: 'node' loops\n nodeParams: function( sourceNode, targetNode ) {\n // for edges between the specified source and target\n // return element object to be passed to cy.add() for intermediary node\n return {};\n },\n edgeParams: function( sourceNode, targetNode, i ) {\n // for edges between the specified source and target\n // return element object to be passed to cy.add() for edge\n // NB: i indicates edge index in case of edgeType: 'node'\n return {};\n },\n start: function( sourceNode )\n {\n // fired when edgehandles interaction starts (drag on handle)\n var type = self.getGlobalEdgeType();\n //self.cy.edgehandles('option', 'ghostEdgeType', type);\n },\n complete: function( sourceNode, targetNodes, addedEntities )\n {\n // // Remove recently added edge !\n // // FBI takes this case from now on :O\n // // We will take care of addition in our manager :)\n self.cy.remove(addedEntities);\n self.editor.addEdge({\n source: sourceNode.id(),\n target: targetNodes[0].id(),\n // @ts-ignore\n type: self.getGlobalEdgeType(window.edgeAddingMode),\n pubmedIDs: [],\n name: \"\"\n });\n },\n stop: function( sourceNode )\n {\n // fired when edgehandles interaction is stopped (either complete with added edges or incomplete)\n //TODO refactor this, so terrible for now\n //$('.edge-palette a').blur().removeClass('active');\n self.edgeAddingMode = -1;\n self.eh.disable();\n self.eh.hide();\n self.props.setActiveEdge(-1);\n },\n };\n //Edge Handles initialization\n this.eh = this.cy.edgehandles(edgeHandleDefaults);\n this.eh.disable();\n this.props.editorHandler(this.editor, this.eh, this.undoRedoManager);\n\n if(!this.isCbioPortal) {\n this.cy.nodeEditing({\n padding: 5, // spacing between node and grapples/rectangle\n undoable: true, // and if cy.undoRedo exists\n\n grappleSize: 8, // size of square dots\n grappleColor: \"#ffc90e\", // color of grapples\n inactiveGrappleStroke: \"inside 1px blue\",\n boundingRectangle: true, // enable/disable bounding rectangle\n boundingRectangleLineDash: [4, 8], // line dash of bounding rectangle\n boundingRectangleLineColor: \"ffc90e\",\n boundingRectangleLineWidth: 1.5,\n zIndex: 999,\n\n moveSelectedNodesOnKeyEvents: function () {\n return true;\n },\n\n minWidth: function (node) {\n var data = node.data(\"resizeMinWidth\");\n return data ? data : 15;\n }, // a function returns min width of node\n minHeight: function (node) {\n var data = node.data(\"resizeMinHeight\");\n return data ? data : 15;\n }, // a function returns min height of node\n\n // Getters for some style properties the defaults returns ele.css('property-name')\n // you are encouraged to override these getters\n getCompoundMinWidth: function (node) {\n return node.style('min-width');\n },\n getCompoundMinHeight: function (node) {\n return node.style('min-height');\n },\n getCompoundMinWidthBiasRight: function (node) {\n return node.style('min-width-bias-right');\n },\n getCompoundMinWidthBiasLeft: function (node) {\n return node.style('min-width-bias-left');\n },\n getCompoundMinHeightBiasTop: function (node) {\n return node.style('min-height-bias-top');\n },\n getCompoundMinHeightBiasBottom: function (node) {\n return node.style('min-height-bias-bottom');\n },\n\n\n isFixedAspectRatioResizeMode: function (node) {\n return node.is(\".fixedAspectRatioResizeMode\")\n },// with only 4 active grapples (at corners)\n isNoResizeMode: function (node) {\n return undefined;\n }, // no active grapples\n\n // These optional function will be executed to set the width/height of a node in this extension\n // Using node.css() is not a recommended way (http://js.cytoscape.org/#eles.style) to do this. Therefore, overriding these defaults\n // so that a data field or something like that will be used to set node dimentions instead of directly calling node.css()\n // is highly recommended (Of course this will require a proper setting in the stylesheet).\n setWidth: function (node, width) {\n node.data('w', width)\n },\n setHeight: function (node, height) {\n node.data('h', height);\n },\n setCompoundMinWidth: function (node, minWidth) {\n node.style('min-width', minWidth);\n },\n setCompoundMinHeight: function (node, minHeight) {\n node.style('min-height', minHeight);\n },\n setCompoundMinWidthBiasLeft: function (node, minWidthBiasLeft) {\n node.style('min-width-bias-left', minWidthBiasLeft);\n },\n setCompoundMinWidthBiasRight: function (node, minHeightBiasRight) {\n node.style('min-width-bias-right', minHeightBiasRight);\n },\n setCompoundMinHeightBiasTop: function (node, minHeightBiasTop) {\n node.style('min-height-bias-top', minHeightBiasTop);\n },\n setCompoundMinHeightBiasBottom: function (node, minHeightBiasBottom) {\n node.style('min-height-bias-bottom', minHeightBiasBottom);\n },\n\n cursors: { // See http://www.w3schools.com/cssref/tryit.asp?filename=trycss_cursor\n // May take any \"cursor\" css property\n default: \"default\", // to be set after resizing finished or mouseleave\n inactive: \"not-allowed\",\n nw: \"nw-resize\",\n n: \"n-resize\",\n ne: \"ne-resize\",\n e: \"e-resize\",\n se: \"se-resize\",\n s: \"s-resize\",\n sw: \"sw-resize\",\n w: \"w-resize\"\n },\n resizeToContentCueImage: resizeCue,\n resizeToContentFunction: this.editor.resizeNodesToContent.bind(this.editor),\n });\n }\n //Navigator for cytoscape js\n var navDefaults = {\n container: '.cytoscape-navigator-wrapper' // can be a HTML or jQuery element or jQuery selector\n , viewLiveFramerate: 0 // set false to update graph pan only on drag end; set 0 to do it instantly; set a number (frames per second) to update not more than N times per second\n , thumbnailEventFramerate: 10 // max thumbnail's updates per second triggered by graph updates\n , thumbnailLiveFramerate: false // max thumbnail's updates per second. Set false to disable\n , dblClickDelay: 200 // milliseconds\n , removeCustomContainer: true // destroy the container specified by user on plugin destroy\n , rerenderDelay: 100 // ms to throttle rerender updates to the panzoom for performance\n };\n\n //TODO: AMENDMENT declaration removed\n this.cy.navigator(navDefaults); // get navigator instance, nav\n\n const viewUtilitiesOpts = {\n node: {\n highlighted: {\n 'border-width': 2,\n 'border-color': '#bc1142'\n }, // styles for when nodes are highlighted.\n unhighlighted: {\n 'opacity': function (ele: any) {\n // We return the same opacity because to override the unhibhlighted ele opacity in view-utilities\n return ele.css('opacity');\n }\n }// styles for when nodes are unhighlighted.}\n },\n edge: {\n highlighted: {}, // styles for when edges are highlighted.\n unhighlighted: {\n 'opacity': function (ele: any) {\n // We return the same opacity because to override the unhibhlighted ele opacity in view-utilities\n return ele.css('opacity');\n }\n } // styles for when edges are unhighlighted.\n },\n setVisibilityOnHide: false, // whether to set visibility on hide/show\n setDisplayOnHide: true, // whether to set display on hide/show\n neighbor: () => { // return desired neighbors of tapheld node\n return false;\n },\n neighborSelectTime: 500 //ms, time to taphold to select desired neighbors\n };\n\n this.viewUtilities = this.cy.viewUtilities(viewUtilitiesOpts);\n\n this.editor.setViewUtilities(this.viewUtilities);\n\n this.placePanzoomAndOverlay();\n }\n\n getGlobalEdgeType()\n {\n var type = \"NONE\";\n // @ts-ignore\n if (window.edgeAddingMode === 1)\n {\n type = 'ACTIVATES';\n }\n // @ts-ignore\n else if (window.edgeAddingMode === 2)\n {\n type = 'INHIBITS';\n }\n // @ts-ignore\n else if (window.edgeAddingMode === 3)\n {\n type = 'INDUCES';\n }\n // @ts-ignore\n else if (window.edgeAddingMode === 4)\n {\n type = 'REPRESSES';\n }\n // @ts-ignore\n else if (window.edgeAddingMode === 5)\n {\n type = 'BINDS';\n }\n return type;\n }\n\n initCyHandlers(){\n var that = this;\n\n var tappedBefore: any;\n var tappedTimeout: number;\n this.cy.on('tap', function (event: any) {\n var tappedNow = event.target;\n if (tappedTimeout !== -1 && tappedBefore !== -1) {\n clearTimeout(tappedTimeout);\n }\n if (tappedBefore === tappedNow) {\n tappedNow.trigger('doubleTap');\n tappedBefore = -1;\n } else {\n // @ts-ignore TODO AMENDMENTsa\n tappedTimeout = setTimeout(function () {\n tappedBefore = -1;\n }, 300);\n tappedBefore = tappedNow;\n }\n });\n\n this.cy.on('doubleTap', 'node', function (e: any) {\n\n // if cBioPortal ignore\n if(that.props.isCbioPortal) return;\n\n const eventIsDirect = (e.target === this);\n \n if (eventIsDirect) { \n that.qtipManager.addQtipToElements(e.target); \n e.target.trigger(\"showqtipevent\");\n }\n });\n \n this.cy.on('doubleTap', 'edge', function (e: any) {\n \n // if cBioPortal ignore\n if(that.props.isCbioPortal) return;\n \n const eventIsDirect = (e.target === this);\n \n if (eventIsDirect) {\n that.qtipManager.addQtipToElements(e.target); \n e.target.trigger(\"showqtipevent\");\n }\n });\n\n this.cy.on('select', 'node', (e: any) => {\n this.editor.pushSelectedNodeStack(e.target);\n });\n\n // this.cy.on('select', 'edge', function( e )\n // {\n // var eventIsDirect = (e.target === this);\n // $(\".qtip\").remove();\n //\n // if( eventIsDirect ) {\n // that.qtipManager.addQtipToElements(e.target);\n // }\n // });\n\n this.cy.on('unselect', 'node', (e: any) => {\n this.editor.removeElementFromSelectedNodeStack(e.target);\n });\n\n this.cy.on('free', 'node', (e: any) => {\n //Collect all nodes with descendants in case of compounds\n var selectedNodes = this.cy.nodes(':selected');\n var nodes = e.target;\n nodes = nodes.union(nodes.descendants());\n nodes = nodes.union(selectedNodes);\n this.editor.moveElements(nodes);\n });\n\n this.cy.on('layoutstop', () => {\n this.editor.postLayout();\n });\n\n this.cy.on(\"nodeediting.resizeend\", (_e: any, _type: any, node: any) => {\n \n //Updates 'data' properties from 'style'\n node.data('w', node.width());\n node.data('h', node.height());\n //Used for collaborative mode\n this.editor.resizeElements(node);\n });\n\n this.cy.on('select', 'edge', (e: any) => {\n this.lastSelectedEdge = e.target;\n });\n\n this.cy.on('bendPointMovement', () => {\n this.editor.updateEdgeAnchorPoints(this.lastSelectedEdge);\n });\n\n this.cy.on('nodeediting.moveend', () => {\n this.editor.changeNodePositionsByArrows(this.cy.nodes(\":selected\"));\n });\n\n }\n\n initKeyboardHandlers() {\n if (!this.isCollaborative && !this.isCbioPortal) {\n $(document).keydown((e: any) => {\n if (e.which === 89 && (e.ctrlKey || e.metaKey)) {\n this.undoRedoManager.redo();\n }\n else if (e.which === 90 && (e.ctrlKey || e.metaKey)) {\n this.undoRedoManager.undo();\n }\n });\n }\n else {\n $('a[role=\"redo\"]').hide();\n $('a[role=\"undo\"]').hide();\n }\n $(document).keydown((e: any) => {\n if (e.which === 65 && (e.ctrlKey || e.metaKey)) {\n // @ts-ignore\n var tn = document.activeElement.tagName;\n if (tn != \"TEXTAREA\" && tn != \"INPUT\") {\n e.preventDefault();\n this.cy.elements().select();\n }\n }\n else if (e.which === 8 || e.which === 46) {\n // @ts-ignore\n var tn = document.activeElement.tagName;\n if (tn != \"TEXTAREA\" && tn != \"INPUT\") {\n var selectedElements = this.cy.$(':selected');\n this.editor.removeElement(selectedElements);\n }\n }\n });\n }\n\n initUndoRedoFunctionality() {\n if (this.isCollaborative || this.isCbioPortal) {\n $('[role=\"undo\"]').hide();\n $('[role=\"redo\"]').hide();\n /* TODO: AMENDMENT\n document.getElementById(\"localOrCollaborativeToolbar\").style.display = \"none\";\n */\n }\n }\n\n\n initCBioPortalFunctionalities() {\n if (this.isCbioPortal) {\n const contextMenu = this.cy.contextMenus('get');\n\n contextMenu.destroy();\n }\n }\n\n\n}","import autobind from \"autobind-decorator\";\nimport { action, computed, makeObservable, observable } from \"mobx\";\nimport { observer } from \"mobx-react\";\nimport { IGeneticAlterationRuleSetParams } from 'oncoprintjs';\nimport React from 'react';\nimport { Col, Row } from \"react-bootstrap\";\nimport { toast, ToastContainer } from 'react-toastify';\nimport 'react-toastify/dist/ReactToastify.min.css';\nimport ReactTooltip from 'react-tooltip';\nimport \"../css/pmv1.css\";\nimport \"../css/pmv2.css\";\nimport '../css/qtip.css';\nimport \"../css/supp.css\";\nimport pathways from \"../data/pathways.json\";\nimport EditorActionsManager from \"../managers/EditorActionsManager\";\nimport FileOperationsManager from '../managers/FileOperationsManager';\nimport GridOptionsManager from '../managers/GridOptionsManager';\nimport ViewOperationsManager from '../managers/ViewOperationsManager';\nimport AboutModal from '../modals/AboutModal';\nimport CBioHelpModal from '../modals/CBioHelpModal';\nimport ConfirmationModal from '../modals/ConfirmationModal';\nimport GridSettings from '../modals/GridSettings';\nimport LayoutProperties from '../modals/LayoutProperties';\nimport PathwayDetailsModal from '../modals/PathwayDetailsModal';\nimport ProfilesColorSchemeModal from \"../modals/ProfilesColorSchemeModal\";\nimport ProfilesModal from '../modals/ProfilesModal';\nimport QuickHelpModal from '../modals/QuickHelpModal';\nimport StudyModal from '../modals/StudyModal';\nimport Ranking from \"../ui/Ranking\";\nimport Toolbar from \"../ui/Toolbar\";\nimport CBioPortalAccessor from '../utils/CBioPortalAccessor';\nimport PathwayActions from '../utils/PathwayActions';\nimport SaveLoadUtility from '../utils/SaveLoadUtility';\nimport Buttonbar from \"./Buttonbar\";\nimport CytoscapeArea from \"./CytoscapeArea\";\nimport Menubar from './Menubar';\nimport Sidebar from './Sidebar';\n\nconst maxHeapFn = require('@datastructures-js/max-heap');\nlet maxHeap = maxHeapFn();\n\ninterface IPathwayMapperProps{\n isCBioPortal: boolean;\n genes: any[];\n isCollaborative?: boolean;\n cBioAlterationData?: ICBioData[];\n sampleIconData?: ISampleIconData,\n pathwayName? : string;\n alterationData?: IAlterationData;\n onAddGenes?: (selectedGenes: string[]) => void;\n changePathwayHandler?: (pathwayGenes: string[]) => void;\n addGenomicDataHandler?: (addGenomicData: (alterationData: ICBioData[]) => void) => void;\n tableComponent?: (data: IPathwayMapperTable[], selectedPathway: string, onPathwaySelect: (pathway: string) => void) => JSX.Element;\n validGenes?: any;\n toast: any;\n showMessage: (message: string) => void;\n //PatientView variable\n patientView ?: boolean;\n messageBanner? : () => JSX.Element;\n}\n\nexport interface ICBioData{\n altered: number;\n gene: string;\n percentAltered: string​;\n sequenced: number;\n geneticTrackData?: any[]; // TODO GeneticTrackDatum[]: this is currently a private type within cbioportal repo\n geneticTrackRuleSetParams?: IGeneticAlterationRuleSetParams;\n}\n\nexport interface ISampleIconData {\n sampleIndex: { [s: string]: number },\n sampleColors: { [s: string]: string }\n}\n\n/**\n * Maps integer values to color code strings\n */\nexport interface IColorValueMap {\n [value: string]: string\n}\n\nexport enum EModalType{\n STUDY,\n CONFIRMATION,\n PROFILES,\n ABOUT,\n PW_DETAILS,\n GRID,\n HELP,\n LAYOUT,\n CHELP,\n PROFILES_COLOR_SCHEME\n}\n\nexport interface IPathwayData{\n title: string;\n description: string;\n nodes: any[];\n edges: any[];\n}\n\nexport interface IAlterationData{\n [key: string]: {[key: string]: number};\n}\n\nexport interface IProfileMetaData{\n profileId: string;\n studyId?: string;\n enabled: boolean;\n}\n\nexport interface IDataTypeMetaData{\n enabled: boolean;\n checked: