diff --git a/extensions/ql-vscode/CHANGELOG.md b/extensions/ql-vscode/CHANGELOG.md
index bf5d9e316b9..78615a87792 100644
--- a/extensions/ql-vscode/CHANGELOG.md
+++ b/extensions/ql-vscode/CHANGELOG.md
@@ -2,6 +2,8 @@
 
 ## [UNRELEASED]
 
+- Remove support for CodeQL CLI versions older than 2.18.4. [#3895](https://github.com/github/vscode-codeql/pull/3895)
+
 ## 1.7.0 - 20 December 2024
 
 - Add a palette command that allows importing all databases directly inside of a parent folder. [#3797](https://github.com/github/vscode-codeql/pull/3797)
diff --git a/extensions/ql-vscode/src/codeql-cli/cli.ts b/extensions/ql-vscode/src/codeql-cli/cli.ts
index 7f090eff2ec..a34b6a351ea 100644
--- a/extensions/ql-vscode/src/codeql-cli/cli.ts
+++ b/extensions/ql-vscode/src/codeql-cli/cli.ts
@@ -1904,7 +1904,7 @@ function shouldDebugCliServer() {
 export class CliVersionConstraint {
   // The oldest version of the CLI that we support. This is used to determine
   // whether to show a warning about the CLI being too old on startup.
-  public static OLDEST_SUPPORTED_CLI_VERSION = new SemVer("2.16.6");
+  public static OLDEST_SUPPORTED_CLI_VERSION = new SemVer("2.18.4");
 
   constructor(private readonly cli: CodeQLCliServer) {
     /**/
diff --git a/extensions/ql-vscode/supported_cli_versions.json b/extensions/ql-vscode/supported_cli_versions.json
index a0a72050ac9..97eddf8b5f3 100644
--- a/extensions/ql-vscode/supported_cli_versions.json
+++ b/extensions/ql-vscode/supported_cli_versions.json
@@ -3,7 +3,5 @@
   "v2.19.4",
   "v2.19.3",
   "v2.18.4",
-  "v2.17.6",
-  "v2.16.6",
   "nightly"
 ]