diff --git a/src/rez_pip/data/patches/pyside6_6_0_0_win_dll_path.patch b/src/rez_pip/data/patches/pyside6_6_0_0_win_dll_path.patch
new file mode 100644
index 0000000..cb60541
--- /dev/null
+++ b/src/rez_pip/data/patches/pyside6_6_0_0_win_dll_path.patch
@@ -0,0 +1,20 @@
+--- python/PySide6/__init__.py	2025-01-11 15:01:54.266726602 -0500
++++ python/PySide6/__init__.py	2025-01-11 15:06:19.646365323 -0500
+@@ -10,14 +10,9 @@
+ 
+ 
+ def _additional_dll_directories(package_dir):
+-    # Find shiboken6 relative to the package directory.
+-    root = os.path.dirname(package_dir)
+-    # Check for a flat .zip as deployed by cx_free(PYSIDE-1257)
+-    if root.endswith('.zip'):
+-        return []
+-    shiboken6 = os.path.join(root, 'shiboken6')
+-    if os.path.isdir(shiboken6): # Standard case, only shiboken6 is needed
+-        return [shiboken6]
++    # rez-pip patch: Return the path to the shiboken rez package
++    return [os.path.join(os.environ["REZ_SHIBOKEN6_ROOT"], "python", "shiboken6")]
++
+     # The below code is for the build process when generate_pyi.py
+     # is executed in the build directory. We need libpyside and Qt in addition.
+     shiboken6 = os.path.join(os.path.dirname(root), 'shiboken6', 'libshiboken')
diff --git a/src/rez_pip/data/patches/pyside6_6_1_0_win_dll_path.patch b/src/rez_pip/data/patches/pyside6_6_1_0_win_dll_path.patch
new file mode 100644
index 0000000..6c9cce8
--- /dev/null
+++ b/src/rez_pip/data/patches/pyside6_6_1_0_win_dll_path.patch
@@ -0,0 +1,20 @@
+--- python/PySide6/__init__.py	2025-01-11 14:43:26.190668073 -0500
++++ python/PySide6/__init__.py	2025-01-11 15:09:43.741718533 -0500
+@@ -11,14 +11,9 @@
+ 
+ 
+ def _additional_dll_directories(package_dir):
+-    # Find shiboken6 relative to the package directory.
+-    root = Path(package_dir).parent
+-    # Check for a flat .zip as deployed by cx_free(PYSIDE-1257)
+-    if root.suffix == '.zip':
+-        return []
+-    shiboken6 = root / 'shiboken6'
+-    if shiboken6.is_dir(): # Standard case, only shiboken6 is needed
+-        return [shiboken6]
++    # rez-pip patch: Return the path to the shiboken rez package
++    return [os.path.join(os.environ["REZ_SHIBOKEN6_ROOT"], "python", "shiboken6")]
++
+     # The below code is for the build process when generate_pyi.py
+     # is executed in the build directory. We need libpyside and Qt in addition.
+     shiboken6 = Path(root).parent / 'shiboken6' / 'libshiboken'
diff --git a/src/rez_pip/data/patches/pyside6_6_2_4_win_dll_path.patch b/src/rez_pip/data/patches/pyside6_6_2_4_win_dll_path.patch
new file mode 100644
index 0000000..9fac2e2
--- /dev/null
+++ b/src/rez_pip/data/patches/pyside6_6_2_4_win_dll_path.patch
@@ -0,0 +1,20 @@
+--- python/PySide6/__init__.py	2025-01-11 14:43:29.390687962 -0500
++++ python/PySide6/__init__.py	2025-01-11 15:11:41.569480197 -0500
+@@ -11,14 +11,9 @@
+ 
+ 
+ def _additional_dll_directories(package_dir):
+-    # Find shiboken6 relative to the package directory.
+-    root = Path(package_dir).parent
+-    # Check for a flat .zip as deployed by cx_free(PYSIDE-1257)
+-    if root.suffix == '.zip':
+-        return []
+-    shiboken6 = root / 'shiboken6'
+-    if shiboken6.is_dir(): # Standard case, only shiboken6 is needed
+-        return [shiboken6]
++    # rez-pip patch: Return the path to the shiboken rez package
++    return [os.path.join(os.environ["REZ_SHIBOKEN6_ROOT"], "python", "shiboken6")]
++
+     # The below code is for the build process when generate_pyi.py
+     # is executed in the build directory. We need libpyside and Qt in addition.
+     shiboken6 = Path(root).parent / 'shiboken6' / 'libshiboken'
diff --git a/src/rez_pip/data/patches/pyside6_6_3_0_win_dll_path.patch b/src/rez_pip/data/patches/pyside6_6_3_0_win_dll_path.patch
new file mode 100644
index 0000000..4744f3c
--- /dev/null
+++ b/src/rez_pip/data/patches/pyside6_6_3_0_win_dll_path.patch
@@ -0,0 +1,20 @@
+--- python/PySide6/__init__.py	2025-01-11 14:43:29.554022310 -0500
++++ python/PySide6/__init__.py	2025-01-11 15:13:40.307210955 -0500
+@@ -12,14 +12,9 @@
+ 
+ 
+ def _additional_dll_directories(package_dir):
+-    # Find shiboken6 relative to the package directory.
+-    root = Path(package_dir).parent
+-    # Check for a flat .zip as deployed by cx_free(PYSIDE-1257)
+-    if root.suffix == '.zip':
+-        return []
+-    shiboken6 = root / 'shiboken6'
+-    if shiboken6.is_dir(): # Standard case, only shiboken6 is needed
+-        return [shiboken6]
++    # rez-pip patch: Return the path to the shiboken rez package
++    return [os.path.join(os.environ["REZ_SHIBOKEN6_ROOT"], "python", "shiboken6")]
++
+     # The below code is for the build process when generate_pyi.py
+     # is executed in the build directory. We need libpyside and Qt in addition.
+     shiboken6 = Path(root).parent / 'shiboken6' / 'libshiboken'
diff --git a/src/rez_pip/plugins/PySide6.py b/src/rez_pip/plugins/PySide6.py
index d56cb04..ac76ffe 100644
--- a/src/rez_pip/plugins/PySide6.py
+++ b/src/rez_pip/plugins/PySide6.py
@@ -7,6 +7,7 @@
 import shutil
 import typing
 import logging
+import platform
 