boolean;\n profile: string;\n}\n\nexport interface IPathwayMapperTable{\n name: string;\n score: number;\n genes: string[];\n}\n\n@observer\nexport class PathwayMapper extends React.Component {\n static readonly CBIO_PROFILE_NAME = \"cBioPortal_data\";\n\n\n readonly MAX_ALLOWED_PROFILES_ENABLED = 6;\n \n @observable\n selectedPathway: string;\n\n fileManager: FileOperationsManager;\n\n @observable\n editor: EditorActionsManager;\n\n pathwayActions: PathwayActions;\n\n @observable\n isModalShown: boolean[];\n\n @observable\n colorValueMap: IColorValueMap;\n\n portalAccessor: CBioPortalAccessor;\n\n @observable\n alterationData: IAlterationData;\n\n @observable\n patientData: any [][] = [];\n\n @observable\n pathwayGeneMap: {[key: string]: {[key: string]: string}} = {};\n\n bestPathwaysAlgos: any[][] = [];\n\n @observable\n oldName = \"\";\n \n @observable\n profiles: IProfileMetaData[] = [];\n\n setActiveEdge: (edgeId: number) => void;\n viewOperationsManager: ViewOperationsManager;\n gridOptionsManager: GridOptionsManager;\n\n\n\n constructor(props: IPathwayMapperProps){\n super(props);\n makeObservable(this);\n \n this.fileManager = new FileOperationsManager();\n this.pathwayActions = new PathwayActions(this.pathwayHandler, this.profiles, this.fileManager, \n this.handleOpen, this.props.isCBioPortal, this.props.isCollaborative);\n this.selectedPathway = \"\";\n if(this.props.pathwayName){\n this.pathwayActions.changePathway(this.props.pathwayName);\n }\n this.isModalShown = [false, false, false, false, false, false, false, false, false, false];\n // TODO: Change below\n this.alterationData = {}; //{\"study1_gistic\" : {\"CDK4\": 11, \"MDM2\": 19, \"TP53\": 29}, \"study2_gistic\" : {\"MDM2\": 99, \"TP53\": 98}, \"study3_mutations\": {\"MDM2\": 1, \"TP53\": 2}};\n this.extractAllGenes();\n\n this.colorValueMap = {\n '-100' : \"#0000ff\",\n '0' : \"#ffffff\",\n '100' : \"#ff0000\"\n }\n\n if(this.props.isCBioPortal){\n //this.overlayPortalData();\n \n // If cBioPortal mode is 'on' it is very likely to have cBioALterationData\n // but to be on the safe side below assertion is made.\n if(this.props.cBioAlterationData ){\n if( this.props.patientView){\n //PatientView PathwayMapper has a different functionality\n //Alteration types are overlayed instead of alterationpercentage\n this.calculatePatientData(this.props.cBioAlterationData);\n this.addSampleIconData(this.props.sampleIconData);\n }\n else{\n this.calculateAlterationData(this.props.cBioAlterationData);\n\n }\n }\n\n if(this.props.addGenomicDataHandler){\n this.props.addGenomicDataHandler(this.addGenomicData);\n }\n\n this.profiles.push({profileId: PathwayMapper.CBIO_PROFILE_NAME, enabled: true});\n this.getBestPathway(0);\n this.getBestPathway(1);\n this.getBestPathway(2);\n this.getBestPathway(3);\n }\n /*\n const profile1 = {profileId: \"study1_gistic\", studyId: \"study1\", enabled: true};\n const profile2 = {profileId: \"study2_gistic\", studyId: \"study2\", enabled: true};\n const profile3 = {profileId: \"study3_mutations\", studyId: \"study3\", enabled: true};\n const profile4 = {profileId: \"study3_mutations\", studyId: \"study3\", enabled: true};\n const profile5 = {profileId: \"study3_mutations\", studyId: \"study3\", enabled: true};\n const profile6 = {profileId: \"study3_mutations\", studyId: \"study3\", enabled: true};\n this.profiles.push(profile1, profile2, profile3, profile4, profile5, profile6);\n */\n\n }\n\n @action.bound\n setColorMapping(colorValueMap: IColorValueMap) {\n this.colorValueMap = colorValueMap;\n this.editor.updateGenomicDataColorScheme(this.colorValueMap);\n }\n\n @action\n setSelectedPathway(pathway: string) {\n this.selectedPathway = pathway;\n }\n\n @action\n setEditor(editor: EditorActionsManager) {\n this.editor = editor;\n }\n\n @action\n addProfile(profile: IProfileMetaData) {\n this.profiles.push(profile);\n }\n\n @action\n toggleProfileEnabled(index: number) {\n this.profiles[index].enabled = !this.profiles[index].enabled;\n }\n\n calculateAlterationData(cBioAlterationData: ICBioData[]){\n // Transform cBioDataAlteration into AlterationData\n this.alterationData[PathwayMapper.CBIO_PROFILE_NAME] = {};\n cBioAlterationData.forEach((geneAltData: ICBioData) => {\n const perc = (geneAltData.altered / geneAltData.sequenced) * 100;\n \n // NaN value is replaced with -101 since NaN value leads to some runtime exceptions (such as with toFixed() function),\n // hence it is represented as -101. It will be recognized in the genomic data svg creation to show N/P instead of\n // a percentage. -101 is chosen because this percentage is impossible to get.