diff --git a/.github/workflows/r-check.yml b/.github/workflows/r-check.yml
index 0b368ca330..1d8c44260d 100644
--- a/.github/workflows/r-check.yml
+++ b/.github/workflows/r-check.yml
@@ -60,7 +60,7 @@ jobs:
 
       - uses: r-lib/actions/setup-r-dependencies@v2
         with:
-          extra-packages: any::rcmdcheck, local::../adbcdrivermanager
+          extra-packages: any::rcmdcheck, local::../adbcdrivermanager, r-dbi/adbi
           needs: check
           working-directory: r/${{ inputs.pkg }}
 
diff --git a/r/adbcsqlite/DESCRIPTION b/r/adbcsqlite/DESCRIPTION
index 27b957b599..0218eaf80b 100644
--- a/r/adbcsqlite/DESCRIPTION
+++ b/r/adbcsqlite/DESCRIPTION
@@ -19,7 +19,10 @@ RoxygenNote: 7.2.3
 SystemRequirements: SQLite3
 Suggests:
     nanoarrow,
+    adbi,
+    DBItest,
     testthat (>= 3.0.0)
+Config/needs/check: bit64
 Config/testthat/edition: 3
 Config/build/bootstrap: TRUE
 URL: https://github.com/apache/arrow-adbc, https://arrow.apache.org/adbc/current/r/adbcsqlite/
diff --git a/r/adbcsqlite/tests/testthat/test-DBItest.R b/r/adbcsqlite/tests/testthat/test-DBItest.R
new file mode 100644
index 0000000000..e24a68e73a
--- /dev/null
+++ b/r/adbcsqlite/tests/testthat/test-DBItest.R
@@ -0,0 +1,107 @@
+# Licensed to the Apache Software Foundation (ASF) under one
+# or more contributor license agreements.  See the NOTICE file
+# distributed with this work for additional information
+# regarding copyright ownership.  The ASF licenses this file
+# to you under the Apache License, Version 2.0 (the
+# "License"); you may not use this file except in compliance
+# with the License.  You may obtain a copy of the License at
+#
+#   http://www.apache.org/licenses/LICENSE-2.0
+#
+# Unless required by applicable law or agreed to in writing,
+# software distributed under the License is distributed on an
+# "AS IS" BASIS, WITHOUT WARRANTIES OR CONDITIONS OF ANY
+# KIND, either express or implied.  See the License for the
+# specific language governing permissions and limitations
+# under the License.
+
+if (identical(Sys.getenv("NOT_CRAN"), "true") &&
+    packageVersion("DBItest") >= "1.7.2") {
+  DBItest::make_context(
+    adbi::adbi("adbcsqlite"),
+    list(
+      uri = tempfile("DBItest", fileext = ".sqlite"),
+      rows_affected_callback = function() function(x) {
+        if (x == -1) testthat::skip("unknown number of `rows_affected`") else x
+      }
+    ),
+    tweaks = suppressWarnings(
+      DBItest::tweaks(
+        dbitest_version = "1.7.2",
+        constructor_relax_args = TRUE,
+        placeholder_pattern = c("?", "$1", "$name", ":name"),
+        date_cast = function(x) paste0("'", x, "'"),
+        time_cast = function(x) paste0("'", x, "'"),
+        timestamp_cast = function(x) paste0("'", x, "'"),
+        logical_return = function(x) as.integer(x),
+        date_typed = FALSE,
+        time_typed = FALSE,
+        timestamp_typed = FALSE,
+        temporary_tables = FALSE, # apache/arrow-adbc#1141
+        strict_identifier = TRUE
+      )
+    ),
+    name = "adbcsqlite"
+  )
+
+  DBItest::test_all(
+    skip = c(
+
+      "package_name",
+
+      # options(adbi.allow_multiple_results = FALSE)
+      "send_query_only_one_result_set",
+      "send_statement_only_one_result_set",
+      "arrow_send_query_only_one_result_set",
+
+      # options(adbi.force_close_results = TRUE)
+      "send_query_stale_warning",
+      "send_statement_stale_warning",
+      "arrow_send_query_stale_warning",
+
+      # int/int64 https://github.com/r-dbi/DBItest/issues/311
+      "data_64_bit_numeric",
+      "data_64_bit_numeric_warning",
+      "data_64_bit_lossless",
+      "arrow_read_table_arrow",
+
+      # `field.types` https://github.com/r-dbi/adbi/issues/14
+      "append_roundtrip_64_bit_roundtrip",
+      "roundtrip_64_bit_numeric",
+      "roundtrip_64_bit_character",
+      "roundtrip_64_bit_roundtrip",
+      "roundtrip_field_types",
+
+      # bind zero length https://github.com/apache/arrow-adbc/issues/1365
+      "bind_multi_row_zero_length",
+      "arrow_bind_multi_row_zero_length",
+      "arrow_stream_bind_multi_row_zero_length",
+      "stream_bind_multi_row_zero_length",
+
+      # misc issues with well understood causes
+      "connect_bigint_character", # apache/arrow-nanoarrow#324
+      "data_logical", # r-dbi/DBItest#308
+      "create_table_visible_in_other_connection", # r-dbi/DBItest#297
+      "quote_identifier_string", # apache/arrow-adbc#1395
+      "read_table_empty", # apache/arrow-adbc#1400
+      "list_objects_features", # r-dbi/DBItest#339
+
+      # misc issues with poorly understood causes
+      "append_table_new",
+      "begin_write_commit",
+
+      # cause segfaults
+      "begin_write_disconnect",
+
+      if (getRversion() < "4.0") {
+        c(
+          "column_info",
+          "column_info_consistent_keywords",
+          "column_info_consistent_unnamed",
+          "column_info_consistent",
+          "column_info_row_names"
+        )
+      }
+    )
+  )
+}