diff --git a/Doxyfile b/Doxyfile
index 9ef485e5..cd12656f 100644
--- a/Doxyfile
+++ b/Doxyfile
@@ -2456,8 +2456,7 @@ INCLUDE_FILE_PATTERNS  =
 # recursively expanded use the := operator instead of the = operator.
 # This tag requires that the tag ENABLE_PREPROCESSING is set to YES.
 
-PREDEFINED             = USE_CALCEPH=1 \
-                         USE_CSPICE=1
+PREDEFINED             =
 
 # If the MACRO_EXPANSION and EXPAND_ONLY_PREDEF tags are set to YES then this
 # tag can be used to specify a list of macro names that should be expanded. The