\n this.alterationData[PathwayMapper.CBIO_PROFILE_NAME][geneAltData.gene] = ((Object.is(perc, NaN) ? -101 : perc));\n \n\n });\n }\n \n calculatePatientData(cBioAlterationData: ICBioData[]){\n // Transform cBioDataAlteration into Patient Data every alteration is accepted 100% altered\n\n this.alterationData[PathwayMapper.CBIO_PROFILE_NAME] = {};\n \n const allTypes = cBioAlterationData.map(x => x.gene); \n //const allTypes = cBioAlterationData.map(x => x.percentAltered);\n const uniqueTypes = allTypes.filter((x, i, a) => a.indexOf(x) == i)\n //This is a flag for GenomicDataOverlayManager showPatientData\n this.patientData[\"PatientView\"] = 1;\n\n uniqueTypes.forEach(x => {\n this.patientData[x]= {};\n });\n\n cBioAlterationData.forEach((geneAltData: ICBioData) => {\n const perc = (geneAltData.altered / geneAltData.sequenced) * 100;\n\n this.alterationData[PathwayMapper.CBIO_PROFILE_NAME][geneAltData.gene] = ((Object.is(perc, NaN) ? -101 : perc));\n\n this.patientData[geneAltData.gene][geneAltData.percentAltered] = ((Object.is(perc, NaN) ? -101 : perc));\n this.patientData[geneAltData.gene][\"geneticTrackData\"] = geneAltData.geneticTrackData;\n this.patientData[geneAltData.gene][\"geneticTrackRuleSetParams\"] = geneAltData.geneticTrackRuleSetParams;\n });\n\n }\n\n addSampleIconData(sampleIconData: any) {\n if (sampleIconData) {\n this.patientData[\"sampleColors\"] = sampleIconData.sampleColors;\n this.patientData[\"sampleIndex\"] = sampleIconData.sampleIndex;\n }\n }\n\n getGeneStudyMap(studyGeneMap: any){\n \n const genomicDataMap: any = {};\n for (const cancerStudy of Object.keys(studyGeneMap)) {\n\n const cancerData = studyGeneMap[cancerStudy];\n\n for (const geneSymbol of Object.keys(cancerData)) {\n if (genomicDataMap[geneSymbol] === undefined) genomicDataMap[geneSymbol] = {};\n\n genomicDataMap[geneSymbol][cancerStudy] = studyGeneMap[cancerStudy][geneSymbol].toFixed(2);\n }\n }\n return genomicDataMap;\n }\n\n getAlterationAveragePerGene(genomicDataMap: any){\n\n const geneAlterationMap: any = {};\n for(const gene of Object.keys(genomicDataMap)){\n let sum = 0, count = 0;\n\n for(const alteration of Object.values(genomicDataMap[gene])){\n sum += parseFloat(alteration as string);\n count++;\n }\n if(count === 0){\n geneAlterationMap[gene] = 0;\n } else {\n geneAlterationMap[gene] = sum / count;\n }\n }\n\n return geneAlterationMap;\n }\n\n\n /**\n * \n * @param rankingMode: number => 0 = Count, 1 = Percentage, 2 = Count with Alteration, 3 = Percentage with Alteration\n * \n */\n getBestPathway(rankingMode: number) {\n \n const genomicDataMap = this.getGeneStudyMap(this.alterationData);\n const alterationPerGene = this.getAlterationAveragePerGene(genomicDataMap);\n maxHeap = maxHeapFn();\n\n const matchedGenesMap: any = {};\n const bestPathways: any[] = [];\n for(const pathwayName in this.pathwayGeneMap){\n if(this.pathwayGeneMap.hasOwnProperty(pathwayName)){\n \n const genesMatching = [];\n // Calculate sum of all alterations\n let sumOfAlterations = 0;\n for(const gene of this.props.genes){\n \n if(this.pathwayGeneMap[pathwayName].hasOwnProperty(gene.hugoGeneSymbol) \n && this.pathwayGeneMap[pathwayName][gene.hugoGeneSymbol] === \"GENE\"){\n genesMatching.push(gene.hugoGeneSymbol);\n sumOfAlterations += alterationPerGene[gene.hugoGeneSymbol];\n }\n }\n matchedGenesMap[pathwayName] = genesMatching;\n let geneCount = 0;\n // Count number of genes *not processess* in a pathway\n for(const geneType of Object.values(this.pathwayGeneMap[pathwayName])){\n if(geneType === \"GENE\"){\n geneCount++;\n }\n }\n\n if(rankingMode === 0){\n maxHeap.insert(genesMatching.length, {pathwayName: pathwayName});\n } else if(rankingMode === 1){\n maxHeap.insert(genesMatching.length / geneCount * 100, {pathwayName: pathwayName}); \n } else if(rankingMode === 2){\n maxHeap.insert(sumOfAlterations, {pathwayName: pathwayName}); \n } else if(rankingMode === 3){\n maxHeap.insert(genesMatching.length * sumOfAlterations / geneCount, {pathwayName: pathwayName});\n }\n\n }\n }\n while(maxHeap.size() > 0){\n const top = maxHeap.extractMax();\n const pathwayName = top.getValue().pathwayName;\n bestPathways.push({score: top.getKey(), genesMatched: matchedGenesMap[pathwayName], pathwayName: pathwayName});\n }\n if(this.bestPathwaysAlgos.length === 0) // First pathway of the first method is shown as the default pathway.\n this.setSelectedPathway(bestPathways[0].pathwayName);\n this.bestPathwaysAlgos.push(bestPathways);\n }\n \n // This method extracts all genes of a pathway and adds it to the pathwayGeneMap\n // so that it can be used by percentage calculation and genomic data \n // Note: Pathway title\n @autobind\n includePathway(pathwayData?: IPathwayData, pathwayName?: string){\n const genes = pathwayData.nodes;\n const geneHash: any = {};\n\n for(const gene of genes){\n\n if(gene.data.type === \"GENE\")\n geneHash[gene.data.name] = gene.data.type;\n }\n\n this.pathwayGeneMap[pathwayData.title] = geneHash;\n\n }\n\n extractAllGenes(){\n for(const pathwayName in pathways){\n if(pathways.hasOwnProperty(pathwayName)){\n\n const pathwayData: IPathwayData = SaveLoadUtility.parseGraph(pathways[pathwayName], true);\n this.includePathway(pathwayData);\n }\n }\n \n }\n\n\n loadRedirectedPortalData(){\n\n if(!this.props.alterationData){ // If size 0 that means it is not redirected.