 import packaging.utils
 import packaging.version
@@ -14,6 +15,7 @@
 import packaging.requirements
 
 import rez_pip.pip
+import rez_pip.patch
 import rez_pip.plugins
 import rez_pip.exceptions
 
@@ -99,6 +101,56 @@ def groupPackages(
     return [rez_pip.pip.PackageGroup[rez_pip.pip.PackageInfo](tuple(data))]
 
 
+@rez_pip.plugins.hookimpl
+def patches(dist: "importlib_metadata.Distribution", path: str) -> typing.List[str]:
+    if dist.name != "PySide6" or platform.system() != "Windows":
+        return []
+
+    patches: typing.List[str] = []
+
+    # To generate the patches:
+    # 1. run srcipts/get_pyside6_files.py
+    # 2. Look at the output and get the different diffs.
+    # 3. Generate a patch for each version range where there is a diff:
+    # 3.1 cp patches/data/6.3.0/__init__.py patches/data/6.3.0/__init__.py.new
+    # 3.2 vim patches/data/6.3.0/__init__.py.new
+    # 3.3 diff --unified patches/data/6.3.0/__init__.py patches/data/6.3.0/__init__.py.new > src/rez_pip/data/patches/pyside6_6_3_0_win_dll_path.patch
+    # 3.4 Edit src/rez_pip/data/patches/pyside6_6_3_0_win_dll_path.patch to make sure the paths
+    #     are good in the patch header. Also make sure CRLF (line ending) is kept as-is.
+    #
+    # I think that it's important that the paths in the look like "python/PySide6/..."
+    # so that it matches the file layout...
+    version = packaging.version.Version(dist.version)
+    if version in packaging.specifiers.SpecifierSet(">=6.0.0,<6.1.0"):
+        patches.append(
+            os.path.join(
+                rez_pip.patch.getBuiltinPatchesDir(), "pyside6_6_0_0_win_dll_path.patch"
+            )
+        )
+
+    elif version in packaging.specifiers.SpecifierSet(">=6.1.0,<6.2.4"):
+        patches.append(
+            os.path.join(
+                rez_pip.patch.getBuiltinPatchesDir(), "pyside6_6_1_0_win_dll_path.patch"
+            )
+        )
+
+    elif version in packaging.specifiers.SpecifierSet(">=6.2.4,<6.3.0"):
+        patches.append(
+            os.path.join(
+                rez_pip.patch.getBuiltinPatchesDir(), "pyside6_6_2_4_win_dll_path.patch"
+            )
+        )
+
+    elif version in packaging.specifiers.SpecifierSet(">=6.3.0"):
+        patches.append(
+            os.path.join(
+                rez_pip.patch.getBuiltinPatchesDir(), "pyside6_6_3_0_win_dll_path.patch"
+            )
+        )
+    return patches
+
+
 @rez_pip.plugins.hookimpl
 def cleanup(dist: "importlib_metadata.Distribution", path: str) -> None:
     if packaging.utils.canonicalize_name(dist.name) not in [