\n return;\n }\n \n const redirectedProfiles = Object.keys(this.props.alterationData).map((data: string) : IProfileMetaData => ({profileId: data, enabled: true}));\n redirectedProfiles.forEach((redirectedProfile) => {\n this.addProfile(redirectedProfile);\n });\n this.editor.addPortalGenomicData(this.props.alterationData, this.editor.getEmptyGroupID());\n }\n\n exists(profileId: string){\n\n let exists = false;\n this.profiles.forEach((profile: IProfileMetaData) => {\n if(profile.profileId === profileId){\n exists = true;\n }\n });\n\n return exists;\n }\n\n @autobind\n loadFromCBio(dataTypes: {[dataType: string]: IDataTypeMetaData}, studyData: any[]){\n if(!this.pathwayActions.doesCyHaveElements()){\n toast.warn('Your pathway is empty!');\n return;\n }\n\n for (const metadata of Object.values(dataTypes))\n {\n if(!metadata.checked) {\n continue;\n } \n if(this.exists(metadata.profile)){\n toast.warn(metadata.profile + \" already exists.\");\n continue;\n }\n\n const studyId = studyData[0];\n const profileId = metadata.profile;\n\n const enableNewProfile = this.profiles.length < this.MAX_ALLOWED_PROFILES_ENABLED;\n\n const newProfile = {\n studyId: studyId,\n profileId: profileId,\n enabled: enableNewProfile\n }\n\n this.addProfile(newProfile);\n\n const genes = this.editor.cy.nodes()\n .filter(node => node.data(\"type\") === \"GENE\")\n .map(node => node.data(\"name\"));\n\n \n this.portalAccessor.getProfileData({\n caseSetId: studyId,\n geneticProfileId: profileId,\n genes: genes\n },\n (data: any) => {\n this.editor.addPortalGenomicData(data, this.editor.getEmptyGroupID());\n let visibilityObject = {};\n visibilityObject[newProfile.profileId] = newProfile.enabled;\n this.editor.updateGenomicDataVisibility(visibilityObject);\n });\n \n }\n }\n\n @autobind\n setActiveEdgeHandler(setActiveEdge: (edgeId: number) => void){\n this.setActiveEdge = setActiveEdge;\n }\n\n @autobind\n colorSchemeChangeCallback(colorScheme: IColorValueMap) {\n this.colorValueMap = colorScheme;\n }\n\n @autobind\n addGenomicData(cBioAlterationData: ICBioData[]){\n\n this.calculateAlterationData(cBioAlterationData);\n this.editor.removeGenomicData();\n this.editor.addPortalGenomicData(this.alterationData, this.editor.getEmptyGroupID());\n }\n\n @autobind\n emphasizeQueryGenes() {\n this.pathwayActions.emphasizeQueryGenes(this.props.genes.map((gene: any) => gene.hugoGeneSymbol));\n }\n\n render() {\n const isCBioPortal = this.props.isCBioPortal; \n\n const cytoComp = ;\n\n return (\n\n
\n
\n {!isCBioPortal && \n \n
\n \n
\n
\n \n
\n
\n }\n { isCBioPortal &&\n \n \n \n \n {this.props.messageBanner ?\n {this.props.messageBanner()}\n :\n \n }\n \n {this.selectedPathway}\n \n \n }\n \n
\n {\n (!isCBioPortal && \n
\n \n
)\n }\n\n { isCBioPortal ?\n (\n {cytoComp}\n
Powered by PathwayMapper
\n )\n : (cytoComp)\n }\n {\n (isCBioPortal &&\n \n \n )\n }\n
\n\n {/* isCBioPortal &&\n \n Powered by PathwayMapper\n */\n }\n\n { (
\n\n {\n (
\n \n \n \n \n \n \n \n \n \n \n
)\n }\n { !this.props.isCBioPortal &&\n \n \n \n \n }\n \n\n {this.pathwayActions.setUploaders(ref, false);}}\n style={{display: 'none'}}\n onChange={(e) => {this.pathwayActions.onChangeFile(e, false);}}\n />\n {this.pathwayActions.setUploaders(ref, true);}}\n style={{display: 'none'}}\n onChange={(e) => {this.pathwayActions.onChangeFile(e, true);}}\n />\n {this.pathwayActions.setOverlayUploader(ref);}}\n style={{display: 'none'}}\n onChange={(e) => {this.pathwayActions.overlayFromText(e.target.files[0]);}}\n />\n
)\n }\n
\n
\n );\n }\n\n componentDidMount(){\n if(!this.props.isCBioPortal){\n $(\".container\").css('width', \"auto\");\n $(\".container\").css('paddingLeft', 0);\n $(\".container\").css('marginLeft', 5);\n } else {\n this.pathwayActions.emphasizeQueryGenes(this.props.genes.map((gene: any) => gene.hugoGeneSymbol));\n }\n }\n\n componentDidUpdate(){\n if(this.props.isCBioPortal){\n this.pathwayActions.emphasizeQueryGenes(this.props.genes.map((gene: any) => gene.hugoGeneSymbol));\n }\n }\n\n @action.bound\n handleOpen(modalId: EModalType){\n this.isModalShown[modalId] = true;\n }\n\n\n @action.bound\n handleClose(modalId: EModalType){\n this.isModalShown[modalId] = false;\n }\n\n @autobind\n editorHandler(editor, eh, undoRedoManager){\n\n this.setEditor(editor);\n this.gridOptionsManager = new GridOptionsManager(this.editor.cy);\n this.viewOperationsManager = new ViewOperationsManager(this.editor, this.editor.cy);\n this.pathwayActions.editorHandler(editor, eh, undoRedoManager, this.viewOperationsManager, this.gridOptionsManager);\n \n if(this.props.isCBioPortal){\n if(this.props.patientView){\n this.editor.addPortalGenomicData(this.patientData, this.editor.getEmptyGroupID());\n }\n else{\n this.editor.addPortalGenomicData(this.alterationData, this.editor.getEmptyGroupID());\n }\n } else {\n this.portalAccessor = new CBioPortalAccessor();\n this.loadRedirectedPortalData();\n }\n\n }\n\n @autobind\n pathwayHandler(pathway: string){\n this.setSelectedPathway(pathway);\n if(this.pathwayGeneMap[pathway] && this.props.changePathwayHandler)\n this.props.changePathwayHandler(\n Object.keys(this.pathwayGeneMap[pathway])\n .filter(gene => (!this.alterationData[PathwayMapper.CBIO_PROFILE_NAME].hasOwnProperty(gene)))\n );\n }\n}\n\nexport default PathwayMapper;","import React from 'react';\nimport { MenuItem, Nav, Navbar, NavDropdown } from 'react-bootstrap';\nimport pathways from \"../data/pathways.json\";\nimport ConfirmationModal from '../modals/ConfirmationModal';\nimport PathwayActions from '../utils/PathwayActions';\nimport { EModalType } from './react-pathway-mapper';\n\ninterface IMenubarProps{\n pathwayActions: PathwayActions;\n handleOpen: (modalId: EModalType) => void;\n setActiveEdge: Function;\n}\n\n\nexport default class Menubar extends React.Component{\n\n\n constructor(props: IMenubarProps){\n super(props);\n }\n\n render(){\n const nodeTypes = [\"Gene\", \"Family\", \"Complex\", \"Compartment\", \"Process\"];\n const edgeTypes = [\"Activates\", \"Inhibits\", \"Induces\", \"Represses\", \"Binds\"];\n\n const pathwayDropdownData: {[pwHead: string]: string[]} = {};\n for(const pwName of Object.keys(pathways)){\n // If a pathway name ain't include 'pathway' word then it is under pancanatlas.\n const isPancanatlas = !pwName.includes('pathway');\n const dashPos = pwName.indexOf('-');\n const pwHead = (isPancanatlas) ? 'PanCanAtlas' : pwName.substring(0, dashPos);\n if(pwHead in pathwayDropdownData){\n pathwayDropdownData[pwHead].push(pwName);\n } else {\n pathwayDropdownData[pwHead] = [pwName];\n }\n }\n\n return(\n \n \n \n \n );\n }\n}","import { action, makeObservable, observable } from \"mobx\";\nimport { observer } from \"mobx-react\";\nimport React from \"react\";\nimport { Button, Panel } from \"react-bootstrap\";\nimport \"../css/supp.css\";\n// @ts-ignore\nimport acImg from \"../images/edges/activates.svg\";\n// @ts-ignore\nimport bindImg from \"../images/edges/binds.svg\";\n// @ts-ignore\nimport indImg from \"../images/edges/induces.svg\";\n// @ts-ignore\nimport inhImg from \"../images/edges/inhibits.svg\";\n// @ts-ignore\nimport repImg from \"../images/edges/represses.svg\";\nimport PathwayActions from \"../utils/PathwayActions\";\nimport { EModalType } from \"./react-pathway-mapper\";\n\n\n\ninterface ISideBarProps{\n pathwayActions: PathwayActions;\n setActiveEdgeHandler: Function;\n handleOpen: Function;\n}\n\n@observer\nexport default class Sidebar extends React.Component{\n\n @observable\n activeEdge: number = -1;\n\n constructor(props: ISideBarProps){\n super(props);\n makeObservable(this);\n props.setActiveEdgeHandler(this.setActiveEdge);\n }\n\n addEdge(edgeIndex: number){\n if(edgeIndex === this.activeEdge){\n this.setActiveEdge(-1);\n this.props.pathwayActions.addEdge(-1);\n return;\n }\n this.setActiveEdge(edgeIndex);\n this.props.pathwayActions.addEdge(edgeIndex);\n }\n\n @action.bound\n setActiveEdge(edgeIndex: number){\n this.activeEdge = edgeIndex;\n }\n\n render(){\n\n const edgeTypes = [\"Activates\", \"Inhibits\", \"Induces\", \"Represses\", \"Binds\"];\n\n const edgeImgs = [acImg, inhImg, indImg, repImg, bindImg];\n\n const nodeIds = [\"simpleNodeDiv\", \"familyNodeDiv\", \"complexNodeDiv\", \"compartmentNodeDiv\", \"processNodeDiv\"];\n\n return(\n
\n \n \n Network\n \n \n \n
\n \n
\n
\n \n
\n
\n \n
\n
\n
\n\n \n \n Node Palette\n \n \n \n {\n nodeIds.map((id) => {\n return (\n
\n
);\n })\n }\n
\n
\n\n \n \n Interaction Palette\n \n \n
\n {\n edgeTypes.map((edgeType: string, i: number) => {\n return ();\n })\n }\n
\n
\n
\n
\n );\n }\n}"],"sourceRoot":""} \ No newline at end of file diff --git a/packages/pathway-mapper/dist/utils/PathwayActions.d.ts b/packages/pathway-mapper/dist/utils/PathwayActions.d.ts index 84498f66..2aae40f9 100644 --- a/packages/pathway-mapper/dist/utils/PathwayActions.d.ts +++ b/packages/pathway-mapper/dist/utils/PathwayActions.d.ts @@ -64,6 +64,7 @@ export default class PathwayActions { processFile(file: File, isMerge: boolean): void; saveAs(type: string): void; editorHandler(editor: any, eh: any, undoRedoManager: any, viewOperationsManager: ViewOperationsManager, gridOptionsManager: GridOptionsManager): void; + exists(profileId: string): boolean; loadSampleData(): void; performLayout(): void; } diff --git a/packages/pathway-mapper/src/managers/EditorActionsManager.tsx b/packages/pathway-mapper/src/managers/EditorActionsManager.tsx index 2f13c614..cedaa05b 100644 --- a/packages/pathway-mapper/src/managers/EditorActionsManager.tsx +++ b/packages/pathway-mapper/src/managers/EditorActionsManager.tsx @@ -216,8 +216,6 @@ export default class EditorActionsManager{ { args.ele.data('w', args.newWidth); args.ele.data('h', args.newHeight); - args.ele.style('width', args.newWidth); - args.ele.style('height', args.newHeight); return args; }; @@ -226,9 +224,6 @@ export default class EditorActionsManager{ { args.ele.data('w', args.oldWidth); args.ele.data('h', args.oldHeight); - args.ele.style('width', args.oldWidth); - args.ele.style('height', args.oldHeight); - return args; }; @@ -955,9 +950,6 @@ export default class EditorActionsManager{ //his.cy.add(newNode); this.cy.nodes().updateCompoundBounds(); this.undoRedoManager.do("add", newNode); - //Width was not properly updated only by changing data property - var thatEle = this.cy.getElementById(nodeData.id); - thatEle.style('width', thatEle.data('w')); }; shareDBNodeAddRemoveEventCallBack(op: any) @@ -1767,6 +1759,17 @@ export default class EditorActionsManager{ this.shareDBManager.addGenomicData(parsedGenomicData.genomicDataMap); this.shareDBManager.groupGenomicData(Object.keys(parsedGenomicData.visibilityMap), groupID); + + let currentVisibleGenomicDataCount = this.genomicDataOverlayManager.countVisibleGenomicDataByType(); + Object.keys(parsedGenomicData.visibilityMap).forEach(study => { + if (parsedGenomicData.visibilityMap[study] && (currentVisibleGenomicDataCount >= 6)) { + parsedGenomicData.visibilityMap[study] = false; + } + else if(parsedGenomicData.visibilityMap[study]) { + currentVisibleGenomicDataCount++; + } + }); + this.shareDBManager.addGenomicVisibilityData(parsedGenomicData.visibilityMap); } else diff --git a/packages/pathway-mapper/src/managers/GenomicDataOverlayManager.ts b/packages/pathway-mapper/src/managers/GenomicDataOverlayManager.ts index 55d456f8..09245d1a 100644 --- a/packages/pathway-mapper/src/managers/GenomicDataOverlayManager.ts +++ b/packages/pathway-mapper/src/managers/GenomicDataOverlayManager.ts @@ -199,6 +199,11 @@ export default class GenomicDataOverlayManager { }; hideGenomicData = function() { + + this.cy.nodes('[type="GENE"]').forEach(node => { + node.data('w', this.getRequiredWidthForGenomicData(0)); + }) + this.cy .style() .selector('node[type="GENE"]') @@ -528,7 +533,7 @@ export default class GenomicDataOverlayManager { this.cy.nodes('[type="GENE"]').forEach(node => { node.data('w', this.getRequiredWidthForGenomicData(genomicDataBoxCount)); - }) + }); this.cy .style() @@ -568,8 +573,9 @@ export default class GenomicDataOverlayManager { // Parse cancer types for (let i = 1; i < metaLineColumns.length; i++) { cancerTypes.push(metaLineColumns[i]); + const visibleGenomicDataCount = Object.keys(this.visibleGenomicDataMapByType).length; // Update initially visible genomic data boxes ! - if (i - 1 < this.DEFAULT_VISIBLE_GENOMIC_DATA_COUNT) { + if (visibleGenomicDataCount < this.DEFAULT_VISIBLE_GENOMIC_DATA_COUNT) { this.visibleGenomicDataMapByType[cancerTypes[i - 1]] = true; } else { this.visibleGenomicDataMapByType[cancerTypes[i - 1]] = false; diff --git a/packages/pathway-mapper/src/managers/ShareDBManager.tsx b/packages/pathway-mapper/src/managers/ShareDBManager.tsx index 8e237403..003244b0 100644 --- a/packages/pathway-mapper/src/managers/ShareDBManager.tsx +++ b/packages/pathway-mapper/src/managers/ShareDBManager.tsx @@ -53,7 +53,7 @@ export default class ShareDBManager { var genomicDataGroupCount = this.doc.data[this.GENOMIC_DATA_GROUP_COUNT]; //Reset all genomic maps for (const key of Object.keys(genomicMap)) { - ops.push({p: [this.GENOMIC_DATA_GROUP_NAME, key], od: genomicMap[key]}); + ops.push({p: [this.GENOMIC_DATA_MAP_NAME, key], od: genomicMap[key]}); } for (const key of Object.keys(visMap)) { ops.push({p: [this.VISIBLE_GENOMIC_DATA_MAP_NAME, key], od: visMap[key]}); @@ -415,6 +415,7 @@ export default class ShareDBManager { this.editor.genomicDataOverlayManager.showGenomicData(); this.editor.genomicDataOverlayManager.notifyObservers(); + this.editor.cy.style().update(); this.editor.cy.fit(50); }; diff --git a/packages/pathway-mapper/src/ui/CytoscapeArea.tsx b/packages/pathway-mapper/src/ui/CytoscapeArea.tsx index 1ab0ee38..0374d817 100644 --- a/packages/pathway-mapper/src/ui/CytoscapeArea.tsx +++ b/packages/pathway-mapper/src/ui/CytoscapeArea.tsx @@ -485,10 +485,10 @@ export default class CytoscapeArea extends React.Component { //Updates 'data' properties from 'style' diff --git a/packages/pathway-mapper/src/utils/PathwayActions.ts b/packages/pathway-mapper/src/utils/PathwayActions.ts index dc15cdfd..f7c562ab 100644 --- a/packages/pathway-mapper/src/utils/PathwayActions.ts +++ b/packages/pathway-mapper/src/utils/PathwayActions.ts @@ -418,24 +418,45 @@ export default class PathwayActions { this.gridOptionsManager = gridOptionsManager; } + @autobind + exists(profileId: string){ + + let exists = false; + this.profiles.forEach((profile: IProfileMetaData) => { + if(profile.profileId === profileId){ + exists = true; + } + }); + + return exists; + } + @autobind loadSampleData() { const data = - "gene\tlung\tovarian\tbreast\ty\n" + - "PTEN\t-7\t-20\t10\t20\n" + - "NF1\t-12\t-4\t30\t20\n" + - "PIK3CA\t18\t40\t-50\t20\n" + - "KRAS\t11\t-5\t0\t20\n" + - "ZIYA\t0\t-2\t0\t20\n" + - "AKT1\t3\t30\t-10\t20\n" + - "AKT2\t6\t-3\t20\t20\n" + - "AKT3\t6\t-3\t20\t20\n" + + "gene\tlung\tovarian\tbreast\n" + + "PTEN\t-7\t-20\t10\n" + + "NF1\t-12\t-4\t30\n" + + "PIK3CA\t18\t40\t-50\n" + + "KRAS\t11\t-5\t0\n" + + "ZIYA\t0\t-2\t0\n" + + "AKT1\t3\t30\t-10\n" + + "AKT2\t6\t-3\t20\n" + + "AKT3\t6\t-3\t20\n" + "\n"; + + if (this.exists("lung") || this.exists("ovarian") || this.exists("breast")) { + return; + } + this.editor.addGenomicData(data); - this.addProfile({ profileId: "lung", enabled: true }); - this.addProfile({ profileId: "ovarian", enabled: true }); - this.addProfile({ profileId: "breast", enabled: true }); + if (!this.isCollaborative) { + this.addProfile({ profileId: "lung", enabled: this.profiles.length < 6 ? true : false }); + this.addProfile({ profileId: "ovarian", enabled: this.profiles.length < 6 ? true : false }); + this.addProfile({ profileId: "breast", enabled: this.profiles.length < 6 ? true : false }); + } + } @autobind